The ameliorative effects of a hypnotic bromvalerylurea in sepsis

Biochemical and Biophysical Research Communications

Volumn 459, Issue 2, 2015, Pages 319-326

  Kikuchi, Satoshi ^a   Nishihara, Tasuku ^a   Kawasaki, Shun ^a   Abe, Naoki ^a   Kuwabara, Jun ^a   Choudhury, Mohammed E ^a   Takahashi, Hisaaki ^a   Yano, Hajime ^a   Nagaro, Takumi ^a   Watanabe, Yuji ^a   Aibiki, Mayuki ^a   Tanaka, Junya ^a  

^a EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Inflammation; LPS; Macrophage; STAT transcription factor; TLR4

Indexed keywords

ANTIINFLAMMATORY AGENT; BROMISOVAL; CARBON TETRACHLORIDE; CREATININE; CXCL3 CHEMOKINE; GAMMA INTERFERON; HYPNOTIC AGENT; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERFERON REGULATORY FACTOR 1; INTERLEUKIN 10; INTERLEUKIN 23; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MESSENGER RNA; MIDAZOLAM; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRITE; STAT1 PROTEIN; STAT3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; HYPNOTIC SEDATIVE AGENT; I KAPPA B; STAT1 PROTEIN, RAT;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD GAS ANALYSIS; CONTROLLED STUDY; CREATININE BLOOD LEVEL; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; KIDNEY FAILURE; LUNG ALVEOLUS MACROPHAGE; MALE; MULTIPLE ORGAN FAILURE; NONHUMAN; PATHOGENESIS; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN PHOSPHORYLATION; RAT; SEPSIS; SYMPTOM; ANIMAL; BLOOD; DISEASE MODEL; DRUG EFFECTS; GENETICS; MACROPHAGE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; WISTAR RAT;

ANIMALS; BROMISOVALUM; CYTOKINES; DISEASE MODELS, ANIMAL; HUMANS; HYPNOTICS AND SEDATIVES; I-KAPPA B PROTEINS; INTERFERON-GAMMA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MULTIPLE ORGAN FAILURE; RATS; RATS, WISTAR; RNA, MESSENGER; SEPSIS; STAT1 TRANSCRIPTION FACTOR;

EID: 84925500062     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.02.111     Document Type: Article

References (31)

1. M.S. Rangel-Frausto, D. Pittet, M. Costigan, T. Hwang, C.S. Davis, and R.P. Wenzel The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study JAMA 273 1995 117 123
2. R.P. Dellinger, M.M. Levy, J.M. Carlet, J. Bion, M.M. Parker, R. Jaeschke, K. Reinhart, D.C. Angus, C. Brun-Buisson, R. Beale, T. Calandra, J.F. Dhainaut, H. Gerlach, M. Harvey, J.J. Marini, J. Marshall, M. Ranieri, G. Ramsay, J. Sevransky, B.T. Thompson, S. Townsend, J.S. Vender, J.L. Zimmerman, and J.L. Vincent Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008 Crit. Care Med. 36 2008 296 327
3. G.S. Martin, D.M. Mannino, S. Eaton, and M. Moss The epidemiology of sepsis in the United States from 1979 through 2000 New. Eng. J. Med. 348 2003 1546 1554
4. F. Souza-Fonseca-Guimaraes, J.M. Cavaillon, and M. Adib-Conquy Bench-to-bedside review: natural killer cells in sepsis - guilty or not guilty? Crit. Care 17 2013 235
5. S.C. Williams After Xigris, researchers look to new targets to combat sepsis Nat. Med. 18 2012 1001
6. O. Huet, and J.P. Chin-Dusting Septic shock: desperately seeking treatment Clin. Sci. 126 2014 31 39
7. A.v.d. Eeckhout Studien über die hypnotische Wirkung in der Vaïerian-süuregruppe Arc. Exp. Path. Pharmak 57 1907 338 357
8. K. Toku, J. Tanaka, S. Fujikata, Y. Hamamoto, Y. Horikawa, K. Miyoshi, N. Tateishi, Y. Suzuki, and N. Maeda Distinctions between microglial cells and peripheral macrophages with regard to adhesive activities and morphology J. Neurosci. Res. 57 1999 855 865
9. J. Tanaka, K. Toku, B. Zhang, K. Ishihara, M. Sakanaka, and N. Maeda Astrocytes prevent neuronal death induced by reactive oxygen and nitrogen species Glia 28 1999 85 96
10. H. Takahashi, H. Matsumoto, A. Smirkin, T. Itai, Y. Nishimura, and J. Tanaka Involvement of heparanase in migration of microglial cells Biochim. Biophys. Acta 1780 2008 709 715
11. M.E. Choudhury, K. Sugimoto, M. Kubo, M. Nagai, M. Nomoto, H. Takahashi, H. Yano, and J. Tanaka A cytokine mixture of GM-CSF and IL-3 that induces a neuroprotective phenotype of microglia leading to amelioration of (6-OHDA)-induced Parkinsonism of rats Brain Behav. 1 2011 26 43
12. D.G. Remick, D.E. Newcomb, G.L. Bolgos, and D.R. Call Comparison of the mortality and inflammatory response of two models of sepsis: lipopolysaccharide vs. cecal ligation and puncture Shock 13 2000 110 116
13. H. Matsumoto, Y. Kumon, H. Watanabe, T. Ohnishi, M. Shudou, C. Ii, H. Takahashi, Y. Imai, and J. Tanaka Antibodies to CD11b, CD68, and lectin label neutrophils rather than microglia in traumatic and ischemic brain lesions J. Neurosci. Res. 85 2007 994 1009
14. L. Shen, H. Mo, L. Cai, T. Kong, W. Zheng, J. Ye, J. Qi, and Z. Xiao Losartan prevents sepsis-induced acute lung injury and decreases activation of nuclear factor kappaB and mitogen-activated protein kinases Shock 31 2009 500 506
15. C.R. Romero, D.S. Herzig, A. Etogo, J. Nunez, R. Mahmoudizad, G. Fang, E.D. Murphey, T. Toliver-Kinsky, and E.R. Sherwood The role of interferon-gamma in the pathogenesis of acute intra-abdominal sepsis J. Leukoc. Biol. 88 2010 725 735
16. G.M. Doherty, J.R. Lange, H.N. Langstein, H.R. Alexander, C.M. Buresh, and J.A. Norton Evidence for IFN-gamma as a mediator of the lethality of endotoxin and tumor necrosis factor-alpha J. Immunol. 149 1992 1666 1670
17. A. Kumar, P. Michael, D. Brabant, A.M. Parissenti, C.V. Ramana, X. Xu, and J.E. Parrillo Human serum from patients with septic shock activates transcription factors STAT1, IRF1, and NF-kappaB and induces apoptosis in human cardiac myocytes J. Biol. Chem. 280 2005 42619 42626
18. P. Damas, D. Ledoux, M. Nys, Y. Vrindts, D. De Groote, P. Franchimont, and M. Lamy Cytokine serum level during severe sepsis in human IL-6 as a marker of severity Ann. Surg. 215 1992 356 362
19. D.M. Cauvi, M.R. Williams, J.A. Bermudez, G. Armijo, and A. De Maio Elevated expression of Il-23/Il-17 pathway-related mediators correlates with exacerbation of pulmonary inflammation during polymicrobial sepsis Shock 42 2014 246 255
20. L. Williams, L. Bradley, A. Smith, and B. Foxwell Signal transducer and activator of transcription 3 is the dominant mediator of the anti-inflammatory effects of IL-10 in human macrophages J. Immunol. 172 2004 567 576
21. J.E. Darnell Jr., I.M. Kerr, and G.R. Stark Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins Science 264 1994 1415 1421
22. A. Al-Shami, W. Mahanna, and P.H. Naccache Granulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils. Selective activation of Jak2, Stat3, and Stat5b J. Biol. Chem. 273 1998 1058 1063
23. H.S. Youn, J.Y. Lee, K.A. Fitzgerald, H.A. Young, S. Akira, and D.H. Hwang Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex J. Immunol. 175 2005 3339 3346
24. S.N. Kim, S.C. Son, S.M. Lee, C.S. Kim, D.G. Yoo, S.K. Lee, G.M. Hur, J.B. Park, and B.H. Jeon Midazolam inhibits proinflammatory mediators in the lipopolysaccharide-activated macrophage Anesthesiology 105 2006 105 110
25. H. Heremans, C. Dillen, M. Groenen, P. Matthys, and A. Billiau Role of interferon-gamma and nitric oxide in pulmonary edema and death induced by lipopolysaccharide Am. J. Resp. Crit. Care Med. 161 2000 110 117
26. R.C. Bone Sir Isaac Newton, sepsis, SIRS, and CARS Crit. Care Med. 24 1996 1125 1128
27. A.R. Novotny, D. Reim, V. Assfalg, F. Altmayr, H.M. Friess, K. Emmanuel, and B. Holzmann Mixed antagonist response and sepsis severity-dependent dysbalance of pro- and anti-inflammatory responses at the onset of postoperative sepsis Immunobiology 217 2012 616 621
28. M. Delgado Inhibition of interferon (IFN) gamma-induced Jak-STAT1 activation in microglia by vasoactive intestinal peptide: inhibitory effect on CD40, IFN-induced protein-10, and inducible nitric-oxide synthase expression J. Biol. Chem. 278 2003 27620 27629
29. C.J. Lowenstein, E.W. Alley, P. Raval, A.M. Snowman, S.H. Snyder, S.W. Russell, and W.J. Murphy Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide Proc. Nat. Acad. Sci. U. S. A. 90 1993 9730 9734
30. E.A. Bach, M. Aguet, and R.D. Schreiber The IFN gamma receptor: a paradigm for cytokine receptor signaling Ann. Rev. Immunol. 15 1997 563 591
31. S. Verstovsek, R.A. Mesa, J. Gotlib, R.S. Levy, V. Gupta, J.F. DiPersio, J.V. Catalano, M. Deininger, C. Miller, R.T. Silver, M. Talpaz, E.F. Winton, J.H. Harvey Jr., M.O. Arcasoy, E. Hexner, R.M. Lyons, R. Paquette, A. Raza, K. Vaddi, S. Erickson-Viitanen, I.L. Koumenis, W. Sun, V. Sandor, and H.M. Kantarjian A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis New. Eng. J. Med. 366 2012 799 807