Enhanced NLRP3, Caspase-1, and IL- 1β Levels in Degenerate Human Intervertebral Disc and Their Association with the Grades of Disc Degeneration

Anatomical Record

Volumn 298, Issue 4, 2015, Pages 720-726

  Chen, Zhong Hua ^a   Jin, Shen Hui ^b   Wang, Min Yan ^c   Jin, Xiao Liang ^c   Lv, Chen ^d   Deng, Ying Feng ^e   Wang, Jun Lu ^b  

^a ZHEJIANG UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIVERSITY   (China)

^c Center of Cardiothoracic Surgery   (China)

^d Department of Orthopaedics   (China)

^e NINGBO UNIVERSITY   (China)

Author keywords

Caspase 1; Human intervertebral disc degeneration; Interleukin 1 ; NLRP3 inflammasome

Indexed keywords

CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MESSENGER RNA; CARRIER PROTEIN; NLRP3 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; INTERVERTEBRAL DISK DEGENERATION; MALE; MIDDLE AGED; NUCLEUS PULPOSUS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN TARGETING; YOUNG ADULT; INTERVERTEBRAL DISC DEGENERATION; INTERVERTEBRAL DISK; LOW BACK PAIN; LUMBAR VERTEBRA; METABOLISM; PATHOLOGY; SEVERITY OF ILLNESS INDEX; SPINE FUSION; TREATMENT OUTCOME; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; CARRIER PROTEINS; CASPASE 1; FEMALE; HUMANS; INFLAMMASOMES; INTERLEUKIN-1BETA; INTERVERTEBRAL DISC; INTERVERTEBRAL DISC DEGENERATION; LOW BACK PAIN; LUMBAR VERTEBRAE; MALE; MIDDLE AGED; SEVERITY OF ILLNESS INDEX; SPINAL FUSION; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84925357274     PISSN: 19328486     EISSN: 19328494     Source Type: Journal    
DOI: 10.1002/ar.23059     Document Type: Article

References (29)

1. Burns K, Martinon F, Tschopp J. 2003. New insights into the mechanism of IL-1beta maturation. Curr Opin Immunol 15:26-30.
2. Boszczyk BM1, Boszczyk AA, Putz R. 2001. Comparative and functional anatomy of the mammalian lumbar spine. Anat Rec 1;264:157-68.
3. Fazzalari NL1, Manthey B, Parkinson IH. 2001. Intervertebral disc disorganisation and its relationship to age adjusted vertebral body morphometry and vertebral bone architecture. Anat Rec 262:331-9.
4. Guarda G, Braun M, Staehli F, Tardivel A, Mattmann C, Förster I, Farlik M, Decker T, Du Pasquier RA, Romero P, Tschopp J. 2011. Type I interferon inhibits interleukin-1 production and inflammasome activation. Immunity 34:213-223.
5. Hoyland JA, Le Maitre C, Freemont AJ. 2008. Investigation of the role of IL-1 and TNF in matrix degradation in the intervertebral disc.Rheumatology (Oxford) 47:809-814.
6. Kastbom A, Verma D, Eriksson P, Skogh T, Wingren G, Söderkvist P. 2008. Genetic variation in proteins of the cryopyrininflammasome influences susceptibility and severity of rheumatoid arthritis (the Swedish TIRA project). Rheumatology (Oxford) 47:415-417.
7. Katz JN. 2006. Lumbar disc disorders and low-back pain: socioeconomic factors and consequences. J Bone Joint Surg Am 2:21-24.
8. Krismer M, van Tulder M. 2007. Low back pain (non-specific). Best Pract Res Clin Rheumatol 21:77-91.
9. Le Maitre CL, Pockert A, Buttle DJ, Freemont AJ, Hoyland JA. 2007a. Matrix synthesis and degradation in human intervertebral disc degeneration. Biochem Soc Trans 35:652-655.
10. Le Maitre CL, Hoyland JA, Freemont AJ. 2007b. Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1β and TNF-α expression profile. Arthritis Res Ther 9:R77.
11. Le Maitre CL, Hoyland JA, Freemont AJ. 2007c. Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: an in situ zymographic and gene therapy study. Arthritis Res Ther 9:R83.
12. Le Maitre CL, Freemont AJ, Hoyland JA. 2006. A preliminary in vitro study into the use of IL-1Ra gene therapy for the inhibition of intervertebral disc degeneration. Int J Exp Pathol 87:17-28.
13. Le Maitre CL, Freemont AJ, Hoyland JA. 2005. The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration. Arthritis Res Ther 7: R732-745.
14. Martinon F, Pétrilli V, Mayor A, Tardivel A, Tschopp J. 2006. Gout-associated uric acid crystals activate the NLRP3 inflammasome. Nature 440:237-241.
15. Martinon F, Tschopp J. 2004. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 117:561-574.
16. Martinon F, Burns K, Tschopp J. 2002. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of pro IL-1β. Mol Cell 10:417-426.
17. Martinon F, Mayor A, Tschopp J. 2009. The inflammasomes: guardians of the body. Annu Rev Immunol 27:229-265.
18. Masuda K, An HS. 2006. Prevention of disc degeneration with growth factors. Eur Spine J 3:S422-432.
19. Millward-Sadler SJ, Costello PW, Freemont AJ, Hoyland JA. 2009. Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration. Arthritis Res Ther 11:R65.
20. Mirza SK, Deyo RA. 2007. Systematic review of randomized trials comparing lumbar fusion surgery to nonoperative care for treatment of chronic back pain. Spine 32:816-823.
21. Niu CC, Yuan LJ, Chen LH, Lin SS, Tsai TT, Liao JC, Lai PL, Chen WJ. 2011. Beneficial effects of hyperbaric oxygen on human degenerated intervertebral disk cells via suppression of IL-1β and p38 MAPK signal. J Orthop Res 29:14-19.
22. Ritty TM1, Ditsios K, Starcher BC. 2002. Distribution of the elastic fiber and associated proteins in flexor tendon reflects function. Anat Rec 268:430-440.
23. Richardson SM, Doyle P, Minogue BM, Gnanalingham K, Hoyland JA. 2009. Increased expression of matrix metalloproteinase-10, nerve growth factor and substance P in the painful degenerate intervertebral disc. Arthritis Res Ther 11:R126.
24. Sive JI, Baird P, Jeziorsk M, Watkins A, Hoyland JA, Freemont AJ. 2002. Expression of chondrocyte markers by cells of normal and degenerate intervertebral discs. Mol Pathol 55:91-97.
25. Spiro RC1, Thompson AY, Poser JW. 2001. Spinal fusion with recombinant human growth and differentiation factor-5 combined with a mineralized collagen matrix. Anat Rec 263:388-395.
26. Vilaysane A, Chun J, Seamone ME, Wang W, Chin R, Hirota S, Li Y, Clark SA, Tschopp J, Trpkov K, Hemmelgarn BR, Beck PL, Muruve DA. 2010. The NLRP3 inflammasome promotes renal inflammation and contributes to CKD. J Am Soc Nephrol 21:1732-1744.
27. Vitale M1, Bassini A, Secchiero P, Mirandola P, Ponti C, Zamai L, Mariani AR, Falconi M, Azzali G. 2002. NK-active cytokines IL-2, IL-12, and IL-15 selectively modulate specific protein kinase C (PKC) isoforms in primary human NK cells. Anat Rec 1;266:87-92.
28. Watanabe H, Gaide O, Pétrilli V, Martinon F, Contassot E, Roques S, Kummer JA, Tschopp J, French LE. 2007. Activation of the IL-1b-processing inflammasome is involved incontact hypersensitivity. J Invest Dermatol 127:1956-1963.
29. Wu J, Fernandes-Alnemri T, Alnemri ES. 2010. Involvement of the AIM2, NLRC4, and NLRP3 inflammasomes in caspase-1 activation by Listeria monocytogenes. J Clin Immunol 30:693-702.