-
1
-
-
18744399001
-
Nosocomial tracheobronchitis in mechanically ventilated patients: Incidence, aetiology and outcome
-
Nseir S, Di Pompeo C, Pronnier P, et al. Nosocomial tracheobronchitis in mechanically ventilated patients: incidence, aetiology and outcome. Eur Respir J 2002;20:1483-1489.
-
(2002)
Eur Respir J
, vol.20
, pp. 1483-1489
-
-
Nseir, S.1
Di Pompeo, C.2
Pronnier, P.3
-
2
-
-
44449112637
-
Antimicrobial treatment for ventilatorassociated tracheobronchitis: A randomized, controlled, multicenter study
-
Nseir S, Favory R, Jozefowicz E, et al. Antimicrobial treatment for ventilatorassociated tracheobronchitis: a randomized, controlled, multicenter study. Crit Care 2008;12:R62.
-
(2008)
Crit Care
, vol.12
, pp. R62
-
-
Nseir, S.1
Favory, R.2
Jozefowicz, E.3
-
3
-
-
47249146963
-
Aerosolized antibiotics and ventilator-associated tracheobronchitis in the intensive care unit
-
Palmer LB, Smaldone GC, Chen JJ, et al. Aerosolized antibiotics and ventilator-associated tracheobronchitis in the intensive care unit. Crit Care Med 2008;36:2008-2013.
-
(2008)
Crit Care Med
, vol.36
, pp. 2008-2013
-
-
Palmer, L.B.1
Smaldone, G.C.2
Chen, J.J.3
-
4
-
-
76449116530
-
Frequency, prevention, outcome and treatment of ventilator-associated tracheobronchitis: Systematic review and meta-analysis
-
Agrafiotis M, Siempos II, Falagas ME. Frequency, prevention, outcome and treatment of ventilator-associated tracheobronchitis: systematic review and meta-analysis. Respir Med 2010;104:325-336.
-
(2010)
Respir Med
, vol.104
, pp. 325-336
-
-
Agrafiotis, M.1
Siempos, I.I.2
Falagas, M.E.3
-
5
-
-
84874938115
-
Diagnosis of ventilator-associated pneumonia: Controversies and working toward a gold standard
-
Grgurich PE, Hudcova J, Lei Y, et al. Diagnosis of ventilator-associated pneumonia: controversies and working toward a gold standard. Curr Opin Infect Dis 2013;26:140-150.
-
(2013)
Curr Opin Infect Dis
, vol.26
, pp. 140-150
-
-
Grgurich, P.E.1
Hudcova, J.2
Lei, Y.3
-
6
-
-
13644269309
-
Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated, pneumonia
-
2005
-
American Thoracic Society Infectious Diseases Society of America. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated, pneumonia. Am J Respir Crit Care Med 2005;171:388-416; 2005.
-
(2005)
Am J Respir Crit Care Med
, vol.171
, pp. 388-416
-
-
American Thoracic Society Infectious Diseases Society of America1
-
8
-
-
77955499601
-
One-year trajectories of care and resource utilization for recipients of prolonged mechanical ventilation: A cohort study
-
Unroe M, Kahn JM, Carson SS, et al. One-year trajectories of care and resource utilization for recipients of prolonged mechanical ventilation: a cohort study. Ann Intern Med 2010;153:167-175.
-
(2010)
Ann Intern Med
, vol.153
, pp. 167-175
-
-
Unroe, M.1
Kahn, J.M.2
Carson, S.S.3
-
10
-
-
79953304702
-
Diagnostics and epidemiology in ventilator-associated pneumonia
-
Shorr AF, Chan CM, Zilberberg MD. Diagnostics and epidemiology in ventilator-associated pneumonia. Ther Adv Respir Dis 2011;5:121-130.
-
(2011)
Ther Adv Respir Dis
, vol.5
, pp. 121-130
-
-
Shorr, A.F.1
Chan, C.M.2
Zilberberg, M.D.3
-
11
-
-
84878019270
-
Incidence and outcomes of ventilatorassociated tracheobronchitis and pneumonia
-
Craven DE, Lei Y, Ruthazer R, et al. Incidence and outcomes of ventilatorassociated tracheobronchitis and pneumonia. Am J Med 2013;126:542-549. This natural study reported a VAT rate of 21 patients (11%) of a mixed medical and surgical population ventilated more than 48 h, of which six (29%) progressed from the VAT to VAP. MDR pathogens were isolated from 39% of the VAP patents. VAT was associated with significant increase in ventilator days and length of stay in the ICU (P<0.02).
-
(2013)
Am J Med
, vol.126
, pp. 542-549
-
-
Craven, D.E.1
Lei, Y.2
Ruthazer, R.3
-
12
-
-
0029865045
-
Nosocomial pneumonia in mechanically ventilated adult patients: Epidemiology and prevention in 1996
-
Craven DE, Steger KA. Nosocomial pneumonia in mechanically ventilated adult patients: epidemiology and prevention in 1996. Semin Respir Infect 1996;11:32-53.
-
(1996)
Semin Respir Infect
, vol.11
, pp. 32-53
-
-
Craven, D.E.1
Steger, K.A.2
-
13
-
-
79952221682
-
Ventilator-associated tracheobronchitis in a mixed surgical and medical ICU population
-
Dallas J, Skrupky L, Abebe N, et al. Ventilator-associated tracheobronchitis in a mixed surgical and medical ICU population. Chest 2011;139:513-518.
-
(2011)
Chest
, vol.139
, pp. 513-518
-
-
Dallas, J.1
Skrupky, L.2
Abebe, N.3
-
14
-
-
27244442773
-
The clinical diagnosis of ventilator-associated pneumonia
-
Niederman MS. The clinical diagnosis of ventilator-associated pneumonia. Respir Care 2005;50:788-796.
-
(2005)
Respir Care
, vol.50
, pp. 788-796
-
-
Niederman, M.S.1
-
15
-
-
0034014440
-
Clinical criteria in the diagnosis of ventilator-associated pneumonia
-
Wunderink RG. Clinical criteria in the diagnosis of ventilator-associated pneumonia. Chest 2000;117(4 Suppl 2):191S-194S.
-
(2000)
Chest
, vol.117
, Issue.4
, pp. 191S-194S
-
-
Wunderink, R.G.1
-
16
-
-
84892215619
-
Ventilator-associated pneumonia
-
O'Donnell J, Nacul F, editors, 2nd ed Springer;, 325-342
-
Chroneou A, Zias N, Gray A, Craven DE. Ventilator-associated pneumonia. In: O'Donnell J, Nacul F, editors. Surgical intensive care medicine, 2nd ed Springer; 2010. pp. 325-342.
-
(2010)
Surgical Intensive Care Medicine
, pp. p
-
-
Chroneou, A.1
Zias, N.2
Gray, A.3
Craven, D.E.4
-
17
-
-
0027742167
-
Quantitative cultures of endotracheal aspirates for the diagnosis of ventilator-associated pneumonia
-
El-Ebiary M, Torres A, Gonzalez J, et al. Quantitative cultures of endotracheal aspirates for the diagnosis of ventilator-associated pneumonia. Am Rev Respir Dis 1993;148(6 Pt 1):1552-1557.
-
(1993)
Am Rev Respir Dis
, vol.148
, Issue.6
, pp. 1552-1557
-
-
El-Ebiary, M.1
Torres, A.2
Gonzalez, J.3
-
18
-
-
27244457431
-
The pathogenesis of ventilator-associated pneumonia: Its relevance to developing effective strategies for prevention
-
Safdar N, Crnich CJ, Maki DG. The pathogenesis of ventilator-associated pneumonia: its relevance to developing effective strategies for prevention. Respir Care 2005;50:725-739.
-
(2005)
Respir Care
, vol.50
, pp. 725-739
-
-
Safdar, N.1
Crnich, C.J.2
Maki, D.G.3
-
19
-
-
32044436073
-
Optimizing antibiotic treatment for ventilator-associated pneumonia
-
Micek ST, Heuring TJ, Hollands JM, et al. Optimizing antibiotic treatment for ventilator-associated pneumonia. Pharmacotherapy 2006;26:204-213.
-
(2006)
Pharmacotherapy
, vol.26
, pp. 204-213
-
-
Micek, S.T.1
Heuring, T.J.2
Hollands, J.M.3
-
20
-
-
84881480127
-
Preemptive broad-spectrum treatment for ventilator-associated pneumonia in high-risk patients
-
Bouza E, Granda MJ, Hortal J, et al. Preemptive broad-spectrum treatment for ventilator-associated pneumonia in high-risk patients. Intensive Care Med 2013;39:1547-1555. This is a study of pre-emptive antibiotic therapy for VAT/VAP in high-risk patients who were randomized to a 3-day course of linezolid and meropenem that demonstrated that the intervention group had significantly lower rates of VAT/VAP/1000 days in the treated group (32 versus 65, P<0.03) and longer time to the first episode of VAT/VAP (9 versus 4.5 days, P=0.02).
-
(2013)
Intensive Care Med
, vol.39
, pp. 1547-1555
-
-
Bouza, E.1
Granda, M.J.2
Hortal, J.3
-
21
-
-
84856937734
-
Linezolid in methicillinresistant Staphylococcus aureus nosocomial pneumonia: A randomized, controlled study
-
Wunderink RG, Niederman MS, Kollef MH, et al. Linezolid in methicillinresistant Staphylococcus aureus nosocomial pneumonia: a randomized, controlled study. Clin Infect Dis 2012;54:621-629.
-
(2012)
Clin Infect Dis
, vol.54
, pp. 621-629
-
-
Wunderink, R.G.1
Niederman, M.S.2
Kollef, M.H.3
-
23
-
-
42649120367
-
Risk factors for relapse of ventilator-associated pneumonia related to nonfermenting Gram negative bacilli: A case-control study
-
Nseir S, Deplanque X, Di Pompeo C, et al. Risk factors for relapse of ventilator-associated pneumonia related to nonfermenting Gram negative bacilli: a case-control study. J Infect 2008;56:319-325.
-
(2008)
J Infect
, vol.56
, pp. 319-325
-
-
Nseir, S.1
Deplanque, X.2
Di Pompeo, C.3
-
24
-
-
84880169306
-
Pseudomonas aeruginosa ventilatorassociated pneumonia. Predictive factors of treatment failure
-
Planquette B, Timsit JF, Misset BY, et al. Pseudomonas aeruginosa ventilatorassociated pneumonia. Predictive factors of treatment failure. Am J Respir Crit Care Med 2013;188:69-76. Excellent review of factors predictive of treatment failure for VAP due to P. aeruginosa.
-
(2013)
Am J Respir Crit Care Med
, vol.188
, pp. 69-76
-
-
Planquette, B.1
Timsit, J.F.2
Misset, B.Y.3
-
25
-
-
18844440476
-
Acinetobacter baumannii ventilator-associated pneumonia: Epidemiological and clinical findings
-
Garnacho-Montero J, Ortiz-Leyba C, Fernandez-Hinojosa E, et al. Acinetobacter baumannii ventilator-associated pneumonia: epidemiological and clinical findings. Intensive Care Med 2005;31:649-655.
-
(2005)
Intensive Care Med
, vol.31
, pp. 649-655
-
-
Garnacho-Montero, J.1
Ortiz-Leyba, C.2
Fernandez-Hinojosa, E.3
-
26
-
-
59649120298
-
Colistin use in ventilator-associated pneumonia due to panresistant Pseudomonas aeruginosa and Acinetobacter baumannii
-
Tasbakan MS, Pullukcu H, Ekren PK, et al. [Colistin use in ventilator-associated pneumonia due to panresistant Pseudomonas aeruginosa and Acinetobacter baumannii]. Mikrobiyol Bul 2009;43:61-70.
-
(2009)
Mikrobiyol Bul
, vol.43
, pp. 61-70
-
-
Tasbakan, M.S.1
Pullukcu, H.2
Ekren, P.K.3
-
27
-
-
84876933127
-
Colistin vs. The combination of colistin and rifampicin for the treatment of carbapenem-resistant Acinetobacter baumannii ventilator-associated pneumonia
-
Aydemir H, Akduman D, Piskin N, et al. Colistin vs. The combination of colistin and rifampicin for the treatment of carbapenem-resistant Acinetobacter baumannii ventilator-associated pneumonia. Epidemiol Infect 2013;141:1214-1222.
-
(2013)
Epidemiol Infect
, vol.141
, pp. 1214-1222
-
-
Aydemir, H.1
Akduman, D.2
Piskin, N.3
-
28
-
-
67649171344
-
Ventilator-associated infection
-
Palmer LB. Ventilator-associated infection. Curr Opin Pulm Med 2009;15:230-235.
-
(2009)
Curr Opin Pulm Med
, vol.15
, pp. 230-235
-
-
Palmer, L.B.1
-
29
-
-
84887320214
-
Aerosolized antibiotics: Do they add to the treatment of pneumonia?
-
Kollef MH, Hamilton CW, Montgomery AB. Aerosolized antibiotics: do they add to the treatment of pneumonia? Curr Opin Infect Dis 2013;26:538-544. State-of-the-art review of the use of intravenous antibiotics plus aerosolized antibiotics to assess broad-spectrum activity against Gram-negative bacilli and MRSA.
-
(2013)
Curr Opin Infect Dis
, vol.26
, pp. 538-544
-
-
Kollef, M.H.1
Hamilton, C.W.2
Montgomery, A.B.3
-
30
-
-
84903151026
-
A randomized double-blind placebo-controlled dose-escalation Phase 1 study of aerosolized amikacin and fosfomycin delivered via the PARI investigational eFlow inline nebulizer system in mechanically ventilated patients
-
Montgomery AB, Vallance S, Abuan T, et al. A randomized double-blind placebo-controlled dose-escalation Phase 1 study of aerosolized amikacin and fosfomycin delivered via the PARI investigational eFlow inline nebulizer system in mechanically ventilated patients. J Aerosol Med Pulm Drug Deliv 2014. [Epub ahead of print] A large multicenter randomized clinical trial in which patients with VAP due to Gram-negative bacilli will be treated with intravenous antibiotics and then randomized to treatment with fosfomycin and an aminoglycoside versus a placebo using a new aerosol antibiotic in-line delivery system; outcomes will then be compared using the win-ratio method. Active and placebo groups will be compared using the 'win ratio' formula calculated on number of matched pairs in the intervention group/total number of pairs with any winner by specified endpoints: that is 28-day mortality, ventilator-free days.
-
(2014)
J Aerosol Med Pulm Drug Deliv
-
-
Montgomery, A.B.1
Vallance, S.2
Abuan, T.3
-
31
-
-
1642525257
-
Guidelines for preventing healthcareassociated pneumonia 2003: Recommendations of CDC and the Healthcare Infection Control Practices Advisory Committee
-
Tablan OC, Anderson LJ, Besser R, et al. Guidelines for preventing healthcareassociated pneumonia 2003: recommendations of CDC and the Healthcare Infection Control Practices Advisory Committee. MMWR Recomm Rep 2004;53:1-36.
-
(2004)
MMWR Recomm Rep
, vol.53
, pp. 1-36
-
-
Tablan, O.C.1
Anderson, L.J.2
Besser, R.3
-
32
-
-
77956125871
-
SDD, SOD, or oropharyngeal chlorhexidine to prevent pneumonia and to reduce mortality in ventilated patients: Which manoeuvre is evidence-based?
-
Silvestri L, Van Saene HK, Zandstra DF, et al. SDD, SOD, or oropharyngeal chlorhexidine to prevent pneumonia and to reduce mortality in ventilated patients: which manoeuvre is evidence-based? Intensive Care Med 2010;36:1436-1437.
-
(2010)
Intensive Care Med
, vol.36
, pp. 1436-1437
-
-
Silvestri, L.1
Van Saene, H.K.2
Zandstra, D.F.3
-
33
-
-
0141537234
-
Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care: A randomised controlled trial
-
De Jonge E, Schultz MJ, Spanjaard L, et al. Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care: a randomised controlled trial. Lancet 2003;362:1011-1016.
-
(2003)
Lancet
, vol.362
, pp. 1011-1016
-
-
De Jonge, E.1
Schultz, M.J.2
Spanjaard, L.3
-
34
-
-
84902707117
-
Impact of appropriate antimicrobial treatment on transition from ventilator-associated tracheobronchitis to ventilatorassociated pneumonia
-
in press
-
Nseir S, Martin-Loeches I, Markris D, et al. Impact of appropriate antimicrobial treatment on transition from ventilator-associated tracheobronchitis to ventilatorassociated pneumonia. Crit Care Med 2014. (in press). A prospective observational multicenter study demonstrating that appropriate antibiotic treatment is independently associated with reduced risk of transition from VAT to VAP.
-
(2014)
Crit Care Med
-
-
Nseir, S.1
Martin-Loeches, I.2
Markris, D.3
-
35
-
-
60249102733
-
Ventilator-associated tracheobronchitis: The impact of targeted antibiotic therapy on patient outcomes
-
Craven DE, Chroneou A, Zias N, Hjalmarson KI. Ventilator-associated tracheobronchitis: the impact of targeted antibiotic therapy on patient outcomes. Chest 2009;135:521-528.
-
(2009)
Chest
, vol.135
, pp. 521-528
-
-
Craven, D.E.1
Chroneou, A.2
Zias, N.3
Hjalmarson, K.I.4
-
36
-
-
77955683345
-
Ventilator-associated tracheobronchitis and pneumonia: Thinking outside the box
-
Craven DE, Hjalmarson KI. Ventilator-associated tracheobronchitis and pneumonia: thinking outside the box. Clin Infect Dis 2010;51(Suppl 1):S59-66.
-
(2010)
Clin Infect Dis
, vol.51
, pp. S59-S66
-
-
Craven, D.E.1
Hjalmarson, K.I.2
-
37
-
-
84925955380
-
Natural history and outcomes of ventilated patients developing heavy bacterial colonization, tracheobronchitis and pneumonia
-
San Diego, California 2012
-
Craven DE, Hudcova J, Lei Y, et al. Natural history and outcomes of ventilated patients developing heavy bacterial colonization, tracheobronchitis and pneumonia. Abstract, IDSA Meeting, 2012, San Diego, California 2012.
-
(2012)
Abstract, IDSA Meeting
-
-
Craven, D.E.1
Hudcova, J.2
Lei, Y.3
-
38
-
-
84880066646
-
Ventilator-associated tracheobronchitis increases the length of intensive care unit stay
-
Karvouniaris M, Makris D, Manoulakas E, et al. Ventilator-associated tracheobronchitis increases the length of intensive care unit stay. Infect Control Hosp Epidemiol 2013;34:800-808. Increased rates of VAT were frequently identified 18% of patients and the 92% were MDR Gram-negative bacilli. Rates were higher in neurosurgical patients, and VAT was associated with longer ICU stay, but no increase in patient mortality.
-
(2013)
Infect Control Hosp Epidemiol
, vol.34
, pp. 800-808
-
-
Karvouniaris, M.1
Makris, D.2
Manoulakas, E.3
-
39
-
-
84880064108
-
Ventilator-associated tracheobronchitis in a mixed medical/surgical pediatric ICU
-
Simpson VS, Bailey A, Higgerson RA, Christie LM. Ventilator-associated tracheobronchitis in a mixed medical/surgical pediatric ICU. Chest 2013;144:32-38. A well done study examining rates of VAT in a pediatric ICU. Rates of VAT were low, but patients required prolonged ventilation and many patients had a tracheostomy.
-
(2013)
Chest
, vol.144
, pp. 32-38
-
-
Simpson, V.S.1
Bailey, A.2
Higgerson, R.A.3
Christie, L.M.4
-
40
-
-
67650859667
-
Ventilator-associated tracheobronchitis (VAT): Questions, answers, and a new paradigm?
-
Craven DE. Ventilator-associated tracheobronchitis (VAT): questions, answers, and a new paradigm? Crit Care 2008;12:157.
-
(2008)
Crit Care
, vol.12
, pp. 157
-
-
Craven, D.E.1
-
41
-
-
82455199209
-
Inhaled antibiotic therapy for ventilator-associated tracheobronchitis and ventilator-associated pneumonia: An update
-
Abu-Salah T, Dhand R. Inhaled antibiotic therapy for ventilator-associated tracheobronchitis and ventilator-associated pneumonia: an update. Adv Ther 2011;28:728-747.
-
(2011)
Adv Ther
, vol.28
, pp. 728-747
-
-
Abu-Salah, T.1
Dhand, R.2
-
42
-
-
84860117833
-
Intubated patients developing tracheobronchitis or pneumonia have distinctive complement system gene expression signatures in the preinfection period: A pilot study
-
Martin-Loeches I, Papiol E, Almansa R, et al. Intubated patients developing tracheobronchitis or pneumonia have distinctive complement system gene expression signatures in the preinfection period: a pilot study. Med Intensiva 2012;36:257-263.
-
(2012)
Med Intensiva
, vol.36
, pp. 257-263
-
-
Martin-Loeches, I.1
Papiol, E.2
Almansa, R.3
-
43
-
-
84884950975
-
Long-term cognitive impairment after critical illness
-
Pandharipande PP, Girard TD, Jackson JC, et al. Long-term cognitive impairment after critical illness. N Engl J Med 2013;369:1306-1316. Excellent study of ICU adult survivors of critical illness due to respiratory failure or shock; 74% had delirum, and 3 months later, 40% of the patients had low global cognition scores and 25% had cognitive impairment 1 year later that was similar to Alzheimer's disease and 33% had impairment similar to traumatic brain injury.
-
(2013)
N Engl J Med
, vol.369
, pp. 1306-1316
-
-
Pandharipande, P.P.1
Girard, T.D.2
Jackson, J.C.3
-
44
-
-
84884923001
-
Disability after critical illness
-
Herridge M, Cameron JI. Disability after critical illness. N Engl J Med 2013;369:1367-1369. Editorial comment on reference 3 emphasizing that cognitive dysfunction is prevalent in patients with critical illness.
-
(2013)
N Engl J Med
, vol.369
, pp. 1367-1369
-
-
Herridge, M.1
Cameron, J.I.2
-
45
-
-
26444480583
-
Clinical and economic consequences of ventilator-associated pneumonia: A systematic review
-
Safdar N, Dezfulian C, Collard HR, Saint S. Clinical and economic consequences of ventilator-associated pneumonia: a systematic review. Crit Care Med 2005;33:2184-2193.
-
(2005)
Crit Care Med
, vol.33
, pp. 2184-2193
-
-
Safdar, N.1
Dezfulian, C.2
Collard, H.R.3
Saint, S.4
-
46
-
-
0000834844
-
Bacteriuria and the diagnosis of infections of the urinary tract; with observations on the use of methionine as a urinary antiseptic
-
Kass EH. Bacteriuria and the diagnosis of infections of the urinary tract; with observations on the use of methionine as a urinary antiseptic. AMA Arch Intern Med 1957;100:709-714.
-
(1957)
AMA Arch Intern Med
, vol.100
, pp. 709-714
-
-
Kass, E.H.1
|