Regulation of desaturase expression in HL60 cells

Scandinavian Journal of Clinical and Laboratory Investigation

Volumn 67, Issue 6, 2007, Pages 632-642

  Slagsvold, J E ^a   Thorstensen, K ^a   Kvitland, M ^a   Mack, M ^a   Bjerve, Kristian S ^a  

^a TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

Author keywords

Arachidonic acid; Docosahexaenoic acid; Eicosapentaenoic acid; Essential fatty acid deficiency; Fatty acid desaturases; HL60 cells; Linoleic acid

Indexed keywords

ACYL COENZYME A DESATURASE; BIOLOGICAL MARKER; DELTA 5 FATTY ACID DESATURASE; DELTA-5 FATTY ACID DESATURASE; EDIBLE OIL; ESSENTIAL FATTY ACID; LINOLEOYL COENZYME A DESATURASE; MESSENGER RNA; UNCLASSIFIED DRUG; UNSATURATED FATTY ACID;

ARTICLE; BLOOD; CELL LINE; CELL STRAIN HL 60; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

BIOLOGICAL MARKERS; CELL LINE; DIETARY FATS, UNSATURATED; FATTY ACID DESATURASES; FATTY ACIDS, ESSENTIAL; FATTY ACIDS, UNSATURATED; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HL-60 CELLS; HUMANS; LINOLEOYL-COA DESATURASE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STEAROYL-COA DESATURASE;

EID: 38749087669     PISSN: 00365513     EISSN: 15027686     Source Type: Journal    
DOI: 10.1080/00365510601175463     Document Type: Article

References (32)

1. Zhang L, Ge L, Parimoo S, Stenn K, Prouty SM. Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites. Biochem J 1999;340 Pt 1:255-64.
2. Ntambi JM, Miyazaki M, Dobrzyn A. Regulation of stearoyl-CoA desaturase expression. Lipids 2004;39:1061-5.
3. Sprecher H. Biochemistry of essential fatty acids. Prog Lipid Res 1981;20:13-22.
4. Zhou L, Nilsson A. Sources of eicosanoid precursor fatty acid pools in tissues. J Lipid Res 2001;42:1521-42.
5. Nakamura MT, Cho HP, Xu J, Tang Z, Clarke SD. Metabolism and functions of highly unsaturated fatty acids: an update. Lipids 2001;36:961-4.
6. Nakamura MT, Nara TY. Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases. Annu Rev Nutr 2004;24:345-76.
7. Zolfaghari R, Ross AC. Recent advances in molecular cloning of fatty acid desaturase genes and the regulation of their expression by dietary vitamin A and retinoic acid. Prostaglandins Leukot Essent Fatty Acids 2003;68:171-9.
8. Nakamura MT, Phinney SD, Tang AB, Oberbauer AM, German JB, Murray JD. Increased hepatic delta 6-desaturase activity with growth hormone expression in the MG101 transgenic mouse. Lipids 1996;31:139-43.
9. Pigeon C, Legrand P, Leroyer P, Bouriel M, Turlin B, Brissot P, et al. Stearoyl coenzyme A desaturase 1 expression and activity are increased in the liver during iron overload. Biochim Biophys Acta 2001;1535:275-84.
10. Lapillonne A, Clarke SD, Heird WC. Polyunsaturated fatty acids and gene expression. Curr Opin Clin Nutr Metab Care 2004;7:151-6.
11. Grimaldi PA. Fatty acid regulation of gene expression. Curr Opin Clin Nutr Metab Care 2001;4:433-7.
12. Ntambi JM, Bene H. Polyunsaturated fatty acid regulation of gene expression. J Mol Neurosci 2001;16:273-8, discussion 9-84.
13. Finstad HS, Kolset SO, Holme JA, Wiger R, Farrants AK, Blomhoff R, et al. Effect of n-3 and n-6 fatty acids on proliferation and differentiation of promyelocytic leukemic HL-60 cells. Blood 1994;84:3799-809.
14. Moore S, Knudsen B, True LD, Hawley S, Etzioni R, Wade C, et al. Loss of stearoyl-CoA desaturase expression is a frequent event in prostate carcinoma. Int J Cancer 2005;114:563-71.
15. Lane JMR, Jiang WG. Expression of human delta-6-desaturase is associated with aggressiveness of human breast cancer. Int J Mol Med 2003;12:253-7.
16. Wong ML, Medrano JF. Real-time PCR for mRNA quantitation. Biotechniques 2005;39:75-85.
17. Cho HP, Nakamura M, Clarke SD. Cloning, expression, and fatty acid regulation of the human delta-5 desaturase. J Biol Chem 1999;274:37335-9.
18. Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959;37:911-17.
19. Bjerve KS, Fischer S, Alme K. Alpha-linolenic acid deficiency in man: effect of ethyl linolenate on plasma and erythrocyte fatty acid composition and biosynthesis of prostanoids. Am J Clin Nutr 1987;46:570-6.
20. Kaluzny MA, Duncan LA, Merritt MV, Epps DE. Rapid separation of lipid classes in high yield and purity using bonded phase columns. J Lipid Res 1985;26:135-40.
21. Brekke OL, Sagen E, Bjerve KS. Specificity of endogenous fatty acid release during tumor necrosis factor-induced apoptosis in WEHI 164 fibrosarcoma cells. J Lipid Res 1999;40:2223-33.
22. Melin T, Nilsson A. Delta-6-desaturase and delta-5-desaturase in human Hep G2 cells are both fatty acid interconversion rate limiting and are upregulated under essential fatty acid deficient conditions. Prostaglandins Leukot Essent Fatty Acids 1997;56:437-42.
23. Ntambi JM. The regulation of stearoyl-CoA desaturase (SCD). Prog Lipid Res 1995;34:139-50.
24. Cho HP, Nakamura MT, Clarke SD. Cloning, expression, and nutritional regulation of the mammalian Delta-6 desaturase. J Biol Chem 1999;274:471-7.
25. Sessler AM, Kaur N, Palta JP, Ntambi JM. Regulation of stearoyl-CoA desaturase 1 mRNA stability by polyunsaturated fatty acids in 3T3-L1 adipocytes. J Biol Chem 1996;271:29854-8.
26. Bene H, Lasky D, Ntambi JM. Cloning and characterization of the human stearoyl-CoA desaturase gene promoter: transcriptional activation by sterol regulatory element binding protein and repression by polyunsaturated fatty acids and cholesterol. Biochem Biophys Res Commun 2001;284:1194-8.
27. Nakamura MT, Nara TY. Essential fatty acid synthesis and its regulation in mammals. Prostaglandins Leukot Essent Fatty Acids 2003;68:145-50.
28. Hannah VC, Ou J, Luong A, Goldstein JL, Brown MS. Unsaturated fatty acids down-regulate srebp isoforms 1a and 1c by two mechanisms in HEK-293 cells. J Biol Chem 2001;276:4365-72.
29. Xu J, Teran-Garcia M, Park JH, Nakamura MT, Clarke SD. Polyunsaturated fatty acids suppress hepatic sterol regulatory element-binding protein-1 expression by accelerating transcript decay. J Biol Chem 2001;276:9800-7.
30. Xu J, Nakamura MT, Cho HP, Clarke SD. Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. A mechanism for the coordinate suppression of lipogenic genes by polyunsaturated fats. J Biol Chem 1999;274:23577-83.
31. Tang C, Cho HP, Nakamura MT, Clarke SD. Regulation of human delta-6 desaturase gene transcription: identification of a functional direct repeat-1 element. J Lipid Res 2003;44:686-95.
32. Nakamura MT, Cho HP, Clarke SD. Regulation of hepatic delta-6 desaturase expression and its role in the polyunsaturated fatty acid inhibition of fatty acid synthase gene expression in mice. J Nutr 2000;130:1561-5.