Circular RNA ITCH has inhibitory effect on ESCC by suppressing the Wnt/β-catenin pathway

Oncotarget

Volumn 6, Issue 8, 2015, Pages 6001-6013

  Li, Fang ^a   Zhang, Liyuan ^b   Li, Wei ^a   Deng, Jieqiong ^a   Zheng, Jian ^a   An, Mingxing ^a   Lu, Jiachun ^c   Zhou, Yifeng ^a  

^a MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

^b THE SECOND AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^c GUANGZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Cir ITCH; ESCC; Wnt catenin pathway

Indexed keywords

BETA CATENIN; CIRCULAR RNA ITCH; DISHEVELLED 2; MICRORNA 17; MICRORNA 214; MICRORNA 7; RNA; UNCLASSIFIED DRUG; CTNNB1 PROTEIN, HUMAN; ITCH PROTEIN, HUMAN; REPRESSOR PROTEIN; RNA, CIRCULAR; UBIQUITIN PROTEIN LIGASE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CYCLE REGULATION; CHINA; CONTROLLED STUDY; ESOPHAGEAL CANCER CELL LINE; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR GROWTH; UBIQUITINATION; WNT SIGNALING PATHWAY; ANIMAL; BIOSYNTHESIS; CELL PROLIFERATION; ESOPHAGUS TUMOR; GENETIC TRANSFECTION; GENETICS; METABOLISM; MIDDLE AGED; PHOSPHORYLATION; PHYSIOLOGY; SQUAMOUS CELL CARCINOMA; XENOGRAFT;

ADULT; ANIMALS; BETA CATENIN; CARCINOMA, SQUAMOUS CELL; CELL PROLIFERATION; ESOPHAGEAL NEOPLASMS; FEMALE; HETEROGRAFTS; HUMANS; MALE; MICE; MIDDLE AGED; PHOSPHORYLATION; REPRESSOR PROTEINS; RNA; TRANSFECTION; UBIQUITIN-PROTEIN LIGASES; WNT SIGNALING PATHWAY;

EID: 84925583141     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.3469     Document Type: Article

References (47)

1. Sakai NS, Samia-Aly E, Barbera M and Fitzgerald RC. A review of the current understanding and clinical utility of miRNAs in esophageal cancer. Seminars in cancer biology. 2013; 23(6 Pt B):512-521.
2. Dong S, Zhang P, Liang S, Wang S, Sun P and Wang Y. The role of the retinoblastoma protein-interacting zinc finger gene 1 tumor suppressor gene in human esophageal squamous cell carcinoma cells. Oncology letters. 2013; 6(6):1656-1662.
3. Chen J, Kwong DL, Cao T, Hu Q, Zhang L, Ming X, Chen J, Fu L and Guan X. Esophageal squamous cell carcinoma (ESCC): advance in genomics and molecular genetics. Diseases of the esophagus: official journal of the International Society for Diseases of the Esophagus/ISDE. 2013.
4. Kranzfelder M, Buchler P and Friess H. Surgery within multimodal therapy concepts for esophageal squamous cell carcinoma (ESCC): the MRI approach and review of the literature. Advances in medical sciences. 2009; 54(2):158-169.
5. Sorek R and Cossart P. Prokaryotic transcriptomics: a new view on regulation, physiology and pathogenicity. Nature reviews Genetics. 2010; 11(1):9-16.
6. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F and Rajewsky N. Circular RNAs are a large class of animal RNAs with regulatory potency. Nature. 2013; 495(7441):333-338.
7. Capel B, Swain A, Nicolis S, Hacker A, Walter M, Koopman P, Goodfellow P and Lovell-Badge R. Circular transcripts of the testis-determining gene Sry in adult mouse testis. Cell. 1993; 73(5):1019-1030.
8. Danan M, Schwartz S, Edelheit S and Sorek R. Transcriptome-wide discovery of circular RNAs in Archaea. Nucleic acids research. 2012; 40(7):3131-3142.
9. Hansen TB, Jensen TI, Clausen BH, Bramsen JB, Finsen B, Damgaard CK and Kjems J. Natural RNA circles function as efficient microRNA sponges. Nature. 2013; 495(7441):384-388.
10. Jeck WR, Sorrentino JA, Wang K, Slevin MK, Burd CE, Liu J, Marzluff WF and Sharpless NE. Circular RNAs are abundant, conserved, and associated with ALU repeats. Rna. 2013; 19(2):141-157.
11. Harvey KF and Kumar S. Nedd4-like proteins: an emerging family of ubiquitin-protein ligases implicated in diverse cellular functions. Trends in cell biology. 1999; 9(5):166-169.
12. Melino G, Gallagher E, Aqeilan RI, Knight R, Peschiaroli A, Rossi M, Scialpi F, Malatesta M, Zocchi L, Browne G, Ciechanover A and Bernassola F. Itch: a HECT-type E3 ligase regulating immunity, skin and cancer. Cell death and differentiation. 2008; 15(7):1103-1112.
13. Gao C and Chen YG. Dishevelled: The hub of Wnt signaling. Cellular signalling. 2010; 22(5):717-727.
14. Boyer A, Goff AK and Boerboom D. WNT signaling in ovarian follicle biology and tumorigenesis. Trends in endocrinology and metabolism: TEM. 2010; 21(1):25-32.
15. Wang W, Xue L, Liu H, Wang P, Xu P and Cai Y. Aberrant changes of Wnt2/beta-catenin signaling pathway induced by sodium nitroprusside in human esophageal squamous cell carcinoma cell lines. Cancer investigation. 2010; 28(3):230-241.
16. Zhi X, Lin L, Yang S, Bhuvaneshwar K, Wang H, Gusev Y, Lee MH, Kallakury B, Shivapurkar N, Cahn K, Tian X, Marshall JL, Byers SW and He AR. betaII-spectrin (SPTBN1) suppresses progression of hepatocellular carcinoma and wnt signaling via regulation of wnt inhibitor kallistatin. Hepatology. 2014.
17. Xu W, Wang Z, Zhang W, Qian K, Li H, Kong D, Li Y and Tang Y. Mutated K-ras activates CDK8 to stimulate the epithelial-to-mesenchymal transition in pancreatic cancer in part via the Wnt/beta-catenin signaling pathway. Cancer letters. 2014.
18. Liu Y, Cui H, Wang W, Li L, Wang Z, Yang S and Zhang X. Construction of circular miRNA sponges targeting miR-21 or miR-221 and demonstration of their excellent anticancer effects on malignant melanoma cells. The international journal of biochemistry & cell biology. 2013; 45(11):2643-2650.
19. Vincent HA and Deutscher MP. Substrate recognition and catalysis by the exoribonuclease RNase R. The Journal of biological chemistry. 2006; 281(40):29769-29775.
20. Vincent HA and Deutscher MP. Insights into how RNase R degrades structured RNA: analysis of the nuclease domain. Journal of molecular biology. 2009; 387(3):570-583.
21. Wei W, Li M, Wang J, Nie F and Li L. The E3 ubiquitin ligase ITCH negatively regulates canonical Wnt signaling by targeting dishevelled protein. Molecular and cellular biology. 2012; 32(19):3903-3912.
22. Rossi M, Inoue S, Walewska R, Knight RA, Dyer MJ, Cohen GM and Melino G. Caspase cleavage of Itch in chronic lymphocytic leukemia cells. Biochemical and biophysical research communications. 2009; 379(3):659-664.
23. Perry WL, Hustad CM, Swing DA, O'Sullivan TN, Jenkins NA and Copeland NG. The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice. Nature genetics. 1998; 18(2):143-146.
24. Rossi M, Aqeilan RI, Neale M, Candi E, Salomoni P, Knight RA, Croce CM and Melino G. The E3 ubiquitin ligase Itch controls the protein stability of p63. Proceedings of the National Academy of Sciences of the United States of America. 2006; 103(34):12753-12758.
25. Rossi M, De Laurenzi V, Munarriz E, Green DR, Liu YC, Vousden KH, Cesareni G and Melino G. The ubiquitin-protein ligase Itch regulates p73 stability. The EMBO journal. 2005; 24(4):836-848.
26. Matesic LE, Haines DC, Copeland NG and Jenkins NA. Itch genetically interacts with Notch1 in a mouse autoimmune disease model. Human molecular genetics. 2006; 15(24):3485-3497.
27. Ambros V. The functions of animal microRNAs. Nature. 2004; 431(7006):350-355.
28. Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell. 2009; 136(2):215-233.
29. Selbach M, Schwanhausser B, Thierfelder N, Fang Z, Khanin R and Rajewsky N. Widespread changes in protein synthesis induced by microRNAs. Nature. 2008; 455(7209):58-63.
30. Sampath D, Calin GA, Puduvalli VK, Gopisetty G, Taccioli C, Liu CG, Ewald B, Liu C, Keating MJ and Plunkett W. Specific activation of microRNA106b enables the p73 apoptotic response in chronic lymphocytic leukemia by targeting the ubiquitin ligase Itch for degradation. Blood. 2009; 113(16):3744-3753.
31. Hansen TB, Wiklund ED, Bramsen JB, Villadsen SB, Statham AL, Clark SJ and Kjems J. miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA. The EMBO journal. 2011; 30(21):4414-4422.
32. Chou YT, Lin HH, Lien YC, Wang YH, Hong CF, Kao YR, Lin SC, Chang YC, Lin SY, Chen SJ, Chen HC, Yeh SD and Wu CW. EGFR promotes lung tumorigenesis by activating miR-7 through a Ras/ERK/Myc pathway that targets the Ets2 transcriptional repressor ERF. Cancer research. 2010; 70(21):8822-8831.
33. Fu HL, Wu de P, Wang XF, Wang JG, Jiao F, Song LL, Xie H, Wen XY, Shan HS, Du YX and Zhao YP. Altered miRNA expression is associated with differentiation, invasion, and metastasis of esophageal squamous cell carcinoma (ESCC) in patients from Huaian, China. Cell biochemistry and biophysics. 2013; 67(2):657-668.
34. Yin G, Chen R, Alvero AB, Fu HH, Holmberg J, Glackin C, Rutherford T and Mor G. TWISTing stemness, inflammation and proliferation of epithelial ovarian cancer cells through MIR199A2/214. Oncogene. 2010; 29(24):3545-3553.
35. Ueda T, Volinia S, Okumura H, Shimizu M, Taccioli C, Rossi S, Alder H, Liu CG, Oue N, Yasui W, Yoshida K, Sasaki H, Nomura S, Seto Y, Kaminishi M, Calin GA, et al. Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysis. The lancet oncology. 2010; 11(2):136-146.
36. Deng M, Tang H, Zhou Y, Zhou M, Xiong W, Zheng Y, Ye Q, Zeng X, Liao Q, Guo X, Li X, Ma J and Li G. miR-216b suppresses tumor growth and invasion by targeting KRAS in nasopharyngeal carcinoma. Journal of cell science. 2011; 124(Pt 17):2997-3005.
37. Xu XL, Jiang YH, Feng JG, Su D, Chen PC and Mao WM. MicroRNA-17, microRNA-18a, and microRNA-19a are prognostic indicators in esophageal squamous cell carcinoma. The Annals of thoracic surgery. 2014; 97(3):1037-1045.
38. Clevers H. Wnt/beta-catenin signaling in development and disease. Cell. 2006; 127(3):469-480.
39. Lu W, Lin C, King TD, Chen H, Reynolds RC and Li Y. Silibinin inhibits Wnt/beta-catenin signaling by suppressing Wnt co-receptor LRP6 expression in human prostate and breast cancer cells. Cellular signalling. 2012; 24(12):2291-2296.
40. Lin SY, Xia W, Wang JC, Kwong KY, Spohn B, Wen Y, Pestell RG and Hung MC. Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression. Proceedings of the National Academy of Sciences of the United States of America. 2000; 97(8):4262-4266.
41. Malbon CC. G proteins in development. Nature reviews Molecular cell biology. 2005; 6(9):689-701.
42. Angers S and Moon RT. Proximal events in Wnt signal transduction. Nature reviews Molecular cell biology. 2009; 10(7):468-477.
43. Wang F, Xia J, Wang N and Zong H. miR-145 inhibits proliferation and invasion of esophageal squamous cell carcinoma in part by targeting c-Myc. Onkologie. 2013; 36(12):754-758.
44. Zheng J, Deng J, Xiao M, Yang L, Zhang L, You Y, Hu M, Li N, Wu H, Li W, Lu J and Zhou Y. A sequence polymorphism in miR-608 predicts recurrence after radiotherapy for nasopharyngeal carcinoma. Cancer Res. 2013; 73(16):5151-5162.
45. Lehmann U and Kreipe H. Real-time PCR analysis of DNA and RNA extracted from formalin-fixed and paraffin-embedded biopsies. Methods. 2001; 25(4):409-418.
46. Wu H, Zheng J, Deng J, Hu M, You Y, Li N, Li W, Lu J and Zhou Y. A genetic polymorphism in lincRNA-uc003opf.1 is associated with susceptibility to esophageal squamous cell carcinoma in Chinese populations. Carcinogenesis. 2013; 34(12):2908-2917.
47. Jiang L, Deng J, Zhu X, Zheng J, You Y, Li N, Wu H, Lu J and Zhou Y. CD44 rs13347 C>T polymorphism predicts breast cancer risk and prognosis in Chinese populations. Breast cancer research: BCR. 2012; 14(4):R105.