Functional analysis of free fatty acid receptor GPR120 in human eosinophils: Implications in metabolic homeostasis

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Konno, Yasunori ^a   Ueki, Shigeharu ^a   Takeda, Masahide ^a   Kobayashi, Yoshiki ^a,b   Tamaki, Mami ^a   Moritoki, Yuki ^a   Oyamada, Hajime ^a   Itoga, Masamichi ^a,c   Kayaba, Hiroyuki ^a,c   Omokawa, Ayumi ^a   Hirokawa, Makoto ^a  

^a AKITA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KANSAI MEDICAL UNIVERSITY   (Japan)

^c HIROSAKI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; FAS ANTIGEN; G PROTEIN COUPLED RECEPTOR 120; INTERLEUKIN 4; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; CASP3 PROTEIN, HUMAN; FAS PROTEIN, HUMAN; G PROTEIN COUPLED RECEPTOR; GW9508; IL4 PROTEIN, HUMAN; METHYLAMINE; O3FAR1 PROTEIN, HUMAN; PROPIONIC ACID DERIVATIVE; PROTEIN KINASE INHIBITOR;

APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE RELEASE; DEGRANULATION; ENZYME INHIBITION; EOSINOPHIL; HOMEOSTASIS; HUMAN; HUMAN CELL; INTERNALIZATION; NEUTROPHIL CHEMOTAXIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR DOWN REGULATION; AGONISTS; DRUG EFFECTS; GENETICS; METABOLISM; PHYSIOLOGY; SECRETION (PROCESS);

ANTIGENS, CD95; APOPTOSIS; CASPASE 3; EOSINOPHILS; HOMEOSTASIS; HUMANS; INTERLEUKIN-4; METHYLAMINES; PROPIONATES; PROTEIN KINASE INHIBITORS; RECEPTORS, G-PROTEIN-COUPLED;

EID: 84925651447     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0120386     Document Type: Article

References (37)

1. Shamri R, Xenakis JJ, Spencer LA (2011) Eosinophils in innate immunity: an evolving story. Cell Tissue Res 343: 57-83. doi: 10.1007/s00441-010-1049-6 PMID: 21042920
2. Giembycz MA, Lindsay MA (1999) Pharmacology of the eosinophil. Pharmacol Rev 51: 213-340. PMID: 10353986
3. Rothenberg ME, Hogan SP (2006) The eosinophil. Annu Rev Immunol 24: 147-174. PMID: 16551246
4. Lloyd CM, Saglani S (2013) Eosinophils in the spotlight: Finding the link between obesity and asthma. Nat Med 19: 976-977. doi: 10.1038/nm.3296 PMID: 23921744
5. Wu D, Molofsky AB, Liang HE, Ricardo-Gonzalez RR, Jouihan HA, et al. (2011) Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science 332: 243-247. doi: 10.1126/science.1201475 PMID: 21436399
6. Molofsky AB, Nussbaum JC, Liang HE, Van Dyken SJ, Cheng LE, et al. (2013) Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. J Exp Med 210: 535-549. doi: 10.1084/jem.20121964 PMID: 23420878
7. Rao RR, Long JZ, White JP, Svensson KJ, Lou J, et al. (2014) Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis. Cell 157: 1279-1291. doi: 10.1016/j.cell.2014.03.065 PMID: 24906147
8. Fredriksson R, Hoglund PJ, Gloriam DE, Lagerstrom MC, Schioth HB (2003) Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. FEBS Lett 554: 381-388. PMID: 14623098
9. Hirasawa A, Tsumaya K, Awaji T, Katsuma S, Adachi T, et al. (2005) Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. Nat Med 11: 90-94. PMID: 15619630
10. Oh DY, Talukdar S, Bae EJ, Imamura T, Morinaga H, et al. (2010) GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell 142: 687-698. doi: 10.1016/j.cell.2010.07.041 PMID: 20813258
11. Ichimura A, Hirasawa A, Poulain-Godefroy O, Bonnefond A, Hara T, et al. (2012) Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature 483: 350-354. doi: 10.1038/nature10798 PMID: 22343897
12. Yamamoto R, Ueki S, Moritoki Y, Kobayashi Y, Oyamada H, et al. (2013) Adiponectin attenuates human eosinophil adhesion and chemotaxis: implications in allergic inflammation. J Asthma.
13. Ueki S, Adachi T, Bourdeaux J, Oyamada H, Yamada Y, et al. (2003) Expression of PPARgamma in eosinophils and its functional role in survival and chemotaxis. Immunol Lett 86: 183-189. PMID: 12644321
14. Ueki S, Mahemuti G, Oyamada H, Kato H, Kihara J, et al. (2008) Retinoic acids are potent inhibitors of spontaneous human eosinophil apoptosis. J Immunol 181: 7689-7698. PMID: 19017957
15. Kobayashi Y, Ueki S, Mahemuti G, Chiba T, Oyamada H, et al. (2005) Physiological levels of 15-deoxy- Delta12,14-prostaglandin J2 prime eotaxin-induced chemotaxis on human eosinophils through peroxisome proliferator-activated receptor-gamma ligation. J Immunol 175: 5744-5750. PMID: 16237065
16. Matsuwaki Y, Ueki S, Adachi T, Oyamada H, Kamada Y, et al. (2005) The synthetic PPARgamma agonist troglitazone inhibits IL-5-induced CD69 upregulation and eosinophil-derived neurotoxin release from eosinophils. Pharmacology 74: 169-173. PMID: 15818060
17. Adachi T, Choudhury BK, Stafford S, Sur S, Alam R (2000) The differential role of extracellular signalregulated kinases and p38 mitogen-activated protein kinase in eosinophil functions. J Immunol 165: 2198-2204. PMID: 10925307
18. Briscoe CP, Peat AJ, McKeown SC, Corbett DF, Goetz AS, et al. (2006) Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules. Br J Pharmacol 148: 619-628. PMID: 16702987
19. Tamaki M, Konno Y, Kobayashi Y, Takeda M, Itoga M, et al. (2014) Expression and functional roles of G-protein-coupled estrogen receptor (GPER) in human eosinophils. Immunol Lett 160: 72-78. doi: 10.1016/j.imlet.2014.03.012 PMID: 24718279
20. Saito Y, Takeda M, Nishikawa J, Konno Y, Tamaki M, et al. (2014) The effect of pharmacological PI3Kgamma inhibitor on eotaxin-induced human eosinophil functions. Pulm Pharmacol Ther 27: 164-169. doi: 10.1016/j.pupt.2013.11.006 PMID: 24333185
21. Bandeira-Melo C, Perez SA, Melo RC, Ghiran I, Weller PF (2003) EliCell assay for the detection of released cytokines from eosinophils. J Immunol Methods 276: 227-237. PMID: 12738376
22. Druilhe A, Cai Z, Haile S, Chouaib S, Pretolani M (1996) Fas-mediated apoptosis in cultured human eosinophils. Blood 87: 2822-2830. PMID: 8639900
23. Tanigai T, Ueki S, Kihara J, Kamada R, Yamauchi Y, et al. (2012) Docosahexaenoic acid exerts anti-inflammatory action on human eosinophils through peroxisome proliferator-activated receptor-independent mechanisms. Int Arch Allergy Immunol 158: 375-386. doi: 10.1159/000332965 PMID: 22487606
24. Wu Q, Wang H, Zhao X, Shi Y, Jin M, et al. (2013) Identification of G-protein-coupled receptor 120 as a tumor-promoting receptor that induces angiogenesis and migration in human colorectal carcinoma. Oncogene 32: 5541-5550. doi: 10.1038/onc.2013.264 PMID: 23851494
25. Carvalheira JB, Qiu Y, Chawla A (2013) Blood spotlight on leukocytes and obesity. Blood 122: 3263-3267. doi: 10.1182/blood-2013-04-459446 PMID: 24065242
26. Sanchez-Reyes OB, Romero-Avila MT, Castillo-Badillo JA, Takei Y, Hirasawa A, et al. (2014) Free fatty acids and protein kinase C activation induce GPR120 (free fatty acid receptor 4) phosphorylation. Eur J Pharmacol 723: 368-374. doi: 10.1016/j.ejphar.2013.11.003 PMID: 24239485
27. Talukdar S, Olefsky JM, Osborn O (2011) Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases. Trends Pharmacol Sci 32: 543-550. doi: 10.1016/j.tips.2011.04.004 PMID: 21663979
28. Hudson BD, Shimpukade B, Mackenzie AE, Butcher AJ, Pediani JD, et al. (2013) The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism. Mol Pharmacol 84: 710-725. doi: 10.1124/mol.113.087783 PMID: 23979972
29. Cartoni C, Yasumatsu K, Ohkuri T, Shigemura N, Yoshida R, et al. (2010) Taste preference for fatty acids is mediated by GPR40 and GPR120. J Neurosci 30: 8376-8382. doi: 10.1523/JNEUROSCI.0496-10.2010 PMID: 20573884
30. Watson SJ, Brown AJ, Holliday ND (2012) Differential signaling by splice variants of the human free fatty acid receptor GPR120. Mol Pharmacol 81: 631-642. doi: 10.1124/mol.111.077388 PMID: 22282525
31. Woerly G, Honda K, Loyens M, Papin JP, Auwerx J, et al. (2003) Peroxisome proliferator-activated receptors alpha and gamma down-regulate allergic inflammation and eosinophil activation. J Exp Med 198: 411-421. PMID: 12900517
32. Kita H, Weiler DA, Abu-Ghazaleh R, Sanderson CJ, Gleich GJ (1992) Release of granule proteins from eosinophils cultured with IL-5. J Immunol 149: 629-635. PMID: 1624806
33. Taneera J, Lang S, Sharma A, Fadista J, Zhou Y, et al. (2012) A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets. Cell Metab 16: 122-134. doi: 10.1016/j.cmet.2012.06.006 PMID: 22768844
34. Katsuma S, Hatae N, Yano T, Ruike Y, Kimura M, et al. (2005) Free fatty acids inhibit serum deprivation-induced apoptosis through GPR120 in a murine enteroendocrine cell line STC-1. J Biol Chem 280: 19507-19515. PMID: 15774482
35. Miyata J, Fukunaga K, Iwamoto R, Isobe Y, Niimi K, et al. (2013) Dysregulated synthesis of protectin D1 in eosinophils from patients with severe asthma. J Allergy Clin Immunol 131: 353-360 e351-352. doi: 10.1016/j.jaci.2012.07.048 PMID: 23006546
36. Kato H, Ueki S, Kamada R, Kihara J, Yamauchi Y, et al. (2011) Leptin has a priming effect on eotaxininduced human eosinophil chemotaxis. Int Arch Allergy Immunol 155: 335-344. doi: 10.1159/000321195 PMID: 21346363
37. Wong CK, Cheung PF, Lam CW (2007) Leptin-mediated cytokine release and migration of eosinophils: implications for immunopathophysiology of allergic inflammation. Eur J Immunol 37: 2337-2348. PMID: 17634954