Developmental exposure to estrogen alters differentiation and epigenetic programming in a human fetal prostate xenograft model

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Saffarini, Camelia M ^a   McDonnell Clark, Elizabeth V ^a   Amin, Ali ^a,b   Huse, Susan M ^a   Boekelheide, Kim ^a  

^a BROWN UNIVERSITY   (United States)

^b RHODE ISLAND HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; ESTROGEN; HORMONE RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TESTOSTERONE; TUMOR SUPPRESSOR PROTEIN; BIOLOGICAL MARKER; PROSTATE SPECIFIC ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; EMBRYO; EPIGENETICS; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LASER CAPTURE MICRODISSECTION; MALE; MOUSE; NONHUMAN; ORGANOGENESIS; POLYMERASE CHAIN REACTION; PRENATAL EXPOSURE; PROSTATE CANCER; PROSTATE HYPERTROPHY; SIGNAL TRANSDUCTION; TUMOR DIFFERENTIATION; TUMOR XENOGRAFT; ANIMAL; CELL TRANSFORMATION; DISEASE MODEL; DRUG EFFECTS; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; NUDE MOUSE; PATHOLOGY; PHENOTYPE; PROSTATE; PROSTATE TUMOR; XENOGRAFT;

RODENTIA;

ANIMALS; BIOMARKERS; CELL TRANSFORMATION, NEOPLASTIC; CPG ISLANDS; DISEASE MODELS, ANIMAL; DNA METHYLATION; EPIGENESIS, GENETIC; EPITHELIAL CELLS; ESTROGENS; GENE EXPRESSION REGULATION; HETEROGRAFTS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, NUDE; PHENOTYPE; PROSTATE; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS; SIGNAL TRANSDUCTION;

EID: 84925799135     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0122290     Document Type: Article

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