Vitamin D deficiency, myositismyalgia, and reversible statin intolerance

Current Medical Research and Opinion

Volumn 27, Issue 9, 2011, Pages 1683-1690

  Glueck, Charles J ^a   Budhani, Shaaista B ^a   Masineni, Silpa S ^a   Abuchaibe, Cesar ^a   Khan, Naseer ^a   Wang, Ping ^a   Goldenberg, Naila ^a  

^a JEWISH HOSPITAL   (United States)

Author keywords

Hypercholesterolemia; Myositismyalgia; Serum 25 (OH) vitamin D deficiency; Statins

Indexed keywords

25 HYDROXYVITAMIN D; ATORVASTATIN; CHOLINE FENOFIBRATE; CREATINE KINASE; FENOFIBRATE; FLUINDOSTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MEVINOLIN; PITAVASTATIN; PRAVASTATIN; ROSUVASTATIN; SIMVASTATIN; VITAMIN D;

ADULT; ARTICLE; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; CREATINE KINASE BLOOD LEVEL; DRUG HYPERSENSITIVITY; DRUG SAFETY; DRUG WITHDRAWAL; FEMALE; HUMAN; HYPERCHOLESTEROLEMIA; MAJOR CLINICAL STUDY; MALE; MYALGIA; MYOSITIS; PATIENT COMPLIANCE; PROSPECTIVE STUDY; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; VITAMIN SUPPLEMENTATION;

CHOLESTEROL, LDL; DIETARY SUPPLEMENTS; DRUG ADMINISTRATION SCHEDULE; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERCHOLESTEROLEMIA; MALE; MIDDLE AGED; MUSCULAR DISEASES; MYOSITIS; TIME FACTORS; VITAMIN D; VITAMIN D DEFICIENCY; WITHHOLDING TREATMENT;

EID: 80051753647     PISSN: 03007995     EISSN: 14734877     Source Type: Journal    
DOI: 10.1185/03007995.2011.598144     Document Type: Article

References (40)

1. Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr 2008;87:1080S-6S (Pubitemid 351549267)
2. Mark S, Gray-Donald K, Delvin EE, et al. Low vitamin D status in a representative sample of youth from Quebec, Canada. Clin Chem 2008;54:1283-1289
3. Goswami R, Mishra SK, Kochupillai N. Prevalence & potential significance of vitamin D deficiency in Asian Indians. Indian J Med Res 2008;127: 229-238 (Pubitemid 351936149)
4. Alsafwah S, Laguardia SP, Nelson MD, et al. Hypovitaminosis D in African Americans residing in Memphis, Tennessee with and without heart failure. Am J Med Sci 2008;335:292-297 (Pubitemid 351548648)
5. Kumar J, Muntner P, Kaskel FJ, et al. Prevalence and associations of 25-hydroxyvitamin D deficiency in US children: NHANES 2001-2004. Pediatrics 124(3):E362-370, 2009 ePUB
6. Draeger A, Monastyrskaya K, Mohaupt M, et al. Statin therapy induces ultrastructural damage in skeletal muscle in patients without myalgia. J Pathol 2006;210:94-102 (Pubitemid 44288185)
7. Adams JS, Hewison M. Update in vitamin D. J Clin Endocrinol Metab 2010;95:471-478
8. Jorde R, Sneve M, Hutchinson M, et al. Tracking of serum 25-hydroxyvitamin D levels during 14 years in a population-based study and during 12 months in an intervention study. Am J Epidemiol 2010;171:903-908
9. Erkal MZ, Wilde J, Bilgin Y, et al. High prevalence of vitamin D deficiency, secondary hyperparathyroidism and generalized bone pain in Turkish immigrants in Germany: identification of risk factors. Osteoporos Int 2006; 17:1133-1140
10. Zittermann A. Vitamin D in preventive medicine: are we ignoring the evidence? Br J Nutr 2003;89:552-572 (Pubitemid 36592083)
11. Pfeifer M, Begerow B, Minne HW. Vitamin D and muscle function. Osteoporos Int 2002;13:187-194 (Pubitemid 34408183)
12. Shinchuk LM, Holick MF. Vitamin D and rehabilitation: improving functional outcomes. Nutr Clin Pract 2007;22:297-304
13. Bischoff-Ferrari HA, Dietrich T, Orav EJ, et al. Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged4or ¼60 y. Am J Clin Nutr 2004; 80:752-758 (Pubitemid 41115542)
14. Lips P. Vitamin D physiology. Prog Biophys Mol Biol 2006;92:4-8 (Pubitemid 43831956)
15. Targher G, Bertolini L, Padovani R, et al. Serum 25-hydroxyvitamin D3 concentrations and carotid artery intima-media thickness among type 2 diabetic patients. Clin Endocrinol (Oxf) 2006;65:593-597 (Pubitemid 44583818)
16. Bunout D, Barrera G, Leiva L, et al. Effects of vitamin D supplementation and exercise training on physical performance in Chilean vitamin D deficient elderly subjects. Exp Gerontol 2006;41:746-752 (Pubitemid 44223892)
17. Ghatak A, Faheem O, Thompson PD. The genetics of statin-induced myopathy. Atherosclerosis 2010;210(3):337-343
18. Voora D, Shah SH, Spasojevic I, et al. The SLCO1B1*5 genetic variant is associated with statin-induced side effects. J Am Coll Cardiol 2009;54: 1609-1616
19. Glueck CJ, Aregawi D, Agloria M, et al. Rosuvastatin 5 and 10 mg/d: a pilot study of the effects in hypercholesterolemic adults unable to tolerate other statins and reach LDL cholesterol goals with nonstatin lipid-lowering therapies. Clin Ther 2006;28:933-942 (Pubitemid 44062693)
20. Siddiqi SA, Thompson PD. How do you treat patients with myalgia who take statins? Curr Atheroscler Rep 2009;11:9-14
21. Lee P, Greenfield JR, Campbell LV. Vitamin D insufficiency-a novel mechanism of statin-induced myalgia? Clin Endocrinol (Oxf) 2009;71:154-155
22. Ahmed W, Khan N, Glueck CJ, et al. Low serum 25 (OH) vitamin D levels (532 ng/mL) are associated with reversible myositis-myalgia in statin-treated patients. Transl Res 2009;153:11-16
23. Nichols GA, Koro CE. Does statin therapy initiation increase the risk for myopathy? An observational study of 32,225 diabetic and nondiabetic patients. Clin Ther 2007;29:1761-1770 (Pubitemid 47494553)
24. McClure DL, Valuck RJ, Glanz M, et al. Statin and statin-fibrate use was significantly associated with increased myositis risk in a managed care population. J Clin Epidemiol 2007;60:812-818 (Pubitemid 47007672)
25. Bell DS. Resolution of statin-induced myalgias by correcting vitamin D deficiency. South Med J 2010;103:690-692
26. Perez-Castrillon JL, Vega G, Abad L, et al. Effects of atorvastatin on vitamin D levels in patients with acute ischemic heart disease. Am J Cardiol 2007; 99:903-905 (Pubitemid 46483276)
27. Yavuz B, Ertugrul DT, Cil H, et al. Increased levels of 25 hydroxyvitamin D and 1,25-dihydroxyvitamin D after rosuvastatin treatment: a novel pleiotropic effect of statins? Cardiovasc Drugs Ther 2009;23:295-299
28. Rejnmark L, Vestergaard P, Heickendorff L, et al. Simvastatin does not affect vitamin D status, but low vitamin D levels are associated with dyslipidemia: results from a randomised, controlled trial. Int J Endocrinol 2010;2010: 957174
29. Tsugawa N, Suhara Y, Kamao M, et al. Determination of 25-hydroxyvitamin D in human plasma using high-performance liquid chromatography-tandem mass spectrometry. Anal Chem 2005;77:3001-3007 (Pubitemid 40617353)
30. Kennel KA, Drake MT, Hurley DL. Vitamin D deficiency in adults: when to test and how to treat. Mayo Clin Proc 2010;85:752-757
31. Grundy SM, Cleeman JI, Merz CN, et al. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation 2004;110:227-239 (Pubitemid 38924592)
32. Sniderman AD. Is there value in liver function test and creatine phosphokinase monitoring with statin use? Am J Cardiol 2004;94:30F-4F (Pubitemid 39425216)
33. Glueck CJ, Rawal B, Khan NA, et al. Should high creatine kinase discourage the initiation or continuance of statins for the treatment of hypercholesterolemia? Metabolism 2009;58:233-238
34. Thompson PD, Clarkson P, Karas RH. Statin-associated myopathy. JAMA 2003;289:1681-1690 (Pubitemid 37430274)
35. Ginde AA, Liu MC, Camargo Jr CA. Demographic differences and trends of vitamin D insufficiency in the US population, 1988-2004. Arch Intern Med 2009;169:626-632
36. Duell PBCW. Vitamin D deficiency is associated with myalgias in hyperlipidemic subjects taking statins (Abstract). Circulation 2008;118:Suppl S470
37. Link E, Parish S, Armitage J, et al. SLCO1B1 variants and statin-induced myopathy-a genomewide study. N Engl J Med 2008;359:789-799
38. Fuleihan GE, Deeb M. Hypovitaminosis D in a sunny country. N Engl J Med 1999;340:1840-1841
39. Nesby-O'Dell S, Scanlon KS, Cogswell ME, et al. Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: third National Health and Nutrition Examination Survey, 1988-1994. Am J Clin Nutr 2002;76:187-192 (Pubitemid 34686565)
40. Hannan MT, Litman HJ, Araujo AB, et al. Serum 25-hydroxyvitamin D and bone mineral density in a racially and ethnically diverse group of men. J Clin Endocrinol Metab 2008;93:40-6