A brief review: The implications of iron supplementation for marathon runners on health and performance

Journal of Strength and Conditioning Research

Volumn 29, Issue 2, 2015, Pages 559-565

  Zourdos, Michael C ^a   Sanchez Gonzalez, Marcos A ^b,c   Mahoney, Sara E ^d  

^a FLORIDA ATLANTIC UNIVERSITY   (United States)

^b Department of Biomedical Sciences Larking Health Sciences Institute   (United States)

^c Larkin Community Hospital   (United States)

^d BELLARMINE UNIVERSITY   (United States)

Author keywords

Iron supplementation; Marathon; Running performance

Indexed keywords

IRON; IRON INTAKE;

ADMINISTRATION AND DOSAGE; ATHLETIC PERFORMANCE; BLOOD; DIET SUPPLEMENTATION; HOMEOSTASIS; HUMAN; IRON INTAKE; PHYSIOLOGY; RUNNING;

ATHLETIC PERFORMANCE; DIETARY SUPPLEMENTS; HOMEOSTASIS; HUMANS; IRON; IRON, DIETARY; RUNNING;

EID: 84925940313     PISSN: 10648011     EISSN: 15334295     Source Type: Journal    
DOI: 10.1519/JSC.0000000000000636     Document Type: Article

References (71)

1. Andrews, NC. Disorders of iron metabolism. N Engl J Med 341:1986-1995, 1999.
2. Atanasova, BD, Li, AC, Bjarnason, I, Tzatchev, KN, and Simpson, RJ. Duodenal ascorbate and ferric reductase in human iron deficiency. Am J Clin Nutr 81:130-133, 2005.
3. Ballard, RE, Watenpaugh, DE, Breit, GA, Murthy, G, Holley, DC, and Hargens, AR. Leg intramuscular pressures during locomotion in humans. J Appl Physiol (1985) 84:1976-1981, 1998.
4. Beard, J and Tobin, B. Iron status and exercise. Am J Clin Nutr 72:594S-597S, 2000.
5. Beard, JL, Dawson, H, and Pinero, DJ. Iron metabolism: A comprehensive review. Nutr Rev 54:295-317, 1996.
6. Beshgetoor, D, Nichols, JF, and Rego, I. Effect of training mode and calcium intake on bone mineral density in female master cyclist, runners, and non-athletes. Int J Sport Nutr Exerc Metab 10:290-301, 2000.
7. Briviba, K, Watzl, B, Nickel, K, Kulling, S, Bos, K, Haertel, S, Rechkemmer, G, and Bub, A. A half-marathon and a marathon run induce oxidative DNA damage, reduce antioxidant capacity to protect DNA against damage and modify immune function in hobby runners. Redox Rep 10:325-331, 2005.
8. Brownlie, T IV, Utermohlen, V, Hinton, PS, and Haas, JD. Tissue iron deficiency without anemia impairs adaptation in endurance capacity after aerobic training in previously untrained women. Am J Clin Nutr 79:437-443, 2004.
9. Brutsaert, TD, Hernandez-Cordero, S, Rivera, J, Viola, T, Hughes, G, and Haas, JD. Iron supplementation improves progressive fatigue resistance during dynamic knee extensor exercise in iron-depleted, nonanemic women. The American Journal of Clinical Nutrition 77:441-448, 2003.
10. Buchman, AL, Keen, C, Commisso, J, Killip, D, Ou, CN, Rognerud, CL, Dennis, K, and Dunn, JK. The effect of a marathon run on plasma and urine mineral and metal concentrations. J Am Coll Nutr 17:124-127, 1998.
11. Burke, LM, Millet, G, and Tarnopolsky, MA; International Association of Athletics Federations. Nutrition for distance events. J Sports Sci 25(Suppl 1):S29-S38, 2007.
12. Busbridge, M, Griffiths, C, Ashby, D, Gale, D, Jayantha, A, Sanwaiya, A, and Chapman, RS. Development of a novel immunoassay for the iron regulatory peptide hepcidin. Br J Biomed Sci 66:150-157, 2009.
13. Castillo, MC, Lapieza, MG, Leon, F, and Nuviala, RJ. Iron intake and pharmacologic supplements in medium and long-distance runners. Sangre (Barc) 41:195-200, 1996.
14. Chi, KJ and Schmitt, D. Mechanical energy and effective foot mass during impact loading of walking and running. J Biomech 38:1387-1395, 2005.
15. Dang, CV. Runner's anemia. JAMA 286:714-716, 2001.
16. Davidson, RJ. Exertional haemoglobinuria: A report on three cases with studies on the haemolytic mechanism. J Clin Pathol 17:536-540, 1964.
17. Del Vecchio, L. Anemia: Guidelines comparison [in Italian]. G Ital Nefrol 26:686-694, 2009.
18. Dressendorfer, RH, Keen, CL, Wade, CE, Claybaugh, JR, and Timmis, GC. Development of runner's anemia during a 20-day road race: Effect of iron supplements. Int J Sports Med 12:332-336, 1991.
19. Duca, L, Da Ponte, A, Cozzi, M, Carbone, A, Pomati, M, Nava, I, Cappellini, MD, and Fiorelli, G. Changes in erythropoiesis, iron metabolism and oxidative stress after half-marathon. Intern Emerg Med 1:30-34, 2006.
20. Endres, HG, Wedding, U, Pittrow, D, Thiem, U, Trampisch, HJ, and Diehm, C. Prevalence of anemia in elderly patients in primary care: Impact on 5-year mortality risk and differences between men and women. Curr Med Res Opin 25:1143-1158, 2009.
21. Fuqua, BK, Vulpe, CD, and Anderson, GJ. Intestinal iron absorption. J Trace Elem Med Biol 26:115-119, 2012.
22. Gardner, GW, Edgerton, VR, Barnard, RJ, and Bernauer, EM. Cardiorespiratory, hematological and physical performance responses of anemic subjects to iron treatment. Am J Clin Nutr 28:982-988, 1975.
23. Garvican, LA, Saunders, PU, Cardoso, T, Macdougall, IC, Lobigs, LM, Fazakerley, R, Fallon, KE, Anderson, B, Anson, JM, Thompson, KG, and Gore, CJ. Intravenous iron supplementation in distance runners with low or suboptimal ferritin. Medicine and Science in Sports and Exercise 46:376-385, 2014.
24. Gilligan, DR, Altschule, MD, and Katersky, EM. Physiological intravascular hemolysis of exercise. hemoglobinemia and hemoglobinuria following cross-country runs. J Clin Invest 22:859-869, 1943.
25. Guyton, AC and Hall, JE. Textbook of Medical Physiology. Philadelphia, PA: W. B. Saunders Company, 1996.
26. Hershko, C, Graham, G, Bates, GW, and Rachmilewitz, EA. Nonspecific serum iron in thalassaemia: An abnormal serum iron fraction of potential toxicity. Br J Haematol 40:255-263, 1978.
27. Hinton, PS, Giordano, C, Brownlie, T, and Haas, JD. Iron supplementation improves endurance after training in iron-depleted, nonanemic women. J Appl Physiol (1985) 88:1103-1111, 2000.
28. Hinton, PS and Sinclair, LM. Iron supplementation maintains ventilatory threshold and improves energetic efficiency in irondeficient nonanemic athletes. Eur J Clin Nutr 61:30-39, 2007.
29. Hunt, JR. High-, but not low-bioavailability diets enable substantial control of women's iron absorption in relation to body iron stores, with minimal adaptation within several weeks. Am J Clin Nutr 78:1168-1177, 2003.
30. Jordan, J, Kiernan, W, Merker, HJ, Wenzel, M, and Beneke, R. Red cell membrane skeletal changes in marathon runners. Int J Sports Med 19:16-19, 1998.
31. Klingshirn, LA, Pate, RR, Bourque, SP, Davis, JM, and Sargent, RG. Effect of iron supplementation on endurance capacity in irondepleted female runners. Medicine and Science in Sports and Exercise 24:819-824, 1992.
32. La Manca, JJ and Haymes, EM. Effects of iron repletion on VO2max, endurance, and blood lactate in women. Med Sci Sports Exerc 25:1386-1392, 1993.
33. Lampe, JW, Slavin, JL, and Apple, FS. Iron status of active women and the effect of running a marathon on bowel function and gastrointestinal blood loss. Int J Sports Med 12:173-179, 1991.
34. Lyle, RM, Weaver, CM, Sedlock, DA, Rajaram, S, Martin, B, and Melby, CL. Iron status in exercising women: The effect of oral iron therapy vs. increased consumption of muscle foods. Am J Clin Nutr 56:1049-1055, 1992.
35. Matter, M, Stittfall, T, Graves, J, Myburgh, K, Adams, B, Jacobs, P, and Noakes, TD. The effect of iron and folate therapy on maximal exercise performance in female marathon runners with iron and folate deficiency. Clinical Science 72:415-422, 1987.
36. Montain, SJ, Cheuvront, SN, and Lukaski, HC. Sweat mineralelement responses during 7 h of exercise-heat stress. Int J Sport Nutr Exerc Metab 17:574-582, 2007.
37. Munoz, C, Rios, E, Olivos, J, Brunser, O, and Olivares, M. Iron, copper and immunocompetence. Br J Nutr 98(Suppl 1):S24-S28, 2007.
38. Muñoz Gómez, M, Campos Garríguez, A, García Erce, JA, and Ramírez Ramírez, G. Fisiopathology of iron metabolism: Diagnostic and therapeutic implications [in Spanish]. Nefrología 25:9-19, 2005.
39. Newhouse, IJ, Clement, DB, Taunton, JE, and McKenzie, DC. The effects of prelatent/latent iron deficiency on physical work capacity. Med Sci Sports Exerc 21:263-268, 1989.
40. Nishiyama, S, Inomoto, T, Nakamura, T, Higashi, A, and Matsuda, I. Zinc status relates to hematological deficits in women endurance runners. J Am Coll Nutr 15:359-363, 1996.
41. Ostojic, SM and Ahmetovic, Z. Weekly training volume and hematological status in female top-level athletes of different sports. J Sports Med Phys Fitness 48:398-403, 2008.
42. Pasricha, SR, Low, M, Thompson, J, Farrell, A, and De-Regil, LM. Iron supplementation benefits physical performance in women of reproductive age: A systematic review and meta-analysis. J Nutr 144:906-914, 2014.
43. Pasricha, SR, McQuilten, Z, Westerman, M, Keller, A, Nemeth, E, Ganz, T, and Wood, E. Serum hepcidin as a diagnostic test of iron deficiency in premenopausal female blood donors. Haematologica 96:1099-1105, 2011.
44. Peeling, P, Blee, T, Goodman, C, Dawson, B, Claydon, G, Beilby, J, and Prins, A. Effect of iron injections on aerobic-exercise performance of iron-depleted female athletes. Int J Sport Nutr Exerc Metab 17:221-231, 2007.
45. Peeling, P, Dawson, B, Goodman, C, Landers, G, Wiegerinck, ET, Swinkels, DW, and Trinder, D. Cumulative effects of consecutive running sessions on hemolysis, inflammation and hepcidin activity. Eur J Appl Physiol 106:51-59, 2009.
46. Peeling, P, Dawson, B, Goodman, C, Landers, G, Wiegerinck, ET, Swinkels, DW, and Trinder, D. Training surface and intensity: Inflammation, hemolysis, and hepcidin expression. Med Sci Sports Exerc 41:1138-1145, 2009.
47. Péneau, S, Dauchet, L, Vergnaud, AC, Estaquio, C, Kesse-Guyot, E, Bertrais, S, Latino-Martel, P, Hercberg, S, and Galan, P. Relationship between iron status and dietary fruit and vegetables based on their vitamin C and fiber content. Am J Clin Nutr 87:1298-1305, 2008.
48. Pizza, FX, Flynn, MG, Boone, JB, Rodriguez-Zayas, JR, and Andres, FF. Serum haptoglobin and ferritin during a competitive running and swimming season. Int J Sports Med 18:233-237, 1997.
49. Powell, PD and Tucker, A. Iron supplementation and running performance in female cross-country runners. Int J Sports Med 12:462-467, 1991.
50. Reid, SA, Speedy, DB, Thompson, JM, Noakes, TD, Mulligan, G, Page, T, Campbell, RG, and Milne, C. Study of hematological and biochemical parameters in runners completing a standard marathon. Clin J Sport Med 14:344-353, 2004.
51. Robertson, JD, Maughan, RJ, and Davidson, RJ. Faecal blood loss in response to exercise. Br Med J (Clin Res Ed) 295:303-305, 1987.
52. Robinson, Y, Cristancho, E, and Boning, D. Intravascular hemolysis and mean red blood cell age in athletes. Med Sci Sports Exerc 38:480-483, 2006.
53. Rodriguez, NR, Di Marco, NM, and Langley, S. American college of sports medicine position stand nutrition and athletic performance. Med Sci Sports Exerc 41:709-731, 2009.
54. Rodriguez, NR, Di Marco, NM, and Langley, S; American Dietetic Association, Dietitians of Canada, and the American College of Sports Medicine Nutrition, and Athletic Performance. Position of the American Dietetic Association, Dietitians of Canada, and the American College of Sports Medicine: Nutrition and Athletic performance. J Am Diet Assoc 109:509-527, 2009.
55. Roecker, L, Meier-Buttermilch, R, Brechtel, L, Nemeth, E, and Ganz, T. Iron-regulatory protein hepcidin is increased in female athletes after a marathon. Eur J Appl Physiol 95:569-571, 2005.
56. Rowland, TW, Deisroth, MB, Green, GM, and Kelleher, JF. The effect of iron therapy on the exercise capacity of nonanemic irondeficient adolescent runners. American Journal of Diseases of Children 142:165-169, 1988.
57. Salonen, JT, Nyyssonen, K, Korpela, H, Tuomilehto, J, Seppanen, R, and Salonen, R. High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men. Circulation 86:803-811, 1992.
58. Schmid, A, Jakob, E, Berg, A, Russmann, T, Konig, D, Irmer, M, and Keul, J. Effect of physical exercise and vitamin C on absorption of ferric sodium citrate. Med Sci Sports Exerc 28:1470-1473, 1996.
59. Schoene, RB, Escourrou, P, Robertson, HT, Nilson, KL, Parsons, JR, and Smith, NJ. Iron repletion decreases maximal exercise lactate concentrations in female athletes with minimal iron-deficiency anemia. J Lab Clin Med 102:306-312, 1983.
60. Schroder, S, Fischer, A, Vock, C, Bohme, M, Schmelzer, C, Dopner, M, Hulsmann, O, and Doring, F. Nutrition concepts for elite distance runners based on macronutrient and energy expenditure. J Athl Train 43:489-504, 2008.
61. Schumacher, YO, Schmid, A, Konig, D, and Berg, A. Effects of exercise on soluble transferrin receptor and other variables of the iron status. Br J Sports Med 36:195-199, 2002.
62. Simpson, RJ, Florida-James, GD, Whyte, GP, Middleton, N, Shave, R, George, K, and Guy, K. The effects of marathon running on expression of the complement regulatory proteins CD55 (DAF) and CD59 (MACIF) on red blood cells. Eur J Appl Physiol 99:201-204, 2007.
63. Sinclair, LM and Hinton, PS. Prevalence of iron deficiency with and without anemia in recreationally active men and women. J Am Diet Assoc 105:975-978, 2005.
64. Stevens, RG, Jones, DY, Micozzi, MS, and Taylor, PR. Body iron stores and the risk of cancer. N Engl J Med 319:1047-1052, 1988.
65. Swanson, CA. Iron intake and regulation: Implications for iron deficiency and iron overload. Alcohol 30:99-102, 2003.
66. Tomten, SE and Hostmark, AT. Serum vitamin E concentration and osmotic fragility in female long-distance runners. J Sports Sci 27:69-76, 2009.
67. Vellar, OD. Studies on sweat losses of nutrients. I. Iron content of whole body sweat and its association with other sweat constituents, serum iron levels, hematological indices, body surface area, and sweat rate. Scand J Clin Lab Inves 21:157-167, 1968.
68. Weight, LM, Byrne, MJ, and Jacobs, P. Haemolytic effects of exercise. Clin Sci (Lond) 81:147-152, 1991.
69. Wu, HJ, Chen, KT, Shee, BW, Chang, HC, Huang, YJ, and Yang, RS. Effects of 24 h ultra-marathon on biochemical and hematological parameters. World J Gastroenterol 10:2711-2714, 2004.
70. Yokoi, K. Numerical methods for estimating iron requirements from population data. Biol Trace Elem Res 95:155-172, 2003.
71. Yusof, A, Leithauser, RM, Roth, HJ, Finkernagel, H, Wilson, MT, and Beneke, R. Exercise-induced hemolysis is caused by protein modification and most evident during the early phase of an ultraendurance race. J Applied Physiol 102:582-586, 2007.