Selective targeting of tumor and stromal cells by a nanocarrier system displaying lipidated cathepsin b inhibitor

Angewandte Chemie - International Edition

Volumn 53, Issue 38, 2014, Pages 10077-10081

  Mikhaylov, G ^a,b   Klimpel, D ^f   Schaschke, N ^f   Mikac, U ^a   Vizovisek, M ^a   Fonovic, M ^a   Turk, V ^a,c   Turk, Boris ^a,c,d,e   Vasiljeva, Olga ^a,g  

^a JO EF STEFAN INSTITUTE   (Slovenia)

^b NATIONAL RESEARCH TOMSK POLYTECHNIC UNIVERSITY   (Russian Federation)

^c Center of Excellence CIPKEBIP   (Slovenia)

^d UNIVERSITY OF LJUBLJANA   (Slovenia)

^e Center of Excellence NIN   (Slovenia)

^f BIELEFELD UNIVERSITY   (Germany)

^g CytomX Therapeutics Inc   (United States)

Author keywords

cancer; cathepsin B; drug delivery; theranostics; tumor microenvironment

Indexed keywords

AMINO ACIDS; DISEASES; DRUG DELIVERY; ENZYME ACTIVITY; TUMORS;

CANCER; CANCER DIAGNOSIS; CANCER PROGRESSION; CATHEPSIN B; CYSTEINE PROTEINASE; EXTRACELLULAR; THERANOSTICS; TUMOR MICROENVIRONMENT;

DIAGNOSIS;

CATHEPSIN B; CYSTEINE PROTEINASE INHIBITOR; DOXORUBICIN; DRUG CARRIER; NANOMATERIAL;

ANIMAL; ANTAGONISTS AND INHIBITORS; CANCER STEM CELL; CELL SURVIVAL; CELL TRANSFORMATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG DELIVERY SYSTEM; DRUG EFFECTS; FEMALE; MAMMARY NEOPLASMS, EXPERIMENTAL; METABOLISM; MOUSE; PATHOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANIMALS; CATHEPSIN B; CELL LINE, TUMOR; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; CYSTEINE PROTEINASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; FEMALE; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MOLECULAR STRUCTURE; NANOSTRUCTURES; NEOPLASTIC STEM CELLS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84925314224     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201402305     Document Type: Article

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