Resolution of statin-induced myalgias by correcting vitamin D deficiency

Southern Medical Journal

Volumn 103, Issue 7, 2010, Pages 690-692

  Bell, David S H ^a  

^a UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

Author keywords

Hyperlipidemi; myalgias; myositis; statins; vitamin D

Indexed keywords

ATORVASTATIN; COLESEVELAM; ERGOCALCIFEROL; EZETIMIBE; FLUINDOSTATIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MEVINOLIN; NICOTINIC ACID; OMEGA 3 FATTY ACID; PRAVASTATIN; ROSUVASTATIN; SIMVASTATIN; TRIACYLGLYCEROL;

ADULT; ARTICLE; CASE REPORT; CHOLESTEROL BLOOD LEVEL; CLINICAL ASSESSMENT; DRUG MEGADOSE; DRUG SUBSTITUTION; DRUG TOLERABILITY; DRUG WITHDRAWAL; EUTHYROIDISM; FEMALE; FLUSHING; HUMAN; HYPERLIPIDEMIA; MEDICAL EXAMINATION; MUSCLE CRAMP; MUSCLE WEAKNESS; MYALGIA; VITAMIN D DEFICIENCY;

CHOLESTEROL; FEMALE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERLIPIDEMIAS; MIDDLE AGED; MUSCULAR DISEASES; REMISSION INDUCTION; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 77954242047     PISSN: 00384348     EISSN: None     Source Type: Journal    
DOI: 10.1097/SMJ.0b013e3181e21088     Document Type: Article

References (15)

1. Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr 2008;87:1080S-1086S.
2. Erkal MZ, Wilde J, Bilgin Y, et al. High prevalence of vitamin D deficiency, secondary hyperparathyroidism and generalized bone pain in Turkish immigrants in Germany: identification of risk factors. Osteoporos Int 2006;17:1133-1140.
3. Armstrong DJ, Meenagh GK, Bickle I, et al. Vitamin D deficiency is associated with anxiety and depression in fibromyalgia. Clin Rheumatol 2007;26:551-554.
4. Lips P. Vitamin D physiology. Prog Biophys Mol Biol 2006;92:4-8.
5. Nichols GA, Koro CE. Does statin therapy initiation increase the risk for myopathy? An observational study of 32,225 diabetic and nondiabetic patients. Clin Ther 2007;29:1761-1770.
6. Lee JH, O'Keefe JH, Bell D, et al. Vitamin D deficiency an important, common, and easily treatable cardiovascular risk factor? J Am Coll Cardiol 2008;52:1949-1956.
7. Shinchuk LM, Holick MF. Vitamin D and rehabilitation: improving functional outcomes. Nutr Clin Pract 2007;22:297-304.
8. Ahmed W, Khan N, Glueck CJ, et al. Low serum 25 (OH) vitamin D levels (32 ng/mL) are associated with reversible myositis-myalgia in statin-treated patients. Transl Res 2009;153:11-16.
9. Lee P, Greenfield JR, Campbell LV. Vitamin D insufficiency-a novel mechanism of statin-induced mylagia? Clin Endocrinol (Oxf) 2009;71: 154-155.
10. Draeger A, Monastyrskaya K, Mohaupt M, et al. Statin therapy induces ultrastructural damage in skeletal muscle in patients without myalgia. J Pathol 2006;210:94-102.
11. Mohaupt MG, Karas RH, Babiychuk EB, et al. Association between statin-associated myopathy and skeletal muscle damage. CMAJ 2009; 181:E11-E18.
12. Smith PF, Eydelloth RS, Grossman SJ, et al. HMG-CoA reductase inhibitor- induced myopathy in the rat: cyclosporine A interaction and mechanism studies. J Pharmacol Exp Ther 1991;257:1225-1235.
13. Pfeifer M, Begerow B, Minne HW. Vitamin D and muscle function. Osteoporos Int 2002;13:187-194.
14. Delahoy PJ, Magliano DJ, Webb K, et al. The relationship between reduction in low-density lipoprotein cholesterol by statins and reduction in risk of cardiovascular outcomes: an updated meta-analysis. Clin Ther 2009;31:236-244.
15. Joy TR, Hegele RA. Narrative review: statin-related myopathy. Ann Intern Med 2009;150:858-868.