Decreased expression and activation of Stat3 in severe preeclampsia

Journal of Molecular Histology

Volumn 46, Issue 2, 2015, Pages 205-219

  Zhang, Zhan ^a   Yang, Xiaoqian ^a   Zhang, Linlin ^a   Duan, Zhenfeng ^b   Jia, Liting ^a   Wang, Peng ^a   Shi, Ying ^a   Li, Ying ^a   Gao, Junjun ^a  

^a ZHENGZHOU UNIVERSITY   (China)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Apoptosis; Invasion; Placenta; Severe preeclampsia; Stat3 signal pathway

Indexed keywords

CYTOKERATIN; GELATINASE A; GELATINASE B; HLA G ANTIGEN; INTERLEUKIN 6; MESSENGER RNA; PROTEIN BCL XL; STAT3 PROTEIN; SURVIVIN; VIMENTIN; BIRC5 PROTEIN, HUMAN; IL6 PROTEIN, HUMAN; INHIBITOR OF APOPTOSIS PROTEIN; MMP2 PROTEIN, HUMAN; MMP9 PROTEIN, HUMAN; STAT3 PROTEIN, HUMAN;

ADULT; APOPTOSIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOPLASM; CYTOTROPHOBLAST; DISEASE SEVERITY; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MACROPHAGE; MALE; NEWBORN; PATHOGENESIS; PLACENTA; PREECLAMPSIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SYNCYTIOTROPHOBLAST; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; TROPHOBLAST; WESTERN BLOTTING; CASE CONTROL STUDY; GENE EXPRESSION; GENETICS; METABOLISM; PATHOLOGY; PREGNANCY; PROTEIN TRANSPORT;

ADULT; CASE-CONTROL STUDIES; FEMALE; GENE EXPRESSION; HUMANS; INFANT, NEWBORN; INHIBITOR OF APOPTOSIS PROTEINS; INTERLEUKIN-6; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; PLACENTA; PRE-ECLAMPSIA; PREGNANCY; PROTEIN TRANSPORT; STAT3 TRANSCRIPTION FACTOR;

EID: 84925492271     PISSN: 15672379     EISSN: 15672387     Source Type: Journal    
DOI: 10.1007/s10735-015-9613-8     Document Type: Article

References (55)

1. Benyo DF, Smarason A, Redman CW, Sims C, Conrad KP (2001) Expression of inflammatory cytokines in placentas from women with preeclampsia. J Clin Endocrinol Metab 86:2505–2512
2. Castellucci M, Kaufmann P (2006) Basic structure of the villous trees. In: Pathology of the human placenta. Springer, New York, pp 50–120. doi:10.1007/0-387-26742-5_6
3. Chen Q, Stone P, Ching LM, Chamley L (2009) A role for interleukin-6 in spreading endothelial cell activation after phagocytosis of necrotic trophoblastic material: implications for the pathogenesis of pre-eclampsia. J Pathol 217:122–130. doi:10.1002/path.2425
4. Corvinus FM, Fitzgerald JS, Friedrich K, Markert UR (2003) Evidence for a correlation between trophoblast invasiveness and STAT3 activity. Am J Reprod Immunol 50:316–321
5. Cozzi V, Garlanda C, Nebuloni M, Maina V, Martinelli A, Calabrese S, Cetin I (2012) PTX3 as a potential endothelial dysfunction biomarker for severity of preeclampsia and IUGR. Placenta 33:1039–1044. doi:10.1016/j.placenta.2012.09.009
6. Crocker IP, Cooper S, Ong SC, Baker PN (2003) Differences in apoptotic susceptibility of cytotrophoblasts and syncytiotrophoblasts in normal pregnancy to those complicated with preeclampsia and intrauterine growth restriction. Am J Pathol 162:637–643. doi:10.1016/S0002-9440(10)63857-6
7. Davison JM et al (2004) New aspects in the pathophysiology of preeclampsia. J Am Soc Nephrol 15:2440–2448. doi:10.1097/01.ASN.0000135975.90889.60
8. Demendi C, Borzsonyi B, Vegh V, Nagy ZB, Rigo J Jr, Pajor A, Joo JG (2012) Gene expression patterns of the Bcl-2 and Bax genes in preterm birth. Acta Obstet Gynecol Scand 91:1212–1217. doi:10.1111/j.1600-0412.2012.01428.x
9. DiFederico E, Genbacev O, Fisher SJ (1999) Preeclampsia is associated with widespread apoptosis of placental cytotrophoblasts within the uterine wall. Am J Pathol 155:293–301. doi:10.1016/S0002-9440(10)65123-1
10. Fitzgerald JS, Poehlmann TG, Schleussner E, Markert UR (2008) Trophoblast invasion: the role of intracellular cytokine signalling via signal transducer and activator of transcription 3 (STAT3). Hum Reprod Update 14:335–344. doi:10.1093/humupd/dmn010
11. Garcia MG et al (2007) High expression of survivin and down-regulation of Stat-3 characterize the feto-maternal interface in failing murine pregnancies during the implantation period. Placenta 28:650–657. doi:10.1016/j.placenta.2006.09.010
12. Gulati S, Bhatnagar S, Raghunandan C, Bhattacharjee J (2012) Interleukin-6 as a predictor of subclinical chorioamnionitis in preterm premature rupture of membranes. Am J Reprod Immunol 67:235–240. doi:10.1111/j.1600-0897.2011.01084.x
13. Guo Y, Xu F, Lu T, Duan Z, Zhang Z (2012) Interleukin-6 signaling pathway in targeted therapy for cancer. Cancer Treat Rev 38:904–910. doi:10.1016/j.ctrv.2012.04.007
14. Halperin R, Peller S, Rotschild M, Bukovsky I, Schneider D (2000) Placental apoptosis in normal and abnormal pregnancies. Gynecol Obstet Investig 50:84–87
15. Heazell AE, Crocker IP (2008) Live and let die—regulation of villous trophoblast apoptosis in normal and abnormal pregnancies. Placenta 29:772–783. doi:10.1016/j.placenta.2008.07.003
16. Heazell AE, Buttle HR, Baker PN, Crocker IP (2008) Altered expression of regulators of caspase activity within trophoblast of normal pregnancies and pregnancies complicated by preeclampsia. Reprod Sci 15:1034–1043. doi:10.1177/1933719108322438
17. Hirano T, Ishihara K, Hibi M (2000) Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors. Oncogene 19:2548–2556. doi:10.1038/sj.onc.1203551
18. Hu C, Smith SD, Pang L, Sadovsky Y, Nelson DM (2006) Enhanced basal apoptosis in cultured term human cytotrophoblasts is associated with a higher expression and physical interaction of p53 and Bak. Placenta 27:978–983. doi:10.1016/j.placenta.2005.11.004
19. Huang WL, Yeh HH, Lin CC, Lai WW, Chang JY, Chang WT, Su WC (2010) Signal transducer and activator of transcription 3 activation up-regulates interleukin-6 autocrine production: a biochemical and genetic study of established cancer cell lines and clinical isolated human cancer cells. Mol Cancer 9:309. doi:10.1186/1476-4598-9-309
20. Huppertz B (2008) Placental origins of preeclampsia: challenging the current hypothesis. Hypertension 51:970–975. doi:10.1161/HYPERTENSIONAHA.107.107607
21. Isaka K et al (2003) Expression and activity of matrix metalloproteinase 2 and 9 in human trophoblasts. Placenta 24:53–64
22. Ishihara N, Matsuo H, Murakoshi H, Laoag-Fernandez JB, Samoto T, Maruo T (2002) Increased apoptosis in the syncytiotrophoblast in human term placentas complicated by either preeclampsia or intrauterine growth retardation. Am J Obstet Gynecol 186:158–166
23. Jovanovic M, Vicovac L (2009) Interleukin-6 stimulates cell migration, invasion and integrin expression in HTR-8/SVneo cell line. Placenta 30:320–328. doi:10.1016/j.placenta.2009.01.013
24. Leung DN, Smith SC, To KF, Sahota DS, Baker PN (2001) Increased placental apoptosis in pregnancies complicated by preeclampsia. Am J Obstet Gynecol 184:1249–1250. doi:10.1067/mob.2001.112906
25. Li JJ et al (2008) Mcl-1 is regulated by IL-6 and mediates the survival activity of the cytokine in a model of late stage prostate carcinoma. In: Hormonal carcinogenesis V, vol 617. Advances in experimental medicine and biology. Springer, New York, pp 547–555. doi:10.1007/978-0-387-69080-3_56
26. Li CF, Gou WL, Li XL, Wang SL, Yang T, Chen Q (2012) Reduced expression of survivin, the inhibitor of apoptosis protein correlates with severity of preeclampsia. Placenta 33:47–51. doi:10.1016/j.placenta.2011.10.008
27. Liu H, Ma Y, Cole SM, Zander C, Chen KH, Karras J, Pope RM (2003) Serine phosphorylation of STAT3 is essential for Mcl-1 expression and macrophage survival. Blood 102:344–352. doi:10.1182/blood-2002-11-3396
28. Lockwood CJ et al (2008a) Preeclampsia-related inflammatory cytokines regulate interleukin-6 expression in human decidual cells. Am J Pathol 172:1571–1579. doi:10.2353/ajpath.2008.070629
29. Lockwood CJ et al (2008b) Preeclampsia-related inflammatory cytokines regulate interleukin-6 expression in human decidual cells. Am J Pathol 172:1571–1579. doi:10.2353/ajpath.2008.070629
30. Lyall F (2011) The placenta in preeclampsia. In: The placenta. Wiley-Blackwell, pp 246–252. doi:10.1002/9781444393927.ch32
31. Muschol-Steinmetz C, Friemel A, Kreis NN, Reinhard J, Yuan J, Louwen F (2013) Function of survivin in trophoblastic cells of the placenta PloS one 8:e73337. doi:10.1371/journal.pone.0073337
32. Myatt L (2002) Role of placenta in preeclampsia. Endocrine 19:103–111. doi:10.1385/ENDO:19:1:103
33. Omran OM, Shokry M, Ismail H, Omar G, Rezk M (2011) Expression of matrix metalloproteinases 2 and 9 in human trophoblasts of normal and preeclamptic placentas. Int J Health Sci 5:21–23
34. Onogi A et al (2011) Hypoxia inhibits invasion of extravillous trophoblast cells through reduction of matrix metalloproteinase (MMP)-2 activation in the early first trimester of human pregnancy. Placenta 32:665–670. doi:10.1016/j.placenta.2011.06.023
35. Palei AC, Sandrim VC, Amaral LM, Machado JS, Cavalli RC, Duarte G, Tanus-Santos JE (2012) Association between matrix metalloproteinase (MMP)-2 polymorphisms and MMP-2 levels in hypertensive disorders of pregnancy. Exp Mol Pathol 92:217–221. doi:10.1016/j.yexmp.2012.01.008
36. Rampersad R, Nelson DM (2007) Trophoblast biology, responses to hypoxia and placental dysfunction in preeclampsia. Front Biosci J Virtual Library 12:2447–2456
37. Robinson CJ, Johnson DD, Chang EY, Armstrong DM, Wang W (2006) Evaluation of placenta growth factor and soluble Fms-like tyrosine kinase 1 receptor levels in mild and severe preeclampsia. Am J Obstet Gynecol 195:255–259. doi:10.1016/j.ajog.2005.12.049
38. Shiozaki A, Kataoka K, Fujimura M, Yuki H, Sakai M, Saito S (2003) Survivin inhibits apoptosis in cytotrophoblasts. Placenta 24:65–76
39. Sibai B, Dekker G, Kupferminc M (2005) Pre-eclampsia. Lancet 365:785–799. doi:10.1016/S0140-6736(05)17987-2
40. Smith SC, Baker PN (1999) Placental apoptosis is increased in post-term pregnancies. Br J Obstet Gynaecol 106:861–862
41. Soleymanlou N et al (2007) Hypoxic switch in mitochondrial myeloid cell leukemia factor-1/Mtd apoptotic rheostat contributes to human trophoblast cell death in preeclampsia. Am J Pathol 171:496–506. doi:10.2353/ajpath.2007.070094
42. Staun-Ram E, Goldman S, Gabarin D, Shalev E (2004) Expression and importance of matrix metalloproteinase 2 and 9 (MMP-2 and -9) in human trophoblast invasion. Reprod Biol Endocrinol 2:59. doi:10.1186/1477-7827-2-59
43. Takeda K et al (1997) Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc Natl Acad Sci USA 94:3801–3804
44. Tomas SZ, Prusac IK, Roje D, Tadin I (2011) Trophoblast apoptosis in placentas from pregnancies complicated by preeclampsia. Gynecol Obstet Investig 71:250–255. doi:10.1159/000320289
45. Unek G, Ozmen A, Mendilcioglu I, Simsek M, Korgun ET (2014) Immunohistochemical distribution of cell cycle proteins p27, p57, cyclin D3, PCNA and Ki67 in normal and diabetic human placentas. J Mol Histol 45:21–34. doi:10.1007/s10735-013-9534-3
46. Wang L, Zhang D, Yu Y, Guan H, Qiao C, Shang T (2013) RNA interference-mediated silencing of laminin receptor 1 (LR1) suppresses migration and invasion and down-regulates matrix metalloproteinase (MMP)-2 and MMP-9 in trophoblast cells: implication in the pathogenesis of preeclampsia. J Mol Histol 44:661–668. doi:10.1007/s10735-013-9515-6
47. Weber M, Kuhn C, Schulze S, Jeschke U, Markert UR (2009) Immunohistochemical analysis of STAT3 and its phosphorylated forms in human placenta. J Reprod Immunol 81:172. doi:10.1016/j.jri.2009.06.249
48. Weber M et al (2012) Expression of signal transducer and activator of transcription 3 (STAT3) and its activated forms is negatively altered in trophoblast and decidual stroma cells derived from preeclampsia placentae. Histopathology 60:657–662. doi:10.1111/j.1365-2559.2011.04063.x
49. Xie TX, Wei D, Liu M, Gao AC, Ali-Osman F, Sawaya R, Huang S (2004) Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis. Oncogene 23:3550–3560. doi:10.1038/sj.onc.1207383
50. Xie C, Yao MZ, Liu JB, Xiong LK (2011) A meta-analysis of tumor necrosis factor-alpha, interleukin-6, and interleukin-10 in preeclampsia. Cytokine 56:550–559. doi:10.1016/j.cyto.2011.09.021
51. Xu L, Lee M, Jeyabalan A, Roberts JM (2014) The relationship of hypovitaminosis D and IL-6 in preeclampsia. Am J Obstet Gynecol 210(149):e141–e147. doi:10.1016/j.ajog.2013.09.037
52. Zhang H, Long Q, Ling L, Gao A, Li H, Lin Q (2011a) Elevated expression of KiSS-1 in placenta of preeclampsia and its effect on trophoblast. Reprod Biol 11:99–115
53. Zhang X et al (2011b) Carnosine pretreatment protects against hypoxia-ischemia brain damage in the neonatal rat model. Eur J Pharmacol 667:202–207. doi:10.1016/j.ejphar.2011.06.003
54. Zhang Z, Zhang L, Jia L, Wang P, Gao Y (2013a) Association of Wnt2 and sFRP4 expression in the third trimester placenta in women with severe preeclampsia. Reprod Sci (Thousand Oaks, Calif) 20:981–989. doi:10.1177/1933719112472740
55. Zhang Z, Zhang L, Jia L, Wang P, Gao Y (2013b) Association of Wnt2 and sFRP4 expression in the third trimester placenta in women with severe preeclampsia. Reprod Sci. doi:10.1177/1933719112472740