Right ventricular dyssynchrony in idiopathic pulmonary arterial hypertension: Determinants and impact on pump function

Journal of Heart and Lung Transplantation

Volumn 34, Issue 3, 2015, Pages 381-389

  Badagliacca, Roberto ^a   Poscia, Roberto ^a   Pezzuto, Beatrice ^a   Papa, Silvia ^a   Gambardella, Cristina ^a   Francone, Marco ^a   Mezzapesa, Mario ^a   Nocioni, Martina ^a   Nona, Alfred ^a   Rosati, Riccardo ^a   Sciomer, Susanna ^a   Fedele, Francesco ^a   Dario Vizza, Carmine ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

2D speckle tracking echocardiography; echocardiography; pulmonary arterial hypertension; right ventricular dyssynchrony; right ventricular function; right ventricular wall stress

Indexed keywords

ADULT; ARTICLE; CARDIOVASCULAR MAGNETIC RESONANCE; CARDIOVASCULAR PARAMETERS; COMPARATIVE STUDY; ECHOCARDIOGRAPHY; FEMALE; HEART CATHETERIZATION; HEART HEMODYNAMICS; HEART INDEX; HEART RIGHT ATRIUM PRESSURE; HEART RIGHT VENTRICLE ENDDIASTOLIC VOLUME; HEART RIGHT VENTRICLE ENDSYSTOLIC VOLUME; HEART RIGHT VENTRICLE FAILURE; HEART VENTRICLE FUNCTION; HEART VENTRICLE REMODELING; HUMAN; LUNG ARTERY PRESSURE; LUNG HEMODYNAMICS; LUNG PRESSURE; LUNG VASCULAR RESISTANCE; LUNG WEDGE PRESSURE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PULMONARY HYPERTENSION; QRS COMPLEX; RIGHT VENTRICULAR DYSSYNCHRONY; TISSUE DOPPLER IMAGING; COMPLICATION; ETIOLOGY; FOLLOW UP; HEART RIGHT VENTRICLE FUNCTION; HEART STROKE VOLUME; HYPERTENSION, PULMONARY; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PHYSIOLOGY; PROGNOSIS; RETROSPECTIVE STUDY; VASCULAR RESISTANCE;

ECHOCARDIOGRAPHY; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYPERTENSION, PULMONARY; MAGNETIC RESONANCE IMAGING, CINE; MALE; MIDDLE AGED; PROGNOSIS; PULMONARY WEDGE PRESSURE; RETROSPECTIVE STUDIES; STROKE VOLUME; VASCULAR RESISTANCE; VENTRICULAR DYSFUNCTION, RIGHT; VENTRICULAR FUNCTION, RIGHT; VENTRICULAR REMODELING;

EID: 84925359178     PISSN: 10532498     EISSN: 15573117     Source Type: Journal    
DOI: 10.1016/j.healun.2014.06.010     Document Type: Article

References (29)

1. N.F. Voelkel, R.A. Quaife, and L.A. Leinwand Right ventricular function and failure: report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure Circulation 114 2006 1883 1891
2. H. Bader, S. Garrigue, and S. Lafitte Intra-left ventricular electromechanical asynchrony. A new independent predictor of severe cardiac events in heart failure patients J Am Coll Cardiol 43 2004 248 256
3. J.G. Cleland, J.C. Daubert, and E. Erdmann The effect of cardiac resynchronization on morbidity and mortality in heart failure N Engl J Med 352 2005 1539 1549
4. A. Lopez-Candales, K. Dohi, and R. Bazaz Relation of right ventricular free wall mechanical delay to right ventricular dysfunction as determined by tissue Doppler imaging Am J Cardiol 96 2005 602 606
5. A.P. Kalogeropoulos, V.V. Georgiopoulou, and S. Howell Evaluation of right intraventricular dyssynchrony by two-dimensional strain echocardiography in patients with pulmonary arterial hypertension J Am Soc Echocardiogr 21 2008 1028 1034
6. J.T. Marcus, C.T. Gan, and J.J.M. Zwanenburg Interventricular mechanical asynchrony in pulmonary arterial hypertension: left-to-right delay in peak shortening is related to right ventricular overload and left ventricular underfilling J Am Coll Cardiol 51 2008 750 757
7. A.C. Hill, D.M. Maxey, and D.N. Rosenthal Electrical and mechanical dyssynchrony in pediatric pulmonary hypertension J Heart Lung Transplant 31 2012 825 830
8. N. Galiè, M.M. Hoeper, and M. Humbert ESC Committee for Practice Guidelines (CPG). Guidelines for the diagnosis and treatment of pulmonary hypertension: the Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT) Eur Heart J 30 2009 2493 2537
9. L.G. Rudski, W.W. Lai, and J. Afilalo Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography. Endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography J Am Soc Echocardiogr 23 2010 685 713
10. H.C. Bazett An analysis of the time-relations of electrocardiograms Heart 7 1920 353 370
11. NTNU-Trondhein Norwegian University of Science and Technology strain rate imaging. www.ntnu.edu/isb/echocardiography.
12. W.X. Zhu, S.B. Johnson, and R. Brandt Impact of volume loading and load reduction on ventricular refractoriness and conduction properties in canine congestive heart failure J Am Coll Cardiol 30 1997 825 833
13. J.K. Lee, I. Kodama, and H. Honjo Stage-dependent changes in membrane currents in rats with monocrotaline-induced right ventricular hypertrophy Am J Physiol 272 1997 H2833 H2842
14. M.A. Simon, C. Deible, and M.A. Mathier Phenotyping the right ventricle in patients with pulmonary hypertension Clin Transl Sci 2 2009 294 299
15. J.M. Norton Toward consistent definitions for preload and afterload Adv Physiol Educ 25 2001 53 61
16. T. Ryan, O. Petrovic, and J.C. Dillon An echocardiographic index for separation of right ventricular volume and pressure overload J Am Coll Cardiol 5 1985 918 924
17. G.J. Mauritz, T. Kind, and J.T. Marcus Progressive changes in right ventricular geometric shortening and long-term survival in pulmonary arterial hypertension Chest 141 2012 935 943
18. A.L. Hinderliter, P.W. Willis, and R.J. Barst Effects of long-term infusion of prostacyclin (epoprostenol) on echocardiographic measures of right ventricular structure and function in primary pulmonary hypertension Circulation 95 1997 1479 1486
19. D.A. Kass An epidemic of dyssynchrony J Am Coll Cardiol 51 2008 12 17
20. B.D. Lowes, W. Minobe, and W.T. Abraham Changes in gene expression in the intact human heart: downregulation of alpha-myosin heavy chain in hypertrophied, failing ventricular myocardium J Clin Invest 100 1997 2315 2324
21. T.J. Herron, and K.S. McDonald Small amounts of alpha-myosin heavy chain isoform expression significantly increase power output of rat cardiac myocyte fragments Circ Res 90 2002 1150 1152
22. M. Adamcova, M. Sterba, and T. Simunek Myocardial regulatory proteins and heart failure Eur J Heart Fail 8 2006 333 342
23. H.J. Bogaard, K. Abe, and A. Vonk Noordegraaf The right ventricle under pressure. Cellular and molecular mechanisms of right heart failure in pulmonary hypertension Chest 135 2009 794 804
24. S.A. van Wolferen, J.T. Marcus, and N. Westerhof Right coronary artery flow impairment in patients with pulmonary hypertension Eur Heart J 29 2008 120 127
25. A. Gomez, D. Bialostozky, and A. Zajarias Right ventricular ischemia in patients with primary pulmonary hypertension J Am Coll Cardiol 38 2001 1137 1142
26. S. Hein, E. Arnon, and S. Kostin Progression from compensated hypertrophy to failure in the pressure-overloaded human heart: structural deterioration and compensatory mechanisms Circulation 107 2003 984 991
27. G. Olivetti, R. Abbi, and F. Quaini Apoptosis in the failing human heart N Engl J Med 336 1997 1131 1141
28. M.U. Braun, P. Szalai, and R.H. Strasser Right ventricular hypertrophy and apoptosis after pulmonary artery banding: regulation of PKC isozymes Cardiovasc Res 59 2003 658 667
29. S. Giusca, V. Dambrauskaite, and C. Scheurwegs Deformation imaging describes right ventricular function better than longitudinal displacement of the tricuspid ring Heart 96 2010 281 288