A preclinical evaluation of the PI3K alpha/delta dominant inhibitor BAY 80-6946 in HER2-positive breast cancer models with acquired resistance to the HER2-targeted therapies trastuzumab and lapatinib

Breast Cancer Research and Treatment

Volumn 149, Issue 2, 2015, Pages 373-383

  Elster, N ^a   Cremona, M ^a   Morgan, C ^a   Toomey, S ^a   Carr, A ^a   O'Grady A ^a   Hennessy, B T ^a   Eustace, A J ^a  

^a BEAUMONT HOSPITAL   (Ireland)

Author keywords

Acquired resistance to HER2 targeted therapies; HER2 positive breast cancer; PI3K inhibitor; Reverse phase protein array; Sequenom MassArray

Indexed keywords

AFATINIB; COPANLISIB; EPIDERMAL GROWTH FACTOR RECEPTOR 2; LAPATINIB; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; PROTEIN KINASE B; PROTEIN P53; TRASTUZUMAB; 2-AMINO-N-(7-METHOXY-8-(3-MORPHOLINOPROPOXY)-2,3-DIHYDROIMIDAZO(1,2-C)QUINAZOLIN-4-YL)PYRIMIDINE-5-CARBOXAMIDE; ANTINEOPLASTIC AGENT; MONOCLONAL ANTIBODY; PROTEIN KINASE INHIBITOR; PTEN PROTEIN, HUMAN; PYRIMIDINE DERIVATIVE; QUINAZOLINE DERIVATIVE; TARGET OF RAPAMYCIN KINASE;

ACQUIRED RESISTANCE; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BREAST CANCER CELL LINE; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; CELL MIGRATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG POTENTIATION; DRUG RESISTANCE; DRUG SCREENING; DRUG SENSITIVITY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IC50; INTRACELLULAR SIGNALING; MOLECULARLY TARGETED THERAPY; MONOTHERAPY; MUTATIONAL ANALYSIS; PIK3CA GENE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE PHASE PROTEIN ARRAY ANALYSIS; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; BREAST NEOPLASMS; DRUG EFFECTS; FEMALE; GENETICS; METABOLISM; MUTATION; SIGNAL TRANSDUCTION;

ANTIBODIES, MONOCLONAL, HUMANIZED; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; MAP KINASE SIGNALING SYSTEM; MUTATION; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN KINASE INHIBITORS; PTEN PHOSPHOHYDROLASE; PYRIMIDINES; QUINAZOLINES; RECEPTOR, ERBB-2; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84925489671     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-014-3239-5     Document Type: Article

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