Polyunsaturated fatty acid regulation of adipocyte FADS1 and FADS2 expression and function

Obesity

Volumn 23, Issue 4, 2015, Pages 725-728

  Ralston, Jessica C ^a   Matravadia, Sarthak ^a   Gaudio, Nicholas ^a   Holloway, Graham P ^a   Mutch, David M ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DESATURASE; ACYL COENZYME A DESATURASE 1; ARACHIDONIC ACID; DOCOSAHEXAENOIC ACID; FATTY ACID DESATURASE 2; ICOSAPENTAENOIC ACID; LINOLEIC ACID; POLYUNSATURATED FATTY ACID; UNCLASSIFIED DRUG; DELTA-5 FATTY ACID DESATURASE; FADS2 PROTEIN, HUMAN; UNSATURATED FATTY ACID;

3T3 CELL LINE; ADIPOCYTE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FATTY ACID ANALYSIS; GAS CHROMATOGRAPHY; GENE EXPRESSION; PROTEIN CONTENT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MOUSE; SINGLE NUCLEOTIDE POLYMORPHISM;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; ARACHIDONIC ACID; DOCOSAHEXAENOIC ACIDS; FATTY ACID DESATURASES; FATTY ACIDS, UNSATURATED; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; MICE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84925852988     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1002/oby.21035     Document Type: Article

References (20)

1. Merino DM, Ma DW, Mutch DM,. Genetic variation in lipid desaturases and its impact on the development of human disease. Lipids Health Dis 2010; 9: 63.
2. Nakamura MT, Nara TY,. Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases. Annu Rev Nutr 2004; 24: 345-376.
3. Slagsvold JE, Thorstensen K, Kvitland M, Mack M, Bjerve KS,. Regulation of desaturase expression in HL60 cells. Scand J Clin Lab Invest 2007; 67: 632-642.
4. Reardon HT, Hsieh AT, Park WJ, et al. Dietary long-chain polyunsaturated fatty acids upregulate expression of FADS3 transcripts. Prostaglandins Leukot Essent Fatty Acids 2013; 88: 15-19.
5. Cho HP, Nakamura MT, Clarke SD,. Cloning, expression, and nutritional regulation of the mammalian Delta-6 desaturase. J Biol Chem 1999; 274: 471-477.
6. Cho HP, Nakamura M, Clarke SD,. Cloning, expression, and fatty acid regulation of the human delta-5 desaturase. J Biol Chem 1999; 274: 37335-37339.
7. Barber E, Sinclair AJ, Cameron-Smith D,. Comparative actions of omega-3 fatty acids on in-vitro lipid droplet formation. Prostaglandins Leukot Essent Fatty Acids 2013; 89: 359-366.
8. Kalupahana NS, Claycombe KJ, Moustaid-Moussa N,. (n-3) Fatty acids alleviate adipose tissue inflammation and insulin resistance: Mechanistic insights. Adv Nutr 2011; 2: 304-316.
9. Lottenberg AM, Afonso Mda S, Lavrador MS, Machado RM, Nakandakare ER,. The role of dietary fatty acids in the pathology of metabolic syndrome. J Nutr Biochem 2012; 23: 1027-1040.
10. Oliver E, McGillicuddy FC, Harford KA, et al. Docosahexaenoic acid attenuates macrophage-induced inflammation and improves insulin sensitivity in adipocytes-specific differential effects between LC n-3 PUFA. J Nutr Biochem 2012; 23: 1192-1200.
11. Siriwardhana N, Kalupahana NS, Fletcher S, et al. n-3 and n-6 polyunsaturated fatty acids differentially regulate adipose angiotensinogen and other inflammatory adipokines in part via NF-kappaB-dependent mechanisms. J Nutr Biochem 2012; 23: 1661-1667.
12. Truong H, DiBello JR, Ruiz-Narvaez E, Kraft P, Campos H, Baylin A,. Does genetic variation in the Delta6-desaturase promoter modify the association between alpha-linolenic acid and the prevalence of metabolic syndrome? Am J Clin Nutr 2009; 89: 920-925.
13. Stoffel W, Hammels I, Jenke B, et al. Obesity resistance and deregulation of lipogenesis in Delta6-fatty acid desaturase (FADS2) deficiency. EMBO Rep 2014; 15: 110-120.
14. Sjogren P, Sierra-Johnson J, Gertow K, et al. Fatty acid desaturases in human adipose tissue: Relationships between gene expression, desaturation indexes and insulin resistance. Diabetologia 2008; 51: 328-335.
15. Ralston JC, Badoud F, Cattrysse B, McNicholas PD, Mutch DM,. Inhibition of stearoyl-CoA desaturase-1 in differentiating 3T3-L1 pre-adipocytes up-regulates elongase 6 and down-regulates genes affecting triacylglycerol synthesis. Int J Obes 2014; 38: 1449-1456.
16. Holloway GP, Perry CG, Thrush AB, et al. PGC-1alpha's relationship with skeletal muscle palmitate oxidation is not present with obesity despite maintained PGC-1alpha and PGC-1beta protein. Am J Physiol Endocrinol Metab 2008; 294: E1060, E1069.
17. Qin X, Park HG, Zhang J, et al. Fatty acid profiles of undifferentiated and differentiated white and brown adipose cell lines supplemented with alpha-linolenic acid. Faseb J 2014; 28: 821.5.
18. Murali G, Desouza CV, Clevenger ME, Ramalingam R,., Saraswathi V,. Differential effects of eicosapentaenoic acid and docosahexaenoic acid in promoting the differentiation of 3T3-L1 preadipocytes. Prostaglandins Leukot Essent Fatty Acids 2014; 90: 13-21.
19. Burdge GC, Finnegan YE, Minihane AM, Williams CM, Wootton SA,. Effect of altered dietary n-3 fatty acid intake upon plasma lipid fatty acid composition, conversion of [13C]alpha-linolenic acid to longer-chain fatty acids and partitioning towards beta-oxidation in older men. Br J Nutr 2003; 90: 311-321.
20. Wang X, Lin H, Gu Y,. Multiple roles of dihomo-gamma-linolenic acid against proliferation diseases. Lipids Health Dis 2012; 11: 25.