Psychological stress increases risk for peptic ulcer, regardless of helicobacter pylori infection or use of nonsteroidal anti-inflammatory drugs

Clinical Gastroenterology and Hepatology

Volumn 13, Issue 3, 2015, Pages 498-506.e1

  Levenstein, Susan ^a   Rosenstock, Steffen ^b   Jacobsen, Rikke Kart ^c   Jorgensen, Torben ^c  

^a Aventino Medical Group   (Italy)

^b HVIDOVRE HOSPITAL   (Denmark)

^c Research Centre for Prevention and Health   (Denmark)

Author keywords

Duodenal; Epidemiology; Gastric; Psychosocial factors

Indexed keywords

ANXIOLYTIC AGENT; IMMUNOGLOBULIN G ANTIBODY; NONSTEROID ANTIINFLAMMATORY AGENT;

0 TO 10 POINT STRESS INDEX SCALE; ADULT; ALCOHOL CONSUMPTION; ARTICLE; BLOOD ANALYSIS; DENMARK; DISTRESS SYNDROME; DRUG USE; EXERCISE; FEMALE; GASTROINTESTINAL MUCOSA; HEALTH BEHAVIOR; HEALTH HAZARD; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; LIFE STRESS; MAJOR CLINICAL STUDY; MALE; MENTAL STRESS; NEUROLOGIC DISEASE ASSESSMENT; PEPTIC ULCER; POPULATION RESEARCH; PREDICTOR VARIABLE; PROSPECTIVE STUDY; RISK FACTOR; SLEEP; SLEEP TIME; SMOKING; SOCIAL ASPECT; SOCIAL STATUS; AGED; COMPLICATION; INCIDENCE; INTERVIEW; MIDDLE AGED; RISK ASSESSMENT;

ADULT; AGED; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DENMARK; FEMALE; HELICOBACTER INFECTIONS; HUMANS; INCIDENCE; INTERVIEWS AS TOPIC; MALE; MIDDLE AGED; PEPTIC ULCER; PROSPECTIVE STUDIES; RISK ASSESSMENT; STRESS, PSYCHOLOGICAL;

EID: 84925357501     PISSN: 15423565     EISSN: 15427714     Source Type: Journal    
DOI: 10.1016/j.cgh.2014.07.052     Document Type: Article

References (56)

1. Malfertheiner P., Chan F.K.L., McColl K.E.L. Peptic ulcer disease. Lancet 2009, 374:1449-1461.
2. Anand BS. Peptic ulcer disease: etiology. Available from: . Accessed September 18, 2012. http://emedicine.medscape.com/article/181753-overview-%20aw2aab6b2b4aa.
3. Graham D.Y. Helicobacter pylori infection in the pathogenesis of duodenal ulcer and gastric cancer: a model. Gastroenterology 1997, 113:1983-1991.
4. Jyotheeswaran S., Shah A.N., Jin H.O., et al. Prevalence of Helicobacter pylori in peptic ulcer patients in greater Rochester, NY: is empirical triple therapy justified?. Am J Gastroenterol 1998, 93:574-578.
5. Gisbert J.P., Calvet X. Review article: Helicobacter pylori-negative duodenal ulcer disease. Aliment Pharmacol Ther 2009, 30:791-815.
6. Levenstein S. Stress and peptic ulcer: life beyond Helicobacter. Br Med J 1998, 316:538-541.
7. Levenstein S. The very model of a modern etiology: a biopsychosocial view of peptic ulcer. Psychosom Med 2000, 62:176-185.
8. Soll A.H. Peptic ulcer disease: genetic, environmental, and psychological risk factors and pathogenesis. UpToDate 2012, UpToDate, Waltham, MA. D.S. Basow (Ed.).
9. Rosenstock S., Jorgensen T., Bonnevie O., et al. Risk factors for peptic ulcer disease: a population based prospective cohort study comprising 2416 Danish adults. Gut 2003, 52:186-193.
10. Rosenstock S.J., Jørgensen T., Bonnevie O., et al. Does Helicobacter pylori infection explain all socio-economic differences in peptic ulcer incidence? genetic and psychosocial markers for incident peptic ulcer disease in a large cohort of Danish adults. Scand J Gastroenterol 2004, 39:823-829.
11. MONICA: monograph and multimedia sourcebook-world's largest study of heart disease, stroke, risk factors, and population trends 1979-2002 2003, World Health Organization, Geneva. H. Tunstall-Pedoe (Ed.).
12. Lynge E., Sandegaard J.L., Rebolj M. The Danish National Patient Register. Scand J Public Health 2011, 39(Suppl 7):30-33.
13. Sabroe K, Kousgaard E, Knox-Seith B, etal. P-faktoren i FOUSHIP-klassificerings-systemet [in Danish, with English summaries]. Copenhagen: MPT, 1968-1970.
14. Eplov L.F., Jørgensen T., Birket-Smith M., et al. Mental vulnerability as a predictor of early mortality. Epidemiology 2005, 16:226-232.
15. Eplov L.F., Jorgensen T., Birket-Smith M., et al. Mental vulnerability: a risk factor for ischemic heart disease. JPsychosom Res 2006, 60:169-176.
16. Eplov L.F., Petersen J., Jørgensen T., et al. The mental vulnerability questionnaire: a psychometric evaluation. Scand J Psychol 2010, 51:548-554.
17. Levenstein S., Kaplan G.A., Smith M. Sociodemographic characteristics, life stressors, and peptic ulcer: a prospective study. JClin Gastroenterol 1995, 21:185-192.
18. Andersen L.P., Espersen F., Souckova A., et al. Isolation and preliminary evaluation of a low molecular (LMW) antigen preparation for improved detection of Helicobacter pylori IgG antibodies. Clin Diagnostic Lab Immunol 1995, 2:156-159.
19. Levenstein S., Kaplan G.A., Smith M.W. Psychological predictors of peptic ulcer incidence in the Alameda County Study. JClin Gastroenterol 1997, 24:140-146.
20. Martin D.F., Montgomery E., Dobek A.D., et al. Campylobacter pylori, NSAIDs, and smoking: risk factors for peptic ulcer disease. Am J Gastroenterol 1989, 84:1268-1272.
21. Kurata J.H., Nogawa A.N. Meta-analysis of risk factors for peptic ulcer: nonsteroidal antiinflammatory drugs, Helicobacter pylori, and smoking. JClin Gastroenterol 1997, 24:2-17.
22. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Available from: . Accessed August 26, 2012. http://digestive.niddk.nih.gov/ddiseases/pubs/hpylori/.
23. Spicer C.C., Stewart D.N., Winser D.M.R. Perforated peptic ulcer during the period of heavy air raids. Lancet 1944, i:14.
24. Aoyama N., Kinoshita Y., Fujimoto S., et al. Peptic ulcers after the Hanshin-Awaji earthquake: increased incidence of bleeding gastric ulcers. Am J Gastroenterol 1998, 93:311-316.
25. Kanno T., Iijima K., Abe Y., et al. Peptic ulcers after the Great East Japan earthquake and tsunami: possible existence of psychosocial stress ulcers in humans. JGastroenterol 2013, 48:483-490.
26. Holtmann G., Armstrong D., Pöppel E., et al. Influence of stress on the healing and relapse of duodenal ulcers. Scand J Gastroenterol 1992, 27:917-923.
27. Levenstein S., Prantera C., Varvo V., et al. Long-term symptom patterns in duodenal ulcer: psychosocial factors. JPsychosom Res 1996, 41:465-472.
28. Levenstein S., Prantera C., Scribano M.L., et al. Psychologic predictors of duodenal ulcer healing. JClin Gastroenterol 1996, 22:84-89.
29. Wilhelmsen I., Berstad A. Reduced relapse rate in duodenal ulcer disease leads to normalization of psychological distress: twelve-year follow-up. Scand J Gastroenterol 2004, 39:717-721.
30. Anda R.F., Williamson D.F., Escobedo L.G., et al. Self-perceived stress and the risk of peptic ulcer disease: a longitudinal study of US adults. Arch Intern Med 1992, 152:829-833.
31. Medalie J.H., Stange K.C., Zyzanski S.J., et al. The importance of biopsychosocial factors in the development of duodenal ulcer in a cohort of middle-aged men. Am J Epidemiol 1992, 136:1280-1287.
32. Raiha I., Kemppainen H., Kaprio J., et al. Lifestyle, stress, and genes in peptic ulcer disease: a nationwide twin cohort study. Arch Intern Med 1998, 158:698-704.
33. Rosenstock S.J., Jorgensen T. Prevalence and incidence of peptic ulcer disease in a Danish County: a prospective cohort study. Gut 1995, 36:819-824.
34. Marshall B.J., Warren R. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1984, i:1311-1315.
35. Lewis J.D., Bilker W.B., Brensinger C., et al. Hospitalization and mortality rates from peptic ulcer disease and GI bleeding in the 1990s: relationship to sales of nonsteroidal anti-inflammatory drugs and acid suppression medications. Am J Gastroenterol 2002, 97:2540-2549.
36. Delaney B., Ford A.C., Forman D., et al. Initial management strategies for dyspepsia. Cochrane Database Syst Rev 2005, 19:CD001961.
37. Sung J.J., Kuipers E.J., El-Serag H.B. Systematic review: the global incidence and prevalence of peptic ulcer disease. Aliment Pharmacol Ther 2009, 29:938-946.
38. Raghuram A., Holub J.L., Lieberman D.A. Lower prevalence of peptic ulcer disease in the era of over the counter proton pump inhibitors. Gastroenterology 2011, 140:S726-S727.
39. Cheng C. Seeking medical consultation: perceptual and behavioral characteristics distinguishing consulters and nonconsulters with functional dyspepsia. Psychosom Med 2000, 62:844-852.
40. Van Oudenhove L., Vandenberghe J., Geeraerts B., et al. Determinants of symptoms in functional dyspepsia: gastric sensorimotor function, psychosocial factors or somatisation?. Gut 2008, 57:1666-1673.
41. Lam S.K., Hui W.M., Shiu L.P., et al. Society stress and peptic ulcer perforation. JGastroenterol Hepatol 1995, 10:570-576.
42. Sandler R.S., Everhart J.E., Donowitz M., et al. The burden of selected digestive diseases in the United States. Gastroenterology 2002, 122:1500-1511.
43. Feinstein L.B., Holman R.C., Yorita Christensen K.L., et al. Trends in hospitalizations for peptic ulcer disease. United States, 1998-2005. Emerg Infect Dis 2010, 6 [serial on the Internet].
44. Laine L., Yang H., Chang S.C., et al. Trends for incidence of hospitalization and death due to GI complications in the United States from 2001 to 2009. Am J Gastroenterol 2012, 107:1190-1195.
45. Rosenstock S., Møller M.H., Larsson H., et al. Improving quality of care in peptic ulcer bleeding: nationwide cohort study of 13,498 consecutive patients in the Danish clinical register of emergency surgery. Am J Gastroenterol 2013, 108:1449-1457.
46. Xia H.H., Talley N.J. Natural acquisition and spontaneous elimination of Helicobacter pylori infection: clinical implications. Am J Gastroenterol 1997, 92:1780-1787.
47. Peters M.N., Richardson C.T. Stressful life events, acid hypersecretion, and ulcer disease. Gastroenterology 1983, 84:114-119.
48. Takeuchi K., Furukawa O., Okabe S. Induction of duodenal ulcers in rats under water-immersion stress conditions: influence of stress on gastric acid and duodenal alkaline secretion. Gastroenterology 1986, 91:554-563.
49. Kiecolt-Glaser J.K., Marucha P.T., Malarkey W.B., et al. Slowing ofwound healing by psychological stress. Lancet 1995, 346:1194-1196.
50. Arakawa T., Watanabe T., Fukuda T., et al. Ulcer recurrence: cytokines and inflammatory response-dependent process. Dig Dis Sci 1998, 43(Suppl):61S-66S.
51. Lazzarino A.I., Hamer M., Stamatakis E., et al. The combined association of psychological distress and socioeconomic status with all-cause mortality: a national cohort study. JAMA Intern Med 2013, 173:22-27.
52. Levenstein S., Prantera C., Varvo V., et al. Patterns of biologic and psychologic risk factors for duodenal ulcer. JClin Gastroenterol 1995, 21:110-117.
53. Matsushima Y., Aoyama N., Fukuda H., et al. Gastric ulcer formation after the Hanshin-Awaji earthquake: a case study of Helicobacter pylori infection and stress-induced gastric ulcers. Helicobacter 1999, 4:94-99.
54. Sriram S., Stratton C.W., Yao S., et al. Chlamydia pneumoniae infection of the central nervous system in multiple sclerosis. Ann Neurol 1999, 46:6-14.
55. Jaeckel E., Manns M., Von Herrath M. Viruses and diabetes. Ann N Y Acad Sci 2002, 958:7-25.
56. Hitchon C.A., El-Gabalawy H.S. Infection and rheumatoid arthritis: still an open question. Curr Opin Rheumatol 2011, 23:352-357.