메뉴 건너뛰기




Volumn 7, Issue 3, 2015, Pages 86-93

Statin intolerance because of myalgia, myositis, myopathy, or myonecrosis can in most cases be safely resolved by vitamin D supplementation

Author keywords

Myalgia; Myonecrosis; Myopathy; Myositis; Rhabdomyolysis; Statin intolerance; Statin rechallenge; Vitamin D deficiency; Vitamin D supplementation

Indexed keywords

ATORVASTATIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MEVINOLIN; ROSUVASTATIN; SIMVASTATIN; TRIACYLGLYCEROL; VITAMIN D;

EID: 84925445316     PISSN: 22501541     EISSN: 19472714     Source Type: Journal    
DOI: 10.4103/1947-2714.153919     Document Type: Article
Times cited : (90)

References (47)
  • 1
    • 33745686588 scopus 로고    scopus 로고
    • High prevalence of vitamin d deficiency, secondary hyperparathyroidism and generalized bone pain in turkish immigrants in germany: Identification of risk factors
    • Erkal MZ, Wilde J, Bilgin Y, Akinci A, Demir E, Bödeker RH, et al. High prevalence of vitamin D deficiency, secondary hyperparathyroidism and generalized bone pain in Turkish immigrants in Germany: Identification of risk factors. Osteoporos Int 2006;17:1133-40.
    • (2006) Osteoporos Int , vol.17 , pp. 1133-1140
    • Erkal, M.Z.1    Wilde, J.2    Bilgin, Y.3    Akinci, A.4    Demir, E.5    Bödeker, R.H.6
  • 2
    • 34347209984 scopus 로고    scopus 로고
    • Vitamin d and rehabilitation: Improving functional outcomes
    • 2. Shinchuk LM, Holick MF. Vitamin D and rehabilitation: Improving functional outcomes. Nutr Clin Pract 2007;22:297-304.
    • (2007) Nutr Clin Pract , vol.22 , pp. 297-304
    • Shinchuk, L.M.1    Holick, M.F.2
  • 4
    • 84883438167 scopus 로고    scopus 로고
    • Severe vitamin d deficiency, myopathy, and rhabdomyolysis
    • Glueck CJ, Conrad B. Severe vitamin d deficiency, myopathy, and rhabdomyolysis. N Am J Med Sci 2013;5:494-5.
    • (2013) N am J Med Sci , vol.5 , pp. 494-495
    • Glueck, C.J.1    Conrad, B.2
  • 5
    • 84878329393 scopus 로고    scopus 로고
    • Severe vitamin d deficiency induced myopathy associated with rhabydomyolysis
    • Rasheed K, Sethi P, Bixby E. Severe vitamin d deficiency induced myopathy associated with rhabydomyolysis. N Am J Med Sci 2013;5:334-6.
    • (2013) N am J Med Sci , vol.5 , pp. 334-336
    • Rasheed, K.1    Sethi, P.2    Bixby, E.3
  • 6
    • 4544297365 scopus 로고    scopus 로고
    • Higher 25-hydroxyvitamin d concentrations are associated with better lower-extremity function in both active and inactive persons aged > or =60 y
    • Bischoff-Ferrari HA, Dietrich T, Orav EJ, Hu FB, Zhang Y, Karlson EW, et al. Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged > or =60 y. Am J Clin Nutr 2004;80:752-8.
    • (2004) Am J Clin Nutr , vol.80 , pp. 752-758
    • Bischoff-Ferrari, H.A.1    Dietrich, T.2    Orav, E.J.3    Hu, F.B.4    Zhang, Y.5    Karlson, E.W.6
  • 7
    • 33747109781 scopus 로고    scopus 로고
    • Effects of vitamin d supplementation and exercise training on physical performance in chilean vitamin d deficient elderly subjects
    • Bunout D, Barrera G, Leiva L, Gattas V, de la Maza MP, Avendaño M, et al. Effects of vitamin D supplementation and exercise training on physical performance in Chilean vitamin D deficient elderly subjects. Exp Gerontol 2006;41:746-52.
    • (2006) Exp Gerontol , vol.41 , pp. 746-752
    • Bunout, D.1    Barrera, G.2    Leiva, L.3    Gattas, V.4    De La Maza, M.P.5    Avendaño, M.6
  • 8
    • 67249111853 scopus 로고    scopus 로고
    • Narrative review: Statin-related myopathy
    • 8. Joy TR, Hegele RA. Narrative review: Statin-related myopathy. Ann Intern Med 2009;150:858-68.
    • (2009) Ann Intern Med , vol.150 , pp. 858-868
    • Joy, T.R.1    Hegele, R.A.2
  • 9
    • 80052627012 scopus 로고    scopus 로고
    • Symptomatic myositis-myalgia in hypercholesterolemic statin-treated patients with concurrent vitamin d deficiency leading to statin intolerance may reflect a reversible interaction between vitamin d deficiency and statins on skeletal muscle
    • Glueck CJ, Abuchaibe C, Wang P. Symptomatic myositis-myalgia in hypercholesterolemic statin-treated patients with concurrent vitamin D deficiency leading to statin intolerance may reflect a reversible interaction between vitamin D deficiency and statins on skeletal muscle. Med Hypotheses 2011;77:658-61.
    • (2011) Med Hypotheses , vol.77 , pp. 658-661
    • Glueck, C.J.1    Abuchaibe, C.2    Wang, P.3
  • 10
    • 57649095363 scopus 로고    scopus 로고
    • Low serum 25 (oh) vitamin d levels (<32 ng/ml) are associated with reversible myositis-myalgia in statin-treated patients
    • Ahmed W, Khan N, Glueck CJ, Pandey S, Wang P, Goldenberg N, et al. Low serum 25 (OH) vitamin D levels (<32 ng/mL) are associated with reversible myositis-myalgia in statin-treated patients. Transl Res 2009;153:11-6.
    • (2009) Transl Res , vol.153 , pp. 11-16
    • Ahmed, W.1    Khan, N.2    Glueck, C.J.3    Pandey, S.4    Wang, P.5    Goldenberg, N.6
  • 12
    • 77149126209 scopus 로고    scopus 로고
    • Management of the patient with statin intolerance
    • Vandenberg BF, Robinson J. Management of the patient with statin intolerance. Curr Atheroscler Rep 2010;12:48-57.
    • (2010) Curr Atheroscler Rep , vol.12 , pp. 48-57
    • Vandenberg, B.F.1    Robinson, J.2
  • 14
    • 69249219154 scopus 로고    scopus 로고
    • Statin therapy, muscle function and falls risk in community-dwelling older adults
    • Scott D, Blizzard L, Fell J, Jones G. Statin therapy, muscle function and falls risk in community-dwelling older adults. QJM 2009;102:625-33.
    • (2009) QJM , vol.102 , pp. 625-633
    • Scott, D.1    Blizzard, L.2    Fell, J.3    Jones, G.4
  • 15
    • 79952105679 scopus 로고    scopus 로고
    • The relationship of vitamin d deficiency to statin myopathy
    • Gupta A, Thompson PD. The relationship of vitamin D deficiency to statin myopathy. Atherosclerosis 2011;215:23-9.
    • (2011) Atherosclerosis , vol.215 , pp. 23-29
    • Gupta, A.1    Thompson, P.D.2
  • 16
    • 84888376623 scopus 로고    scopus 로고
    • Epidemiology of cyp3a4-mediated clopidogrel drug-drug interactions and their clinical consequences
    • Tirkkonen T, Heikkila P, Vahlberg T, Huupponen R, Laine K. Epidemiology of CYP3A4-mediated clopidogrel drug-drug interactions and their clinical consequences. Cardiovasc Ther 2013;31:344-51.
    • (2013) Cardiovasc Ther , vol.31 , pp. 344-351
    • Tirkkonen, T.1    Heikkila, P.2    Vahlberg, T.3    Huupponen, R.4    Laine, K.5
  • 18
    • 84896770249 scopus 로고    scopus 로고
    • Association of vitamin d and incident statin induced myalgia--a retrospective cohort study
    • Palamaner Subash Shantha G, Ramos J, Thomas-Hemak L, Pancholy SB. Association of vitamin D and incident statin induced myalgia--a retrospective cohort study. PLoS One 2014;9:e88877.
    • (2014) Plos One , pp. 9
    • Palamaner Subash Shantha, G.1    Ramos, J.2    Thomas-Hemak, L.3    Pancholy, S.B.4
  • 19
    • 66949125356 scopus 로고    scopus 로고
    • Vitamin d insufficiency — a novel mechanism of statin-induced myalgia?
    • Lee P, Greenfield JR, Campbell LV. Vitamin D insufficiency — A novel mechanism of statin-induced myalgia? Clin Endocrinol (Oxf) 2009;71:154-5.
    • (2009) Clin Endocrinol (Oxf) , vol.71 , pp. 154-155
    • Lee, P.1    Greenfield, J.R.2    Campbell, L.V.3
  • 20
    • 79955592820 scopus 로고    scopus 로고
    • Resolution of statin-induced myalgias by correcting vitamin d deficiency
    • Fang S, Wu J. Resolution of statin-induced myalgias by correcting vitamin D deficiency. South Med J 2011;104:380.
    • (2011) South Med J , vol.104 , pp. 380
    • Fang, S.1    Wu, J.2
  • 21
    • 77954242047 scopus 로고    scopus 로고
    • Resolution of statin-induced myalgias by correcting vitamin d deficiency
    • Bell DS. Resolution of statin-induced myalgias by correcting vitamin D deficiency. South Med J 2010;103:690-2.
    • (2010) South Med J , vol.103 , pp. 690-692
    • Bell, D.S.1
  • 22
    • 84901440042 scopus 로고    scopus 로고
    • Low vitamin d as a risk factor for the development of myalgia in patients taking high-dose simvastatin: A retrospective review
    • 22. Mergenhagen K, Ott M, Heckman K, Rubin LM, Kellick K. Low vitamin D as a risk factor for the development of myalgia in patients taking high-dose simvastatin: A retrospective review. Clin Ther 2014;36:770-7.
    • (2014) Clin Ther , vol.36 , pp. 770-777
    • Mergenhagen, K.1    Ott, M.2    Heckman, K.3    Rubin, L.M.4    Kellick, K.5
  • 23
    • 78751541922 scopus 로고    scopus 로고
    • The role of vitamin d and slco1b1*5 gene polymorphism in statin-associated myalgias
    • Linde R, Peng L, Desai M, Feldman D. The role of vitamin D and SLCO1B1*5 gene polymorphism in statin-associated myalgias. Dermatoendocrinol 2010;2:77-84.
    • (2010) Dermatoendocrinol , vol.2 , pp. 77-84
    • Linde, R.1    Peng, L.2    Desai, M.3    Feldman, D.4
  • 24
    • 84912083886 scopus 로고    scopus 로고
    • Vitamin d status modifies the association between statin use and musculoskeletal pain: A population based study
    • 24. Morioka TY, Lee AJ, Bertisch S, Buettner C. Vitamin D status modifies the association between statin use and musculoskeletal pain: A population based study. Atherosclerosis 2015;238:77-82.
    • (2015) Atherosclerosis , vol.238 , pp. 77-82
    • Morioka, T.Y.1    Lee, A.J.2    Bertisch, S.3    Buettner, C.4
  • 25
    • 84862007842 scopus 로고    scopus 로고
    • Muscle pain and serum creatine kinase are not associated with low serum 25(oh) vitamin d levels in patients receiving statins
    • Kurnik D, Hochman I, Vesterman-Landes J, Kenig T, Katzir I, Lomnicky Y, et al. Muscle pain and serum creatine kinase are not associated with low serum 25(OH) vitamin D levels in patients receiving statins. Clin Endocrinol (Oxf) 2012;77:36-41.
    • (2012) Clin Endocrinol (Oxf) , vol.77 , pp. 36-41
    • Kurnik, D.1    Hochman, I.2    Vesterman-Landes, J.3    Kenig, T.4    Katzir, I.5    Lomnicky, Y.6
  • 26
    • 84863621057 scopus 로고    scopus 로고
    • Myopathy during statin therapy in the daily practice of an outpatient cardiology clinic: Prevalence, predictors and relation with vitamin d
    • Riphagen IJ, van der Veer E, Muskiet FA, DeJongste MJ. Myopathy during statin therapy in the daily practice of an outpatient cardiology clinic: Prevalence, predictors and relation with vitamin D. Curr Med Res Opin 2012;28:1247-52.
    • (2012) Curr Med Res Opin , vol.28 , pp. 1247-1252
    • Riphagen, I.J.1    Van Der Veer, E.2    Muskiet, F.A.3    Dejongste, M.J.4
  • 29
    • 33744784615 scopus 로고    scopus 로고
    • Vitamin d physiology
    • Lips P. Vitamin D physiology. Prog Biophys Mol Biol 2006;92:4-8.
    • (2006) Prog Biophys Mol Biol , vol.92 , pp. 4-8
    • Lips, P.1
  • 30
    • 18144364293 scopus 로고    scopus 로고
    • Determination of 25-hydroxyvitamin d in human plasma using high-performance liquid chromatography — tandem mass spectrometry
    • Tsugawa N, Suhara Y, Kamao M, Okano T. Determination of 25-hydroxyvitamin D in human plasma using high-performance liquid chromatography — tandem mass spectrometry. Anal Chem 2005;77:3001-7.
    • (2005) Anal Chem , vol.77 , pp. 3001-3007
    • Tsugawa, N.1    Suhara, Y.2    Kamao, M.3    Okano, T.4
  • 31
    • 77955130077 scopus 로고    scopus 로고
    • Vitamin d deficiency in adults: When to test and how to treat
    • 31. Kennel KA, Drake MT, Hurley DL. Vitamin D deficiency in adults: When to test and how to treat. Mayo Clin Proc 2010;85:752-8.
    • (2010) Mayo Clin Proc , vol.85 , pp. 752-758
    • Kennel, K.A.1    Drake, M.T.2    Hurley, D.L.3
  • 32
    • 3142729178 scopus 로고    scopus 로고
    • Coordinating committee of the national cholesterol education program. Implications of recent clinical trials for the national cholesterol education program adult treatment panel iii guidelines
    • Grundy SM, Cleeman JI, Merz CN, Brewer HB Jr, Clark LT, Hunninghake DB, et al.; Coordinating Committee of the National Cholesterol Education Program. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation 2004;110:227-39.
    • (2004) Circulation , vol.110 , pp. 227-239
    • Grundy, S.M.1    Cleeman, J.I.2    Merz, C.N.3    Brewer, H.B.4    Clark, L.T.5    Hunninghake, D.B.6
  • 33
    • 84899893293 scopus 로고    scopus 로고
    • The national lipid association’s muscle safety expert panel. An assessment by the statin muscle safety task force: 2014 update
    • Rosenson RS, Baker SK, Jacobson TA, Kopecky SL, Parker BA; The National Lipid Association’s Muscle Safety Expert Panel. An assessment by the statin muscle safety task force: 2014 update. J Clin Lipidol 2014;8(Suppl):S58-71.
    • (2014) J Clin Lipidol , vol.8 , pp. S58-S71
    • Rosenson, R.S.1    Baker, S.K.2    Jacobson, T.A.3    Kopecky, S.L.4    Parker, B.A.5
  • 34
    • 34848906510 scopus 로고    scopus 로고
    • Does statin therapy initiation increase the risk for myopathy? An observational study of 32,225 diabetic and nondiabetic patients
    • Nichols GA, Koro CE. Does statin therapy initiation increase the risk for myopathy? An observational study of 32,225 diabetic and nondiabetic patients. Clin Ther 2007;29:1761-70.
    • (2007) Clin Ther , vol.29 , pp. 1761-1770
    • Nichols, G.A.1    Koro, C.E.2
  • 35
    • 33747882182 scopus 로고    scopus 로고
    • Statin therapy induces ultrastructural damage in skeletal muscle in patients without myalgia
    • Draeger A, Monastyrskaya K, Mohaupt M, Hoppeler H, Savolainen H, Allemann C, et al. Statin therapy induces ultrastructural damage in skeletal muscle in patients without myalgia. J Pathol 2006;210:94-102.
    • (2006) J Pathol , vol.210 , pp. 94-102
    • Draeger, A.1    Monastyrskaya, K.2    Mohaupt, M.3    Hoppeler, H.4    Savolainen, H.5    Allemann, C.6
  • 36
    • 7044272752 scopus 로고    scopus 로고
    • Is there value in liver function test and creatine phosphokinase monitoring with statin use?
    • Sniderman AD. Is there value in liver function test and creatine phosphokinase monitoring with statin use? Am J Cardiol 2004;94:30F-4F.
    • (2004) Am J Cardiol , vol.94 , pp. 30F-34F
    • Sniderman, A.D.1
  • 37
    • 58249092064 scopus 로고    scopus 로고
    • Should high creatine kinase discourage the initiation or continuance of statins for the treatment of hypercholesterolemia?
    • Glueck CJ, Rawal B, Khan NA, Yeramaneni S, Goldenberg N, Wang P. Should high creatine kinase discourage the initiation or continuance of statins for the treatment of hypercholesterolemia? Metabolism 2009;58:233-8.
    • (2009) Metabolism , vol.58 , pp. 233-238
    • Glueck, C.J.1    Rawal, B.2    Khan, N.A.3    Yeramaneni, S.4    Goldenberg, N.5    Wang, P.6
  • 38
    • 79957619795 scopus 로고    scopus 로고
    • Increased vitamin d serum levels correlate with clinical improvement of rheumatic diseases after dead sea climatotherapy
    • Harari M, Dramsdahl E, Shany S, Baumfeld Y, Ingber A, Novack V, et al. Increased vitamin D serum levels correlate with clinical improvement of rheumatic diseases after Dead Sea climatotherapy. Isr Med Assoc J 2011;13:212-5.
    • (2011) Isr Med Assoc J , vol.13 , pp. 212-215
    • Harari, M.1    Dramsdahl, E.2    Shany, S.3    Baumfeld, Y.4    Ingber, A.5    Novack, V.6
  • 40
    • 77951661110 scopus 로고    scopus 로고
    • Vitamin d and human skeletal muscle
    • 40. Hamilton B. Vitamin D and human skeletal muscle. Scand J Med Sci Sports 2010;20:182-90.
    • (2010) Scand J Med Sci Sports , vol.20 , pp. 182-190
    • Hamilton, B.1
  • 41
    • 1542289964 scopus 로고    scopus 로고
    • The rapid effects of 1,25-dihydroxyvitamin d3 require the vitamin d receptor and influence 24-hydroxylase activity: Studies in human skin fibroblasts bearing vitamin d receptor mutations
    • Nguyen TM, Lieberherr M, Fritsch J, Guillozo H, Alvarez ML, Fitouri Z, et al. The rapid effects of 1,25-dihydroxyvitamin D3 require the vitamin D receptor and influence 24-hydroxylase activity: Studies in human skin fibroblasts bearing vitamin D receptor mutations. J Biol Chem 2004;279:7591-7.
    • (2004) J Biol Chem , vol.279 , pp. 7591-7597
    • Nguyen, T.M.1    Lieberherr, M.2    Fritsch, J.3    Guillozo, H.4    Alvarez, M.L.5    Fitouri, Z.6
  • 42
    • 0022256118 scopus 로고
    • Identification of 1,25-dihydroxyvitamin d3 receptors and activities in muscle
    • Simpson RU, Thomas GA, Arnold AJ. Identification of 1,25-dihydroxyvitamin D3 receptors and activities in muscle. J Biol Chem 1985;260:8882-91.
    • (1985) J Biol Chem , vol.260 , pp. 8882-8891
    • Simpson, R.U.1    Thomas, G.A.2    Arnold, A.J.3
  • 44
    • 82455162445 scopus 로고    scopus 로고
    • Vdr activation of intracellular signaling pathways in skeletal muscle
    • Boland RL. VDR activation of intracellular signaling pathways in skeletal muscle. Mol Cell Endocrinol 2011;347:11-6.
    • (2011) Mol Cell Endocrinol , vol.347 , pp. 11-16
    • Boland, R.L.1
  • 45
    • 84859940521 scopus 로고    scopus 로고
    • Possible mechanisms of interaction between statins and vitamin d
    • Bhattacharyya S, Bhattacharyya K, Maitra A. Possible mechanisms of interaction between statins and vitamin D. QJM 2012;105:487-91.
    • (2012) QJM , vol.105 , pp. 487-491
    • Bhattacharyya, S.1    Bhattacharyya, K.2    Maitra, A.3
  • 46
    • 56749106312 scopus 로고    scopus 로고
    • Jupiter study group. Rosuvastatin to prevent vascular events in men and women with elevated c-reactive protein
    • Ridker PM, Danielson E, Fonseca FA, Genest J, Gotto AM Jr, Kastelein JJ, et al.; JUPITER Study Group. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med 2008;359:2195-207.
    • (2008) N Engl J Med , vol.359 , pp. 2195-2207
    • Ridker, P.M.1    Danielson, E.2    Fonseca, F.A.3    Genest, J.4    Gotto, A.M.5    Kastelein, J.J.6
  • 47
    • 84866048045 scopus 로고    scopus 로고
    • Statin myopathy: A lipid clinic experience on the tolerability of statin rechallenge
    • 47. Fung EC, Crook MA. Statin myopathy: A lipid clinic experience on the tolerability of statin rechallenge. Cardiovasc Ther 2012;30:e212-8.
    • (2012) Cardiovasc Ther , vol.30 , pp. e212-e218
    • Fung, E.C.1    Crook, M.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.