Establishment of a human glioblastoma stemlike brainstem rodent tumor model: Laboratory investigation

Journal of Neurosurgery: Pediatrics

Volumn 6, Issue 1, 2010, Pages 92-97

  Siu, I Mei ^a   Tyler, Betty M ^a   Chen, James X ^a   Eberhart, Charles G ^a   Thomale, Ulrich Wilhelm ^b   Olivi, Alessandro ^a   Jallo, George I ^a   Riggins, Gregory J ^a   Gallia, Gary L ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Animal model; Brainstem; Glioblastoma; Glioma; Human; Neurospheres; Stemlike cells

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN STEM TUMOR; CANCER SURVIVAL; CONTROLLED STUDY; FEMALE; GLIOBLASTOMA; GLIOMA CELL; HISTOPATHOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; TEGMENTUM; VASCULAR TUMOR;

ANIMALS; BRAIN STEM; BRAIN STEM NEOPLASMS; CELL LINE, TUMOR; CHILD; DISEASE MODELS, ANIMAL; FEMALE; GLIOBLASTOMA; GLIOMA; HUMANS; MICE; MICE, NUDE; MULTIPOTENT STEM CELLS; NEOPLASM TRANSPLANTATION; NEOPLASTIC STEM CELLS; RATS; RATS, INBRED F344; RATS, NUDE; SPHEROIDS, CELLULAR;

EID: 77954370520     PISSN: 19330707     EISSN: 19330715     Source Type: Journal    
DOI: 10.3171/2010.3.PEDS09366     Document Type: Article

References (9)

1. Barth RF: Rat brain tumor models in experimental neurooncology: the 9L, C6, T9, F98, RG2 (D74), RT-2 and CNS-1 gliomas. J Neurooncol 36:91-102, 1998
2. Frazier JL, Lee J, Thomale UW, Noggle JC, Cohen KJ, Jallo GI: Treatment of diffuse intrinsic brainstem gliomas: failed approaches and future strategies. A review. J Neurosurg Pediatr 3:259-269, 2009
3. Galli R, Binda E, Orfanelli U, Cipelletti B, Gritti A, De Vitis S, et al: Isolation and characterization of tumorigenic, stemlike neural precursors from human glioblastoma. Cancer Res 64:7011-7021, 2004
4. Jallo GI, Volkov A, Wong C, Carson BS Sr, Penno MB: A novel brainstem tumor model: functional and histopathological characterization. Childs Nerv Syst 22:1519-1525, 2006
5. Lee J, Jallo GI, Guarnieri M, Carson BS Sr, Penno MB: A novel brainstem tumor model: guide screw technology with functional, radiological, and histopathological characterization. Neurosurg Focus 18 (6A):E11, 2005
6. Lee J, Kotliarova S, Kotliarov Y, Li A, Su Q, Donin NM, et al: Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell 9:391-403, 2006
7. Parsons DW, Jones S, Zhang X, Lin JC, Leary RJ, Angenendt P, et al: An integrated genomic analysis of human glioblastoma multiforme. Science 321:1807-1812, 2008
8. Singh SK, Hawkins C, Clarke ID, Squire JA, Bayani J, Hide T, et al: Identification of human brain tumour initiating cells. Nature 432:396-401, 2004
9. Thomale UW, Tyler B, Renard V, Dorfman B, Chacko VP, Carson BS, et al: Neurological grading, survival, MR imaging, and histological evaluation in the rat brainstem glioma model. Childs Nerv Syst 25:433-441, 2009