메뉴 건너뛰기




Volumn 20, Issue 2, 2015, Pages 221-235

Expression, function, and regulation of the testis-enriched heat shock HSPA2 gene in rodents and humans

Author keywords

Cancer; Cytoprotection; Heat shock genes; HSPA2; Regulation of expression; Somatic cells; Spermatogenic cells

Indexed keywords

HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN A2; UNCLASSIFIED DRUG; HSPA2 PROTEIN, HUMAN;

EID: 84925465588     PISSN: 13558145     EISSN: 14661268     Source Type: Journal    
DOI: 10.1007/s12192-014-0548-x     Document Type: Review
Times cited : (52)

References (103)
  • 1
    • 74049152341 scopus 로고    scopus 로고
    • Linker histones stimulate HSPA2 ATPase activity through NASP binding and inhibit CDC2/cyclin B1 complex formation during meiosis in the mouse
    • COI: 1:CAS:528:DC%2BD1MXhtFyhsLnJ, PID: 19553603
    • Alekseev OM, Richardson RT, O’Rand G (2009) Linker histones stimulate HSPA2 ATPase activity through NASP binding and inhibit CDC2/cyclin B1 complex formation during meiosis in the mouse. Biol Reprod 81:739–748
    • (2009) Biol Reprod , vol.81 , pp. 739-748
    • Alekseev, O.M.1    Richardson, R.T.2    O’Rand, G.3
  • 2
    • 79955092713 scopus 로고    scopus 로고
    • Depletion of the histone chaperone tNASP inhibits proliferation and induces apoptosis in prostate cancer PC-3 cells
    • COI: 1:CAS:528:DC%2BC3MXltlGrsrc%3D, PID: 21496299
    • Alekseev OM, Richardson RT, Tsuruta JK, O’Rand MG (2011) Depletion of the histone chaperone tNASP inhibits proliferation and induces apoptosis in prostate cancer PC-3 cells. Reprod Biol Endocrinol 9:50
    • (2011) Reprod Biol Endocrinol , vol.9 , pp. 50
    • Alekseev, O.M.1    Richardson, R.T.2    Tsuruta, J.K.3    O’Rand, M.G.4
  • 3
    • 0029981194 scopus 로고    scopus 로고
    • HSP70-2 is part of the synaptonemal complex in mouse and hamster spermatocytes
    • COI: 1:CAS:528:DyaK28XivVGmtb8%3D, PID: 8601336
    • Allen JW, Dix DJ, Collins BW, Merrick BA, He C, Selkirk JK et al (1996) HSP70-2 is part of the synaptonemal complex in mouse and hamster spermatocytes. Chromosoma 104:414–421
    • (1996) Chromosoma , vol.104 , pp. 414-421
    • Allen, J.W.1    Dix, D.J.2    Collins, B.W.3    Merrick, B.A.4    He, C.5    Selkirk, J.K.6
  • 4
    • 0027965687 scopus 로고
    • Cloning, sequencing, and mapping of the human chromosome 14 heat shock protein gene (HSPA2)
    • COI: 1:CAS:528:DyaK2MXptVGnuw%3D%3D, PID: 7829106
    • Bonnycastle LL, Yu CE, Hunt CR, Trask BJ, Clancy KP, Weber JL et al (1994) Cloning, sequencing, and mapping of the human chromosome 14 heat shock protein gene (HSPA2). Genomics 23:85–93
    • (1994) Genomics , vol.23 , pp. 85-93
    • Bonnycastle, L.L.1    Yu, C.E.2    Hunt, C.R.3    Trask, B.J.4    Clancy, K.P.5    Weber, J.L.6
  • 5
    • 40749101072 scopus 로고    scopus 로고
    • hsp70 genes in the human genome: conservation and differentiation patterns predict a wide array of overlapping and specialized functions
    • PID: 18215318
    • Brocchieri L, Conway de Macario E, Macario AJ (2008) hsp70 genes in the human genome: conservation and differentiation patterns predict a wide array of overlapping and specialized functions. BMC Evol Biol 8:19
    • (2008) BMC Evol Biol , vol.8 , pp. 19
    • Brocchieri, L.1    Conway de Macario, E.2    Macario, A.J.3
  • 6
    • 33746020449 scopus 로고    scopus 로고
    • Oligozoospermia and heat-shock protein expression in ejaculated spermatozoa
    • COI: 1:CAS:528:DC%2BD28Xms1Ont74%3D, PID: 16517558
    • Cedenho AP, Lima SB, Cenedeze MA, Spaine DM, Ortiz V, Oehninger S (2006) Oligozoospermia and heat-shock protein expression in ejaculated spermatozoa. Hum Reprod 21:1791–1794
    • (2006) Hum Reprod , vol.21 , pp. 1791-1794
    • Cedenho, A.P.1    Lima, S.B.2    Cenedeze, M.A.3    Spaine, D.M.4    Ortiz, V.5    Oehninger, S.6
  • 7
    • 80051693551 scopus 로고    scopus 로고
    • The RNA-binding protein ELAVL1/HuR is essential for mouse spermatogenesis, acting both at meiotic and postmeiotic stages
    • COI: 1:CAS:528:DC%2BC3MXhtVOlu7zE, PID: 21737689
    • Chi MN, Auriol J, Jégou B, Kontoyiannis DL, Turner JM, de Rooij DG et al (2011) The RNA-binding protein ELAVL1/HuR is essential for mouse spermatogenesis, acting both at meiotic and postmeiotic stages. Mol Biol Cell 22:2875–2885
    • (2011) Mol Biol Cell , vol.22 , pp. 2875-2885
    • Chi, M.N.1    Auriol, J.2    Jégou, B.3    Kontoyiannis, D.L.4    Turner, J.M.5    de Rooij, D.G.6
  • 8
    • 38349058266 scopus 로고    scopus 로고
    • HIF-1alpha controls keratinocyte proliferation by up-regulating p21(WAF1/Cip1)
    • COI: 1:CAS:528:DC%2BD1cXoslWmug%3D%3D, PID: 18166158
    • Cho YS, Bae JM, Chun YS, Chung JH, Jeon YK, Kim IS et al (2008) HIF-1alpha controls keratinocyte proliferation by up-regulating p21(WAF1/Cip1). Biochim Biophys Acta 1783:323–333
    • (2008) Biochim Biophys Acta , vol.1783 , pp. 323-333
    • Cho, Y.S.1    Bae, J.M.2    Chun, Y.S.3    Chung, J.H.4    Jeon, Y.K.5    Kim, I.S.6
  • 9
    • 77955712560 scopus 로고    scopus 로고
    • Heteromeric complexes of heat shock protein 70 (HSP70) family members, including Hsp70B’, in differentiated human neuronal cells
    • COI: 1:CAS:528:DC%2BC3cXpvV2jsb8%3D, PID: 20084477
    • Chow AM, Mok P, Xiao D, Khalouei S, Brown IR (2010) Heteromeric complexes of heat shock protein 70 (HSP70) family members, including Hsp70B’, in differentiated human neuronal cells. Cell Stress Chaperones 15:545–553
    • (2010) Cell Stress Chaperones , vol.15 , pp. 545-553
    • Chow, A.M.1    Mok, P.2    Xiao, D.3    Khalouei, S.4    Brown, I.R.5
  • 10
    • 84872358363 scopus 로고    scopus 로고
    • Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update
    • COI: 1:CAS:528:DC%2BC38XhtFOgsb3M, PID: 22885793
    • Ciocca DR, Arrigo AP, Calderwood SK (2013) Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update. Arch Toxicol 87:19–48
    • (2013) Arch Toxicol , vol.87 , pp. 19-48
    • Ciocca, D.R.1    Arrigo, A.P.2    Calderwood, S.K.3
  • 11
    • 78650354147 scopus 로고    scopus 로고
    • Three epigenetic biomarkers, GDF15, TMEFF2, and VIM, accurately predict bladder cancer from DNA-based analyses of urine samples
    • COI: 1:CAS:528:DC%2BC3cXhsFamtLvJ, PID: 20975101
    • Costa VL, Henrique R, Danielsen SA, Duarte-Pereira S, Eknaes M, Skotheim RI et al (2010) Three epigenetic biomarkers, GDF15, TMEFF2, and VIM, accurately predict bladder cancer from DNA-based analyses of urine samples. Clin Cancer Res 16:5842–5851
    • (2010) Clin Cancer Res , vol.16 , pp. 5842-5851
    • Costa, V.L.1    Henrique, R.2    Danielsen, S.A.3    Duarte-Pereira, S.4    Eknaes, M.5    Skotheim, R.I.6
  • 12
    • 33749530027 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase-2 contributes to the fidelity of male meiosis I and spermiogenesis
    • COI: 1:CAS:528:DC%2BD28XhtVyhtL%2FJ, PID: 17001008
    • Dantzer F, Mark M, Quenet D, Scherthan H, Huber A, Liebe B et al (2006) Poly(ADP-ribose) polymerase-2 contributes to the fidelity of male meiosis I and spermiogenesis. Proc Natl Acad Sci U S A 103:14854–14859
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 14854-14859
    • Dantzer, F.1    Mark, M.2    Quenet, D.3    Scherthan, H.4    Huber, A.5    Liebe, B.6
  • 13
    • 34047274469 scopus 로고    scopus 로고
    • Lens epithelium-derived growth factor is an Hsp70-2 regulated guardian of lysosomal stability in human cancer
    • COI: 1:CAS:528:DC%2BD2sXivV2nsrw%3D, PID: 17363574
    • Daugaard M, Kirkegaard-Sørensen T, Ostenfeld MS, Aaboe M, Høyer-Hansen M, Orntoft TF et al (2007) Lens epithelium-derived growth factor is an Hsp70-2 regulated guardian of lysosomal stability in human cancer. Cancer Res 67:2559–2567
    • (2007) Cancer Res , vol.67 , pp. 2559-2567
    • Daugaard, M.1    Kirkegaard-Sørensen, T.2    Ostenfeld, M.S.3    Aaboe, M.4    Høyer-Hansen, M.5    Orntoft, T.F.6
  • 14
    • 0029991234 scopus 로고    scopus 로고
    • Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility
    • COI: 1:CAS:528:DyaK28XisVWis7g%3D, PID: 8622925
    • Dix DJ, Allen JW, Collins BW, Mori C, Nakamura N, Poorman-Allen P et al (1996a) Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility. Proc Natl Acad Sci U S A 93:3264–3268
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 3264-3268
    • Dix, D.J.1    Allen, J.W.2    Collins, B.W.3    Mori, C.4    Nakamura, N.5    Poorman-Allen, P.6
  • 15
    • 0029879539 scopus 로고    scopus 로고
    • Developmentally regulated expression of Hsp70-2 and a Hsp70-2/lacZ transgene during spermatogenesis
    • COI: 1:CAS:528:DyaK28XhvVSgsbg%3D, PID: 8631503
    • Dix DJ, Rosario-Herrle M, Gotoh H, Mori C, Goulding EH, Barrett CV et al (1996b) Developmentally regulated expression of Hsp70-2 and a Hsp70-2/lacZ transgene during spermatogenesis. Dev Biol 174:310–321
    • (1996) Dev Biol , vol.174 , pp. 310-321
    • Dix, D.J.1    Rosario-Herrle, M.2    Gotoh, H.3    Mori, C.4    Goulding, E.H.5    Barrett, C.V.6
  • 16
    • 0030721027 scopus 로고    scopus 로고
    • HSP70-2 is required for desynapsis of synaptonemal complexes during meiotic prophase in juvenile and adult mouse spermatocytes
    • COI: 1:CAS:528:DyaK1cXht12jsg%3D%3D, PID: 9409676
    • Dix DJ, Allen JW, Collins BW, Poorman-Allen P, Mori C, Blizard DR et al (1997) HSP70-2 is required for desynapsis of synaptonemal complexes during meiotic prophase in juvenile and adult mouse spermatocytes. Development 124:4595–4603
    • (1997) Development , vol.124 , pp. 4595-4603
    • Dix, D.J.1    Allen, J.W.2    Collins, B.W.3    Poorman-Allen, P.4    Mori, C.5    Blizard, D.R.6
  • 17
    • 0036257410 scopus 로고    scopus 로고
    • Sperm maturity and treatment choice of in vitro fertilization (IVF) or intracytoplasmic sperm injection: diminished sperm HspA2 chaperone levels predict IVF failure
    • PID: 12009343
    • Ergur AR, Dokras A, Giraldo JL, Habana A, Kovanci E, Huszar G (2002) Sperm maturity and treatment choice of in vitro fertilization (IVF) or intracytoplasmic sperm injection: diminished sperm HspA2 chaperone levels predict IVF failure. Fertil Steril 77:910–918
    • (2002) Fertil Steril , vol.77 , pp. 910-918
    • Ergur, A.R.1    Dokras, A.2    Giraldo, J.L.3    Habana, A.4    Kovanci, E.5    Huszar, G.6
  • 18
    • 33751089299 scopus 로고    scopus 로고
    • Oxygen levels in normal and previously irradiated human skin as assessed by EF5 binding
    • COI: 1:CAS:528:DC%2BD28Xht1Sgt7vL, PID: 16810299
    • Evans SM, Schrlau AE, Chalian AA, Zhang P, Koch CJ (2006) Oxygen levels in normal and previously irradiated human skin as assessed by EF5 binding. J Investig Dermatol 126:2596–2606
    • (2006) J Investig Dermatol , vol.126 , pp. 2596-2606
    • Evans, S.M.1    Schrlau, A.E.2    Chalian, A.A.3    Zhang, P.4    Koch, C.J.5
  • 19
    • 0035199033 scopus 로고    scopus 로고
    • Decreased expression of the heat shock protein hsp70-2 is associated with the pathogenesis of male infertility
    • COI: 1:STN:280:DC%2BD3MnosVynuw%3D%3D, PID: 11730740
    • Feng HL, Sandlow JI, Sparks AE (2001) Decreased expression of the heat shock protein hsp70-2 is associated with the pathogenesis of male infertility. Fertil Steril 76:1136–1139
    • (2001) Fertil Steril , vol.76 , pp. 1136-1139
    • Feng, H.L.1    Sandlow, J.I.2    Sparks, A.E.3
  • 21
    • 84862750260 scopus 로고    scopus 로고
    • HSPA2 overexpression protects V79 fibroblasts against bortezomib-induced apoptosis
    • COI: 1:CAS:528:DC%2BC38XntlShtLc%3D, PID: 22397456
    • Filipczak PT, Piglowski W, Glowala-Kosinska M, Krawczyk Z, Scieglinska D (2012) HSPA2 overexpression protects V79 fibroblasts against bortezomib-induced apoptosis. Biochem Cell Biol 90:224–231
    • (2012) Biochem Cell Biol , vol.90 , pp. 224-231
    • Filipczak, P.T.1    Piglowski, W.2    Glowala-Kosinska, M.3    Krawczyk, Z.4    Scieglinska, D.5
  • 22
    • 84870352601 scopus 로고    scopus 로고
    • Vertebrate nucleoplasmin and NASP: egg histone storage proteins with multiple chaperone activities
    • COI: 1:CAS:528:DC%2BC38XhvVCgtrvL, PID: 22968912
    • Finn RM, Ellard K, Eirin-Lopez JM, Ausio J (2012) Vertebrate nucleoplasmin and NASP: egg histone storage proteins with multiple chaperone activities. FASEB J 26:4788–4804
    • (2012) FASEB J , vol.26 , pp. 4788-4804
    • Finn, R.M.1    Ellard, K.2    Eirin-Lopez, J.M.3    Ausio, J.4
  • 23
    • 77952638661 scopus 로고    scopus 로고
    • Loss of protein phosphatase 1cc (PPP1CC) leads to impaired spermatogenesis associated with defects in chromatin condensation and acrosome development: an ultrastructural analysis
    • COI: 1:CAS:528:DC%2BC3cXns12qsbw%3D, PID: 20385779
    • Forgione N, Vogl WA, Varmuza S (2010) Loss of protein phosphatase 1cc (PPP1CC) leads to impaired spermatogenesis associated with defects in chromatin condensation and acrosome development: an ultrastructural analysis. Reproduction 139:1021–1029
    • (2010) Reproduction , vol.139 , pp. 1021-1029
    • Forgione, N.1    Vogl, W.A.2    Varmuza, S.3
  • 24
    • 84920937541 scopus 로고    scopus 로고
    • Expression of HSPA2 in human hepatocellular carcinoma and its clinical significance
    • Fu Y, Zhao H, Li XS, Kang HR, Ma JX, Yao FF et al (2014) Expression of HSPA2 in human hepatocellular carcinoma and its clinical significance. Tumour Biol. doi:10.1007/s13277-014-2430-y
    • (2014) Tumour Biol
    • Fu, Y.1    Zhao, H.2    Li, X.S.3    Kang, H.R.4    Ma, J.X.5    Yao, F.F.6
  • 25
    • 77956825499 scopus 로고    scopus 로고
    • Germ cell-specific heat shock protein 70–2 is expressed in cervical carcinoma and is involved in the growth, migration, and invasion of cervical cells
    • COI: 1:CAS:528:DC%2BC3cXhtFWgsLfP, PID: 20564126
    • Garg M, Kanojia D, Saini S, Suri S, Gupta A, Surolia A et al (2010a) Germ cell-specific heat shock protein 70–2 is expressed in cervical carcinoma and is involved in the growth, migration, and invasion of cervical cells. Cancer 116:3785–3796
    • (2010) Cancer , vol.116 , pp. 3785-3796
    • Garg, M.1    Kanojia, D.2    Saini, S.3    Suri, S.4    Gupta, A.5    Surolia, A.6
  • 26
    • 71049173726 scopus 로고    scopus 로고
    • Heat-shock protein 70–2 (HSP70-2) expression in bladder urothelial carcinoma is associated with tumour progression and promotes migration and invasion
    • COI: 1:CAS:528:DC%2BD1MXhsFGrsbvI, PID: 19914824
    • Garg M, Kanojia D, Seth A, Kumar R, Gupta A, Surolia A et al (2010b) Heat-shock protein 70–2 (HSP70-2) expression in bladder urothelial carcinoma is associated with tumour progression and promotes migration and invasion. Eur J Cancer 46:207–215
    • (2010) Eur J Cancer , vol.46 , pp. 207-215
    • Garg, M.1    Kanojia, D.2    Seth, A.3    Kumar, R.4    Gupta, A.5    Surolia, A.6
  • 27
    • 75149186088 scopus 로고    scopus 로고
    • From meiosis to postmeiotic events: the secrets of histone disappearance
    • COI: 1:CAS:528:DC%2BC3cXhsFars74%3D, PID: 20015078
    • Gaucher J, Reynoird N, Montellier E, al Boussouar F, Rousseaux S, Khochbin S (2010) From meiosis to postmeiotic events: the secrets of histone disappearance. FEBS J 277:599–604
    • (2010) FEBS J , vol.277 , pp. 599-604
    • Gaucher, J.1    Reynoird, N.2    Montellier, E.3    al Boussouar, F.4    Rousseaux, S.5    Khochbin, S.6
  • 28
    • 84863533791 scopus 로고    scopus 로고
    • The stress of protein misfolding: from single cells to multicellular organisms
    • PID: 21536706
    • Gidalevitz T, Prahlad V, Morimoto RI (2011) The stress of protein misfolding: from single cells to multicellular organisms. Cold Spring Harb Perspect Biol 3:a009704
    • (2011) Cold Spring Harb Perspect Biol , vol.3 , pp. a009704
    • Gidalevitz, T.1    Prahlad, V.2    Morimoto, R.I.3
  • 29
    • 33845999596 scopus 로고    scopus 로고
    • Post-meiotic shifts in HSPA2/HSP70.2 chaperone activity during mouse spermatogenesis
    • COI: 1:CAS:528:DC%2BD28Xht1Kit7%2FP, PID: 17035236
    • Govin J, Caron C, Escoffier E, Ferro M, Kuhn L, Rousseaux S et al (2006) Post-meiotic shifts in HSPA2/HSP70.2 chaperone activity during mouse spermatogenesis. J Biol Chem 281:37888–37892
    • (2006) J Biol Chem , vol.281 , pp. 37888-37892
    • Govin, J.1    Caron, C.2    Escoffier, E.3    Ferro, M.4    Kuhn, L.5    Rousseaux, S.6
  • 30
    • 79952833763 scopus 로고    scopus 로고
    • The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities
    • COI: 1:CAS:528:DC%2BC3MXjt1GmsLc%3D, PID: 21231916
    • Hageman J, van Waarde MA, Zylicz A, Walerych D, Kampinga HH (2011) The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities. Biochem J 435:127–142
    • (2011) Biochem J , vol.435 , pp. 127-142
    • Hageman, J.1    van Waarde, M.A.2    Zylicz, A.3    Walerych, D.4    Kampinga, H.H.5
  • 31
    • 79960543318 scopus 로고    scopus 로고
    • New candidate targets of protein phosphatase-1c-gamma-2 in mouse testis revealed by a differential phosphoproteome analysis
    • COI: 1:CAS:528:DC%2BC3MXhtFCrurrF, PID: 20618881
    • Henderson H, Macleod G, Hrabchak C, Varmuza S (2011) New candidate targets of protein phosphatase-1c-gamma-2 in mouse testis revealed by a differential phosphoproteome analysis. Int J Androl 34:339–351
    • (2011) Int J Androl , vol.34 , pp. 339-351
    • Henderson, H.1    Macleod, G.2    Hrabchak, C.3    Varmuza, S.4
  • 32
    • 58249088475 scopus 로고    scopus 로고
    • Transcriptional upregulation of HSP70-2 by HIF-1 in cancer cells in response to hypoxia
    • COI: 1:CAS:528:DC%2BD1MXhvFaqsA%3D%3D, PID: 18844219
    • Huang WJ, Xia LM, Zhu F, Huang B, Zhou C, Zhu HF et al (2009) Transcriptional upregulation of HSP70-2 by HIF-1 in cancer cells in response to hypoxia. Int J Cancer 124:298–305
    • (2009) Int J Cancer , vol.124 , pp. 298-305
    • Huang, W.J.1    Xia, L.M.2    Zhu, F.3    Huang, B.4    Zhou, C.5    Zhu, H.F.6
  • 33
    • 0028120752 scopus 로고
    • Creatine kinase immunocytochemistry of human sperm-hemizona complexes: selective binding of sperm with mature creatine kinase-staining pattern
    • COI: 1:STN:280:DyaK2c7itlOrtg%3D%3D, PID: 8293828
    • Huszar G, Vigue L, Oehninger S (1994) Creatine kinase immunocytochemistry of human sperm-hemizona complexes: selective binding of sperm with mature creatine kinase-staining pattern. Fertil Steril 61:136–142
    • (1994) Fertil Steril , vol.61 , pp. 136-142
    • Huszar, G.1    Vigue, L.2    Oehninger, S.3
  • 34
    • 0030978645 scopus 로고    scopus 로고
    • Sperm plasma membrane remodeling during spermiogenetic maturation in men: relationship among plasma membrane beta 1,4-galactosyltransferase, cytoplasmic creatine phosphokinase, and creatine phosphokinase isoform ratios
    • COI: 1:CAS:528:DyaK2sXitFKnuro%3D, PID: 9096886
    • Huszar G, Sbracia M, Vigue L, Miller DJ, Shur BD (1997) Sperm plasma membrane remodeling during spermiogenetic maturation in men: relationship among plasma membrane beta 1,4-galactosyltransferase, cytoplasmic creatine phosphokinase, and creatine phosphokinase isoform ratios. Biol Reprod 56:1020–1024
    • (1997) Biol Reprod , vol.56 , pp. 1020-1024
    • Huszar, G.1    Sbracia, M.2    Vigue, L.3    Miller, D.J.4    Shur, B.D.5
  • 35
    • 0031951882 scopus 로고    scopus 로고
    • Cytoplasmic extrusion and the switch from creatine kinase B to M isoform are completed by the commencement of epididymal transport in human and stallion spermatozoa
    • COI: 1:CAS:528:DyaK1cXhs1aisb4%3D, PID: 9537287
    • Huszar G, Patrizio P, Vigue L, Willets M, Wilker C, Adhoot D et al (1998) Cytoplasmic extrusion and the switch from creatine kinase B to M isoform are completed by the commencement of epididymal transport in human and stallion spermatozoa. J Androl 19:11–20
    • (1998) J Androl , vol.19 , pp. 11-20
    • Huszar, G.1    Patrizio, P.2    Vigue, L.3    Willets, M.4    Wilker, C.5    Adhoot, D.6
  • 36
    • 0033837992 scopus 로고    scopus 로고
    • Putative creatine kinase M-isoform in human sperm is identified as the 70-kilodalton heat shock protein HspA2
    • COI: 1:CAS:528:DC%2BD3cXmtFChsrY%3D, PID: 10952940
    • Huszar G, Stone K, Dix D, Vigue L (2000) Putative creatine kinase M-isoform in human sperm is identified as the 70-kilodalton heat shock protein HspA2. Biol Reprod 63:925–932
    • (2000) Biol Reprod , vol.63 , pp. 925-932
    • Huszar, G.1    Stone, K.2    Dix, D.3    Vigue, L.4
  • 37
    • 23044444001 scopus 로고    scopus 로고
    • Hsp70 protects mitotic cells against heat-induced centrosome damage and division abnormalities
    • COI: 1:CAS:528:DC%2BD2MXosVCns7w%3D, PID: 15930131
    • Hut HM, Kampinga HH, Sibon OC (2005) Hsp70 protects mitotic cells against heat-induced centrosome damage and division abnormalities. Mol Biol Cell 16:3776–3785
    • (2005) Mol Biol Cell , vol.16 , pp. 3776-3785
    • Hut, H.M.1    Kampinga, H.H.2    Sibon, O.C.3
  • 38
    • 77249088180 scopus 로고    scopus 로고
    • Heat shock protein 2 promoter drives Cre expression in spermatocytes of transgenic mice
    • COI: 1:CAS:528:DC%2BC3cXjsFymtb4%3D, PID: 20027617
    • Inselman AL, Nakamura N, Brown PR, Willis WD, Goulding EH, Eddy EM (2010) Heat shock protein 2 promoter drives Cre expression in spermatocytes of transgenic mice. Genesis 48:114–220
    • (2010) Genesis , vol.48 , pp. 114-220
    • Inselman, A.L.1    Nakamura, N.2    Brown, P.R.3    Willis, W.D.4    Goulding, E.H.5    Eddy, E.M.6
  • 39
    • 84897939278 scopus 로고    scopus 로고
    • Barcoding heat shock proteins to human diseases: looking beyond the heat shock response
    • COI: 1:CAS:528:DC%2BC2cXhtlGqsLfJ, PID: 24719117
    • Kakkar V, Meister-Broekema M, Minoia M, Carra S, Kampinga HH (2014) Barcoding heat shock proteins to human diseases: looking beyond the heat shock response. Dis Model Mech 7:421–434
    • (2014) Dis Model Mech , vol.7 , pp. 421-434
    • Kakkar, V.1    Meister-Broekema, M.2    Minoia, M.3    Carra, S.4    Kampinga, H.H.5
  • 41
    • 84878191743 scopus 로고    scopus 로고
    • BAG6/BAT3: emerging roles in quality control for nascent polypeptides
    • COI: 1:CAS:528:DC%2BC3sXhsFejtbo%3D, PID: 23275523
    • Kawahara H, Minami R, Yokota N (2013) BAG6/BAT3: emerging roles in quality control for nascent polypeptides. J Biochem 153:147–160
    • (2013) J Biochem , vol.153 , pp. 147-160
    • Kawahara, H.1    Minami, R.2    Yokota, N.3
  • 42
    • 84899115233 scopus 로고    scopus 로고
    • Stress-induced localization of HSPA6 (HSP70B’) and HSPA1A (HSP70-1) proteins to centrioles in human neuronal cells
    • COI: 1:CAS:528:DC%2BC2cXmsV2nsL0%3D, PID: 24061851
    • Khalouei S, Chow AM, Brown IR (2014) Stress-induced localization of HSPA6 (HSP70B’) and HSPA1A (HSP70-1) proteins to centrioles in human neuronal cells. Cell Stress Chaperones 19:321–327
    • (2014) Cell Stress Chaperones , vol.19 , pp. 321-327
    • Khalouei, S.1    Chow, A.M.2    Brown, I.R.3
  • 43
    • 75749102680 scopus 로고    scopus 로고
    • Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology
    • COI: 1:CAS:528:DC%2BC3cXht1Sksro%3D, PID: 20111001
    • Kirkegaard T, Roth AG, Petersen NH, Mahalka AK, Olsen OD, Moilanen I et al (2010) Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology. Nature 463:549–553
    • (2010) Nature , vol.463 , pp. 549-553
    • Kirkegaard, T.1    Roth, A.G.2    Petersen, N.H.3    Mahalka, A.K.4    Olsen, O.D.5    Moilanen, I.6
  • 44
    • 0034964960 scopus 로고    scopus 로고
    • FISH assessment of aneuploidy frequencies in mature and immature human spermatozoa classified by the absence or presence of cytoplasmic retention
    • COI: 1:STN:280:DC%2BD3MzhsVWhug%3D%3D, PID: 11387294
    • Kovanci E, Kovacs T, Moretti E, Vigue L, Bray-Ward P, Ward DC et al (2001) FISH assessment of aneuploidy frequencies in mature and immature human spermatozoa classified by the absence or presence of cytoplasmic retention. Hum Reprod 16:1209–1217
    • (2001) Hum Reprod , vol.16 , pp. 1209-1217
    • Kovanci, E.1    Kovacs, T.2    Moretti, E.3    Vigue, L.4    Bray-Ward, P.5    Ward, D.C.6
  • 45
    • 0024603312 scopus 로고
    • Effect of age and busulphan on the hsp70 gene-related transcript in rat testes
    • COI: 1:CAS:528:DyaL1MXhvVOnsbk%3D, PID: 2469655
    • Krawczyk Z, Szymik N (1989) Effect of age and busulphan on the hsp70 gene-related transcript in rat testes. Int J Androl 12:72–79
    • (1989) Int J Androl , vol.12 , pp. 72-79
    • Krawczyk, Z.1    Szymik, N.2
  • 46
    • 0023081165 scopus 로고
    • Expression of hsp70-related gene in developing and degenerating rat testis
    • COI: 1:CAS:528:DyaL2sXkslGjt70%3D, PID: 2442598
    • Krawczyk Z, Szymik N, Wiśniewski J (1987a) Expression of hsp70-related gene in developing and degenerating rat testis. Mol Biol Rep 12:35–41
    • (1987) Mol Biol Rep , vol.12 , pp. 35-41
    • Krawczyk, Z.1    Szymik, N.2    Wiśniewski, J.3
  • 47
    • 0023062578 scopus 로고
    • A hsp70-related gene is constitutively highly expressed in testis of rat and mouse
    • COI: 1:CAS:528:DyaL2sXkslGjtb0%3D, PID: 2442597
    • Krawczyk Z, Wiśniewski J, Biesiada E (1987b) A hsp70-related gene is constitutively highly expressed in testis of rat and mouse. Mol Biol Rep 12:27–34
    • (1987) Mol Biol Rep , vol.12 , pp. 27-34
    • Krawczyk, Z.1    Wiśniewski, J.2    Biesiada, E.3
  • 48
    • 0024095741 scopus 로고
    • Expression of a testis-specific hsp70 gene-related RNA in defined stages of rat seminiferous epithelium
    • COI: 1:CAS:528:DyaL1cXlvVCkt7g%3D, PID: 3170632
    • Krawczyk Z, Mali P, Parvinen M (1988) Expression of a testis-specific hsp70 gene-related RNA in defined stages of rat seminiferous epithelium. J Cell Biol 107:1317–1323
    • (1988) J Cell Biol , vol.107 , pp. 1317-1323
    • Krawczyk, Z.1    Mali, P.2    Parvinen, M.3
  • 49
    • 0026730704 scopus 로고
    • The ERE-like sequences from the promoter region of the testis specific hsp70-related gene is not estrogen responsive
    • COI: 1:CAS:528:DyaK3sXhslerug%3D%3D, PID: 1423660
    • Krawczyk Z, Schmid W, Harkonen P, Wolniczek P (1992) The ERE-like sequences from the promoter region of the testis specific hsp70-related gene is not estrogen responsive. Cell Biol Int Rep 16:937–948
    • (1992) Cell Biol Int Rep , vol.16 , pp. 937-948
    • Krawczyk, Z.1    Schmid, W.2    Harkonen, P.3    Wolniczek, P.4
  • 50
    • 33751170221 scopus 로고    scopus 로고
    • Expression of the HSPA2 gene in ejaculated spermatozoa from adolescents with and without varicocele
    • COI: 1:CAS:528:DC%2BD2sXkt1aksg%3D%3D, PID: 17007855
    • Lima SB, Cenedeze MA, Bertolla RP, Filho PA, Oehninger S, Cedenho AP (2006) Expression of the HSPA2 gene in ejaculated spermatozoa from adolescents with and without varicocele. Fertil Steril 86:1659–1663
    • (2006) Fertil Steril , vol.86 , pp. 1659-1663
    • Lima, S.B.1    Cenedeze, M.A.2    Bertolla, R.P.3    Filho, P.A.4    Oehninger, S.5    Cedenho, A.P.6
  • 51
    • 0025058935 scopus 로고
    • Cloning of a hsp70-related gene expressed in mouse spermatids
    • COI: 1:CAS:528:DyaK3cXhvFaqsbg%3D, PID: 2302214
    • Matsumoto M, Fujimoto H (1990) Cloning of a hsp70-related gene expressed in mouse spermatids. Biochem Biophys Res Commun 166:43–49
    • (1990) Biochem Biophys Res Commun , vol.166 , pp. 43-49
    • Matsumoto, M.1    Fujimoto, H.2
  • 52
    • 67649672425 scopus 로고    scopus 로고
    • Disruption of poly(ADP-ribose) homeostasis affects spermiogenesis and sperm chromatin integrity in mice
    • COI: 1:CAS:528:DC%2BD1MXnslaru7g%3D, PID: 19264700
    • Meyer-Ficca ML, Lonchar J, Credidio C, Ihara M, Li Y, Wang ZQ et al (2009) Disruption of poly(ADP-ribose) homeostasis affects spermiogenesis and sperm chromatin integrity in mice. Biol Reprod 81:46–55
    • (2009) Biol Reprod , vol.81 , pp. 46-55
    • Meyer-Ficca, M.L.1    Lonchar, J.2    Credidio, C.3    Ihara, M.4    Li, Y.5    Wang, Z.Q.6
  • 54
    • 0030034672 scopus 로고    scopus 로고
    • Distinct transcripts are recognized by sense and antisense riboprobes for a member of the murine HSP70 gene family, HSP70.2, in various reproductive tissues
    • COI: 1:CAS:528:DyaK28XjtFeitw%3D%3D, PID: 9110944
    • Murashov AK, Wolgemuth DJ (1996a) Distinct transcripts are recognized by sense and antisense riboprobes for a member of the murine HSP70 gene family, HSP70.2, in various reproductive tissues. Mol Reprod Dev 43:17–24
    • (1996) Mol Reprod Dev , vol.43 , pp. 17-24
    • Murashov, A.K.1    Wolgemuth, D.J.2
  • 55
    • 0029929488 scopus 로고    scopus 로고
    • Sense and antisense transcripts of the developmentally regulated murine hsp70.2 gene are expressed in distinct and only partially overlapping areas in the adult brain
    • COI: 1:CAS:528:DyaK28Xisl2qtLw%3D, PID: 8738139
    • Murashov AK, Wolgemuth DJ (1996b) Sense and antisense transcripts of the developmentally regulated murine hsp70.2 gene are expressed in distinct and only partially overlapping areas in the adult brain. Brain Res Mol Brain Res 37:85–95
    • (1996) Brain Res Mol Brain Res , vol.37 , pp. 85-95
    • Murashov, A.K.1    Wolgemuth, D.J.2
  • 56
    • 73149115984 scopus 로고    scopus 로고
    • Heat shock proteins on the human sperm surface
    • COI: 1:CAS:528:DC%2BC3cXkt1aqsQ%3D%3D, PID: 19962198
    • Naaby-Hansen S, Herr JC (2010) Heat shock proteins on the human sperm surface. J Reprod Immunol 84:32–40
    • (2010) J Reprod Immunol , vol.84 , pp. 32-40
    • Naaby-Hansen, S.1    Herr, J.C.2
  • 57
    • 0034599517 scopus 로고    scopus 로고
    • Arrest of spermatogenesis in mice expressing an active heat shock transcription factor 1
    • COI: 1:CAS:528:DC%2BD3cXislymt7w%3D, PID: 10747023
    • Nakai A, Suzuki M, Tanabe M (2000) Arrest of spermatogenesis in mice expressing an active heat shock transcription factor 1. EMBO J 19:1545–1554
    • (2000) EMBO J , vol.19 , pp. 1545-1554
    • Nakai, A.1    Suzuki, M.2    Tanabe, M.3
  • 58
    • 63749116934 scopus 로고    scopus 로고
    • Temporally regulated traffic of HuR and its associated ARE-containing mRNAs from the chromatoid body to polysomes during mouse spermatogenesis
    • PID: 19333380
    • Nguyen Chi M, Chalmel F, Agius E, Vanzo N, Khabar KS, Jégou B et al (2009) Temporally regulated traffic of HuR and its associated ARE-containing mRNAs from the chromatoid body to polysomes during mouse spermatogenesis. PLoS One 4:e4900
    • (2009) PLoS One , vol.4 , pp. e4900
    • Nguyen Chi, M.1    Chalmel, F.2    Agius, E.3    Vanzo, N.4    Khabar, K.S.5    Jégou, B.6
  • 59
    • 0021767876 scopus 로고
    • Hsp70 accelerates the recovery of nucleolar morphology after heat shock
    • COI: 1:CAS:528:DyaL2MXktlKnsQ%3D%3D, PID: 6441707
    • Pelham HR (1984) Hsp70 accelerates the recovery of nucleolar morphology after heat shock. EMBO J 3:3095–3100
    • (1984) EMBO J , vol.3 , pp. 3095-3100
    • Pelham, H.R.1
  • 60
    • 33947591338 scopus 로고    scopus 로고
    • The structural and functional analysis of the human HSPA2 gene promoter region
    • COI: 1:CAS:528:DC%2BD2sXntlCrs7Y%3D, PID: 17369882
    • Piglowski W, Nowak R, Krawczyk Z, Scieglinska D (2007) The structural and functional analysis of the human HSPA2 gene promoter region. Acta Biochim Pol 54:99–106
    • (2007) Acta Biochim Pol , vol.54 , pp. 99-106
    • Piglowski, W.1    Nowak, R.2    Krawczyk, Z.3    Scieglinska, D.4
  • 61
    • 84867395408 scopus 로고    scopus 로고
    • The stem cell signature of CHH/CHG methylation is not present in 271 cancer associated 5’UTR gene regions
    • COI: 1:CAS:528:DC%2BC38XhtVSgu77E, PID: 22750649
    • Pulverer W, Wielscher M, Panzer-Grümayer R, Plessl T, Kriegner A, Vierlinger K et al (2012) The stem cell signature of CHH/CHG methylation is not present in 271 cancer associated 5’UTR gene regions. Biochimie 94:2345–2352
    • (2012) Biochimie , vol.94 , pp. 2345-2352
    • Pulverer, W.1    Wielscher, M.2    Panzer-Grümayer, R.3    Plessl, T.4    Kriegner, A.5    Vierlinger, K.6
  • 62
    • 69049091761 scopus 로고    scopus 로고
    • Parp2 is required for the differentiation of post-meiotic germ cells: identification of a spermatid-specific complex containing Parp1, Parp2, TP2 and HSPA2
    • COI: 1:CAS:528:DC%2BD1MXhtVentb3E, PID: 19607827
    • Quenet D, Mark M, Govin J, van Dorsselear A, Schreiber V, Khochbin S et al (2009) Parp2 is required for the differentiation of post-meiotic germ cells: identification of a spermatid-specific complex containing Parp1, Parp2, TP2 and HSPA2. Exp Cell Res 315:2824–2834
    • (2009) Exp Cell Res , vol.315 , pp. 2824-2834
    • Quenet, D.1    Mark, M.2    Govin, J.3    van Dorsselear, A.4    Schreiber, V.5    Khochbin, S.6
  • 63
    • 84870562813 scopus 로고    scopus 로고
    • The molecular chaperone HSPA2 plays a key role in regulating the expression of sperm surface receptors that mediate sperm-egg recognition
    • COI: 1:CAS:528:DC%2BC38XhvVKqsbjN, PID: 23209833
    • Redgrove KA, Nixon B, Baker MA, Hetherington L, Baker G, Liu DY et al (2012) The molecular chaperone HSPA2 plays a key role in regulating the expression of sperm surface receptors that mediate sperm-egg recognition. PLoS One 7:e50851
    • (2012) PLoS One , vol.7 , pp. e50851
    • Redgrove, K.A.1    Nixon, B.2    Baker, M.A.3    Hetherington, L.4    Baker, G.5    Liu, D.Y.6
  • 64
    • 84876460101 scopus 로고    scopus 로고
    • Investigation of the mechanisms by which the molecular chaperone HSPA2 regulates the expression of sperm surface receptors involved in human sperm-oocyte recognition
    • COI: 1:CAS:528:DC%2BC3sXjtF2ktr4%3D, PID: 23247813
    • Redgrove KA, Anderson AL, McLaughlin EA, O’Bryan MK, Aitken RJ, Nixon B (2013) Investigation of the mechanisms by which the molecular chaperone HSPA2 regulates the expression of sperm surface receptors involved in human sperm-oocyte recognition. Mol Hum Reprod 19:120–135
    • (2013) Mol Hum Reprod , vol.19 , pp. 120-135
    • Redgrove, K.A.1    Anderson, A.L.2    McLaughlin, E.A.3    O’Bryan, M.K.4    Aitken, R.J.5    Nixon, B.6
  • 65
    • 80052470636 scopus 로고    scopus 로고
    • Comprehensive genome methylation analysis in bladder cancer: identification and validation of novel methylated genes and application of these as urinary tumor markers
    • COI: 1:CAS:528:DC%2BC3MXhtFSmtLbI, PID: 21788354
    • Reinert T, Modin C, Castano FM, Lamy P, Wojdacz TK, Hansen LL et al (2011) Comprehensive genome methylation analysis in bladder cancer: identification and validation of novel methylated genes and application of these as urinary tumor markers. Clin Cancer Res 17:5582–5592
    • (2011) Clin Cancer Res , vol.17 , pp. 5582-5592
    • Reinert, T.1    Modin, C.2    Castano, F.M.3    Lamy, P.4    Wojdacz, T.K.5    Hansen, L.L.6
  • 66
    • 84856905397 scopus 로고    scopus 로고
    • Loss of epidermal hypoxia-inducible factor-1α accelerates epidermal aging and affects re-epithelialization in human and mouse
    • COI: 1:CAS:528:DC%2BC38Xis1Kkurk%3D, PID: 22193962
    • Rezvani HR, Ali N, Serrano-Sanchez M, Dubus P, Varon C, Ged C et al (2011) Loss of epidermal hypoxia-inducible factor-1α accelerates epidermal aging and affects re-epithelialization in human and mouse. J Cell Sci 124:4172–4183
    • (2011) J Cell Sci , vol.124 , pp. 4172-4183
    • Rezvani, H.R.1    Ali, N.2    Serrano-Sanchez, M.3    Dubus, P.4    Varon, C.5    Ged, C.6
  • 67
    • 34250561475 scopus 로고
    • A new puffing pattern induced by temperature shock and DNP in Drosophila
    • COI: 1:CAS:528:DyaF3sXivVOgtw%3D%3D
    • Ritossa F (1962) A new puffing pattern induced by temperature shock and DNP in Drosophila. Experientia 18:571–573. doi:10.1007/BF02172188
    • (1962) Experientia , vol.18 , pp. 571-573
    • Ritossa, F.1
  • 68
    • 84905281354 scopus 로고    scopus 로고
    • HSP70-binding protein HSPBP1 regulates chaperone expression at a posttranslational level and is essential for spermatogenesis
    • COI: 1:CAS:528:DC%2BC2cXhs1als7fP, PID: 24899640
    • Rogon C, Ulbricht A, Hesse M, Alberti S, Vijayaraj P, Best D et al (2014) HSP70-binding protein HSPBP1 regulates chaperone expression at a posttranslational level and is essential for spermatogenesis. Mol Biol Cell 25:2260–2271
    • (2014) Mol Biol Cell , vol.25 , pp. 2260-2271
    • Rogon, C.1    Ulbricht, A.2    Hesse, M.3    Alberti, S.4    Vijayaraj, P.5    Best, D.6
  • 69
    • 14644435819 scopus 로고    scopus 로고
    • Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms
    • COI: 1:CAS:528:DC%2BD2MXitFOks7o%3D, PID: 15741319
    • Rohde M, Daugaard M, Jensen MH, Helin K, Nylandsted J, Jäättelä M (2005) Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms. Genes Dev 19:570–582
    • (2005) Genes Dev , vol.19 , pp. 570-582
    • Rohde, M.1    Daugaard, M.2    Jensen, M.H.3    Helin, K.4    Nylandsted, J.5    Jäättelä, M.6
  • 70
    • 0026517306 scopus 로고
    • Identification of the gene for the developmentally expressed 70 kDa heat-shock protein (P70) of mouse spermatogenic cells
    • COI: 1:CAS:528:DyaK38XhvFWlurY%3D, PID: 1537426
    • Rosario MO, Perkins SL, O’Brien DA, Allen RL, Eddy EM (1992) Identification of the gene for the developmentally expressed 70 kDa heat-shock protein (P70) of mouse spermatogenic cells. Dev Biol 150:1–11
    • (1992) Dev Biol , vol.150 , pp. 1-11
    • Rosario, M.O.1    Perkins, S.L.2    O’Brien, D.A.3    Allen, R.L.4    Eddy, E.M.5
  • 71
    • 33845363014 scopus 로고    scopus 로고
    • Promoter of the heat shock testis-specific Hsp70.2/Hst70 gene is active in nervous system during embryonic development of mice
    • COI: 1:CAS:528:DC%2BD28Xht1KmtrjL
    • Rupik W, Stawierej A, Stolarczyk I, Widłak W (2006) Promoter of the heat shock testis-specific Hsp70.2/Hst70 gene is active in nervous system during embryonic development of mice. Anat Embryol (Berl) 211:631–638
    • (2006) Anat Embryol (Berl) , vol.211 , pp. 631-638
    • Rupik, W.1    Stawierej, A.2    Stolarczyk, I.3    Widłak, W.4
  • 72
    • 49749130037 scopus 로고    scopus 로고
    • Bat3 deficiency accelerates the degradation of Hsp70-2/HspA2 during spermatogenesis
    • COI: 1:CAS:528:DC%2BD1cXpvFKltrc%3D, PID: 18678708
    • Sasaki T, Marcon E, McQuire T, Arai Y, Moens PB, Okada H (2008) Bat3 deficiency accelerates the degradation of Hsp70-2/HspA2 during spermatogenesis. J Cell Biol 182:449–458
    • (2008) J Cell Biol , vol.182 , pp. 449-458
    • Sasaki, T.1    Marcon, E.2    McQuire, T.3    Arai, Y.4    Moens, P.B.5    Okada, H.6
  • 73
    • 0031391809 scopus 로고    scopus 로고
    • Expression of the testis-specific HSP70-related gene (hst70 gene) in somatic non-testicular rat tissues revealed by RT-PCR and transgenic mice analysis
    • PID: 9812345
    • Scieglińska D, Widłak W, Rusin M, Markkula M, Krawczyk Z (1997) Expression of the testis-specific HSP70-related gene (hst70 gene) in somatic non-testicular rat tissues revealed by RT-PCR and transgenic mice analysis. Cell Biol Int 21:813–821
    • (1997) Cell Biol Int , vol.21 , pp. 813-821
    • Scieglińska, D.1    Widłak, W.2    Rusin, M.3    Markkula, M.4    Krawczyk, Z.5
  • 74
    • 0035477925 scopus 로고    scopus 로고
    • Structure of the 5′ region of the hst70 gene transcription unit: presence of an intron and multiple transcription initiation sites
    • COI: 1:CAS:528:DC%2BD3MXnslGnsbk%3D, PID: 11563976
    • Scieglinska D, Widłak W, Konopka W, Poutanen M, Rahman N, Huhtaniemi I et al (2001) Structure of the 5′ region of the hst70 gene transcription unit: presence of an intron and multiple transcription initiation sites. Biochem J 359:129–137
    • (2001) Biochem J , vol.359 , pp. 129-137
    • Scieglinska, D.1    Widłak, W.2    Konopka, W.3    Poutanen, M.4    Rahman, N.5    Huhtaniemi, I.6
  • 75
    • 2542529207 scopus 로고    scopus 로고
    • Location of promoter elements necessary and sufficient to direct testis-specific expression of the Hst70/Hsp70.2 gene
    • PID: 14766014
    • Scieglińska D, Vydra N, Krawczyk Z, Widłak W (2004) Location of promoter elements necessary and sufficient to direct testis-specific expression of the Hst70/Hsp70.2 gene. Biochem J 379:739–747
    • (2004) Biochem J , vol.379 , pp. 739-747
    • Scieglińska, D.1    Vydra, N.2    Krawczyk, Z.3    Widłak, W.4
  • 77
    • 79956219069 scopus 로고    scopus 로고
    • Differential expression of HSPA1 and HSPA2 proteins in human tissues; tissue microarray-based immunohistochemical study
    • COI: 1:CAS:528:DC%2BC3MXjvVSlu74%3D, PID: 21373891
    • Scieglinska D, Piglowski W, Chekan M, Mazurek A, Krawczyk Z (2011) Differential expression of HSPA1 and HSPA2 proteins in human tissues; tissue microarray-based immunohistochemical study. Histochem Cell Biol 135:337–350
    • (2011) Histochem Cell Biol , vol.135 , pp. 337-350
    • Scieglinska, D.1    Piglowski, W.2    Chekan, M.3    Mazurek, A.4    Krawczyk, Z.5
  • 78
    • 84906317931 scopus 로고    scopus 로고
    • HSPA2 chaperone protein is expressed in various human tumors and correlates with clinical features in non-small cell lung carcinoma
    • PID: 24922646
    • Scieglinska D, Gogler-Piglowska A, Butkiewicz D, Chekan M, Malusecka E, Harasim J et al (2014) HSPA2 chaperone protein is expressed in various human tumors and correlates with clinical features in non-small cell lung carcinoma. Anticancer Res 34:2833–2840
    • (2014) Anticancer Res , vol.34 , pp. 2833-2840
    • Scieglinska, D.1    Gogler-Piglowska, A.2    Butkiewicz, D.3    Chekan, M.4    Malusecka, E.5    Harasim, J.6
  • 79
    • 0032697684 scopus 로고    scopus 로고
    • Specific expression of heat shock protein HspA2 in human male germ cells
    • COI: 1:CAS:528:DC%2BD3cXivVeltg%3D%3D, PID: 10587366
    • Son WY, Hwang SH, Han CT, Lee JH, Kim S, Kim YC (1999) Specific expression of heat shock protein HspA2 in human male germ cells. Mol Hum Reprod 5:1122–1126
    • (1999) Mol Hum Reprod , vol.5 , pp. 1122-1126
    • Son, W.Y.1    Hwang, S.H.2    Han, C.T.3    Lee, J.H.4    Kim, S.5    Kim, Y.C.6
  • 80
    • 33645461015 scopus 로고    scopus 로고
    • Discovery of novel methylation biomarkers in cervical carcinoma by global demethylation and microarray analysis
    • COI: 1:CAS:528:DC%2BD28XmvVSgtw%3D%3D, PID: 16434596
    • Sova P, Feng Q, Geiss G, Wood T, Strauss R, Rudolf V et al (2006) Discovery of novel methylation biomarkers in cervical carcinoma by global demethylation and microarray analysis. Cancer Epidemiol Biomarkers Prev 15:114–123
    • (2006) Cancer Epidemiol Biomarkers Prev , vol.15 , pp. 114-123
    • Sova, P.1    Feng, Q.2    Geiss, G.3    Wood, T.4    Strauss, R.5    Rudolf, V.6
  • 81
    • 77952233318 scopus 로고    scopus 로고
    • Mutation of Eif4g3, encoding a eukaryotic translation initiation factor, causes male infertility and meiotic arrest of mouse spermatocytes
    • COI: 1:CAS:528:DC%2BC3cXnsFOqsL8%3D, PID: 20430745
    • Sun F, Palmer K, Handel MA (2010) Mutation of Eif4g3, encoding a eukaryotic translation initiation factor, causes male infertility and meiotic arrest of mouse spermatocytes. Development 137:1699–1707
    • (2010) Development , vol.137 , pp. 1699-1707
    • Sun, F.1    Palmer, K.2    Handel, M.A.3
  • 82
    • 77956840942 scopus 로고    scopus 로고
    • Changes in the expression profile of the meiosis-involved mismatch repair genes in impaired human spermatogenesis
    • COI: 1:CAS:528:DC%2BC3cXht1KmsbvJ, PID: 20075417
    • Terribas E, Bonache S, García-Arévalo M, Sánchez J, Franco E, Bassas L et al (2010) Changes in the expression profile of the meiosis-involved mismatch repair genes in impaired human spermatogenesis. J Androl 31:346–357
    • (2010) J Androl , vol.31 , pp. 346-357
    • Terribas, E.1    Bonache, S.2    García-Arévalo, M.3    Sánchez, J.4    Franco, E.5    Bassas, L.6
  • 83
    • 1542338426 scopus 로고    scopus 로고
    • Transcriptional regulation and binding of heat shock factor 1 and heat shock factor 2 to 32 human heat shock genes during thermal stress and differentiation
    • COI: 1:CAS:528:DC%2BD2cXjs1yjs74%3D, PID: 15270074
    • Trinklein ND, Chen WC, Kingston RE, Myers RM (2004) Transcriptional regulation and binding of heat shock factor 1 and heat shock factor 2 to 32 human heat shock genes during thermal stress and differentiation. Cell Stress Chaperones 9:21–28
    • (2004) Cell Stress Chaperones , vol.9 , pp. 21-28
    • Trinklein, N.D.1    Chen, W.C.2    Kingston, R.E.3    Myers, R.M.4
  • 84
    • 0032944179 scopus 로고    scopus 로고
    • Spermiogenesis is impaired in mice bearing a targeted mutation in the protein phosphatase 1cgamma gene
    • COI: 1:CAS:528:DyaK1MXmslCisg%3D%3D, PID: 9882500
    • Varmuza S, Jurisicova A, Okano K, Hudson J, Boekelheide K, Shipp EB (1999) Spermiogenesis is impaired in mice bearing a targeted mutation in the protein phosphatase 1cgamma gene. Dev Biol 205:98–110
    • (1999) Dev Biol , vol.205 , pp. 98-110
    • Varmuza, S.1    Jurisicova, A.2    Okano, K.3    Hudson, J.4    Boekelheide, K.5    Shipp, E.B.6
  • 85
    • 84883321205 scopus 로고    scopus 로고
    • Transcriptional response to stress in the dynamic chromatin environment of cycling and mitotic cells
    • COI: 1:CAS:528:DC%2BC3sXhsVKksLnE, PID: 23959860
    • Vihervaara A, Sergelius C, Vasara J, Blom MA, Elsing AN, Roos-Mattjus P et al (2013) Transcriptional response to stress in the dynamic chromatin environment of cycling and mitotic cells. Proc Natl Acad Sci U S A 110:E3388–E3397
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. E3388-E3397
    • Vihervaara, A.1    Sergelius, C.2    Vasara, J.3    Blom, M.A.4    Elsing, A.N.5    Roos-Mattjus, P.6
  • 86
    • 30844456876 scopus 로고    scopus 로고
    • Spermatocyte-specific expression of constitutively active heat shock factor 1 induces HSP70i-resistant apoptosis in male germ cells
    • COI: 1:CAS:528:DC%2BD28XjtVyqsA%3D%3D, PID: 16151457
    • Vydra N, Malusecka E, Jarzab M, Lisowska K, Glowala-Kosinska M, Benedyk K et al (2006) Spermatocyte-specific expression of constitutively active heat shock factor 1 induces HSP70i-resistant apoptosis in male germ cells. Cell Death Differ 13:212–222
    • (2006) Cell Death Differ , vol.13 , pp. 212-222
    • Vydra, N.1    Malusecka, E.2    Jarzab, M.3    Lisowska, K.4    Glowala-Kosinska, M.5    Benedyk, K.6
  • 88
    • 33947679370 scopus 로고    scopus 로고
    • Heat shock transcription factor 1 down-regulates spermatocyte-specific 70 kDa heat shock protein expression prior to the induction of apoptosis in mouse testes
    • COI: 1:CAS:528:DC%2BD2sXlsVWqsLs%3D, PID: 17397396
    • Widlak W, Vydra N, Malusecka E, Dudaladava V, Winiarski B, Scieglińska D et al (2007a) Heat shock transcription factor 1 down-regulates spermatocyte-specific 70 kDa heat shock protein expression prior to the induction of apoptosis in mouse testes. Genes Cells 12:487–499
    • (2007) Genes Cells , vol.12 , pp. 487-499
    • Widlak, W.1    Vydra, N.2    Malusecka, E.3    Dudaladava, V.4    Winiarski, B.5    Scieglińska, D.6
  • 89
    • 33947628135 scopus 로고    scopus 로고
    • Inducible 70 kDa heat shock protein does not protect spermatogenic cells from damage induced by cryptorchidism
    • COI: 1:CAS:528:DC%2BD2sXltFKkt7k%3D, PID: 17014532
    • Widlak W, Winiarski B, Krawczyk A, Vydra N, Malusecka E, Krawczyk Z (2007b) Inducible 70 kDa heat shock protein does not protect spermatogenic cells from damage induced by cryptorchidism. Int J Androl 30:80–87
    • (2007) Int J Androl , vol.30 , pp. 80-87
    • Widlak, W.1    Winiarski, B.2    Krawczyk, A.3    Vydra, N.4    Malusecka, E.5    Krawczyk, Z.6
  • 90
    • 0028247842 scopus 로고
    • Functional analysis of spermatocyte-specific hst70 gene promoter in transgenic mice
    • PID: 7976013
    • Widłak W, Markkula M, Krawczyk Z, Huhtaniemi I (1994) Functional analysis of spermatocyte-specific hst70 gene promoter in transgenic mice. Acta Biochim Pol 41:103–105
    • (1994) Acta Biochim Pol , vol.41 , pp. 103-105
    • Widłak, W.1    Markkula, M.2    Krawczyk, Z.3    Huhtaniemi, I.4
  • 91
    • 0028811602 scopus 로고
    • A 252 bp upstream region of the rat spermatocyte-specific hst70 gene is sufficient to promote expression of the hst70-CAT hybrid gene in testis and brain of transgenic mice
    • PID: 7495863
    • Widłak W, Markkula M, Krawczyk Z, Kananen K, Huhtaniemi I (1995) A 252 bp upstream region of the rat spermatocyte-specific hst70 gene is sufficient to promote expression of the hst70-CAT hybrid gene in testis and brain of transgenic mice. Biochim Biophys Acta 1264:191–200
    • (1995) Biochim Biophys Acta , vol.1264 , pp. 191-200
    • Widłak, W.1    Markkula, M.2    Krawczyk, Z.3    Kananen, K.4    Huhtaniemi, I.5
  • 92
    • 0042882534 scopus 로고    scopus 로고
    • Expression of a constitutively active mutant of heat shock factor 1 under the control of testis-specific hst70 gene promoter in transgenic mice induces degeneration of seminiferous epithelium
    • PID: 12833178
    • Widłak W, Benedyk K, Vydra N, Głowala M, Scieglińska D, Małusecka E et al (2003a) Expression of a constitutively active mutant of heat shock factor 1 under the control of testis-specific hst70 gene promoter in transgenic mice induces degeneration of seminiferous epithelium. Acta Biochim Pol 50:535–541
    • (2003) Acta Biochim Pol , vol.50 , pp. 535-541
    • Widłak, W.1    Benedyk, K.2    Vydra, N.3    Głowala, M.4    Scieglińska, D.5    Małusecka, E.6
  • 93
    • 0037482002 scopus 로고    scopus 로고
    • In vivo electroporation of the testis versus transgenic mice model in functional studies of spermatocyte-specific hst70 gene promoter: a comparative study
    • PID: 12840811
    • Widłak W, Scieglińska D, Vydra N, Małusecka E, Krawczyk Z (2003b) In vivo electroporation of the testis versus transgenic mice model in functional studies of spermatocyte-specific hst70 gene promoter: a comparative study. Mol Reprod Dev 65:382–388
    • (2003) Mol Reprod Dev , vol.65 , pp. 382-388
    • Widłak, W.1    Scieglińska, D.2    Vydra, N.3    Małusecka, E.4    Krawczyk, Z.5
  • 95
    • 2542429289 scopus 로고    scopus 로고
    • Analysis of aberrant DNA methylation and human papillomavirus DNA in cervicovaginal specimens to detect invasive cervical cancer and its precursors
    • COI: 1:CAS:528:DC%2BD2cXkt1GhsLg%3D, PID: 15161694
    • Widschwendter A, Gattringer C, Ivarsson L, Fiegl H, Schneitter A, Ramoni A et al (2004) Analysis of aberrant DNA methylation and human papillomavirus DNA in cervicovaginal specimens to detect invasive cervical cancer and its precursors. Clin Cancer Res 10:3396–3400
    • (2004) Clin Cancer Res , vol.10 , pp. 3396-3400
    • Widschwendter, A.1    Gattringer, C.2    Ivarsson, L.3    Fiegl, H.4    Schneitter, A.5    Ramoni, A.6
  • 96
    • 0025017783 scopus 로고
    • Isolation and nucleotide sequence analysis of rat testis-specific major heat shock (hsp70)-related gene
    • COI: 1:CAS:528:DyaK3cXltFSitLY%3D, PID: 1688714
    • Wisniewski J, Kordula T, Krawczyk Z (1990) Isolation and nucleotide sequence analysis of rat testis-specific major heat shock (hsp70)-related gene. Biochim Biophys Acta 1048:93–99
    • (1990) Biochim Biophys Acta , vol.1048 , pp. 93-99
    • Wisniewski, J.1    Kordula, T.2    Krawczyk, Z.3
  • 97
    • 79958254987 scopus 로고    scopus 로고
    • Developmental expression of heat shock proteins 60, 70, 90, and A2 in rabbit testis
    • COI: 1:CAS:528:DC%2BC3MXlsFKisLs%3D, PID: 21538228
    • Wu Y, Pei Y, Qin Y (2011) Developmental expression of heat shock proteins 60, 70, 90, and A2 in rabbit testis. Cell Tissue Res 344:355–363
    • (2011) Cell Tissue Res , vol.344 , pp. 355-363
    • Wu, Y.1    Pei, Y.2    Qin, Y.3
  • 98
    • 85018153088 scopus 로고    scopus 로고
    • Identification of novel breast cancer methylation biomarkers by global demethylation, cDNA microarray, and quantitative methylation analysis
    • Ye Ch HZ, Courtney R, Zheng W, Cai Q (2012) Identification of novel breast cancer methylation biomarkers by global demethylation, cDNA microarray, and quantitative methylation analysis. Cancer Res 72(8 Supplement):4094. doi:10.1158/1538-7445.AM2012-4094
    • (2012) Cancer Res , vol.72 , Issue.8 , pp. 4094
    • Ye Ch, H.Z.1    Courtney, R.2    Zheng, W.3    Cai, Q.4
  • 99
    • 0023114144 scopus 로고
    • Developmental-stage-specific expression of the hsp70 gene family during differentiation of the mammalian male germ line
    • COI: 1:CAS:528:DyaL2sXhvFelsbc%3D, PID: 3600644
    • Zakeri ZF, Wolgemuth DJ (1987) Developmental-stage-specific expression of the hsp70 gene family during differentiation of the mammalian male germ line. Mol Cell Biol 7:1791–1796
    • (1987) Mol Cell Biol , vol.7 , pp. 1791-1796
    • Zakeri, Z.F.1    Wolgemuth, D.J.2
  • 100
    • 0023921692 scopus 로고
    • Identification and sequence analysis of a new member of the mouse HSP70 gene family and characterization of its unique cellular and developmental pattern of expression in the male germ line
    • COI: 1:CAS:528:DyaL1cXlvVClsrg%3D, PID: 3405224
    • Zakeri ZF, Wolgemuth DJ, Hunt CR (1988) Identification and sequence analysis of a new member of the mouse HSP70 gene family and characterization of its unique cellular and developmental pattern of expression in the male germ line. Mol Cell Biol 8:2925–2932
    • (1988) Mol Cell Biol , vol.8 , pp. 2925-2932
    • Zakeri, Z.F.1    Wolgemuth, D.J.2    Hunt, C.R.3
  • 101
    • 0025151869 scopus 로고
    • Characterization and inducibility of hsp 70 proteins in the male mouse germ line
    • COI: 1:CAS:528:DyaK3cXlvVyrtbk%3D, PID: 2229174
    • Zakeri ZF, Welch WJ, Wolgemuth DJ (1990) Characterization and inducibility of hsp 70 proteins in the male mouse germ line. J Cell Biol 111:1785–1792
    • (1990) J Cell Biol , vol.111 , pp. 1785-1792
    • Zakeri, Z.F.1    Welch, W.J.2    Wolgemuth, D.J.3
  • 102
    • 84879059303 scopus 로고    scopus 로고
    • Overexpression of HSPA2 is correlated with poor prognosis in esophageal squamous cell carcinoma
    • COI: 1:CAS:528:DC%2BC3sXovF2quro%3D, PID: 23777267
    • Zhang H, Chen W, Duan CJ, Zhang CF (2013) Overexpression of HSPA2 is correlated with poor prognosis in esophageal squamous cell carcinoma. World J Surg Oncol 11:141
    • (2013) World J Surg Oncol , vol.11 , pp. 141
    • Zhang, H.1    Chen, W.2    Duan, C.J.3    Zhang, C.F.4
  • 103
    • 0030864750 scopus 로고    scopus 로고
    • HSP70-2 is required for CDC2 kinase activity in meiosis I of mouse spermatocytes
    • COI: 1:CAS:528:DyaK2sXltlSmtro%3D, PID: 9247342
    • Zhu D, Dix DJ, Eddy EM (1997) HSP70-2 is required for CDC2 kinase activity in meiosis I of mouse spermatocytes. Development 124:3007–3014
    • (1997) Development , vol.124 , pp. 3007-3014
    • Zhu, D.1    Dix, D.J.2    Eddy, E.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.