Frequency, prevention, outcome and treatment of ventilator-associated tracheobronchitis: Systematic review and meta-analysis

Respiratory Medicine

Volumn 104, Issue 3, 2010, Pages 325-336

  Agrafiotis, Michalis ^a   Siempos, Ilias I ^a   Falagas, Matthew E ^a,b,c  

^a ALFA INSTITUTE OF BIOMEDICAL SCIENCES AIBS   (Greece)

^b HENRY DUNANT HOSPITAL   (Greece)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acinetobacter spp; Aerosolized; Infection control; Pseudomonas aeruginosa; Staphylococcus aureus; Ventilator associated pneumonia

Indexed keywords

AMPHOTERICIN B; CEFOTAXIME; CHLORHEXIDINE; COLISTIN; GENTAMICIN; NETILMICIN; NORFLOXACIN; NYSTATIN; POLYMYXIN; TOBRAMYCIN;

ANTIBIOTIC PROPHYLAXIS; ARTIFICIAL VENTILATION; ASSISTED VENTILATION; CLINICAL TRIAL; HOSPITALIZATION; HUMAN; INFECTION PREVENTION; INTENSIVE CARE UNIT; LENGTH OF STAY; LUNG PARENCHYMA; MEDLINE; META ANALYSIS; PRIORITY JOURNAL; REVIEW; SYSTEMATIC REVIEW; TRACHEOBRONCHITIS; TREATMENT OUTCOME; VENTILATED PATIENT; VENTILATOR ASSOCIATED PNEUMONIA; VENTILATOR ASSOCIATED TRACHEOBRONCHITIS;

ANTI-BACTERIAL AGENTS; BRONCHITIS; CROSS INFECTION; HUMANS; INTENSIVE CARE UNITS; RESPIRATION, ARTIFICIAL; TRACHEITIS;

EID: 76449116530     PISSN: 09546111     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rmed.2009.09.001     Document Type: Review

References (31)

1. American Thoracic Society and Infectious Disease Society of America. Guidelines for the management of adults with hospital-acquired, ventilator-assocated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 171 (2005) 388-416
2. Chastre J., and Fagon J.Y. Ventilator-associated pneumonia. Am J Respir Crit Care Med 165 (2002) 867-903
3. Siempos I.I., Vardakas K.Z., Kopterides P., and Falagas M.E. Impact of passive humidification on clinical outcomes of mechanically ventilated patients: a meta-analysis of randomized controlled trials. Crit Care Med 35 (2007) 2843-2851
4. Siempos I.I., Vardakas K.Z., and Falagas M.E. Closed tracheal suction systems for prevention of ventilator-associated pneumonia. Br J Anaesth 100 (2008) 299-306
5. Craven D.E. Ventilator-associated tracheobronchitis (VAT): questions, answers, and a new paradigm?. Crit Care 12 (2008) 157
6. Weiss G., Benedix F., and Lippert H. Diagnostic problems of nosocomial infections in patients with sever sepsis ongoing antimicrobial treatment-efficiency and value of serum inflammatory markers and routine microbiological monitoring. Clin Intens Care 17 (2006) 113-123
7. Nseir S., Di Pompeo C., Soubrier S., Lenci H., Delour P., Onimus T., et al. Effect of ventilator-associated tracheobronchitis on outcome in patients without chronic respiratory failure: a case-control study. Crit Care 9 (2005) R238-R245
8. Nseir S., Di Pompeo C., Soubrier S., Delour P., Onimus T., Saulnier F., et al. Outcomes of ventilated COPD patients with nosocomial tracheobronchitis: a case-control study. Infection 32 (2004) 210-216
9. Bouza E., Pérez A., Muñoz P., Jesús Pérez M., Rincón C., Sánchez C., et al., Cardiovascular Infection Study Group. Ventilator-associated pneumonia after heart surgery: a prospective analysis and the value of surveillance. Crit Care Med 31 (2003) 1964-1970
10. Nseir S., Di Pompeo C., Pronnier P., Beague S., Onimus T., Saulnier F., et al. Nosocomial tracheobronchitis in mechanically ventilated patients: incidence, aetiology and outcome. Eur Respir J 20 (2002) 1483-1489
11. Humphrey M.A., Simpson G.T., and Grindlinger G.A. Clinical characteristics of nosocomial sinusitis. Ann Otol Rhinol Laryngol 96 (1987) 687-690
12. Arola M.K. Tracheostomy and its complications. A retrospective study of 794 tracheostomized patients. Ann Chir Gynaecol 70 (1981) 96-106
13. Valencia M., Ferrer M., Farre R., Navajas D., Badia J.R., Nicolas J.M., et al. Automatic control of tracheal tube cuff pressure in ventilated patients in semirecumbent position: a randomized trial. Crit Care Med 35 (2007) 1543-1549
14. Fourrier F., Dubois D., Pronnier P., Herbecq P., Leroy O., Desmettre T., et al., PIRAD Study Group. Effect of gingival and dental plaque antiseptic decontamination on nosocomial infections acquired in the intensive care unit: a double-blind placebo-controlled multicenter study. Crit Care Med 33 (2005) 1728-1735
15. Lorente L., Lecuona M., Málaga J., Revert C., Mora M.L., and Sierra A. Bacterial filters in respiratory circuits: an unnecessary cost?. Crit Care Med 31 (2003) 2126-2130
16. Gastinne H., Wolff M., Delatour F., Faurisson F., and Chevret S. A controlled trial in intensive care units of selective decontamination of thedigestive tract with nonabsorbable antibiotics. The French Study Group on Selective Decontamination of the Digestive Tract. N Engl J Med 326 (1992) 594-599
17. Hammond J.M., Potgieter P.D., Saunders G.L., and Forder A.A. Double-blind study of selective decontamination of the digestive tract in intensive care. Lancet 340 (1992) 5-9
18. Aerdts S.J., van Dalen R., Clasener H.A., Festen J., van Lier H.J., and Vollaard E.J. Antibiotic prophylaxis of respiratory tract infection in mechanically ventilated patients. A prospective, blinded, randomized trial of the effect of a novel regimen. Chest 100 (1991) 783-791
19. Rodríguez-Roldán J.M., Altuna-Cuesta A., López A., Carrillo A., Garcia J., León J., et al. Prevention of nosocomial lung infection in ventilated patients: use of an antimicrobial pharyngeal nonabsorbable paste. Crit Care Med 18 (1990) 1239-1242
20. Unertl K., Ruckdeschel G., Selbmann H.K., Jensen U., Forst H., Lenhart F.P., et al. Prevention of colonization and respiratory infections in long-term ventilated patients by local antimicrobial prophylaxis. Intensive Care Med 13 (1987) 106-113
21. Nseir S., Favory R., Jozefowicz E., Decamps F., Dewavrin F., Brunin G., et al., VAT Study Group. Antimicrobial treatment for ventilator-associated tracheobronchitis: a randomized, controlled, multicenter study. Crit Care 12 (2008) R62
22. Palmer L.B., Smaldone G.C., Chen J.J., Baram D., Duan T., Monteforte M., et al. Aerosolized antibiotics and ventilator-associated tracheobronchitis in the intensive care unit. Crit Care Med 36 (2008) 2008-2013
23. Wunderink R.G. Radiologic diagnosis of ventilator-associated pneumonia. Chest 117 4 Suppl. 2 (2000) 188S-190S
24. Rouby J.J., Martin De Lassale E., Poete P., Nicolas M.H., Bodin L., Jarlier V., et al. Nosocomial bronchopneumonia in the critically ill. Histologic and bacteriologic aspects. Am Rev Respir Dis 146 (1992) 1059-1066
25. Craven D.E., Chroneou A., Zias N., and Hjalmarson K. Ventilator-associated tracheobronchitis: the impact of targeted antibiotic therapy on patient outcomes. Chest 35 (2009) 521-528
26. Klech H., and Pohl W. Technical recommendations and guidelines for bronchoalveolar lavage (BAL). Eur Respir J 2 (1989) 561-585
27. Kollef M.H. The role of selective digestive tract decontamination on mortality and respiratory tract infections. A meta-analysis. Chest 105 (1994) 1101-1108
28. Falagas M.E., Siempos I.I., Bliziotis I.A., and Michalopoulos A. Administration of antibiotics via the respiratory tract for the prevention of ICU-acquired pneumonia: a meta-analysis of comparative trials. Crit Care 10 (2006) R123
29. Falagas M.E., and Siempos I.I. Prevention of ventilator-associated pneumonia: possible role of antimicrobials administered via the respiratory tract. Eur Respir J 31 (2008) 1138-1139
30. Ioannidou E., Siempos I.I., and Falagas M.E. Administration of antimicrobials via the respiratory tract for the treatment of patients with nosocomial pneumonia: a meta-analysis. J Antimicrob Chemother 60 (2007) 1216-1226
31. Falagas M.E., Agrafiotis M., Athanassa Z., and Siempos I.I. Administration of antibiotics via the respiratory tract as monotherapy for pneumonia. Expert Rev Anti Infect Ther 6 4 (2008 Aug) 447-452