Synthesis, structure and anticancer activity of novel 2,4-diamino-1,3,5- triazine derivatives

European Journal of Medicinal Chemistry

Volumn 41, Issue 2, 2006, Pages 219-225

  Saczewski F ^a   Bulakowska A ^a   Bednarski, P ^b   Grunert, R ^b  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

^b UNIVERSITY OF GREIFSWALD   (Germany)

Author keywords

2,4 Diamino 1,3,5 triazine derivatives; Antitumor effect; Synthesis

Indexed keywords

2 (4 AMINO 6 MORPHOLIN 4 YL 1,3,5 TRIAZIN 2 YL) 2 [[4 (DIMETHYLAMINO) PHENYL]IMINO]ACETONITRILE; 2 (4 AMINO 6 PYRROLIDIN 1 YL 1,3,5 TRIAZIN 2 YL) 2 [[4 (DIMETHYLAMINO) PHENYL]IMINO]ACETONITRILE; 2 (4 AMINO 6 PYRROLIDIN 1 YL 1,3,5 TRIAZIN 2 YL)ACETONITRILE; 2 [4 AMINO 6 (3,5,5 TRIMETHYL 4,5 DIHYDRO 1H PYRAZOL 1 YL) 1,3,5 TRIAZIN 2 YL] 2 [[4 (DIMETHYLAMINO)PHENYL]IMINO]ACETONITRILE; 2 [4 AMINO 6 (3,5,5 TRIMETHYL 4,5 DIHYDRO 1H PYRAZOL 1 YL) 1,3,5 TRIAZIN 2 YL]ACETONITRILE; 2 [4 AMINO 6 (4 PHENYLPIPERAZIN 1 YL) 1,3,5 TRIAZIN 2 YL] 2 [[4 (DIMETHYLAMINO)PHENYL]IMINO]ACETONITRILE; 2 [4 AMINO 6 (4 PHENYLPIPERAZIN 1 YL) 1,3,5 TRIAZIN 2 YL]ACETONITRILE; 2 [4 AMINO 6 (5 ETHYL 4 METHYL 4,5 DIHYDRO 1H PYRAZOL 1 YL) 1,3,5 TRIAZIN 2 YL]ACETONITRILE; 2 [4 AMINO 6 [4 (2 METHYLPHENYL)PIPERAZIN 1 YL] 1,3,5 TRIAZIN 2 YL] 2 [[4 (DIMETHYLAMINO)PHENYL]IMINO]ACETONITRILE; 2 [4 AMINO 6 [4 (2 METHYLPHENYL)PIPERAZIN 1 YL] 1,3,5 TRIAZIN 2 YL]ACETONITRILE; 2 [4 AMINO 6 [4 (3 CHLOROPHENYL)PIPERAZIN 1 YL] 1,3,5 TRIAZIN 2 YL] 2 [[4 (DIMETHYLAMINO)PHENYL]IMINO]ACETONITRILE; 2 [4 AMINO 6 [4 (3 CHLOROPHENYL)PIPERAZIN 1 YL] 1,3,5 TRIAZIN 2 YL]ACETONITRILE; 2 [4 AMINO 6 [4 (4 FLUOROPHENYL)PIPERAZIN 1 YL] 1,3,5 TRIAZIN 2 YL]ACETONITRILE; 2 [4 AMINO 6 [4 (4 FLUOROPHENYL)PIPERAZIN 1YL] 1,3,5 TRAIZIN 2 YL] 2 [[4 (DIMETHYLAMINO)PHENYL]IMINO]ACETONITRILE; 2 [4 AMINO 6 [4 (4 NITROPHENYL)PIPERAZIN 1 YL] 1,3,5 TRIAZIN 2 YL] 2 [[4 (DIMETHYLAMINO)PHENYL]IMINO]ACETONITRILE; 2 [4 AMINO 6 [5 ETHYL 4 METHYL 4,5 DIHYDRO 1H PYRAZOL 1 YL) 1,3,5 TRIAZIN 2 YL] 2 [[4 (DIMETHYLAMINO)PHENYL]IMINO]ACETONITRILE; 4 AMINO 6 MORPHOLIN 4 YL N PHENYL 1,3,5 TRIAZINE 2 CARBOXAMIDE; 4 AMINO N PHENYL 6 (3,5,5 TRIMETHYL 4,5 DIHYDRO 1H PYRAZOL 1 YL] 1,3,5 TRIAZINE 2 CARBOXAMIDE; 4 AMINO N PHENYL 6 (4 PHENYLPIPERAZIN 1 YL) 1,3,5 TRIAZINE 2 CARBOXAMIDE; 4 AMINO N PHENYL 6 (5 ETHYL 4 METHYL 4,5 DIHYDRO 1H PYRAZOL 1 YL) 1,3,5 TRIAZINE 2 CARBOXAMIDE; 4 AMINO N PHENYL 6 [(3,5,5 TRIMETHYL ) 4,5 DIHYDRO 1H PYRAZOL 1 YL] 1,3,5 TRIAZINE 2 CARBOXAMIDE; 4 AMINO N PHENYL 6 [(5 ETHYL 4 METHYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL] 1,3,5 TRIAZINE 2 CARBOXAMIDE; 4 AMINO N PHENYL 6 PYRROLIDIN 1 YL 1,3,5 TRIAZINE 2 CARBOXAMIDE; 4 NITROSODIMETHYLANILINE; ACETONITRILE DERIVATIVE; AMIDE; ANILINE DERIVATIVE; NITROSOBENZENE; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; HUMANS; MELANOMA; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZINES;

EID: 33644939607     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2005.10.013     Document Type: Article

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