Clostridium difficile spore-macrophage interactions: Spore survival

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Paredes Sabja, Daniel ^a,b   Cofre Araneda, Glenda ^a   Brito Silva, Christian ^a   Pizarro Guajardo, Marjorie ^a   Sarker, Mahfuzur R ^b  

^a UNIVERSIDAD ANDRÉS BELLO   (Chile)

^b OREGON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE PROTEIN;

ACTIN POLYMERIZATION; ANIMAL CELL; ARTICLE; BACTERIAL SPORE; BACTERIAL SURVIVAL; BACTERIUM ADHERENCE; CELL DEATH; CELL SURFACE; CELL VIABILITY; CLOSTRIDIUM DIFFICILE; CONTROLLED STUDY; ELECTRON MICROSCOPY; FLUORESCENCE MICROSCOPY; INNATE IMMUNITY; INTERNALIZATION; MACROPHAGE; MOUSE; NONHUMAN; PHAGOCYTOSIS; PHAGOSOME; PROTEIN PROTEIN INTERACTION; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; CELL LINE; CELL SURVIVAL; CLOSTRIDIUM DIFFICILE; HOST-PATHOGEN INTERACTIONS; MACROPHAGES; MICE; PHAGOCYTOSIS; PHAGOSOMES; SONICATION; SPORES, BACTERIAL;

EID: 84865423020     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0043635     Document Type: Article

References (47)

1. Deneve C, Janoir C, Poilane I, Fantinato C, Collignon A, (2009) New trends in Clostridium difficile virulence and pathogenesis. Int J Antimicrob Agents 33 (Suppl 1):: S24-28.
2. Rupnik M, Wilcox MH, Gerding DN, (2009) Clostridium difficile infection: new developments in epidemiology and pathogenesis. Nat Rev Microbiol 7: 526-536.
3. Goulding D, Thompson H, Emerson J, Fairweather NF, Dougan G, et al. (2009) Distinctive profiles of infection and pathology in hamsters infected with Clostridium difficile strains 630 and B1. Infect Immun 77: 5478-5485.
4. Sethi AK, Al-Nassir WN, Nerandzic MM, Bobulsky GS, Donskey CJ, (2010) Persistence of skin contamination and environmental shedding of Clostridium difficile during and after treatment of C. difficile infection. Infect Control Hosp Epidemiol 31: 21-27.
5. Paredes-Sabja D, Sarker MR (2012) Adherence of Clostridium difficile spores to Caco-2 cells in culture. J Med Microbiol In Press.
6. Baines SD, O'Connor R, Saxton K, Freeman J, Wilcox MH, (2009) Activity of vancomycin against epidemic Clostridium difficile strains in a human gut model. J Antimicrob Chemother 63: 520-525.
7. Sarker MR, Paredes-Sabja D (2012) Molecular basis of early stages of Clostridium difficile infection: germination and colonization. Future Microbiol In Press.
8. Sorg JA, Sonenshein AL, (2008) Bile salts and glycine as co-germinants for Clostridium difficile spores. J Bacteriol 190: 2505-2512.
9. Sorg JA, Sonenshein AL, (2009) Chenodeoxycholate is an inhibitor of Clostridium difficile spore germination. J Bacteriol 191: 1115-1117.
10. Wheeldon LJ, Worthington T, Lambert PA (2011) Histidine acts as a co-germinant with glycine and taurocholate for Clostridium difficile spores. J Appl Microbiol.
11. Hasegawa M, Yamazaki T, Kamada N, Tawaratsumida K, Kim YG, et al. (2011) Nucleotide-binding oligomerization domain 1 mediates recognition of Clostridium difficile and induces neutrophil recruitment and protection against the pathogen. J Immunol 186: 4872-4880.
12. Ryan A, Lynch M, Smith SM, Amu S, Nel HJ, et al. (2011) A role for TLR4 in Clostridium difficile infection and the recognition of surface layer proteins. PLoS Pathog 7: e1002076.
13. Paredes-Sabja D, Sarker MR, (2012) Interactions between Clostridium perfringens spores and Raw 264.7 macrophages. Anaerobe 18: 148-156.
14. Paredes-Sabja D, Sarker N, Setlow B, Setlow P, Sarker MR, (2008) Roles of DacB and Spm proteins in Clostridium perfringens spore resistance to moist heat, chemicals and UV radiation. Appl Environ Microbiol 74: 3730-3738.
15. Raju D, Waters M, Setlow P, Sarker MR, (2006) Investigating the role of small, acid-soluble spore proteins (SASPs) in the resistance of Clostridium perfringens spores to heat. BMC Microbiol 6: 50.
16. Raju D, Setlow P, Sarker MR, (2007) Antisense-RNA-mediated decreased synthesis of small, acid-soluble spore proteins leads to decreased resistance of Clostridium perfringens spores to moist heat and UV radiation. Appl Environ Microbiol 73: 2048-2053.
17. Paredes-Sabja D, Raju D, Torres JA, Sarker MR, (2008) Role of small, acid-soluble spore proteins in the resistance of Clostridium perfringens spores to chemicals. Int J Food Microbiol 122: 333-335.
18. Paredes-Sabja D, Setlow B, Setlow P, Sarker MR, (2008) Characterization of Clostridium perfringens spores that lack SpoVA proteins and dipicolinic acid. J Bacteriol 190: 4648-4659.
19. Guidi-Rontani C, Pereira Y, Ruffie S, Sirard JC, Weber-Levy M, et al. (1999) Identification and characterization of a germination operon on the virulence plasmid pXO1 of Bacillus anthracis. Mol Microbiol 33: 407-414.
20. Guidi-Rontani C, Weber-Levy M, Labruyere E, Mock M, (1999) Germination of Bacillus anthracis spores within alveolar macrophages. Mol Microbiol 31: 9-17.
21. Guidi-Rontani C, Levy M, Ohayon H, Mock M, (2001) Fate of germinated Bacillus anthracis spores in primary murine macrophages. Mol Microbiol 42: 931-938.
22. Kang TJ, Fenton MJ, Weiner MA, Hibbs S, Basu S, et al. (2005) Murine macrophages kill the vegetative form of Bacillus anthracis. Infect Immun 73: 7495-7501.
23. Wust J, Sullivan NM, Hardegger U, Wilkins TD, (1982) Investigation of an outbreak of antibiotic-associated colitis by various typing methods. J Clin Microbiol 16: 1096-1101.
24. Paredes-Sabja D, Sarker MR, (2011) Germination response of spores of the pathoenic bacetrium Clostridium perfringens and Clostridium difficile to cultured human epithelial cells. Anaerobe 17: 78-84.
25. McEllistrem MC, Carman RJ, Gerding DN, Genheimer CW, Zheng L, (2005) A hospital outbreak of Clostridium difficile disease associated with isolates carrying binary toxin genes. Clin Infect Dis 40: 265-272.
26. Pelczar PL, Igarashi T, Setlow B, Setlow P, (2007) Role of GerD in germination of Bacillus subtilis spores. J Bacteriol 189: 1090-1098.
27. Nicholson WL, Setlow P (1990) Sporulation, germination and outgrowth. In: Harwood CR, Cutting SM, editors. Molecular biological methods for Bacillus. Chichester: John Wiley and Sons. 391-450.
28. May JA, Ratan H, Glenn JR, Losche W, Spangenberg P, et al. (1998) GPIIb-IIIa antagonists cause rapid disaggregation of platelets pre-treated with cytochalasin D. Evidence that the stability of platelet aggregates depends on normal cytoskeletal assembly. Platelets 9: 227-232.
29. Allen LA, Aderem A, (1996) Molecular definition of distinct cytoskeletal structures involved in complement- and Fc receptor-mediated phagocytosis in macrophages. J Exp Med 184: 627-637.
30. Henriques AO, Moran CP Jr, (2007) Structure, assembly, and function of the spore surface layers. Annu Rev Microbiol 61: 555-588.
31. Lawley TD, Croucher NJ, Yu L, Clare S, Sebaihia M, et al. (2009) Proteomic and genomic characterization of highly infectious Clostridium difficile 630 spores. J Bacteriol 191: 5377-5386.
32. Horwitz MA, (1984) Phagocytosis of the Legionnaires' disease bacterium (Legionella pneumophila) occurs by a novel mechanism: engulfment within a pseudopod coil. Cell 36: 27-33.
33. Groves E, Dart AE, Covarelli V, Caron E, (2008) Molecular mechanisms of phagocytic uptake in mammalian cells. Cellular and molecular life sciences: CMLS 65: 1957-1976.
34. Sebaihia M, Wren BW, Mullany P, Fairweather NF, Minton N, et al. (2006) The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome. Nat Genet 38: 779-786.
35. O'Brien DK, Melville SB, (2000) The anaerobic pathogen Clostridium perfringens can escape the phagosome of macrophages under aerobic conditions. Cell Microbiol 2: 505-519.
36. Paredes-Sabja D, Sarker MR (2011) Host serum factor triggers germination of Clostridium perfringens spores lacking cortex hydrolysis machinery. J Med Microbiol In Press.
37. Giebel JD, Carr KA, Anderson EC, Hanna PC, (2009) The germination-specific lytic enzymes SleB, CwlJ1, and CwlJ2 each contribute to Bacillus anthracis spore germination and virulence. J Bacteriol 191: 5569-5576.
38. Setlow P, (2003) Spore germination. Curr Opin Microbiol 6: 550-556.
39. Flannagan RS, Jaumouille V, Grinstein S, (2012) The cell biology of phagocytosis. Annual review of pathology 7: 61-98.
40. Gros P, Milder FJ, Janssen BJ, (2008) Complement driven by conformational changes. Nat Rev Immunol 8: 48-58.
41. Chung MC, Tonry JH, Narayanan A, Manes NP, Mackie RS, et al. (2011) Bacillus anthracis interacts with plasmin(ogen) to evade C3b-dependent innate immunity. PLoS One 6: e18119.
42. Mueller-Ortiz SL, Wanger AR, Norris SJ, (2001) Mycobacterial protein HbhA binds human complement component C3. Infect Immun 69: 7501-7511.
43. Lahteenmaki K, Edelman S, Korhonen TK, (2005) Bacterial metastasis: the host plasminogen system in bacterial invasion. Trends Microbiol 13: 79-85.
44. Okumura Y, Yano M, Murakami M, Mori S, Towatari T, et al. (1999) The extracellular processing of HIV-1 envelope glycoprotein gp160 by human plasmin. FEBS Lett 442: 39-42.
45. Stie J, Bruni G, Fox D, (2009) Surface-associated plasminogen binding of Cryptococcus neoformans promotes extracellular matrix invasion. PLoS One 4: e5780.
46. Hu H, Emerson J, Aronson AI, (2007) Factors involved in the germination and inactivation of Bacillus anthracis spores in murine primary macrophages. FEMS Microbiol Lett 272: 245-250.
47. Lawley TD, Clare S, Walker AW, Goulding D, Stabler RA, et al. (2009) Antibiotic treatment of Clostridium difficile carrier mice triggers a supershedder state, spore-mediated transmission, and severe disease in immunocompromised hosts. Infect Immun 77: 3661-3669.