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Volumn 23, Issue 8, 2015, Pages 1776-1787
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Design, synthesis, and structure-activity relationships of 1-ethylpyrazole-3-carboxamide compounds as novel hypoxia-inducible factor (HIF)-1 inhibitors
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Author keywords
Cancer; Chemotherapy; Hypoxia inducible factor (HIF); Structure activity relationship
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Indexed keywords
1 ETHYLPYRAZOLE 3 CARBOXAMIDE;
4 [5[(4 BROMO 3,5 DIMETHYL 1H PYRAZOL 1 YL)METHYL]FURAN 2 CARBOXAMIDO] 1 ETHYL 1H PYRAZOLE 3 CARBOXAMIDE;
ANTINEOPLASTIC AGENT;
CARBONATE DEHYDRATASE IX;
CLB 016;
HYPOXIA INDUCIBLE FACTOR 1;
MOLECULAR SCAFFOLD;
UNCLASSIFIED DRUG;
MOLECULAR LIBRARY;
PYRAZOLE DERIVATIVE;
ANTINEOPLASTIC ACTIVITY;
ARTICLE;
CANCER INHIBITION;
CONTROLLED STUDY;
DRUG DESIGN;
DRUG IDENTIFICATION;
DRUG SCREENING;
DRUG STRUCTURE;
DRUG SYNTHESIS;
HUMAN;
HUMAN CELL;
IC50;
STRUCTURE ACTIVITY RELATION;
ANTAGONISTS AND INHIBITORS;
CELL HYPOXIA;
CHEMISTRY;
DRUG EFFECTS;
METABOLISM;
MOLECULAR LIBRARY;
NEOPLASMS;
PHARMACOLOGY;
SYNTHESIS;
TUMOR CELL LINE;
ANTINEOPLASTIC AGENTS;
CELL HYPOXIA;
CELL LINE, TUMOR;
DRUG DESIGN;
HUMANS;
HYPOXIA-INDUCIBLE FACTOR 1;
NEOPLASMS;
PYRAZOLES;
SMALL MOLECULE LIBRARIES;
STRUCTURE-ACTIVITY RELATIONSHIP;
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EID: 84925658448
PISSN: 09680896
EISSN: 14643391
Source Type: Journal
DOI: 10.1016/j.bmc.2015.02.038 Document Type: Article |
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Times cited : (28)
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References (12)
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