Dual inhibition of allosteric mitogen-activated protein kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) oncogenic targets with a bifunctional inhibitor

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 7, 2015, Pages 1386-1394

  Van Dort, Marcian E ^a   Galbán, Stefanie ^a   Wang, Hanxiao ^a   Sebolt Leopold, Judith ^a   Whitehead, Christopher ^a   Hong, Hao ^a   Rehemtulla, Alnawaz ^a   Ross, Brian D ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Akt; Driven oncogenesis; Dual inhibition; ERK; Kinase; KRAS; MAP; MEK1; Oncogenic signaling; PI 3

Indexed keywords

2 (2 DIFLUOROMETHYLBENZIMIDAZOL 1 YL) 4,6 DIMORPHOLINO 1,3,5 TRIAZINE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE INHIBITOR; RO 5126766; UNCLASSIFIED DRUG; COUMARIN DERIVATIVE; ENZYME INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; RO5126766; TRIAZINE DERIVATIVE;

ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DRUG BINDING; DRUG DESIGN; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG CANCER CELL LINE; MOLECULAR DOCKING; PANCREATIC CANCER CELL LINE; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ALLOSTERISM; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMISTRY; DRUG DELIVERY SYSTEM; DRUG EFFECTS; METABOLISM; MOUSE; PROCEDURES; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

ALLOSTERIC REGULATION; ANIMALS; CELL LINE; COUMARINS; CRYSTALLOGRAPHY, X-RAY; DRUG DELIVERY SYSTEMS; ENZYME INHIBITORS; HUMANS; MAP KINASE KINASE 1; MICE; PHOSPHATIDYLINOSITOL 3-KINASE; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; TRIAZINES;

EID: 84925483104     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.02.053     Document Type: Article

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