Treatment of PD-1-/- mice with amodiaquine and anti-CTLA4 leads to liver injury similar to idiosyncratic liver injury in patients

Hepatology

Volumn 61, Issue 4, 2015, Pages 1332-1342

  Metushi, Imir G ^a   Hayes, M Anthony ^b   Uetrecht, Jack ^a,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF GUELPH   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; AMODIAQUINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; GRANZYME; PERFORIN; PROGRAMMED DEATH 1 RECEPTOR; ANTIBODY;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL AGGREGATION; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HELPER CELL; IDIOSYNCRATIC DRUG INDUCED LIVER INJURY; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; IMMUNOLOGICAL TOLERANCE; LIVER INJURY; LIVER NECROSIS; LYMPHOCYTIC INFILTRATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; TOXIC HEPATITIS; WEIGHT REDUCTION; ANIMAL; C57BL MOUSE; DISEASE MODEL; DRUG-INDUCED LIVER INJURY; IMMUNOLOGY;

AMODIAQUINE; ANIMALS; ANTIBODIES; CTLA-4 ANTIGEN; DISEASE MODELS, ANIMAL; DRUG-INDUCED LIVER INJURY; FEMALE; MICE; MICE, INBRED C57BL;

EID: 84925361897     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.27549     Document Type: Article

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