Influence of small amorphous amounts in hydrophilic and hydrophobic APIs on storage stability of dry powder inhalation products

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 92, Issue , 2015, Pages 130-138

  Müller, Thorsten ^a   Krehl, Regina ^a   Schiewe, Jörg ^b   Weiler, Claudius ^b   Steckel, Hartwig ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

Amorphous content; Ciclesonide; Dynamic vapor sorption; Fine particle fraction; Next Generation Impactor; Salbutamol sulfate

Indexed keywords

CICLESONIDE; SALBUTAMOL SULFATE; ZIRCONIUM OXIDE; POWDER; PREGNANE DERIVATIVE; SALBUTAMOL;

ARTICLE; CONDITIONING; CRYSTALLIZATION; DISPERSION; DRUG DELIVERY SYSTEM; DRY POWDER; DRY POWDER INHALER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHILICITY; HYDROPHOBICITY; INHALATION; MIXER; PARTICLE SIZE; PHYSICAL CHEMISTRY; SCANNING ELECTRON MICROSCOPY; SPRAY DRYING; STORAGE; WATER VAPOR; CHEMICAL PHENOMENA; CHEMISTRY; DRUG STABILITY; DRUG STORAGE; INHALATIONAL DRUG ADMINISTRATION; MEDICINAL CHEMISTRY; PHARMACEUTICS; POWDER; PROCEDURES; TIME;

ADMINISTRATION, INHALATION; ALBUTEROL; CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; DRUG DELIVERY SYSTEMS; DRUG STABILITY; DRUG STORAGE; DRY POWDER INHALERS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; PARTICLE SIZE; POWDERS; PREGNENEDIONES; TECHNOLOGY, PHARMACEUTICAL; TIME FACTORS;

EID: 84925346097     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2015.03.006     Document Type: Article

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