Antibodies to the extracellular pore loop of TRPM8 act as antagonists of channel activation

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Miller, Silke ^a   Rao, Sara ^a   Wang, Weiya ^a   Liu, Hantao ^a   Wang, Judy ^a   Gavva, Narender R ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MENTHOL; MONOCLONAL ANTIBODY; POLYCLONAL ANTIBODY; TRANSIENT RECEPTOR POTENTIAL CHANNEL M8; TRANSIENT RECEPTOR POTENTIAL CHANNEL M;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN NERVE CELL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; IC50; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; SPINAL GANGLION; AMINO ACID SEQUENCE; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CHO CELL LINE; COLD; CRICETULUS; DRUG EFFECTS; HUMAN; HYPERALGESIA; METABOLISM; MOLECULAR GENETICS; NERVE CELL; SPRAGUE DAWLEY RAT;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; CELL LINE; CHO CELLS; COLD TEMPERATURE; CRICETULUS; GANGLIA, SPINAL; HUMANS; HYPERALGESIA; MALE; MOLECULAR SEQUENCE DATA; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; TRPM CATION CHANNELS;

EID: 84925777968     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0107151     Document Type: Article

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