Obesity and metabolic phenotypes (metabolically healthy and unhealthy variants) are significantly associated with prevalence of elevated C-reactive protein and hepatic steatosis in a large healthy Brazilian population

Journal of Obesity

Volumn 2015, Issue , 2015, Pages

  Shaharyar, Sameer ^a   Roberson, Lara L ^b   Jamal, Omar ^b   Younus, Adnan ^b   Blaha, Michael J ^c   Ali, Shozab S ^b   Zide, Kenneth ^a   Agatston, Arthur A ^b   Blumenthal, Roger S ^d   Conceição, Raquel D ^e   Santos, Raul D ^e,f   Nasir, Khurram ^b,c,d,g  

^a Aventura Hospital and Medical Center   (United States)

^b Baptist Health South Florida   (United States)

^c FLORIDA INTERNATIONAL UNIVERSITY   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e Preventive Medicine Center   (Brazil)

^f UNIVERSITY OF SÃO PAULO   (Brazil)

^g FLORIDA INTERNATIONAL UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; GLUCOSE BLOOD LEVEL;

ADULT; ARTICLE; BODY MASS; BODY WEIGHT; BRAZILIAN; CARDIOMETABOLIC RISK; CARDIOVASCULAR DISEASE; FATTY LIVER; FEMALE; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; METABOLIC DISORDER; METABOLIC PARAMETERS; METABOLIC SYNDROME X; OBESITY; PHENOTYPE; PHYSICIAN; PREVALENCE; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; ULTRASOUND; WAIST CIRCUMFERENCE; ABDOMEN; BRAZIL; CARDIOVASCULAR DISEASES; COMPLICATION; DIET RESTRICTION; ECHOGRAPHY; GLUCOSE BLOOD LEVEL; METABOLISM;

ABDOMEN; ADULT; BLOOD GLUCOSE; BODY MASS INDEX; BRAZIL; C-REACTIVE PROTEIN; CARDIOVASCULAR DISEASES; FASTING; FEMALE; HUMANS; INFLAMMATION; MALE; METABOLIC SYNDROME X; OBESITY; PHENOTYPE; PREVALENCE; RISK FACTORS; WAIST CIRCUMFERENCE;

EID: 84925764013     PISSN: 20900708     EISSN: 20900716     Source Type: Journal    
DOI: 10.1155/2015/178526     Document Type: Article

References (24)

1. C. G. Solomon and J. E. Manson, "Obesity and mortality: a review of the epidemiologic data," The American Journal of Clinical Nutrition, vol. 66, supplement 4, pp. 1044S-1050S, 1997.
2. S. Velho, F. Paccaud, G. Waeber, P. Vollenweider, and P. Marques-Vidal, "Metabolically healthy obesity: diferent prevalences using diferent criteria," European Journal of Clinical Nutrition, vol. 64, no. 10, pp. 1043-1051, 2010.
3. M. Blüher, "Te distinction of metabolically 'healthy' from 'unhealthy' obese individuals," Current Opinion in Lipidology, vol. 21, no. 1, pp. 38-43, 2010.
4. A. D. Karelis, "Obesity: to be obese-does it matter if you are metabolically healthy?" Nature Reviews Endocrinology, vol. 7, no. 12, pp. 699-700, 2011.
5. P. T. Katzmarzyk, I. Janssen, R. Ross, T. S. Church, and S. N. Blair, "Te importance of waist circumference in the defnition of metabolic syndrome: prospective analyses of mortality in men," Diabetes Care, vol. 29, no. 2, pp. 404-409, 2006.
6. K. E. Kip, O. C. Marroquin, D. E. Kelley et al., "Clinical importance of obesity versus the metabolic syndrome in cardiovascular risk in women: a report from the Women's Ischemia Syndrome Evaluation (WISE) study," Circulation, vol. 109, no. 6, pp. 706-713, 2004.
7. Y. Song, J. E. Manson, J. B. Meigs, P. M. Ridker, J. E. Buring, and S. Liu, "Comparison of usefulness of body mass index versus metabolic risk factors in predicting 10-year risk of cardiovascular events in women," The American Journal of Cardiology, vol. 100, no. 11, pp. 1654-1658, 2007.
8. J. B. Meigs, P. W. F. Wilson, C. S. Fox et al., "Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease," Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 8, pp. 2906-2912, 2006.
9. A. C. St-Pierre, B. Cantin, P. Maurìege et al., "Insulin resistance syndrome, body mass index and the risk of ischemic heart disease," Canadian Medical Association Journal, vol. 172, no. 10, pp. 1301-1305, 2005.
10. G. Calori, G. Lattuada, L. Piemonti et al., "Prevalence, metabolic features, and prognosis of metabolically healthy obese Italian individuals: the cremona study," Diabetes Care, vol. 34, no. 1, pp. 210-215, 2011.
11. A. D. Ogorodnikova, M. Kim, A. P. McGinn, P. Muntner, U. Khan, and R. P. Wildman, "Incident cardiovascular disease events in metabolically benign obese individuals," Obesity, vol. 20, no. 3, pp. 651-659, 2012.
12. J. Arnlöv, E. Ingelsson, J. Sundström, and L. Lind, "Impact of body mass index and the metabolic syndrome on the risk of cardiovascular disease and death in middle-aged men," Circulation, vol. 121, no. 2, pp. 230-236, 2010.
13. A. J. Flint, F. B. Hu, R. J. Glynn et al., "Excess weight and the risk of incident coronary heart disease among men and women," Obesity, vol. 18, no. 2, pp. 377-383, 2010.
14. R. V. Dvorak, W. F. DeNino, P. A. Ades, and E. T. Poehlman, "Phenotypic characteristics associated with insulin resistance in metabolically obese but normal-weight young women," Diabetes, vol. 48, no. 11, pp. 2210-2214, 1999.
15. S. Bellentani, G. Saccoccio, F. Masutti et al., "Prevalence of and risk factors for hepatic steatosis in northern Italy," Annals of Internal Medicine, vol. 132, no. 2, pp. 112-117, 2000.
16. P. L. Huang, "A comprehensive defnition for metabolic syndrome," Disease Models & Mechanisms, vol. 2, no. 5-6, pp. 231-237, 2009.
17. R. S. Ahima and J. S. Flier, "Adipose tissue as an endocrine organ," Trends in Endocrinology and Metabolism, vol. 11, no. 8, pp. 327-332, 2000.
18. T. H. Lee, W. S. Jeon, K. J. Han et al., "Comparison of serum adipocytokine levels according to metabolic health and obesity status," Endocrinology and Metabolism. In press.
19. H. Ofaz, N. Ozbey, F. Mantar et al., "Determination of endothe-lial function and early atherosclerotic changes in healthy obese women," Diabetes, Nutrition and Metabolism: Clinical and Experimental, vol. 16, no. 3, pp. 176-181, 2003.
20. M. A. Marini, E. Succurro, S. Frontoni et al., "Metabolically healthy but obese women have an intermediate cardiovascular risk profle between healthy nonobese women and obese insulin-resistant women," Diabetes Care, vol. 30, no. 8, pp. 2145-2147, 2007.
21. C. H. Jung, M. J. Lee, J. Y. Hwang et al., "Association of metabolically healthy obesity (MHO) with subclinical coronary atherosclerosis in a Korean population," Obesity, vol. 22, no. 12, pp. 2613-2620, 2014.
22. R. Eshtiaghi, S. Keihani, F. Hosseinpanah, M. Barzin, and F. Azizi, "Natural course of metabolically healthy abdominal obese adults afer 10 years of follow-up: the Tehran Lipid and Glucose Study," International Journal of Obesity, 2014.
23. L. L. Roberson, E. C. Aneni, W. Maziak et al., "Beyond BMI: the 'metabolically healthy obese' phenotype & its association with clinical/subclinical cardiovascular disease and all-cause mortality-a systematic review," BMC Public Health, vol. 14, no. 1, article 14, 2014.
24. A. Seppälä-Lindroos, S. Vehkavaara, A.-M. Häkkinen et al., "Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men," Journal of Clinical Endocrinology and Metabolism, vol. 87, no. 7, pp. 3023-3028, 2002.