Germ cell-specific heat shock protein 70-2 is expressed in cervical carcinoma and is involved in the growth, migration, and invasion of cervical cells

Cancer

Volumn 116, Issue 16, 2010, Pages 3785-3796

  Garg, Manoj ^a   Kanojia, Deepika ^a   Saini, Shikha ^a   Suri, Sushma ^b   Gupta, Anju ^c   Surolia, Avadhesha ^a   Suri, Anil ^a  

^a NATIONAL INSTITUTE OF IMMUNOLOGY   (India)

^b SAFDARJUNG HOSPITAL   (India)

^c Moolchand Hospital   (India)

Author keywords

Cervical carcinoma; Early detection; Germ cell specific protein; Heat shock protein 70 2; Invasion

Indexed keywords

HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 70 2; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; HEAT SHOCK PROTEIN 70; HSPA1B PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INVASION; CARCINOGENESIS; CELL MIGRATION; COLONY FORMATION; CONTROLLED STUDY; DISEASE COURSE; DNA MICROARRAY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MAJOR CLINICAL STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UTERINE CERVIX CARCINOMA; ANIMAL; CANCER TRANSPLANTATION; CELL MOTION; CELL PROLIFERATION; GENE SILENCING; METABOLISM; NUDE MOUSE; PATHOLOGY; TUMOR CELL LINE; TUMOR INVASION; UTERINE CERVIX TUMOR;

ANIMALS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DISEASE PROGRESSION; FEMALE; GENE KNOCKDOWN TECHNIQUES; HSP70 HEAT-SHOCK PROTEINS; HUMANS; MICE; MICE, NUDE; NEOPLASM INVASIVENESS; NEOPLASM TRANSPLANTATION; UTERINE CERVICAL NEOPLASMS;

EID: 77956825499     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.25218     Document Type: Article

References (16)

1. Bonnycastle LL, Yu CE, Hunt CR, et al. Cloning, sequencing, and mapping of the human chromosome 14 heat shock protein gene (HSPA2). Genomics. 1994;23:85-93.
2. Dix DJ, Allen JW, Collins BW, et al. Targeted gene disruption of HSP70-2 results in failed meiosis, germ cell apoptosis, and male infertility. Proc Natl Acad Sci U S A. 1996;93:3264-3268.
3. Son WY, Hwang SH, Han CT, Lee JH, Kim S, Kim YC. Specific expression of heat shock protein HspA2 in human male germ cells. Mol Hum Reprod. 1999;5:1122-1126.
4. Fourie AM, Peterson PA, Yang Y. Characterization and regulation of the major histocompatibility complex-encoded proteins Hsp70-Hom and Hsp70-1/2. Cell Stress Chaperones. 2001;6:282-295.
5. Zhu D, Dix DJ, Eddy EM. HSP 70-2 is required for CDC2 kinase activity in meiosis I of mouse spermatocytes. Development. 1997;124:3007-3014.
6. Rohde M, Daugaard M, Jensen MH, Helin K, Nylandsted J, Jaattela M. Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms. Genes Dev. 2005;19:570-582.
7. Waggoner SE. Cervical cancer. Lancet. 2003;361:2217-2225.
8. Mandic A. Neoadjuvant chemotherapy in treatment of cervical cancer - controversies. Arch Oncol. 2005;13:89-90.
9. Landoni F, Maneo A, Colombo A, et al. Randomised study of radical surgery versus radiotherapy for stage IB-IIA cervical cancer. Lancet. 1997;350:535-540.
10. Garg M, Chaurasiya D, Rana R, et al. Sperm-associated antigen 9, a novel cancer testis antigen, is a potential target for immunotherapy in epithelial ovarian cancer. Clin Cancer Res. 2007;13:1421-1428.
11. Jagadish N, Rana R, Selvi R, et al. Characterization of a novel human sperm-associated antigen 9 (SPAG9) having structural homology with c-Jun N-terminal kinase-interacting protein. Biochem J. 2005;389:73-82.
12. Garg M, Kanojia D, Khosla A, et al. Sperm-associated antigen 9 is associated with tumor growth, migration, and invasion in renal cell carcinoma. Cancer Res. 2008;68:8240-8248.
13. Kanojia D, Garg M, Gupta S, Gupta A, Suri A. Sperm-associated antigen 9, a novel biomarker for early detection of breast cancer. Cancer Epidemiol Biomarkers Prev. 2009;18:630-639.
14. Garg M, Kanojia D, Salhan S, et al. Sperm-associated antigen 9 (SPAG9) is a biomarker for early cervical carcinoma. Cancer. 2009;115:2671-2683.
15. Legood R, Gray AM, Mahe C, et al. Screening for cervical cancer in India: how much will it cost? A trial based analysis of the cost per case detected. Int J Cancer. 2005;117:981-987.
16. Davelaar EM, van de Lande J, von Mensdorff-Pouilly S, Blankenstein MA, Verheijen RHM, Kenemans P. Combination of serum tumor markers identifies high-risk patients with early stage squamous cervical cancer. Tumor Biol. 2008;29:9-17.