Free fatty acids and protein kinase C activation induce GPR120 (free fatty acid receptor 4) phosphorylation

European Journal of Pharmacology

Volumn 723, Issue 1, 2014, Pages 368-374

  Sánchez Reyes, Omar B ^a   Romero Ávila, M Teresa ^a   Castillo Badillo, Jean A ^a   Takei, Yoshinori ^b   Hirasawa, Akira ^b   Tsujimoto, Gozoh ^b   Villalobos Molina, Rafael ^c   García Sáinz, J Adolfo ^a  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^b KYOTO UNIVERSITY   (Japan)

^c UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

Free fatty acid receptor 4; GPR120; Protein kinase C; Receptor phosphorylation

Indexed keywords

DOCOSAHEXAENOIC ACID; FATTY ACID; FREE FATTY ACID RECEPTOR 4; G PROTEIN COUPLED RECEPTOR 120; LINOLEIC ACID; PHORBOL ESTER; PROTEIN KINASE C; UNCLASSIFIED DRUG;

ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CROSS REACTION; ENZYME ACTIVATION; EPIFLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; INTERNALIZATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

FREE FATTY ACID RECEPTOR 4; GPR120; PROTEIN KINASE C; RECEPTOR PHOSPHORYLATION;

ALPHA-LINOLENIC ACID; DOCOSAHEXAENOIC ACIDS; FATTY ACIDS, NONESTERIFIED; HEK293 CELLS; HUMANS; PHORBOL ESTERS; PHOSPHORYLATION; PROTEIN KINASE C; RECEPTORS, G-PROTEIN-COUPLED; RECOMBINANT FUSION PROTEINS; TETRADECANOYLPHORBOL ACETATE;

EID: 84893765954     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.11.003     Document Type: Article

References (30)

1. S.E. Avendaño-Vázquez, A. García-Caballero, and J.A. García-Sáinz Phosphorylation and desensitization of the lysophosphatidic acid receptor LPA1 Biochem. J. 385 2005 677 684 (Pubitemid 40208827)
2. R.N. Burns, and N.H. Moniri Agonism with the omega-3 fatty acids alpha-linolenic acid and docosahexaenoic acid mediates phosphorylation of both the short and long isoforms of the human GPR120 receptor Biochem. Biophys. Res. Commun. 396 2010 1030 1035
3. 1B-adrenoceptor desensitization and phosphorylation. Direct and paracrine/autocrine actions Biochim. Biophys. Acta 1823 2012 245 254
4. A. Chawla, J.J. Repa, R.M. Evans, and D.J. Mangelsdorf Nuclear receptors and lipid physiology: opening the X-files Science 294 2001 1866 1870 (Pubitemid 33101573)
5. A. García-Caballero, J.A. Olivares-Reyes, K.J. Catt, and J.A. García-Sáinz Angiotensin AT(1) receptor phosphorylation and desensitization in a hepatic cell line. Roles of protein kinase c and phosphoinositide 3-kinase Mol. Pharmacol. 59 2001 576 585 (Pubitemid 32179937)
6. 1B- adrenoceptor desensitization IUBMB Life 63 2011 811 815
7. 1D- adrenergic receptors Biochem. J. 353 2001 603 610
8. C. Gonindard, C. Bergonzi, C. Denier, C. Sergheraert, A. Klaebe, L. Chavant, and E. Hollande Synthetic hispidin, a PKC inhibitor, is more cytotoxic toward cancer cells than normal cells in vitro Cell Biol. Toxicol. 13 1997 141 153 (Pubitemid 27135257)
9. 2+ indicators with greatly improved fluorescence properties J. Biol. Chem. 260 1985 3440 3450 (Pubitemid 15114340)
10. M. Gschwendt, H.J. Muller, K. Kielbassa, R. Zang, W. Kittstein, G. Rincke, and F. Marks Rottlerin, a novel protein kinase inhibitor Biochem. Biophys. Res. Commun. 199 1994 93 98 (Pubitemid 24179919)
11. T. Hara, A. Hirasawa, A. Ichimura, I. Kimura, and G. Tsujimoto Free fatty acid receptors FFAR1 and GPR120 as novel therapeutic targets for metabolic disorders J. Pharm. Sci. 100 2011 3594 3601
12. T. Hara, A. Hirasawa, Q. Sun, K. Sadakane, C. Itsubo, T. Iga, T. Adachi, T.A. Koshimizu, T. Hashimoto, Y. Asakawa, and G. Tsujimoto Novel selective ligands for free fatty acid receptors GPR120 and GPR40 Naunyn-Schmiedeberg's Arch. Pharmacol. 380 2009 247 255
13. A. Hirasawa, T. Hara, S. Katsuma, T. Adachi, and G. Tsujimoto Free fatty acid receptors and drug discovery Biol. Pharm. Bull. 31 2008 1847 1851
14. A. Hirasawa, K. Tsumaya, T. Awaji, S. Katsuma, T. Adachi, M. Yamada, Y. Sugimoto, S. Miyazaki, and G. Tsujimoto Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120 Nat. Med. 11 2005 90 94 (Pubitemid 40215843)
15. Hudson, B.D., Shimpukade, B., Mackenzie, A.E., Butcher, A.J., Pediani, J.D., Christiansen, E., Heathcote, H., Tobin, A.B., Ulven, T., Milligan, G., 2013. The Pharmacology of a Potent and Selective Agonist, TUG-891, Demonstrates Both Potential Opportunity and Possible Challenges to Therapeutic Agonism of FFA4 (GPR120). Mol. Pharmacol. 84, 710-725
16. A. Ichimura, A. Hirasawa, O. Poulain-Godefroy, A. Bonnefond, T. Hara, L. Yengo, I. Kimura, A. Leloire, N. Liu, K. Iida, H. Choquet, P. Besnard, C. Lecoeur, S. Vivequin, K. Ayukawa, M. Takeuchi, K. Ozawa, M. Tauber, C. Maffeis, A. Morandi, R. Buzzetti, P. Elliott, A. Pouta, M.R. Jarvelin, A. Korner, W. Kiess, M. Pigeyre, R. Caiazzo, W. Van Hul, L. Van Gaal, F. Horber, B. Balkau, C. Levy-Marchal, K. Rouskas, A. Kouvatsi, J. Hebebrand, A. Hinney, A. Scherag, F. Pattou, D. Meyre, T.A. Koshimizu, I. Wolowczuk, G. Tsujimoto, and P. Froguel Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human Nature 483 2012 350 354
17. G. Martiny-Baron, M.G. Kazanietz, H. Mischak, P.M. Blumberg, G. Kochs, H. Hug, D. Marme, and C. Schachtele Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976 J. Biol. Chem. 268 1993 9194 9197 (Pubitemid 23145960)
18. K. Moore, Q. Zhang, N. Murgolo, T. Hosted, and R. Duffy Cloning, expression, and pharmacological characterization of the GPR120 free fatty acid receptor from cynomolgus monkey: comparison with human GPR120 splice variants Comp. Biochem. Physiol. B 154 2009 419 426
19. A.C. Newton Protein kinase C: poised to signal Am. J. Physiol. Endocrinol. Metab. 298 2010 E395 E402
20. D.Y. Oh, S. Talukdar, E.J. Bae, T. Imamura, H. Morinaga, W. Fan, P. Li, W.J. Lu, S.M. Watkins, and J.M. Olefsky GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects Cell 142 2010 687 698
21. R.B. Penn, A.N. Pronin, and J.L. Benovic Regulation of G protein-coupled receptor kinases Trends Cardiovasc. Med. 10 2000 81 89 (Pubitemid 32012684)
22. Rasband, W.S., 1997-2004. ImageJ, National Institutes of Health, 〈http://rsb.info.nih.gov/ij/âŒ.
23. A. Salahpour, S. Angers, and M. Bouvier Functional significance of oligomerization of G-protein-coupled receptors Trends Endocrinol. Metab. 11 2000 163 168 (Pubitemid 30457135)
24. O. Sánchez-Reyes, J. Castillo-Badillo, M. Romero-Ávila, Y. Takei, A. Hirasawa, G. Tsujimoto, R. Villalobos-Molina, and J. García-Sáinz Phosphorylation and internalization of short splicing variant of the omega 3 fatty acid sensor, GPR120 FASEB J. 27 2013 (Abstract 1173.5)
25. L.A. Stoddart, N.J. Smith, and G. Milligan International Union of Pharmacology. LXXI. Free fatty acid receptors FFA1, -2, and -3: pharmacology and pathophysiological functions Pharmacol. Rev. 60 2008 405 417
26. J. Vázquez-Prado, P. Casas-González, and J.A. García-Sáinz G protein-coupled receptor cross-talk: pivotal roles of protein phosphorylation and protein-protein interactions Cell. Signal 15 2003 549 557 (Pubitemid 36385160)
27. J. Vázquez-Prado, L.C. Medina, and J.A. García-Sáinz Activation of endothelin ETA receptors induces phosphorylation of alpha1b-adrenoreceptors in Rat-1 fibroblasts J. Biol. Chem. 272 1997 27330 27337 (Pubitemid 27452699)
28. J. Vázquez-Prado, L.C. Medina, M.T. Romero-Ávila, C. González-Espinosa, and J.A. García-Sáinz Norepinephrine- and phorbol ester-induced phosphorylation of alpha(1a)-adrenergic receptors. Functional aspects J. Biol. Chem. 275 2000 6553 6559 (Pubitemid 30129955)
29. J.D. Violin, and R.J. Lefkowitz Beta-arrestin-biased ligands at seven-transmembrane receptors Trends Pharmacol. Sci. 28 2007 416 422
30. S.J. Watson, A.J. Brown, and N.D. Holliday Differential signaling by splice variants of the human free fatty acid receptor GPR120 Mol. Pharmacol. 81 2012 631 642