Liver-specific Fas silencing prevents galactosamine/lipopolysaccharide-induced liver injury

Apoptosis

Volumn 20, Issue 4, 2015, Pages 500-511

  Kuhla, Angela ^a   Thrum, Michael ^a   Schaeper, Ute ^b   Fehring, Volker ^b   Schulze Topphoff, Ulf ^b   Abshagen, Kerstin ^a   Vollmar, Brigitte ^a  

^a ROSTOCK UNIVERSITY MEDICAL CENTER   (Germany)

^b Silence Therapeutics GmbH   (Germany)

Author keywords

DBTC; Fas FasL system; Hepatocellular apoptosis; siRNA

Indexed keywords

DBTC; FAS ANTIGEN; GALACTOSAMINE; INTERLEUKIN 6; LIPOPLEX; LIPOPOLYSACCHARIDE; MESSENGER RNA; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; FAS LIGAND;

ACUTE LIVER FAILURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CD3+ T LYMPHOCYTE; CELL POPULATION; CONTROLLED STUDY; DENDRITIC CELL; DRUG FORMULATION; EXPERIMENTAL LIVER INJURY; GENE EXPRESSION; GENE TARGETING; INFLAMMATION; LEUKOCYTE ADHERENCE; LIPOSOMAL GENE DELIVERY SYSTEM; LIVER PERFUSION; MACROPHAGE; MALE; MOLECULAR PATHOLOGY; MOUSE; NATURAL KILLER CELL; NEUTROPHIL; NONHUMAN; NONVIRAL GENE THERAPY; POSTTRANSCRIPTIONAL GENE SILENCING; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN TARGETING; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANIMAL; C57BL MOUSE; CYTOLOGY; GENE SILENCING; GENETICS; HUMAN; INJURIES; LIVER; LIVER FAILURE, ACUTE; METABOLISM;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; FAS LIGAND PROTEIN; GALACTOSAMINE; GENE SILENCING; HUMANS; LIPOPOLYSACCHARIDES; LIVER; LIVER FAILURE, ACUTE; MALE; MICE; MICE, INBRED C57BL;

EID: 84925503306     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-015-1088-2     Document Type: Article

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