Down-regulation of suppressor of cytokine signaling 3 by miR-122 enhances interferon-mediated suppression of hepatitis B virus

Antiviral Research

Volumn 118, Issue , 2015, Pages 20-28

  Gao, Dongni ^a,b   Zhai, Aixia ^a   Qian, Jun ^a   Li, Aimei ^a   Li, Yujun ^a   Song, Wuqi ^a   Zhao, Hong ^a   Yu, Xin ^a   Wu, Jing ^a   Zhang, Qingmeng ^a   Kao, Wenping ^a   Wei, Lanlan ^a   Zhang, Fengmin ^a   Zhong, Zhaohua ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b HEILONGJIANG UNIVERSITY   (China)

Author keywords

Hepatitis B virus; Hepatocytes; Interferon; MicroRNA 122; Suppressor of cytokine signaling 3

Indexed keywords

INTERFERON; MICRORNA 122; SUPPRESSOR OF CYTOKINE SIGNALING 3; 3' UNTRANSLATED REGION; MICRORNA; MIRN122 MICRORNA, HUMAN; SOCS3 PROTEIN, HUMAN; SUPPRESSOR OF CYTOKINE SIGNALING;

3' UNTRANSLATED REGION; ARTICLE; BINDING SITE; CYTOKINE PRODUCTION; DOWN REGULATION; HEPATITIS B; HEPATITIS B VIRUS; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA SEQUENCE; VIRUS REPLICATION; ANTAGONISTS AND INHIBITORS; CELL LINE; GENETICS; HUMAN; IMMUNE EVASION; IMMUNOLOGY; METABOLISM; VIROLOGY;

HEPATITIS B VIRUS;

3' UNTRANSLATED REGIONS; BINDING SITES; CELL LINE; DOWN-REGULATION; HEPATITIS B; HEPATITIS B VIRUS; HEPATOCYTES; HUMANS; IMMUNE EVASION; INTERFERON TYPE I; MICRORNAS; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS;

EID: 84925868126     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2015.03.001     Document Type: Article

References (43)

1. S. Bai, and M.W. Nasser et al. MicroRNA-122 inhibits tumorigenic properties of hepatocellular carcinoma cells and sensitizes these cells to sorafenib J. Biol. Chem. 284 46 2009 32015 32027
2. J.G. Bode, and S. Ludwig et al. IFN-alpha antagonistic activity of HCV core protein involves induction of suppressor of cytokine signaling-3 FASEB J. 17 3 2003 488 490
3. Y. Chen, and A. Shen et al. A liver-specific microRNA binds to a highly conserved RNA sequence of hepatitis B virus and negatively regulates viral gene expression and replication FASEB J. 25 12 2011 4511 4521
4. C. Coulouarn, and V.M. Factor et al. Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties Oncogene 28 40 2009 3526 3536
5. C.G. Fan, and C.M. Wang et al. MiR-122 inhibits viral replication and cell proliferation in hepatitis B virus-related hepatocellular carcinoma and targets NDRG3 Oncol. Rep. 26 5 2011 1281 1286
6. W. Filipowicz, and H. Grosshans The liver-specific microRNA miR-122: biology and therapeutic potential Prog. Drug Res. 67 2011 221 238
7. F. Fornari, and L. Gramantieri et al. MiR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cells Cancer Res. 69 14 2009 5761 5767
8. M. Girard, and E. Jacquemin et al. MiR-122, a paradigm for the role of microRNAs in the liver J. Hepatol. 48 4 2008 648 656
9. L. Gramantieri, and M. Ferracin et al. Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma Cancer Res. 67 13 2007 6092 6099
10. A. Grundhoff, and C.S. Sullivan Virus-encoded microRNAs Virology 411 2 2011 325 343
11. J. Hao, and W. Jin et al. Inhibition of alpha interferon (IFN-alpha)-induced microRNA-122 negatively affects the anti-hepatitis B virus efficiency of IFN-alpha J. Virol. 87 1 2013 137 147
12. J. Hu, and Y. Xu et al. MiR-122 in hepatic function and liver diseases Protein Cell. 3 5 2012 364 371
13. Y. Huang, and J.J. Feld et al. Defective hepatic response to interferon and activation of suppressor of cytokine signaling 3 in chronic hepatitis C Gastroenterology 132 2 2007 733 744
14. K.A. Kim, and W. Lin et al. Hepatic SOCS3 expression is strongly associated with non-response to therapy and race in HCV and HCV/HIV infection J. Hepatol. 50 4 2009 705 711
15. B. Koeberlein, and A. zur Hausen et al. Hepatitis B virus overexpresses suppressor of cytokine signaling-3 (SOCS3) thereby contributing to severity of inflammation in the liver Virus Res. 148 1-2 2010 51 59
16. A. Li, and W. Song et al. MiR-122 modulates type I interferon expression through blocking suppressor of cytokine signaling 1 Int. J. Biochem. Cell Biol. 45 4 2013 858 865
17. C. Li, and Y. Wang et al. Hepatitis B virus mRNA-mediated miR-122 inhibition upregulates PTTG1-binding protein, which promotes hepatocellular carcinoma tumor growth and cell invasion J. Virol. 87 4 2013 2193 2205
18. Y.P. Li, and J.M. Gottwein et al. MicroRNA-122 antagonism against hepatitis C virus genotypes 1-6 and reduced efficacy by host RNA insertion or mutations in the HCV 5′ UTR Proc. Natl. Acad. Sci. USA 108 12 2011 4991 4996
19. X. Ling, and F. Marini et al. Mesenchymal stem cells overexpressing IFN-beta inhibit breast cancer growth and metastases through Stat3 signaling in a syngeneic tumor model Cancer Microenviron. 3 1 2010 83 95
20. W.H. Liu, and S.H. Yeh et al. Role of microRNAs in hepatitis B virus replication and pathogenesis Biochim. Biophys. Acta. 1809 11-12 2011 678 685
21. C.J. Marsit, and K. Eddy et al. MicroRNA responses to cellular stress Cancer Res. 66 22 2006 10843 10848
22. K.J. Moore, and K.J. Rayner et al. The role of microRNAs in cholesterol efflux and hepatic lipid metabolism Annu. Rev. Nutr. 31 2011 49 63
23. K.L. Norman, and P. Sarnow Modulation of hepatitis C virus RNA abundance and the isoprenoid biosynthesis pathway by microRNA miR-122 involves distinct mechanisms J. Virol. 84 1 2010 666 670
24. M. Persico, and M. Capasso et al. Elevated expression and polymorphisms of SOCS3 influence patient response to antiviral therapy in chronic hepatitis C Gut 57 4 2008 507 515
25. L.M. Pfeffer, and M.A. Madey et al. The induction of type I interferon production in hepatitis C-infected patients J. Interferon Cytokine Res. 29 5 2009 299 306
26. J. Qian, and A. Zhai et al. Modulation of miR-122 on persistently Borna disease virus infected human oligodendroglial cells Antiviral Res. 87 2 2010 249 256
27. L. Qiu, and H. Fan et al. MiR-122-induced down-regulation of HO-1 negatively affects miR-122-mediated suppression of HBV Biochem. Biophys. Res. Commun. 398 4 2010 771 777
28. M. Sarasin-Filipowicz, and J. Krol et al. Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy Nat. Med. 15 1 2009 31 33
29. M. Sarasin-Filipowicz, and E.J. Oakeley et al. Interferon signaling and treatment outcome in chronic hepatitis C PNAS 105 19 2008 7034 7039
30. H. Sendi Dual Role of miR-122 in molecular pathogenesis of viral hepatitis Hepat. Mon. 12 5 2012 312 314
31. R.X. Shao, and L. Zhang et al. Suppressor of cytokine signaling 3 suppresses hepatitis C virus replication in an mTOR-dependent manner J. Virol. 84 12 2010 6060 6069
32. M. Silva, and J. Poo et al. A randomised trial to compare the pharmacokinetic, pharmacodynamic, and antiviral effects of peginterferon alfa-2b and peginterferon alfa-2a in patients with chronic hepatitis C J. Hepatol. 45 2 2006 204 213
33. M.W. Taylor, and T. Tsukahara et al. Changes in gene expression during pegylated interferon and ribavirin therapy of chronic hepatitis C virus distinguish responders from nonresponders to antiviral therapy J. Virol. 81 7 2007 3391 3401
34. W.C. Tsai, and P.W. Hsu et al. MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma Hepatology 49 5 2009 1571 1582
35. L. Wang, and Y. Qin et al. MiR-342-5p suppresses coxsackievirus B3 biosynthesis by targeting the 2C-coding region Antiviral Res. 93 2 2012 270 279
36. S. Wang, and L. Qiu et al. Loss of microRNA 122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G(1) -modulated P53 activity Hepatology 55 3 2012 730 741
37. D.B. Wu, and F.W. Liu et al. Intrahepatic IFN-alpha expression in liver specimens from HBV-infected patients with different outcomes Eur. Rev. Med. Pharmacol. Sci. 17 18 2013 2474 2480
38. H. Xu, and J.H. He et al. Liver-enriched transcription factors regulate microRNA-122 that targets CUTL1 during liver development Hepatology 52 4 2010 1431 1442
39. J. Xu, and X. Zhu et al. MicroRNA-122 suppresses cell proliferation and induces cell apoptosis in hepatocellular carcinoma by directly targeting Wnt/beta-catenin pathway Liver Int. 32 5 2012 752 760
40. W. Xu, and Y. Fang et al. Construction and expression of eukaryotic plasmids containing lamivudine-resistant or wild-type strains of Hepatitis B Virus genotype C World J. Gastroenterol. 14 23 2008 3733
41. S. Yokota, and N. Yokosawa et al. Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway J. Virol. 78 12 2004 6282 6286
42. T. Yoshikawa, and A. Takata et al. Silencing of microRNA-122 enhances interferon-alpha signaling in the liver through regulating SOCS3 promoter methylation Sci. Rep. 2 2012 637
43. C. Zeng, and R. Wang et al. A novel GSK-3 beta-C/EBP alpha-miR-122-insulin-like growth factor 1 receptor regulatory circuitry in human hepatocellular carcinoma Hepatology 52 5 2010 1702 1712