Amphiphilic polyelectrolyte/prodrug nanoparticles constructed by synergetic electrostatic and hydrophobic interactions with cooperative pH-sensitivity for controlled doxorubicin delivery

ACS Applied Materials and Interfaces

Volumn 7, Issue 11, 2015, Pages 6340-6350

  Huang, Pingsheng ^a,b   Wang, Weiwei ^c   Zhou, Junhui ^a   Zhao, Fuli ^a   Zhang, Yumin ^d   Liu, Jinjian ^d   Liu, Jianfeng ^d   Dong, Anjie ^a,b   Kong, Deling ^c   Zhang, Jianhua ^a,b  

^a TIANJIN UNIVERSITY   (China)

^b SynBio Research Platform   (China)

^c INSTITUTE OF BIOMEDICAL ENGINEERING   (China)

^d INSTITUTE OF RADIATION MEDICINE   (China)

Author keywords

doxorubicin; nanoparticle; pH sensitive; switchable delivery; tumor treatment

Indexed keywords

COMPUTER AIDED DESIGN; DRUG INTERACTIONS; EFFICIENCY; ELECTROSTATICS; FLUORESCENCE IMAGING; HYDROPHOBICITY; IONS; MEDICAL NANOTECHNOLOGY; MOLECULAR BIOLOGY; NANOPARTICLES; PH SENSORS; POLYELECTROLYTES; TARGETED DRUG DELIVERY; TUMORS;

AMPHIPHILIC POLYELECTROLYTES; DOXORUBICIN; HYDROPHOBIC INTERACTIONS; METHOXYPOLYETHYLENE GLYCOL; NON-COVALENT INTERACTION; PH SENSITIVE; SWITCHABLE; TUMOR TREATMENT;

CONTROLLED DRUG DELIVERY;

ANTINEOPLASTIC ANTIBIOTIC; DELAYED RELEASE FORMULATION; DOXORUBICIN; ELECTROLYTE; NANOCAPSULE; POLYMER; PRODRUG; SURFACTANT;

3T3 CELL LINE; ADMINISTRATION AND DOSAGE; ANIMAL; CELL SURVIVAL; CHEMISTRY; DELAYED RELEASE FORMULATION; DIFFUSION; DRUG EFFECTS; HELA CELL LINE; HEPG2 CELL LINE; HUMAN; MOUSE; NEOPLASMS, EXPERIMENTAL; PATHOLOGY; PH; STATIC ELECTRICITY; SYNTHESIS; TREATMENT OUTCOME; ULTRASTRUCTURE;

3T3 CELLS; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CELL SURVIVAL; DELAYED-ACTION PREPARATIONS; DIFFUSION; DOXORUBICIN; ELECTROLYTES; HELA CELLS; HEP G2 CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; MICE; NANOCAPSULES; NEOPLASMS, EXPERIMENTAL; POLYMERS; PRODRUGS; STATIC ELECTRICITY; SURFACE-ACTIVE AGENTS; TREATMENT OUTCOME;

EID: 84925808794     PISSN: 19448244     EISSN: 19448252     Source Type: Journal    
DOI: 10.1021/acsami.5b00962     Document Type: Article

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