Identification of tetrahydropyrido[4,3-d]pyrimidine amides as a new class of orally bioavailable TGR5 agonists

ACS Medicinal Chemistry Letters

Volumn 4, Issue 1, 2013, Pages 63-68

  Piotrowski, David W ^a   Futatsugi, Kentaro ^a   Warmus, Joseph S ^a   Orr, Suvi T M ^a   Freeman Cook, Kevin D ^a   Londregan, Allyn T ^a   Wei, Liuqing ^a   Jennings, Sandra M ^a   Herr, Michael ^a   Coffey, Steven B ^a   Jiao, Wenhua ^a   Storer, Gregory ^a   Hepworth, David ^a   Wang, Jian ^a   Lavergne, Sophie Y ^a   Chin, Janice E ^a   Hadcock, John R ^a   Brenner, Martin B ^a   Wolford, Angela C ^a   Janssen, Ann M ^a   Roush, Nicole S ^a   Buxton, Joanne ^a   Hinchey, Terri ^a   Kalgutkar, Amit S ^a   Sharma, Raman ^a   Flynn, Declan A ^a   more..

^a PFIZER INC   (United States)

Author keywords

agonist; diabetes; GLP 1; GPCR; TGR5

Indexed keywords

G PROTEIN COUPLED RECEPTOR; PYRIMIDINE DERIVATIVE; TAKEDA G PROTEIN COUPLED RECEPTOR 5; TETRAHYDROPYRIDO[4,3 D]PYRIMIDINE AMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EXPOSURE; DRUG POTENCY; EX VIVO STUDY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VIVO STUDY; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

CANIS FAMILIARIS;

EID: 84872285850     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml300277t     Document Type: Article

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