Self-assembled targeted nanoparticles: Evolution of technologies and bench to bedside translation

Accounts of Chemical Research

Volumn 44, Issue 10, 2011, Pages 1123-1134

  Shi, Jinjun ^a   Xiao, Zeyu ^a   Kamaly, Nazila ^a   Farokhzad, Omid C ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIAGNOSTIC AGENT; NANOPARTICLE;

ANIMAL; CHEMISTRY; HUMAN; INSTRUMENTATION; METHODOLOGY; MOLECULARLY TARGETED THERAPY; NANOMEDICINE; NEOPLASM; REVIEW; TRANSLATIONAL RESEARCH;

ANIMALS; HUMANS; MOLECULAR TARGETED THERAPY; NANOMEDICINE; NANOPARTICLES; NEOPLASMS; TRANSLATIONAL MEDICAL RESEARCH;

EID: 80054741757     PISSN: 00014842     EISSN: 15204898     Source Type: Journal    
DOI: 10.1021/ar200054n     Document Type: Review

References (39)

1. Farokhzad, O. C.; Langer, R. Impact of nanotechnology on drug delivery ACS Nano 2009, 3, 16-20
2. Riehemann, K.; Schneider, S. W.; Luger, T. A.; Godin, B.; Ferrari, M.; Fuchs, H. Nanomedicine-challenge and perspectives Angew. Chem., Int. Ed. 2009, 48, 872-897
3. Petros, R. A.; DeSimone, J. M. Strategies in the design of nanoparticles for therapeutic applications Nat. Rev. Drug Discovery 2010, 9, 615-627
4. Executive Office of the President President's Council of Advisors on Science and Technology. Report to the President and Congress on the third assessment of the National Nanotechnology Initiative, 2010, pp 3.
5. Bangham, A. D.; Horne, R. W. Negative staining of phospholipids + their structural modification by surface active agents as observed in electron microscope J. Mol. Biol. 1964, 8, 660-668
6. Maggon, K. Monoclonal antibody market 2009: Global market analysis & top ten mAbs; http://knol.google.com/k/krishan-maggon/monoclonal-antibody- market-2009/3fy5eowy8suq3/86 (1/18/2011).
7. Ishida, T.; Kiwada, H. Accelerated blood clearance (ABC) phenomenon upon repeated injection of PEGylated liposomes Int. J. Pharm. 2008, 354, 56-62
8. Cheon, D. J.; Orsulic, S. Mouse models of cancer Annu. Rev. Pathol. 2011, 6, 95-119
9. Campos, S. M.; Penson, R. T.; Mays, A. R.; Berkowitz, R. S.; Fuller, A. F.; Goodman, A.; Matulonis, U. A.; Muzikansky, A.; Seiden, M. V. The clinical utility of liposomal doxorubicin in recurrent ovarian cancer Gynecol. Oncol. 2001, 81, 206-212 (Pubitemid 32424162)
10. Gradishar, W. J.; Tjulandin, S.; Davidson, N.; Shaw, H.; Desai, N.; Bhar, P.; Hawkins, M.; O'Shaughnessy, J. Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer J. Clin. Oncol. 2005, 23, 7794-7803 (Pubitemid 46657376)
11. Sparreboom, A.; Scripture, C. D.; Trieu, V.; Williams, P. J.; De, T. P.; Yang, A.; Beals, B.; Figg, W. D.; Hawkins, M.; Desai, N. Comparative preclinical and clinical pharmacokinetics of a cremophor-free, nanoparticle albumin-bound paclitaxel (ABI-007) and paclitaxel formulated in cremophor (Taxol) Clin. Cancer Res. 2005, 11, 4136-4143 (Pubitemid 40791578)
12. Langer, R.; Folkman, J. Polymers for the sustained release of proteins and other macromolecules Nature 1976, 263, 797-800
13. BIND Biosciences initiates Phase 1 clinical study of BIND-014; http://www.bindbio.com/content/pages/news/news-detail.jsp/q/news-id/55 (1/18/2011).
14. Zhang, L.; Gu, F. X.; Chan, J. M.; Wang, A. Z.; Langer, R. S.; Farokhzad, O. C. Nanoparticles in medicine: Therapeutic applications and developments Clin. Pharmacol. Ther. 2008, 83, 761-769 (Pubitemid 351556021)
15. Wagner, V.; Dullaart, A.; Bock, A. K.; Zweck, A. The emerging nanomedicine landscape Nat. Biotechnol. 2006, 24, 1211-1217 (Pubitemid 44564760)
16. Matsumura, Y.; Maeda, H. A New concept for macromolecular therapeutics in cancer chemotherapy-Mechanism of tumoritropic accumulation of proteins and the antitumor agent Smancs Cancer Res. 1986, 46, 6387-6392 (Pubitemid 17221789)
17. Davis, M. E.; Chen, Z.; Shin, D. M. Nanoparticle therapeutics: An emerging treatment modality for cancer Nat. Rev. Drug Discovery 2008, 7, 771-782
18. Gu, F.; Zhang, L.; Teply, B. A.; Mann, N.; Wang, A.; Radovic-Moreno, A. F.; Langer, R.; Farokhzad, O. C. Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 2586-2591 (Pubitemid 351520557)
19. Davis, M. E. The first targeted delivery of siRNA in humans via a self-assembling, cyclodextrin polymer-based nanoparticle: from concept to clinic Mol. Pharmaceutics 2009, 6, 659-668
20. Sankhala, K. K.; Mita, A. C.; Adinin, R.; Wood, L.; Beeram, M.; Bullock, S.; Yamagata, N.; Matsuno, K.; Fujisawa, T.; Phan, A. A phase I pharmacokinetic (PK) study of MBP-426, a novel liposome encapsulated oxaliplatin J. Clin. Oncol. 2009, 27, S2535
21. Matsumura, Y.; Gotoh, M.; Muro, K.; Yamada, Y.; Shirao, K.; Shimada, Y.; Okuwa, M.; Matsumoto, S.; Miyata, Y.; Ohkura, H.; Chin, K.; Baba, S.; Yama, T.; Kannami, A.; Takamatsu, Y.; Ito, K.; Takahashi, K. Phase I and pharmacokinetic study of MCC-465, a doxorubicin (DXR) encapsulated in PEG immunoliposome, in patients with metastatic stomach cancer Ann. Oncol. 2004, 15, 517-525 (Pubitemid 38444560)
22. Nemunaitis, J.; Senzer, N.; Bedell, C.; Nunan, R.; Sleer, L.; Chang, E. A phase I study of escalating doses of SGT-53 for intravenous infusion of patients with advanced solid tumors Mol. Ther. 2009, 17, S226
23. Farokhzad, O. C.; Jon, S. Y.; Khademhosseini, A.; Tran, T. N. T.; LaVan, D. A.; Langer, R. Nanopartide-aptamer bioconjugates: A new approach for targeting prostate cancer cells Cancer Res. 2004, 64, 7668-7672 (Pubitemid 39446893)
24. Farokhzad, O. C.; Cheng, J. J.; Teply, B. A.; Sherifi, I.; Jon, S.; Kantoff, P. W.; Richie, J. P.; Langer, R. Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 6315-6320
25. Dhar, S.; Kolishetti, N.; Lippard, S. J.; Farokhzad, O. C. Targeted delivery of cisplatin prodrug for safer and more effective prostate cancer therapy in vivo Proc. Natl. Acad. Sci. U.S.A. 2011, 108, 1850-1855
26. Kolishetti, N.; Dhar, S.; Valencia, P. M.; Lin, L. Q.; Karnik, R.; Lippard, S. J.; Langer, R.; Farokhzad, O. C. Engineering of self-assembled nanoparticle platform for precisely controlled combination drug therapy Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 17939-17944
27. Wang, A. Z.; Yuet, K.; Zhang, L. F.; Gu, F. X.; Huynh-Le, M.; Radovic-Moreno, A. F.; Kantoff, P. W.; Bander, N. H.; Langer, R.; Farokhzad, O. C. ChemoRad nanoparticles: A novel multifunctional nanoparticle platform for targeted delivery of concurrent chemoradiation Nanomedicine 2010, 5, 361-368
28. Zhang, L. F.; Chan, J. M.; Gu, F. X.; Rhee, J. W.; Wang, A. Z.; Radovic-Moreno, A. F.; Alexis, F.; Langer, R.; Farokhzad, O. C. Self-assembled lipid-polymer hybrid nanoparticles: A robust drug delivery platform ACS Nano 2008, 2, 1696-1702
29. Lammers, T.; Kiessling, F.; Hennink, W. E.; Storm, G. Nanotheranostics and image-guided drug delivery: Current concepts and future directions Mol. Pharmaceutics 2010, 7, 1899-1912
30. Cai, W.; Chen, X. Nanoplatforms for targeted molecular imaging in living subjects Small 2007, 3, 1840-1854 (Pubitemid 350099850)
31. Lee, J. H.; Lee, K.; Moon, S. H.; Lee, Y.; Park, T. G.; Cheon, J. All-in-one target-cell-specific magnetic nanoparticles for simultaneous molecular imaging and siRNA delivery Angew. Chem., Int. Ed. 2009, 48, 4174-4179
32. Wang, A. Z.; Bagalkot, V.; Vasilliou, C. C.; Gu, F.; Alexis, F.; Zhang, L.; Shaikh, M.; Yuet, K.; Cima, M. J.; Langer, R.; Kantoff, P. W.; Bander, N. H.; Jon, S. Y.; Farokhzad, O. C. Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy ChemMedChem 2008, 3, 1311-1315
33. Bagalkot, V.; Zhang, L.; Levy-Nissenbaum, E.; Jon, S.; Kantoff, P. W.; Langer, R.; Farokhzad, O. C. Quantum dot-Aptamer conjugates for synchronous cancer imaging, therapy, and sensing of drug delivery based on Bi-fluorescence resonance energy transfer Nano Lett. 2007, 7, 3065-3070 (Pubitemid 350132931)
34. Alexis, F.; Pridgen, E.; Molnar, L. K.; Farokhzad, O. C. Factors affecting the clearance and biodistribution of polymeric nanoparticles Mol. Pharmaceutics 2008, 5, 505-515
35. Karnik, R.; Gu, F.; Basto, P.; Cannizzaro, C.; Dean, L.; Kyei-Manu, W.; Langer, R.; Farokhzad, O. C. Microfluidic platform for controlled synthesis of polymeric nanoparticles Nano Lett. 2008, 8, 2906-2912
36. Valencia, P. M.; Basto, P. A.; Zhang, L. F.; Rhee, M.; Langer, R.; Farokhzad, O. C.; Karnik, R. Single-step assembly of homogenous lipid-polymeric and lipid-quantum dot nanoparticles enabled by microfluidic rapid mixing ACS Nano 2010, 4, 1671-1679
37. Farokhzad, O. C.; Khademhosseini, A.; Yon, S. Y.; Hermann, A.; Cheng, J. J.; Chin, C.; Kiselyuk, A.; Teply, B.; Eng, G.; Langer, R. Microfluidic system for studying nanoparticles and microparticles the interaction of with cells Anal. Chem. 2005, 77, 5453-5459 (Pubitemid 41266036)
38. Huh, D.; Matthews, B. D.; Mammoto, A.; Montoya-Zavala, M.; Hsin, H. Y.; Ingber, D. E. Reconstituting organ-level lung functions on a chip Science 2010, 328, 1662-1668
39. Chan, J. M.; Zhang, L. F.; Tong, R.; Ghosh, D.; Gao, W. W.; Liao, G.; Yuet, K. P.; Gray, D.; Rhee, J. W.; Cheng, J. J.; Golomb, G.; Libby, P.; Langer, R.; Farokhzad, O. C. Spatiotemporal controlled delivery of nanoparticles to injured vasculature Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 2213-2218