Clostridium novyi-NT can cause regression of orthotopically implanted glioblastomas in rats

Oncotarget

Volumn 6, Issue 8, 2015, Pages 5536-5546

  Staedtke, Verena ^a   Bai, Ren Yuan ^a   Sun, Weiyun ^a   Huang, Judy ^a   Kibler, Kathleen Kazuko ^b   Tyler, Betty M ^a   Gallia, Gary L ^a   Kinzler, Kenneth ^a   Vogelstein, Bert ^a   Zhou, Shibin ^a   Riggins, Gregory J ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Bacterial therapy; Clostridium novyi NT; Glioblastoma multiforme; Stroke

Indexed keywords

CARBOPLATIN; DEXAMETHASONE; DOCETAXEL; DOXORUBICIN; IRINOTECAN; LUCIFERIN; PACLITAXEL; TEMOZOLOMIDE; TOPOTECAN; ANTINEOPLASTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL SPORE; BACTERIOLYSIS; BACTERIOLYTIC THERAPY; BRAIN EDEMA; CANCER CELL; CANCER REGRESSION; CANCER RESISTANCE; CANCER TRANSPLANTATION; CELL SURVIVAL; CLOSTRIDIUM NOVYI; CONTROLLED STUDY; FEMALE; GLIOBLASTOMA; HYPOXIA; INTRACRANIAL HYPERTENSION; NONHUMAN; POSTOPERATIVE EDEMA; PRIMARY TUMOR; RAT; REHYDRATION; SPORE GERMINATION; SURVIVAL; THERAPY; TUMOR MICROENVIRONMENT; ANIMAL; BRAIN NEOPLASMS; CELL HYPOXIA; CLOSTRIDIUM; CLOSTRIDIUM INFECTION; DRUG SCREENING; FISCHER 344 RAT; GROWTH, DEVELOPMENT AND AGING; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; MICROBIOLOGY; NUDE RAT; PATHOLOGY; PHYSIOLOGY; VETERINARY;

ANIMALS; ANTINEOPLASTIC AGENTS; BRAIN NEOPLASMS; CELL HYPOXIA; CLOSTRIDIUM; CLOSTRIDIUM INFECTIONS; FEMALE; GLIOBLASTOMA; HUMANS; INJECTIONS, INTRAVENOUS; RATS; RATS, INBRED F344; RATS, NUDE; SPORES, BACTERIAL; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84925665480     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.3627     Document Type: Article

References (28)

1. Dolecek TA, Propp JM, Stroup NE, & Kruchko C. CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2005-2009. Neuro-oncology. 2012; 14 Suppl 5:v1-49.
2. Bai RY, Staedtke V, & Riggins GJ. Molecular targeting of glioblastoma: Drug discovery and therapies. Trends in molecular medicine. 2011; 17(6):301-312.
3. Tanaka S, Louis DN, Curry WT, Batchelor TT, & Dietrich J. Diagnostic and therapeutic avenues for glioblastoma: no longer a dead end? Nature reviews. Clinical oncology. 2013; 10(1):14-26.
4. Bertout JA, Patel SA, & Simon MC. The impact of O2 availability on human cancer. Nature reviews. Cancer. 2008; 8(12):967-975.
5. Horsman MR, Mortensen LS, Petersen JB, Busk M, & Overgaard J. Imaging hypoxia to improve radiotherapy outcome. Nature reviews. Clinical oncology. 2012; 9(12):674-687.
6. Wilson WR & Hay MP. Targeting hypoxia in cancer therapy. Nature reviews. Cancer. 2011; 11(6):393-410.
7. Coley WB. The Treatment of Inoperable Sarcoma by Bacterial Toxins (the Mixed Toxins of the Streptococcus erysipelas and the Bacillus prodigiosus). Proceedings of the Royal Society of Medicine. 1910; 3(Surg Sect):1-48.
8. Forbes NS. Engineering the perfect (bacterial) cancer therapy. Nature reviews. Cancer. 2010; 10(11):785-794.
9. Dang LH, Bettegowda C, Huso DL, Kinzler KW, & Vogelstein B. Combination bacteriolytic therapy for the treatment of experimental tumors. Proceedings of the National Academy of Sciences of the United States of America. 2001; 98(26):15155-15160.
10. Wells CL & Wilkins TD. Clostridia: Sporeforming Anaerobic Bacilli. Medical Microbiology, ed Baron SGalveston (TX), 4th Ed. 1996.
11. Dang LH, Bettegowda C, Agrawal N, Cheong I, Huso D, Frost P, Loganzo F, Greenberger L, Barkoczy J, Pettit GR, Smith AB 3rd, Gurulingappa H, Khan S, et al. Targeting vascular and avascular compartments of tumors with C. novyi-NT and anti-microtubule agents. Cancer biology & therapy. 2004; 3(3):326-337.
12. Diaz LA, Jr., Cheong I, Foss CA, Zhang X, Peters BA, Agrawal N, Bettegowda C, Karim B, Liu G, Khan K, Huang X, Kohli M, Dang LH, et al. Pharmacologic and toxicologic evaluation of C. novyi-NT spores. Toxicological sciences: an official journal of the Society of Toxicology. 2005; 88(2):562-575.
13. Siu IM, Tyler BM, Chen JX, Eberhart CG, Thomale UW, Olivi A, Jallo GI, Riggins GJ, Gallia GL. Establishment of a human glioblastoma stemlike brainstem rodent tumor model. Journal of neurosurgery: Pediatrics. 2010; 6(1):92-97.
14. Cheong I, Huang X, Bettegowda C, Diaz LA Jr, Kinzler KW, Zhou S, Vogelstein B. A bacterial protein enhances the release and efficacy of liposomal cancer drugs. Science. 2006; 314(5803):1308-1311.
15. Sharp FR & Bernaudin M. HIF1 and oxygen sensing in the brain. Nature reviews. Neuroscience. 2004; 5(6):437-448.
16. Lacroix M, Abi-Said D, Fourney DR, Gokaslan ZL, Shi W, DeMonte F, Lang FF, McCutcheon IE, Hassenbusch SJ, Holland E, Hess K, Michael C, Miller D, et al. A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival. Journal of neurosurgery. 2001; 95(2):190-198.
17. Garraway LA & Janne PA. Circumventing cancer drug resistance in the era of personalized medicine. Cancer discovery. 2012; 2(3):214-226.
18. Linkermann A, Stockwell BR, Krautwald S, & Anders HJ. Regulated cell death and inflammation: an auto-amplification loop causes organ failure. Nature reviews. Immunology. 2014; 14(11):759-767.
19. Paredes-Sabja D, Cofre-Araneda G, Brito-Silva C, Pizarro-Guajardo M, Sarker MR. Clostridium difficile spore-macrophage interactions: spore survival. PLoS one. 2012; 7(8):e43635.
20. Bette P, Frevert J, Mauler F, Suttorp N, & Habermann E. Pharmacological and biochemical studies of cytotoxicity of Clostridium novyi type A alpha-toxin. Infection and immunity. 1989; 57(8):2507-2513.
21. Roberts NJ, Zhang L, Janku F, Collins A, Bai RY, Staedtke V, Rusk AW, Tung D, Miller M, Roix J, Khanna KV, Murthy R, Benjamin RS, et al. Intratumoral injection of Clostridium novyi-NT spores induces antitumor responses. Science translational medicine. 2014; 6(249):249ra111.
22. Agrawal N, Bettegowda C, Cheong I, Geschwind JF, Drake CG, Hipkiss EL, Tatsumi M, Dang LH, Diaz LA Jr, Pomper M, Abusedera M, Wahl RL, Kinzler KW, et al. Bacteriolytic therapy can generate a potent immune response against experimental tumors. Proceedings of the National Academy of Sciences of the United States of America. 2004; 101(42):15172-15177.
23. Bai RY, Staedtke V, Aprhys CM, Gallia GL, & Riggins GJ. Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme. Neuro-oncology. 2011; 13(9):974-982.
24. Huang J, Kim LJ, Poisik A, Pinsky DJ, Connolly ES Jr. Titration of postischemic cerebral hypoperfusion by variation of ischemic severity in a murine model of stroke. Neurosurgery. 1999; 45(2):328-33.
25. Popp A, Jaenisch N, Witte OW, & Frahm C. Identification of ischemic regions in a rat model of stroke. PloS one. 2009; 4(3):e4764.
26. Bettegowda C, Huang X, Lin J, Cheong I, Kohli M, Szabo SA, Zhang X, Diaz LA Jr, Velculescu VE, Parmigiani G, Kinzler KW, Vogelstein B, Zhou S. The genome and transcriptomes of the anti-tumor agent Clostridium novyi-NT. Nature biotechnology. 2006; 24(12):1573-1580.
27. Rago C, Huso DL, Diehl F, Karim B, Liu G, Papadopoulos N, Samuels Y, Velculescu VE, Vogelstein B, Kinzler KW, Diaz LA Jr. Serial assessment of human tumor burdens in mice by the analysis of circulating DNA. Cancer research. 2007; 67(19):9364-9370.
28. Bai RY, Staedtke V, Lidov HG, Eberhart CG, & Riggins GJ. OTX2 represses myogenic and neuronal differentiation in medulloblastoma cells. Cancer research. 2012; 72(22):5988-6001.