A rapid method for breath analysis in cystic fibrosis patients

European Journal of Clinical Microbiology and Infectious Diseases

Volumn 34, Issue 4, 2015, Pages 745-751

  Kramer, R ^a   Sauer Heilborn, A ^b   Welte, T ^b,c   Guzman, C A ^a   Hofle M G ^a   Abraham, W R ^a  

^a HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c German Centre for Infection Research   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

VOLATILE ORGANIC COMPOUND;

ADULT; ARTICLE; BACTERIAL GROWTH; BREATH ANALYSIS; CHEMICAL COMPOSITION; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; CYSTIC FIBROSIS; FEASIBILITY STUDY; FEMALE; HOST PATHOGEN INTERACTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG ALVEOLUS CELL; LUNG ALVEOLUS EPITHELIUM; LUNG INFECTION; MALE; MASS FRAGMENTOGRAPHY; MIDDLE AGED; OUTPATIENT DEPARTMENT; PRIORITY JOURNAL; SOLID PHASE MICROEXTRACTION; BACTERIAL INFECTIONS; COMPLICATION; LABORATORY DIAGNOSIS; PROCEDURES; TIME;

ADULT; BACTERIAL INFECTIONS; BREATH TESTS; CYSTIC FIBROSIS; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; MALE; MIDDLE AGED; SPECIMEN HANDLING; TIME FACTORS; VOLATILE ORGANIC COMPOUNDS;

EID: 84925504419     PISSN: 09349723     EISSN: 14354373     Source Type: Journal    
DOI: 10.1007/s10096-014-2286-5     Document Type: Article

References (29)

1. Fournier P-E, Drancourt M, Colson P, Rolain J-M, La Scola B, Raoult D (2013) Modern clinical microbiology: new challenges and solutions. Nat Rev Microbiol 11:574–585
2. Horváth I, Lázár Z, Gyulai N, Kollai M, Losonczy G (2009) Exhaled biomarkers in lung cancer. Eur Respir J 34:261–275
3. Schulz S, Dickschat JS (2007) Bacterial volatiles: the smell of small organisms. Nat Prod Rep 24:814–842
4. Dallinga JW, Robroeks CMHHT, van Berkel JJBN, Moonen EJC, Godschalk RWL, Jöbsis Q, Dompeling E, Wouters EFM, van Schooten FJ (2010) Volatile organic compounds in exhaled breath as a diagnostic tool for asthma in children. Clin Exp Allergy 40:68–76
5. Sethi S, Nanda R, Chakraborty T (2013) Clinical application of volatile organic compound analysis for detecting infectious diseases. Clin Microbiol Rev 26:462–475
6. Kramer R, Abraham W-R (2012) Volatile sesquiterpenes from fungi: what are they good for? Phytochem Rev 11:15–37
7. Syhre M, Manning L, Phuanukoonnon S, Harino P, Chambers ST (2009) The scent of Mycobacterium tuberculosis—part II breath. Tuberculosis (Edinb) 89:263–266
8. Phillips M, Basa-Dalay V, Bothamley G, Cataneo RN, Lam PK, Natividad MPR, Schmitt P, Wai J (2010) Breath biomarkers of active pulmonary tuberculosis. Tuberculosis (Edinb) 90:145–151
9. Goeminne PC, Vandendriessche T, Van Eldere J, Nicolai BM, Hertog ML, Dupont LJ (2012) Detection of Pseudomonas aeruginosa in sputum headspace through volatile organic compound analysis. Respir Res 13:87
10. Chambers ST, Bhandari S, Scott-Thomas A, Syhre M (2011) Novel diagnostics: progress toward a breath test for invasive Aspergillus fumigatus. Med Mycol 49(Suppl 1):S54–S61
11. Pawliszyn J (2009) Handbook of solid phase microextraction. Chemical Industry Press of China, Beijing
12. Woolfenden E (2010) Sorbent-based sampling methods for volatile and semi-volatile organic compounds in air. Part 2. Sorbent selection and other aspects of optimizing air monitoring methods. J Chromatogr A 1217:2685–2694
13. Hogardt M (2006) MIQ 24: Atemwegsinfektionen bei Mukoviszidose: Qualitätsstandards in der mikrobiologisch-infektiologischen Diagnostik. Urban & Fischer in Elsevier
14. 2O using the Bio-VOC breath sampler. J Expo Anal Environ Epidemiol 12:309–312
15. R Development Core Team. R: a language and environment for statistical computing. Home page at: http://www.R-project.org
16. Boots AW, van Berkel JJ, Dallinga JW, Smolinska A, Wouters EF, van Schooten FJ (2012) The versatile use of exhaled volatile organic compounds in human health and disease. J Breath Res 6:027108
17. Labows JN, McGinley KJ, Webster GF, Leyden JJ (1980) Headspace analysis of volatile metabolites of Pseudomonas aeruginosa and related species by gas chromatography–mass spectrometry. J Clin Microbiol 12:521–526
18. Shestivska V, Nemec A, Dřevínek P, Sovová K, Dryahina K, Španěl P (2011) Quantification of methyl thiocyanate in the headspace of Pseudomonas aeruginosa cultures and in the breath of cystic fibrosis patients by selected ion flow tube mass spectrometry. Rapid Commun Mass Spectrom 25:2459–2467
19. Filipiak W, Sponring A, Baur MM, Filipiak A, Ager C, Wiesenhofer H, Nagl M, Troppmair J, Amann A (2012) Molecular analysis of volatile metabolites released specifically by Staphylococcus aureus and Pseudomonas aeruginosa. BMC Microbiol 12:113
20. Cox CD, Parker J (1979) Use of 2-aminoacetophenone production in identification of Pseudomonas aeruginosa. J Clin Microbiol 9:479–484
21. Scott-Thomas AJ, Syhre M, Pattemore PK, Epton M, Laing R, Pearson J, Chambers ST (2010) 2-Aminoacetophenone as a potential breath biomarker for Pseudomonas aeruginosa in the cystic fibrosis lung. BMC Pulm Med 10:56
22. Groenhagen U, Baumgartner R, Bailly A, Gardiner A, Eberl L, Schulz S, Weisskopf L (2013) Production of bioactive volatiles by different Burkholderia ambifaria strains. J Chem Ecol 39:892–906. Erratum in: J Chem Ecol 39:1343–1345
23. Scott-Thomas A, Pearson J, Chambers S (2011) Potential sources of 2-aminoacetophenone to confound the Pseudomonas aeruginosa breath test, including analysis of a food challenge study. J Breath Res 5:046002
24. Preti G, Thaler E, Hanson CW, Troy M, Eades J, Gelperin A (2009) Volatile compounds characteristic of sinus-related bacteria and infected sinus mucus: analysis by solid-phase microextraction and gas chromatography–mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 877:2011–2018
25. Barker M, Hengst M, Schmid J, Buers H-J, Mittermaier B, Klemp D, Koppmann R (2006) Volatile organic compounds in the exhaled breath of young patients with cystic fibrosis. Eur Respir J 27:929–936
26. Robroeks CMHHT, van Berkel JJBN, Dallinga JW, Jöbsis Q, Zimmermann LJ, Hendriks HJ, Wouters MF, van der Grinten CP, van de Kant KD, van Schooten FJ, Dompeling E (2010) Metabolomics of volatile organic compounds in cystic fibrosis patients and controls. Pediatr Res 68:75–80
27. Enderby B, Smith D, Carroll W, Lenney W (2009) Hydrogen cyanide as a biomarker for Pseudomonas aeruginosa in the breath of children with cystic fibrosis. Pediatr Pulmonol 44:142–147
28. Thorn RMS, Reynolds DM, Greenman J (2011) Multivariate analysis of bacterial volatile compound profiles for discrimination between selected species and strains in vitro. J Microbiol Methods 84:258–264
29. Chambers ST, Scott-Thomas A, Epton M (2012) Developments in novel breath tests for bacterial and fungal pulmonary infection. Curr Opin Pulm Med 18:228–232