Computational design and experimental characterization of peptides intended for pH-dependent membrane insertion and pore formation

ACS Chemical Biology

Volumn 10, Issue 4, 2015, Pages 1082-1093

  Zhang, Yao ^a   Bartz, René ^b   Grigoryan, Gevorg ^a   Bryant, Michael ^a   Aaronson, Jeff ^b   Beck, Stephen ^b   Innocent, Nathalie ^b   Klein, Lee ^b   Procopio, William ^b   Tucker, Tom ^b   Jadhav, Vasant ^b   Tellers, David M ^b   Degrado, William F ^c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; HEMOGLOBIN; MICRORNA; MICRORNA 16; PEPTIDE; SYNTHETIC PEPTIDE; LIPID BILAYER; TRYPTOPHAN;

ARTICLE; CHANNEL GATING; CIRCULAR DICHROISM; CYTOSOL; ERYTHROCYTE; GEL PERMEATION CHROMATOGRAPHY; HEMOLYSIS; HUMAN; HUMAN CELL; HYDRODYNAMICS; HYDROPHOBICITY; INFRARED SPECTROSCOPY; LIPID BILAYER; MACROMOLECULE; MEMBRANE CHANNEL; MEMBRANE DAMAGE; MEMBRANE STRUCTURE; MEMBRANE TRANSPORT; MICELLE; PH; PRIORITY JOURNAL; PROTEIN LIPID INTERACTION; PROTEIN MOTIF; SEDIMENTATION; ULTRACENTRIFUGATION; AMINO ACID SEQUENCE; CELL MEMBRANE; CHEMISTRY; DRUG DESIGN; DRUG EFFECTS; METABOLISM; MOLECULAR GENETICS; PROCEDURES; PROTEIN ENGINEERING; SIZE EXCLUSION CHROMATOGRAPHY; SOLUBILITY; SPECTROFLUOROMETRY;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; CELL MEMBRANE; CHROMATOGRAPHY, GEL; CIRCULAR DICHROISM; DRUG DESIGN; ERYTHROCYTES; HEMOLYSIS; HUMANS; HYDROGEN-ION CONCENTRATION; LIPID BILAYERS; MICRORNAS; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN ENGINEERING; SOLUBILITY; SPECTROMETRY, FLUORESCENCE; TRYPTOPHAN;

EID: 84925882058     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb500759p     Document Type: Article

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