Demethylation of the RORC2 and IL17A in human CD4+ T lymphocytes defines Th17 origin of nonclassic Th1 cells

Journal of Immunology

Volumn 194, Issue 7, 2015, Pages 3116-3126

  Mazzoni, Alessio ^a,b,c   Santarlasci, Veronica ^a,b,d   Maggi, Laura ^a,b,d   Capone, Manuela ^a,b   Rossi, Maria Caterina ^a,b   Querci, Valentina ^a,b   De Palma, Raffaele ^c   Chang, Hyun Dong ^e   Thiel, Andreas ^f   Cimaz, Rolando ^g   Liotta, Francesco ^a,b,d   Cosmi, Lorenzo ^a,b,d   Maggi, Enrico ^a,b,d   Radbruch, Andreas ^e   Romagnani, Sergio ^a,b   Dong, Jun ^e   Annunziato, Francesco ^a,b,d  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

^c SECOND UNIVERSITY OF NAPLES   (Italy)

^d CAREGGI UNIVERSITY HOSPITAL   (Italy)

^e German Rheumatism Research Center Berlin   (Germany)

^f CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^g UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD161 ANTIGEN; CD4 ANTIGEN; INTERLEUKIN 17; MESSENGER RNA; RETINOIC ACID ORPHAN RECEPTOR C2; RETINOID RELATED ORPHAN RECEPTOR GAMMA; UNCLASSIFIED DRUG; CYTOKINE; GAMMA INTERFERON; NATURAL KILLER CELL LECTIN LIKE RECEPTOR SUBFAMILY B; NUCLEAR RECEPTOR NR2C2; T BOX TRANSCRIPTION FACTOR; T-BOX TRANSCRIPTION FACTOR TBX21;

ARTICLE; CD4+ CD161+ T LYMPHOCYTE; CD4+ CD161- T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL FUNCTION; CONTROLLED STUDY; DEMETHYLATION; DNA METHYLATION; EPIGENETICS; GENE EXPRESSION; GENE IDENTIFICATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IL17A GENE; POLYMERASE CHAIN REACTION; PRE T LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RORC2 GENE; TH1 CELL; TH17 CELL; UMBILICAL CORD BLOOD; BIOLOGICAL MODEL; BIOSYNTHESIS; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; IMMUNOPHENOTYPING; METABOLISM; PHENOTYPE; PROMOTER REGION; T LYMPHOCYTE SUBPOPULATION;

ANTIGENS, CD4; CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; DNA METHYLATION; GENE EXPRESSION REGULATION; HUMANS; IMMUNOPHENOTYPING; INTERFERON-GAMMA; INTERLEUKIN-17; MODELS, BIOLOGICAL; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY B; NUCLEAR RECEPTOR SUBFAMILY 2, GROUP C, MEMBER 2; PHENOTYPE; PRECURSOR CELLS, T-LYMPHOID; PROMOTER REGIONS, GENETIC; T-BOX DOMAIN PROTEINS; T-LYMPHOCYTE SUBSETS; TH1 CELLS; TH17 CELLS;

EID: 84925840424     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1401303     Document Type: Article

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