Smad3-deficient mice have reduced esophageal fibrosis and angiogenesis in a model of egg-induced eosinophilic esophagitis

Journal of Pediatric Gastroenterology and Nutrition

Volumn 59, Issue 1, 2014, Pages 10-16

  Cho, Jae Youn ^a   Doshi, Ashmi ^a   Rosenthal, Peter ^a   Beppu, Andrew ^a   Miller, Marina ^a   Aceves, Seema ^b   Broide, David ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Eosinophil; Fibronectin; Fibrosis

Indexed keywords

EOTAXIN; INTERLEUKIN 5; MAJOR BASIC PROTEIN; MESSENGER RNA; OVALBUMIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; VASCULOTROPIN; SMAD3 PROTEIN, MOUSE; VASCULOTROPIN A;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; EOSINOPHIL; EOSINOPHILIC ESOPHAGITIS; ESOPHAGEAL FIBROSIS; ESOPHAGUS DISEASE; ESOPHAGUS STENOSIS; FEMALE; FIBROSIS; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; LAMINA PROPRIA; MAST CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; SIGNAL TRANSDUCTION; ANIMAL; CHEMICALLY INDUCED; CHEMISTRY; DEFICIENCY; DISEASE MODEL; ESOPHAGUS; GENETICS; HYPERPLASIA; KNOCKOUT MOUSE; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; VASCULARIZATION;

MURINAE; MUS;

ANIMALS; DISEASE MODELS, ANIMAL; EOSINOPHIL MAJOR BASIC PROTEIN; EOSINOPHILIC ESOPHAGITIS; EOSINOPHILS; ESOPHAGUS; FEMALE; FIBROSIS; HYPERPLASIA; MICE; MICE, KNOCKOUT; NEOVASCULARIZATION, PATHOLOGIC; OVALBUMIN; RNA, MESSENGER; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84925865113     PISSN: 02772116     EISSN: 15364801     Source Type: Journal    
DOI: 10.1097/MPG.0000000000000343     Document Type: Article

References (25)

1. Liacouras CA, Furuta GT, Hirano I, et al. Eosinophilic esophagitis: updated consensus recommendations for children and adults. J Allergy Clin Immunol 2011;128:3-20.
2. Sherrill JD, Rothenberg ME. Genetic dissection of eosinophilic esophagitis provides insight into disease pathogenesis and treatment strategies. J Allergy Clin Immunol 2011;128:23-32.
3. Wolfe JL, Aceves SS. Gastrointestinal manifestations of food allergies. Pediatr Clin North Am 2011;58:389-405.
4. Straumann A, Schoepfer AM. Therapeutic concepts in adult and pediatric eosinophilic esophagitis. Nat Rev Gastroenterol Hepatol 2012;9:697-704.
5. Sperry SL, Crockett SD, Miller CB, et al. Esophageal foreign-body impactions: epidemiology, time trends, and the impact of the increasing prevalence of eosinophilic esophagitis. Gastrointest Endosc 2011;74: 985-91.
6. Wynn TA. Integrating mechanisms of pulmonary fibrosis. J Exp Med 2011;208:1339-50.
7. Rubinstein E, Cho JY, Rosenthal P, et al. Siglec-F inhibition reduces esophageal eosinophilia and angiogenesis in a mouse model of eosinophilic esophagitis. J Pediatr Gastroenterol Nutr 2011;53:409-16.
8. Aceves SS, Newbury RO, Dohil R, et al. Esophageal remodeling in pediatric eosinophilic esophagitis. J Allergy Clin Immunol 2007;119: 206-12.
9. Aceves SS, Chen D, Newbury RO, et al. Mast cells infiltrate the esophageal smooth muscle in patients with eosinophilic esophagitis, express TGF-b1, and increase esophageal smooth muscle contraction. J Allergy Clin Immunol 2010;126:1198-204.
10. Aceves SS, Newbury RO, Chen D, et al. Resolution of remodeling in eosinophilic esophagitis correlates with epithelial response to topical corticosteroids. Allergy 2010;65:109-16.
11. Mishra A, Wang M, Pemmaraju VR, et al. Esophageal remodeling develops as a consequence of tissue specific IL-5 induced eosinophilia. Gastroenterology 2008;134:204-14.
12. Kagalwalla AF, Akhtar N,Woodruff SA, et al. Eosinophilic esophagitis: epithelial mesenchymal transition contributes to esophageal remodeling and reverses with treatment. J Allergy Clin Immunol 2012;129:1387-96.
13. Verrecchia F, Chu ML, Mauviel A. Identification of novel TGF-b/Smad gene targets in dermal fibroblasts using a combined cDNA microarray/ promoter transactivation approach. J Biol Chem 2001;276:17058-62.
14. Le AV, Cho JY, Miller M, et al. Inhibition of allergen-induced airway remodeling in Smad 3-deficient mice. J Immunol 2007;178:7310-6.
15. McMillan SJ, Xanthou G, Lloyd CM. Manipulation of allergen-induced airway remodeling by treatment with anti-TGFb antibody: effect on the Smad signaling pathway. J Immunol 2005;174:5774-80.
16. Cho JY, Miller M, Baek KJ, et al. Inhibition of airway remodeling in IL-5-deficient mice. J Clin Invest 2004;113:551-60.
17. Miller M, Tam AB, Cho JY, et al. ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6. Proc Natl Acad Sci U S A 2012;109:16648-53.
18. Broide DH, Waserman SI, Alvaro-Gracia J, et al. Transforming growth factor-beta 1 selectively inhibits IL-3-dependent mast cell proliferation without affecting mast cell function or differentiation. J Immunol 1989;143:1591-7.
19. Detmar M, Brown LF, Schon MP, et al. Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice. J Invest Dermatol 1998;111:1-6.
20. Lee CG, Ma B, Takyar S, et al. Studies of vascular endothelial growth factor in asthma and chronic obstructive pulmonary disease. Proc Am Thorac Soc 2011;8:512-5.
21. Dickson MC, Martin JS, Cousins FM, et al. Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice. Development 1995;121:1845-54.
22. Li DY, Sorensen LK, Brooke BS, et al. Defective angiogenesis in mice lacking endoglin. Science 1999;284:1534-7.
23. Oshima M, Oshima H, Taketo MM. TGF-b receptor type II deficiency results in defects of yolk sachematopoiesis and vasculogenesis. Dev Biol 1996;179:297-302.
24. Roberts AB, Sporn MB, Assoian RK, et al. Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci U S A 1986;83:4167-71.
25. Ferrari G, Cook BD, Terushkin V, et al. Transforming growth factor-beta 1 (TGF-b1) induces angiogenesis through vascular endothelial growth factor (VEGF)-mediated apoptosis. J Cell Physiol 2009;219:449-58.