An improved synthesis of 6α-ethylchenodeoxycholic acid (6ECDCA), a potent and selective agonist for the Farnesoid X Receptor (FXR)

Steroids

Volumn 77, Issue 13, 2012, Pages 1335-1338

  Yu, Donna ^a   Mattern, Daniell L ^b   Forman, Barry M ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

6 Ethylchenodeoxycholic acid (6ECDCA); Chenodeoxycholic acid (CDCA); Farnesoid X Receptor (FXR); High density lipoprotein (HDL); Pyridinium chlorochromate (PCC); Stereoselective synthesis

Indexed keywords

3ALPHA HDROXY 6ALPHA ETHYL 7 KETO 5BETA CHOLAN 24 OIC ACID; 3ALPHA HYDROXY 7 KETO 5BETA CHOLAN 24 OIC ACID; 3ALPHA TETRAHYDROPYRANYLOXY 7 KETO 5BETA CHOLAN 24 OIC ACID; 3ALPHA,7ALPHA DIHYDROXY 6ALPHA ETHYL 5BETA CHOLAN 24 OIC ACID; CHENODEOXYCHOLIC ACID; FARNESOID X RECEPTOR; HEMPA; HYDROXYL GROUP; LITHOCHOLIC ACID; OBETICHOLIC ACID; PYRIDINIUM 4 TOLUENESULFONATE; SULFONATED IMMUNOGLOBULIN; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CONTROLLED STUDY; DEPROTECTION REACTION; DRUG STRUCTURE; DRUG SYNTHESIS; OXIDATION; PROTON TRANSPORT; STEREOCHEMISTRY;

ANIMALS; CHEMISTRY TECHNIQUES, SYNTHETIC; CHENODEOXYCHOLIC ACID; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SUBSTRATE SPECIFICITY;

EID: 84867022099     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2012.09.002     Document Type: Article

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