Stereoselective synthesis, biological evaluation, and modeling of novel bile acid-derived G-protein coupled Bile acid receptor 1 (GP-BAR1, TGR5) agonists

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 7, 2015, Pages 1613-1628

  Yu, Donna D ^a   Sousa, Kyle M ^a,c   Mattern, Daniell L ^b   Wagner, Jeffrey ^a   Fu, Xianghui ^a   Vaidehi, Nagarajan ^a   Forman, Barry M ^a   Huang, Wendong ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF MISSISSIPPI   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

23 METHYL 3,7 DIKETO 5BETA CHOLAN 24 OIC ACID; 23 METHYL 3ALPHA HYDROXY 5BETA CHOLAN 24 OIC ACID; 23 METHYL 3ALPHA,7ALPHA DIHYDROXY 5BETA CHOLAN 24 OIC ACID; 23 METHYL LITHOCHOLIC ACID; 3ALPHA 7BETA DIHYDROXY 6ALPHA ETHYL 5BETA CHOLAN 24 OIC ACID; 3ALPHA HYDROXY 6ALPHA ETHYL 23 METHYL 5BETA CHOLAN 24 OIC ACID; 3ALPHA HYDROXY 6ALPHA ETHYL 7 KETO 5BETA CHOLAN 24 OATE; 3ALPHA HYDROXY 6ALPHA ETHYL 7 KETO 5BETA CHOLAN 24 OIC ACID; 3ALPHA,7BETA DIHYDROXY 23 METHYL 5BETA CHOLAN 24 OIC ACID; 3ALPHA,7BETA DIHYDROXY 23 METHYL 6ALPHA ETHYL 5BETA CHOLAN 24 OIC ACID; 3BETA ETHYL 3ALPHA HYDROXY LITHOCHOLIC ACID; 5BETA CHOLANIC ACID 3 ONE; ANTIDIABETIC AGENT; ANTIMETABOLITE; CELL SURFACE RECEPTOR; CHENODEOXYCHOLIC ACID; G PROTEIN COUPLED BILE ACID RECEPTOR 1; LITHOCHOLIC ACID; METHYL 3ALPHA 7BETA TETRAHYDROPYRANYLOXY 5BETA CHOLAN 24 OATE; METHYL 3ALPHA TETRAHYDROPYRANYLOXY 5BETA CHOLAN 24 OATE; METHYL 3ALPHA TETRAHYDROPYRANYLOXY 6ALPHA ETHYL 7 KETO 5BETA CHOLAN 24 OATE; METHYL 3ALPHA,7ALPHA DITETRAHYDROPYRANYLOXY 5BETA CHOLAN 24 OATE; METHYL 3ALPHA,7BETA TETRAHYDROPYRANYLOXY 6ALPHA ETHYL 5BETA CHOLAN24 OATE; UNCLASSIFIED DRUG; URSODEOXYCHOLIC ACID; BILE ACID; G PROTEIN COUPLED RECEPTOR; GPBAR1 PROTEIN, HUMAN;

ALKYLATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CAMP ASSAY; CONTROLLED STUDY; DIABETES MELLITUS; DRUG POTENCY; DRUG SYNTHESIS; GLUCOSE HOMEOSTASIS; HUMAN; HUMAN CELL; IN VIVO STUDY; LUCIFERASE ASSAY; MALE; MATHEMATICAL COMPUTING; MOUSE; NONHUMAN; OBESITY; PROTEIN FUNCTION; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; AGONISTS; AMINO ACID SEQUENCE; ANIMAL; C57BL MOUSE; GENETICS; MOLECULAR GENETICS; MOLECULAR MODEL; PRECLINICAL STUDY; PROCEDURES; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; STEREOISOMERISM; SYNTHESIS;

AMINO ACID SEQUENCE; ANIMALS; BILE ACIDS AND SALTS; DRUG EVALUATION, PRECLINICAL; HUMANS; MICE; MICE, INBRED C57BL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, G-PROTEIN-COUPLED; STEREOISOMERISM;

EID: 84925500666     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.01.048     Document Type: Article

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