HPV16E7-Specific siRNA Inhibits Cell Proliferation in CaSki Cells

Cell Biochemistry and Biophysics

Volumn 71, Issue 2, 2015, Pages 529-534

  Li, Jun guo ^a   Li, Li ^b   Zhang, Shui wen ^a   Wei, Xiaoguang ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Cervical carcinomas; E7 gene; HPV; siRNA

Indexed keywords

SMALL INTERFERING RNA;

CELL PROLIFERATION; GENETICS; HUMAN; HUMAN PAPILLOMAVIRUS TYPE 16; RNA INTERFERENCE; TUMOR CELL LINE;

CELL LINE, TUMOR; CELL PROLIFERATION; HUMAN PAPILLOMAVIRUS 16; HUMANS; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 84925519807     PISSN: 10859195     EISSN: 15590283     Source Type: Journal    
DOI: 10.1007/s12013-014-0223-y     Document Type: Article

References (12)

1. Scheffner, M., & Whitaker, N. J. (2003). Human papillomavirus-induced carcinogenesis and the ubiquitin–proteasome system. Cancer Biology,13, 59–67.
2. Scheurer, M. E., Tortolero-Luna, G., Adler-Storthz, K., et al. (2005). Human papillomavirus infection: Biology, epidemiology, and prevention. International Journal of Gynecological Cancer,15, 727–746.
3. Smotkin, D., & Wettstein, F. O. (1986). Transcription of human papillomavirus type 16 early genes in a cervical cancer and a cancer-derived cell line and identification of the E7 protein. Proceedings of the National Academy of Sciences of the United States of America,83, 4680–4684.
4. Elbashir, S. M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K., & Tuschl, T. (2001). Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature,411, 494–498.
5. Hong, D., Lu, W., Ye, F., Hu, Y., & Xie, X. (2009). Gene silencing of HPV16 E6/E7 induced by promoter-targeting siRNA in SiHa cells. British Journal of Cancer,101, 1798–1804.
6. Sima, N., Wang, W., Kong, D., Deng, D., Xu, Q., Zhou, J., et al. (2008). RNA interference against HPV16 E7 oncogene leads to viral E6 and E7 suppression in cervical cancer cells and apoptosis via upregulation of Rb and p53. Apoptosis,13, 273–281.
7. Denny, L. (2005). The prevention of cervical cancer in developing countries. BJOG,112, 1204–1212.
8. Santin, A. D. (2005). Gene expression profiles of primary HPV16- and HPV18-infected early stage cervical cancers and normal cervical epithelium: Identification of novel candidate molecular markers for cervical cancer diagnosis and therapy. Virology,331, 269–291.
9. Unger, E. R. (2004). Human papillomavirus and cervical cancer. Emerging Infectious Diseases,10, 2031–2032.
10. Dallenbach-Hellweg, G. (2004). Traditional and new molecular methods for early detection of cervical cancer. Arkh-Patol,66, 35–39.
11. Gao, Q., Singh, L., Kumar, A., et al. (2001). Human papillomavirus type 16 E6 induced degradation of E6 TP1 correlates with it’s ability to immortalize human mammary epit helial cells. Journal of Virology,75, 4459–4466.
12. Yoshinouchi, M., Yamada, T., Kizaki, M., et al. (2003). In vitro and in vivo growth suppression of human papillomavirus 16-positive cervical cancer cells by E6 siRNA. Molecular Therapy,8, 762–768.