Are 1,4-and 1,5-disubstituted 1,2,3-triazoles good pharmacophoric groups?

ChemMedChem

Volumn 9, Issue 11, 2014, Pages 2497-2508

  Massarotti, Alberto ^a   Aprile, Silvio ^a   Mercalli, Valentina ^a   Del Grosso, Erika ^a   Grosa, Giorgio ^a   Sorba, Giovanni ^a   Tron, Gian Cesare ^a  

^a UNIVERSITY OF EASTERN PIEDMONT   (Italy)

Author keywords

click chemistry; medicinal chemistry; metabolism; triazoles; X ray structures

Indexed keywords

ALKYNE; AZIDE; COPPER; PROTEIN; RUTHENIUM; TRIAZOLE DERIVATIVE; WATER; AMIDE; AMINOPYRINE N DEMETHYLASE; CYTOCHROME; CYTOCHROME P450; DNA; DRUG BINDING PROTEIN; O DEMETHYLASE; RNA;

BINDING SITE; CATALYSIS; CHEMISTRY; CLICK CHEMISTRY; CYCLOADDITION; METABOLISM; PROTEIN DATABASE; PROTEIN TERTIARY STRUCTURE; SOLUBILITY; STATIC ELECTRICITY; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOTRANSFORMATION; CRYSTAL STRUCTURE; CYTOSOLIC FRACTION; HYDROGEN BOND; HYDROLYSIS; HYDROXYLATION; LIVER MICROSOME; MALE; MEDICINAL CHEMISTRY; METABOLIC STABILITY; MOLECULAR RECOGNITION; NONHUMAN; OXIDATION; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DNA INTERACTION; PROTEIN RNA BINDING; PROTEIN STRUCTURE; RAT; SUBSTRATE CONCENTRATION; X RAY;

ALKYNES; AZIDES; BINDING SITES; CATALYSIS; CLICK CHEMISTRY; COPPER; CYCLOADDITION REACTION; DATABASES, PROTEIN; PROTEIN STRUCTURE, TERTIARY; PROTEINS; RUTHENIUM; SOLUBILITY; STATIC ELECTRICITY; TRIAZOLES; WATER;

EID: 84925366787     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201402233     Document Type: Article

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