Intracellular screening of a peptide library to derive a potent peptide inhibitor of α-synuclein aggregation

Journal of Biological Chemistry

Volumn 290, Issue 12, 2015, Pages 7426-7435

  Cheruvara, Harish ^a   Allen Baume, Victoria L ^a   Kad, Neil M ^b   Mason, Jody M ^c  

^a UNIVERSITY OF ESSEX   (United Kingdom)

^b UNIVERSITY OF KENT   (United Kingdom)

^c University of Bath   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ATOMIC FORCE MICROSCOPY; DIAGNOSIS; DICHROISM;

CELL SURVIVAL; GROWTH COMPETITION; GROWTH MEASUREMENT; PARKINSON DISEASE; PEPTIDE INHIBITORS; PEPTIDE LIBRARY; RANDOM-COIL STRUCTURES; WILD TYPES;

PEPTIDES;

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ALPHA SYNUCLEIN; AMYLOID; PEPTIDE; PEPTIDE LIBRARY; PRIMER DNA;

AMINO ACID SEQUENCE; ARTICLE; ATOMIC FORCE MICROSCOPY; BETA SHEET; CELL ASSAY; CELL GROWTH; CELL SURVIVAL; CIRCULAR DICHROISM; CONTROLLED STUDY; CYTOTOXICITY; INTRACELLULAR PROTEIN FRAGMENT COMPLEMENTATION ASSAY; PEPTIDE ANALYSIS; PEPTIDE LIBRARY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROCESS DEVELOPMENT; PROTEIN AGGREGATION; PROTEIN ISOLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; SCREENING TEST; STOICHIOMETRY; ALZHEIMER DISEASE; ANTAGONISTS AND INHIBITORS; CHEMISTRY; LEWY BODY; METABOLISM; NUCLEOTIDE SEQUENCE; PARKINSON DISEASE; POLYMERASE CHAIN REACTION;

ALPHA-SYNUCLEIN; ALZHEIMER DISEASE; AMINO ACID SEQUENCE; BASE SEQUENCE; CIRCULAR DICHROISM; DNA PRIMERS; LEWY BODIES; MICROSCOPY, ATOMIC FORCE; PARKINSON DISEASE; PEPTIDE LIBRARY; PEPTIDES; POLYMERASE CHAIN REACTION;

EID: 84925324980     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.620484     Document Type: Article

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