Endothelin-Bone morphogenetic protein type 2 receptor interaction induces pulmonary artery smooth muscle cell hyperplasia in pulmonary arterial hypertension

Journal of Heart and Lung Transplantation

Volumn 34, Issue 3, 2015, Pages 468-478

  Maruyama, Hidekazu ^a   Dewachter, Céline ^a   Belhaj, Asmae ^a,b,c   Rondelet, Benoit ^a,b,c   Sakai, Satoshi ^d   Remmelink, Myriam ^b   Vachiery, Jean Luc ^b   Naeije, Robert ^a   Dewachter, Laurence ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b ERASME HOSPITAL   (Belgium)

^c UNIVERSITY HOSPITAL OF MONT GODINNE   (Belgium)

^d UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

BMPR2; endothelin; gremlin; proliferation; Pulmonary arterial hypertension; pulmonary artery smooth muscle cell

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 2 RECEPTOR; BONE MORPHOGENETIC PROTEIN 4; COMPLEMENTARY DNA; CYCLIN D1; CYCLINE; ENDOTHELIN 1; ENDOTHELIN RECEPTOR; GREMLIN 1; GREMLIN 2; GROWTH FACTOR RECEPTOR; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; INHIBITOR OF DIFFERENTIATION 1; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN; PROTEIN BAX; PROTEIN BCL 2; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; UNCLASSIFIED DRUG; BMPR2 PROTEIN, HUMAN; BONE MORPHOGENETIC PROTEIN RECEPTOR 2; RNA;

ADULT; AIRWAY REMODELING; APOPTOSIS; ARTICLE; CELL CYCLE PROGRESSION; CELL HYPERPLASIA; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; LUNG PARENCHYMA; MALE; MIDDLE AGED; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PULMONARY ARTERY; PULMONARY ARTERY SMOOTH MUSCLE CELL; PULMONARY HYPERTENSION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; CELL CULTURE; GENETICS; HYPERPLASIA; METABOLISM; MUTATION; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; VASCULAR SMOOTH MUSCLE;

APOPTOSIS; BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE II; CELL PROLIFERATION; CELLS, CULTURED; FEMALE; HUMANS; HYPERPLASIA; HYPERTENSION, PULMONARY; MALE; MIDDLE AGED; MUSCLE, SMOOTH, VASCULAR; MUTATION; PULMONARY ARTERY; REAL-TIME POLYMERASE CHAIN REACTION; RNA; SIGNAL TRANSDUCTION;

EID: 84925338108     PISSN: 10532498     EISSN: 15573117     Source Type: Journal    
DOI: 10.1016/j.healun.2014.09.011     Document Type: Article

References (29)

1. N.W. Morrell, S. Adnot, and S.L. Archer Cellular and molecular basis of pulmonary arterial hypertension J Am Coll Cardiol 54 2009 S20 S31
2. R.M. Tuder, S.L. Archer, and P. Dorfmuller Relevant issues in the pathology and pathobiology of pulmonary hypertension J Am Coll Cardiol 62 2013 D4 D12
3. N. Galie, P.A. Corris, and A. Frost Updated treatment algorithm of pulmonary arterial hypertension J Am Coll Cardiol 62 2013 D60 D72
4. F. Soubrier, W.K. Chung, and R. Machado Genetics and genomics of pulmonary arterial hypertension J Am Coll Cardiol 62 2013 D13 D21
5. B. Sztrymf, F. Coulet, and B. Girerd Clinical outcomes of pulmonary arterial hypertension in carriers of bmpr2 mutation Am J Respir Crit Care Med 177 2008 1377 1383
6. C. Atkinson, S. Stewart, and P.D. Upton Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type ii bone morphogenetic protein receptor Circulation 105 2002 1672 1678
7. L. Dewachter, S. Adnot, and C. Guignabert Bone morphogenetic protein signalling in heritable versus idiopathic pulmonary hypertension Eur Respir J 34 2009 1100 1110
8. E. Cahill, C.M. Costello, and S.C. Rowan Gremlin plays a key role in the pathogenesis of pulmonary hypertension Circulation 125 2012 920 930
9. S. Hafizi, S.P. Allen, A.T. Goodwin, A.H. Chester, and M.H. Yacoub Endothelin-1 stimulates proliferation of human coronary smooth muscle cells via the ET(A) receptor and is co-mitogenic with growth factors Atherosclerosis 146 1999 351 359
10. R.A. Panettieri Jr, R.G. Goldie, P.J. Rigby, A.J. Eszterhas, and D.W. Hay Endothelin-1-induced potentiation of human airway smooth muscle proliferation: an ETA receptor-mediated phenomenon Br J Pharmacol 118 1996 191 197
11. Z. Yang, N. Krasnici, and T.F. Luscher Endothelin-1 potentiates human smooth muscle cell growth to PDGF: effects of ETA and ETB receptor blockade Circulation 100 1999 5 8
12. R. Yamanaka, F. Otsuka, and K. Nakamura Involvement of the bone morphogenetic protein system in endothelin- and aldosterone-induced cell proliferation of pulmonary arterial smooth muscle cells isolated from human patients with pulmonary arterial hypertension Hypertens Res 33 2010 435 445
13. L. Dewachter, S. Adnot, and E. Fadel Angiopoietin/tie2 pathway influences smooth muscle hyperplasia in idiopathic pulmonary hypertension Am J Respir Crit Care Med 174 2006 1025 1033
14. P. Chomczynski, and N. Sacchi Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction Anal Biochem 162 1987 156 159
15. P.D. Upton, L. Long, R.C. Trembath, and N.W. Morrell Functional characterization of bone morphogenetic protein binding sites and Smad1/5 activation in human vascular cells Molec Pharmacol 73 2008 539 552
16. Y. Song, J.E. Jones, H. Beppu, J.F. Keaney Jr, J. Loscalzo, and Y.Y. Zhang Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice Circulation 112 2005 553 562
17. A.M. Reynolds, W. Xia, and M.D. Holmes Bone morphogenetic protein type 2 receptor gene therapy attenuates hypoxic pulmonary hypertension Am J Physiol Lung Cell Mol Physiol 292 2007 L1182 L1192
18. L. Ciuclan, K. Sheppard, and L. Dong Treatment with anti-gremlin 1 antibody ameliorates chronic hypoxia/SU5416-induced pulmonary arterial hypertension in mice Am J Pathol 183 2013 1461 1473
19. T.T. Maciel, R.S. Melo, N. Schor, and A.H. Campos Gremlin promotes vascular smooth muscle cell proliferation and migration J Mol Cell Cardiol 44 2008 370 379
20. L. Anderson, J.W. Lowery, and D.B. Frank Bmp2 and Bmp4 exert opposing effects in hypoxic pulmonary hypertension Am J Physiol Regul Integr Comp Physiol 298 2010 R833 R842
21. M. Brock, M. Trenkmann, and R.E. Gay Interleukin-6 modulates the expression of the bone morphogenic protein receptor type ii through a novel Stat3-microrna cluster 17/92 pathway Circ Res 104 2009 1184 1191
22. 1 represses bone morphogenetic protein-mediated Smad signaling in pulmonary artery smooth muscle cells via Smad3 Am J Respir Cell Mol Biol 49 2013 1135 1145
23. G.P. Star, M. Giovinazzo, and D. Langleben Bone morphogenic protein-9 stimulates endothelin-1 release from human pulmonary microvascular endothelial cells: a potential mechanism for elevated ET-1 levels in pulmonary arterial hypertension Microvasc Res 80 2010 349 354
24. S. Din, P. Sarathchandra, M.H. Yacoub, and A.H. Chester Interaction between bone morphogenetic proteins and endothelin-1 in human pulmonary artery smooth muscle Vasc Pharmacol 51 2009 344 349
25. X. Yang, L. Long, and M. Southwood Dysfunctional Smad signaling contributes to abnormal smooth muscle cell proliferation in familial pulmonary arterial hypertension Circ Res 96 2005 1053 1063
26. L. Gallelli, G. Pelaia, and B. D'Agostino Endothelin-1 induces proliferation of human lung fibroblasts and il-11 secretion through an ET(A) receptor-dependent activation of MAP kinases J Cell Biochem 96 2005 858 868
27. A. Yogi, G.E. Callera, and A.C. Montezano Endothelin-1, but not AngII, activates MAP kinases through c-Src independent Ras-Raf dependent pathways in vascular smooth muscle cells Arterioscler Thromb Vasc Biol 27 2007 1960 1967
28. B. Rondelet, F. Kerbaul, and S. Motte Bosentan for the prevention of overcirculation-induced experimental pulmonary arterial hypertension Circulation 107 2003 1329 1335
29. B. Rondelet, F. Kerbaul, and G.F. Vivian Sitaxsentan for the prevention of experimental shunt-induced pulmonary hypertension Pediatr Res 61 2007 284 288