The Wilms' tumor gene (WT1) regulates E-cadherin expression and migration of prostate cancer cells

Molecular Cancer

Volumn 12, Issue 1, 2013, Pages

  Brett, Adina ^a   Pandey, Sony ^a   Fraizer, Gail ^a  

^a KENT STATE UNIVERSITY   (United States)

Author keywords

E cadherin; Metastasis; Migration; Prostate cancer; WT1

Indexed keywords

MESSENGER RNA; UVOMORULIN; WT1 PROTEIN;

ARTICLE; BINDING SITE; CELL MIGRATION; CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; HUMAN; HUMAN CELL; MALE; PROSTATE CANCER; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SITE DIRECTED MUTAGENESIS;

BASE SEQUENCE; CADHERINS; CELL LINE, TUMOR; CELL MOVEMENT; DNA PRIMERS; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, WILMS TUMOR; HUMANS; MALE; MUTAGENESIS, SITE-DIRECTED; PROMOTER REGIONS, GENETIC; PROSTATIC NEOPLASMS; PROTEIN BINDING; WT1 PROTEINS;

EID: 84871974907     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-12-3     Document Type: Article

References (39)

1. Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin 2010, 60(5):277-300. 10.3322/caac.20073, 20610543.
2. Kingsley LA, Fournier PGJ, Chirgwin JM, Guise TA. Molecular biology of bone metastasis. Mol Cancer Ther 2007, 6(10):2609-2617. 10.1158/1535-7163.MCT-07-0234, 17938257.
3. Arya M, Bott SR, Shergill IS, Ahmed HU, Williamson M, Patel HR. The metastatic cascade in prostate cancer. Surg Oncol 2006, 15(3):117-128. 10.1016/j.suronc.2006.10.002, 17150354.
4. Christiansen JJ, Rajasekaran AK. Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis. Cancer Res 2006, 66(17):8319-8326. 10.1158/0008-5472.CAN-06-0410, 16951136.
5. Guarino M, Rubino B, Ballabio G. The role of epithelial-mesenchymal transition in cancer pathology. Pathology 2007, 39(3):305-318. 10.1080/00313020701329914, 17558857.
6. Davies G, Jiang W, Mason M. Cell-cell adhesion molecules and signaling intermediates and their role in the invasive potential of prostate cancer cells. J Urol 2000, 163(3):985-992. 10.1016/S0022-5347(05)67869-X, 10688036.
7. Annicotte JS, Iankova I, Miard S, Fritz V, Sarruf D, Abella A, Berthe ML, Noël D, Pillon A, Iborra F. Peroxisome proliferator-activated receptor gamma regulates E-cadherin expression and inhibits growth and invasion of prostate cancer. Mol Cell Biol 2006, 26(20):7561. 10.1128/MCB.00605-06, 1636859, 17015477.
8. Cheng L, Nagabhushan M, Pretlow TP, Amini SB, Pretlow TG. Expression of E-cadherin in primary and metastatic prostate cancer. Am J Pathol 1996, 148(5):1375-1380. 1861553, 8623909.
9. Umbas R, Isaacs WB, Bringuier PP, Schaafsma HE, Karthaus HFM, Oosterhof GON, Debruyne FMJ, Schalken JA. Decreased E-cadherin expression is associated with poor prognosis in patients with prostate cancer. Cancer Res 1994, 54(14):3929-3933.
10. Umbas R, Isaacs WB, Bringuier PP, Xue Y, Debruyne FMJ, Schalken JA. Relation between aberrant α-catenin expression and loss of E-cadherin function in prostate cancer. Int J Cancer 1997, 74(4):374-377. 10.1002/(SICI)1097-0215(19970822)74:4<374::AID-IJC2>3.0.CO;2-S, 9291424.
11. Graff JR, Herman JG, Lapidus RG, Chopra H, Xu R, Jarrard DF, Isaacs WB, Pitha PM, Davidson NE, Baylin SB. E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas. Cancer Res 1995, 55(22):5195-5199.
12. Graff JR, Greenberg VE, Herman JG, Westra WH, Boghaert ER, Ain KB, Saji M, Zeiger MA, Zimmer SG, Baylin SB. Distinct patterns of E-cadherin CpG island methylation in papillary, follicular, Hurthle's cell, and poorly differentiated human thyroid carcinoma. Cancer Res 1998, 58(10):2063-2066.
13. Guilford P, Hopkins J, Harraway J, McLeod M, McLeod N, Harawira P, Taite H, Scoular R, Miller A, Reeve AE. E-cadherin germline mutations in familial gastric cancer. Nature 1998, 392(6674):402-405. 10.1038/32918, 9537325.
14. Battle E, Sancho E, Franci C, Dominguez D, Monfar M, Baulida J, De Herreros AG. The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol 2000, 2(2):84-89. 10.1038/35000034, 10655587.
15. Cano A, Pérez-Moreno MA, Rodrigo I, Locascio A, Blanco MJ, del Barrio MG, Portillo F, Nieto MA. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol 2000, 2(2):76-83. 10.1038/35000025, 10655586.
16. Bolós V, Peinado H, Pérez-Moreno MA, Fraga MF, Esteller M, Cano A. The transcription factor slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with snail and E47 repressors. J Cell Sci 2003, 116(3):499-511. 10.1242/jcs.00224, 12508111.
17. Comijn J, Berx G, Vermassen P, Verschueren K, van Grunsven L, Bruyneel E, Mareel M, Huylebroeck D, Van Roy F. The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion. Mol Cell 2001, 7(6):1267-1278. 10.1016/S1097-2765(01)00260-X, 11430829.
18. Pérez-Moreno MA, Locascio A, Rodrigo I, Dhondt G, Portillo F, Nieto MA, Cano A. A New role for E12/E47 in the repression of E-cadherin expression and epithelial-mesenchymal transitions. J Biol Chem 2001, 276(29):27424-27431. 10.1074/jbc.M100827200, 11309385.
19. Vesuna F, van Diest P, Chen JH, Raman V. Twist is a transcriptional repressor of E-cadherin gene expression in breast cancer. Biochem Biophys Res Commun 2008, 367(2):235-241. 10.1016/j.bbrc.2007.11.151, 2696127, 18062917.
20. Hosono S, Gross I, English MA, Hajra KM, Fearon ER, Licht JD. E-cadherin Is a WT1 Target Gene. J Biol Chem 2000, 275(15):10943-10953. 10.1074/jbc.275.15.10943, 10753894.
21. Martínez-Estrada OM, Lettice LA, Essafi A, Guadix JA, Slight J, Velecela V, Hall E, Reichmann J, Devenney PS, Hohenstein P. Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and E-cadherin. Nat Genet 2009, 42(1):89-93. 2799392, 20023660.
22. Haber DA. Alternative splicing and genomic structure of the Wilms tumor gene WT1. Proc Natl Acad Sci USA 1991, 88:9618-9622. 10.1073/pnas.88.21.9618, 52769, 1658787.
23. Haber DA, Buckler AJ, Glaser T, Call KM, Pelletier J, Sohn RL, Douglass EC, Housman DE. An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor. Cell 1990, 61(7):1257-1269. 10.1016/0092-8674(90)90690-G, 2163761.
24. Netinatsunthorn W, Hanprasertpong J, Dechsukhum C, Leetanaporn R, Geater A. WT1 gene expression as a prognostic marker in advanced serous epithelial ovarian carcinoma: an immunohistochemical study. BMC Cancer 2006, 6(1):90-98. 10.1186/1471-2407-6-90, 1479357, 16606472.
25. Ohno S, Dohi S, Ohno Y, Kyo S, Sugiyama H, Suzuki N, Inoue M. Immunohistochemical detection of WT1 protein in endometrial cancer. Anticancer Res 2009, 29(5):1691-1695.
26. Oji Y, Miyoshi Y, Koga S, Nakano Y, Ando A, Nakatsuka S, Ikeba A, Takahashi E, Sakaguchi N, Yokota A. Overexpression of the Wilms' tumor gene WT1 in primary thyroid cancer. Cancer Sci 2003, 94(7):606-611. 10.1111/j.1349-7006.2003.tb01490.x, 12841869.
27. Oji Y, Nakamori S, Fujikawa M, Nakatsuka S, Yokota A, Tatsumi N, Abeno S, Ikeba A, Takashima S, Tsujie M. Overexpression of the Wilms' tumor gene WT1 in pancreatic ductal adenocarcinoma. Cancer Sci 2004, 95(7):583-587. 10.1111/j.1349-7006.2004.tb02490.x, 15245594.
28. Patmasiriwat P, Fraizer G, Kantarjian H, Saunders G. WT1 and GATA1 expression in myelodysplastic syndrome and acute leukemia. Leukemia 1999, 13(6):891-900. 10.1038/sj.leu.2401414, 10360378.
29. Devilard E, Bladou F, Ramuz O, Karsenty G, Dalès JP, Gravis G, Nguyen C, Bertucci F, Xerri L, Birnbaum D. FGFR1 and WT1 are markers of human prostate cancer progression. BMC Cancer 2006, 6(1):272-282. 10.1186/1471-2407-6-272, 1698935, 17137506.
30. Gregg J, Brown K, Mintz E, Piontkivska H, Fraizer G. Analysis of gene expression in prostate cancer epithelial and interstitial stromal cells using laser capture microdissection. BMC Cancer 2010, 10(1):165-178. 10.1186/1471-2407-10-165, 2876079, 20426842.
31. Morton RA, Ewing CM, Nagafuchi A, Tsukita S, Isaacs WB. Reduction of E-cadherin levels and deletion of the α-catenin gene in human prostate cancer cells. Cancer Res 1993, 53(15):3585.
32. Liu YN, Lee WW, Wang CY, Chao TH, Chen Y, Chen JH. Regulatory mechanisms controlling human E-cadherin gene expression. Oncogene 2005, 24(56):8277-8290. 10.1038/sj.onc.1208991, 16116478.
33. Eisermann K, Tandon S, Bazarov A, Brett A, Fraizer G, Piontkivska H. Evolutionary conservation of zinc finger transcription factor binding sites in promoters of genes co-expressed with WT1 in prostate cancer. BMC Genomics 2008, 9(1):337. 10.1186/1471-2164-9-337, 2515153, 18631392.
34. Dutton J, Lahiri D, Ward A. Different isoforms of the Wilms' tumour protein WT1 have distinct patterns of distribution and trafficking within the nucleus. Cell Prolif 2006, 39(6):519-536. 10.1111/j.1365-2184.2006.00409.x, 17109636.
35. Wagner N, Michiels J, Schedl A, Wagner K. The Wilms' tumour suppressor WT1 is involved in endothelial cell proliferation and migration: expression in tumour vessels in vivo. Oncogene 2008, 27(26):3662-3672. 10.1038/sj.onc.1211044, 18212735.
36. Jomgeow T, Oji Y, Tsuji N, Ikeda Y, Ito K, Tsuda A, Nakazawa T, Tatsumi N, Sakaguchi N, Takashima S. Wilms' tumor gene WT1 17AA (-)/KTS (-) isoform induces morphological changes and promotes cell migration and invasion in vitro. Cancer Sci 2006, 97(4):259-270. 10.1111/j.1349-7006.2006.00169.x, 16630117.
37. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011, 144(5):646-674. 10.1016/j.cell.2011.02.013, 21376230.
38. Dozmorov MG, Hurst RE, Culkin DJ, Kropp BP, Frank MB, Osban J, Penning TM, Lin HK. Unique patterns of molecular profiling between human prostate cancer LNCaP and PC-3 cells. Prostate 2009, 69(10):1077-1090. 10.1002/pros.20960, 2755240, 19343732.
39. Geback T, Schulz MM, Koumoutsakos P, Detmar M. TScratch: a novel and simple software tool for automated analysis of monolayer wound healing assays. Biotechniques 2009, 46:265-274.