Triazine-benzimidazole hybrids: Anticancer activity, DNA interaction and dihydrofolate reductase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 8, 2015, Pages 1691-1700

  Singla, Prinka ^a   Luxami, Vijay ^a   Paul, Kamaldeep ^a  

^a THAPAR UNIVERSITY   (India)

Author keywords

Anticancer; DHFR; DNA interaction; Molecular modelling; Triazine benzimidazole hybrids

Indexed keywords

(1 BENZYL 2 METHYL 1H BENZIMIDAZOL 5 YL)(4,6 DIMORPHOLIN 4 YL[1,3,5]TRIAZIN 2 YL)AMINE; (1 BENZYL 2 METHYL 1H BENZIMIDAZOL 5 YL)[(4 MORPHOLIN 4 YL 6 PIPERIDIN 1 YL)[1,3,5]TRIAZIN 2 YL]AMINE; (1 BENZYL 2 METHYL 1H BENZIMIDAZOL 5 YL)[4 (4 CHLOROPHENYL) 6 MORPHOLIN 4 YL[1,3,5]TRIAZIN 2 YL]AMINE; (1 BENZYL 2 METHYL 1H BENZIMIDAZOL 5 YL)[4 (4 METHYLPIPERAZIN 1 YL) 6 MORPHOLIN 4 YL[1,3,5]TRIAZIN 2 YL]AMINE; (3 BENZYL 2 METHYL 3H BENZIMIDAZOL 5 YL)(4 CHLORO 6 MORPHOLIN 4 YL[1,3,5]TRIAZIN 2 YL)AMINE; (3 BENZYL 2 METHYL 3H BENZIMIDAZOL 5 YL)(4 MORPHOLIN 4 YL 6 PYRROLIDIN 1 YL[1,3,5]TRIAZIN 2 YL)AMINE; (3 BENZYL 2 METHYL 3H BENZIMIDAZOL 5 YL)(4,6 DI MORPHOLIN 4 YL[1,3,5]TRIAZIN 2 YL)AMINE; (3 BENZYL 2 METHYL 3H BENZIMIDAZOL 5 YL)[4 (4 METHYLPIPERAZIN 1 YL) 6 MORPHOLIN 4 YL[1,3,5]TRIAZIN 2 YL]AMINE; 2 [4 (3 BENZYL 2 METHYL 3H BENZIMIDAZOL 5 YLAMINO) 6 MORPHOLIN 4 YL[1,3,5]TRIAZIN 2 YLAMINO]ETHANOL; ANTINEOPLASTIC AGENT; BENZIMIDAZOLE DERIVATIVE; DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE REDUCTASE INHIBITOR; N (1 BENZYL 2 METHYL 1H BENZIMIDAZOL 5 YL) N' (4 FLUOROPHENYL) 6 MORPHOLIN 4 YL[1,3,5]TRIAZINE 2,4 DIAMINE; N (2 AMINO ETHYL) N' (1 BENZYL 2 METHYL 1H BENZIMIDAZOL 5 YL) 6 MORPHOLIN 4 YL[1,3,5]TRIAZINE 2,4 DIAMINE; N (2 AMINO ETHYL) N' (3 BENZYL 2 METHYL 3H BENZIMIDAZOL 5 YL) 6 MORPHOLIN 4 YL[1,3,5]TRIAZINE 2,4 DIAMINE; N (3 BENZYL 2 METHYL 1H BENZIMIDAZOL 5 YL) 6 MORPHOLIN 4 YL N' (2 MORPHOLIN 4 YL ETHYL)[1,3,5]TRIAZINE 2,4 DIAMINE; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG; BENZIMIDAZOLE; DNA; FOLIC ACID ANTAGONIST; INTERCALATING AGENT;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DNA BINDING; DRUG DNA INTERACTION; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME IMMUNOASSAY; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; HYDROGEN BOND; IC50; IN VITRO STUDY; LC50; MALE; MOLECULAR DOCKING; MOLECULAR INTERACTION; MOLECULAR MODEL; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; NEOPLASMS;

MAMMALIA;

ANTINEOPLASTIC AGENTS; BENZIMIDAZOLES; CELL LINE, TUMOR; DNA; DRUG SCREENING ASSAYS, ANTITUMOR; FOLIC ACID ANTAGONISTS; HUMANS; INTERCALATING AGENTS; MODELS, MOLECULAR; NEOPLASMS; TETRAHYDROFOLATE DEHYDROGENASE; TRIAZINES;

EID: 84925620122     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.03.012     Document Type: Article

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