Prevention and management of stroke in women

Expert Review of Cardiovascular Therapy

Volumn 13, Issue 4, 2015, Pages 403-415

  Howe, Matthew D ^a   Mccullough, Louise D ^a,b  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b HARTFORD HOSPITAL   (United States)

Author keywords

atrial fibrillation; carotid stenosis; hormones; hypertension; obesity; pregnancy; sex; stroke; women

Indexed keywords

ALTEPLASE; FIBRINOLYTIC AGENT; HEPARIN; LOW MOLECULAR WEIGHT HEPARIN; ORAL CONTRACEPTIVE AGENT; WARFARIN;

ABDOMINAL OBESITY; ANTICOAGULANT THERAPY; CAROTID ARTERY OBSTRUCTION; CEREBROVASCULAR ACCIDENT; DEPRESSION; DRUG SAFETY; FEMALE; FUNCTIONAL STATUS; HEART ATRIUM FIBRILLATION; HORMONAL THERAPY; HUMAN; HYPERTENSION; METABOLIC SYNDROME X; OBESITY; POSTMENOPAUSE; PREGNANCY; PUERPERIUM; QUALITY OF LIFE; REVIEW; RISK REDUCTION; SEX DIFFERENCE; TREATMENT RESPONSE; ATRIAL FIBRILLATION; CAROTID STENOSIS; COMPLICATION; DISEASE MANAGEMENT; ESTROGEN THERAPY; PREGNANCY COMPLICATIONS, CARDIOVASCULAR; RISK FACTOR; STATISTICS AND NUMERICAL DATA; STROKE;

ATRIAL FIBRILLATION; CAROTID STENOSIS; CONTRACEPTIVES, ORAL, HORMONAL; DISEASE MANAGEMENT; ESTROGEN REPLACEMENT THERAPY; FEMALE; HUMANS; HYPERTENSION; METABOLIC SYNDROME X; OBESITY; PREGNANCY; PREGNANCY COMPLICATIONS, CARDIOVASCULAR; RISK FACTORS; RISK REDUCTION BEHAVIOR; STROKE;

EID: 84925307505     PISSN: 14779072     EISSN: 17448344     Source Type: Journal    
DOI: 10.1586/14779072.2015.1020300     Document Type: Review

References (128)

1. Go AS, Mozaffarian D, Roger VL, et al. Executive summary: heart disease and stroke statistics-2014 update: a report from the American Heart Association. Circulation 2014;129:399-410
2. Health, United States, 2013. 2014 Available from www.cdc.gov/nchs/hus/contents2011.htm#031
3. Reeves MJ, Bushnell CD, Howard G, et al. Sex differences in stroke: epidemiology, clinical presentation, medical care, and outcomes. Lancet Neurol 2008;7:915-26
4. Kelly-Hayes M, Beiser A, Kase CS, et al. The influence of gender and age on disability following ischemic stroke: the Framingham study. J Stroke Cerebrovasc Dis 2003;12:119-26
5. Holroyd-Leduc JM, Kapral MK, Austin PC, et al. Sex differences and similarities in the management and outcome of stroke patients. Stroke 2000;31:1833-7
6. Roy-O'Reilly M, McCullough LD. Sex differences in stroke: the contribution of coagulation. Exp Neurol 2014;259:16-27
7. Petrone AB, Simpkins JW, Barr TL. 17beta-estradiol and inflammation: implications for ischemic stroke. Aging Dis 2014;5:340-5
8. Koellhoffer EC, McCullough LD. The effects of estrogen in ischemic stroke. Transl Stroke Res 2013;4:390-401
9. Seshadri S, Beiser A, Kelly-Hayes M, et al. The lifetime risk of stroke: estimates from the Framingham Study. Stroke 2006;37: 345-50
10. Carandang R, Seshadri S, Beiser A, et al. Trends in incidence, lifetime risk, severity, and 30-day mortality of stroke over the past 50 years. JAMA 2006;296:2939-46
11. Kamel H, Navi BB, Sriram N, et al. Risk of a thrombotic event after the 6-week postpartum period. N Engl J Med 2014;370:1307-15
12. Appelros P, Stegmayr B, Terent A. Sex differences in stroke epidemiology: a systematic review. Stroke 2009;40:1082-90
13. Weinstein G, Preis SR, Beiser AS, et al. Cognitive performance after stroke-The Framingham Heart Study. Int J Stroke 2014;9(Suppl A100):48-54
14. Petrea RE, Beiser AS, Seshadri S, et al. Gender differences in stroke incidence and poststroke disability in the Framingham heart study. Stroke 2009;40:1032-7
15. The Next Four Decades: the Older Population in the United States, 2010 to 2050. 2010. Available from: www.aoa.acl. gov/Aging-Statistics/futurégrowth/futurégrowth.aspx
16. Bushnell C, McCullough L. Stroke prevention in women: synopsis of the 2014 American Heart Association/American Stroke Association guideline. Ann Intern Med 2014 853-7
17. Bentsen L, Christensen L, Christensen A, et al. Outcome and risk factors presented in old patients above 80 years of age versus younger patients after ischemic stroke. J Stroke Cerebrovasc Dis 2014;23:1944-8
18. Howard VJ, Lutsep HL, Mackey A, et al. Influence of sex on outcomes of stenting versus endarterectomy: a subgroup analysis of the Carotid Revascularization Endarterectomy versus Stenting Trial (CREST). Lancet Neurol 2011;10:530-7
19. Di Carlo A, Lamassa M, Baldereschi M, et al. Risk factors and outcome of subtypes of ischemic stroke. Data from a multicenter multinational hospital-based registry. The European Community Stroke Project. J Neurol Sci 2006;244:143-50
20. Hsia J, Margolis KL, Eaton CB, et al. Prehypertension and cardiovascular disease risk in the Women's Health Initiative. Circulation 2007;115:855-60
21. Gonzales RJ. Androgens and the cerebrovasculature: modulation of vascular function during normal and pathophysiological conditions. Pflugers Arch 2013;465:627-42
22. Maric-Bilkan C, Gilbert EL, Ryan MJ. Impact of ovarian function on cardiovascular health in women: focus on hypertension. Int J Womens Health 2014;6: 131-9
23. Wenner MM, Stachenfeld NS. Blood pressure and water regulation: understanding sex hormone effects within and between men and women. J Physiol 2012; 590(Pt 23):5949-61
24. Gu Q, Burt VL, Paulose-Ram R, et al. Gender differences in hypertension treatment, drug utilization patterns, and blood pressure control among US adults with hypertension: data from the National Health and Nutrition Examination Survey 1999-2004. Am J Hypertens 2008;21: 789-98
25. Turnbull F, Woodward M, Neal B, et al. Do men and women respond differently to blood pressure-lowering treatment?. Results of prospectively designed overviews of randomized trials. Eur Heart J 2008;29: 2669-80
26. Lewis CE, Grandits A, Flack J, et al. Efficacy and tolerance of antihypertensive treatment in men and women with stage 1 diastolic hypertension. Results of the Treatment of Mild Hypertension Study. Arch Intern Med 1996;156:377-85
27. Bushnell C, McCullough LD, Awad IA, et al. Guidelines for the prevention of stroke in women: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2014;45:1545-88
28. Strazzullo P, D'Elia L, Cairella G, et al. Excess body weight and incidence of stroke: meta-analysis of prospective studies with 2 million participants. Stroke 2010;41: e418-26
29. Ford ES, Li C, Zhao G, et al. Trends in obesity and abdominal obesity among adults in the United States from 1999-2008. Int J Obes (Lond) 2011;35:736-43
30. Cornier MA, Despres JP, Davis N, et al. Assessing adiposity: a scientific statement from the American Heart Association. Circulation 2011;124(18):1996-2019
31. Ford ES, Li C, Zhao G. Prevalence and correlates of metabolic syndrome based on a harmonious definition among adults in the US. J Diabetes 2010;2(3):180-93
32. Boden-Albala B, Sacco RL, Lee HS, et al. Metabolic syndrome and ischemic stroke risk: northern Manhattan Study. Stroke 2008;39:30-5
33. Della-Morte D, Gardener H, Denaro F, et al. Metabolic syndrome increases carotid artery stiffness: the Northern Manhattan Study. Int J Stroke 2010;5:138-44
34. Kloting N, Bluher M. Adipocyte dysfunction, inflammation and metabolic syndrome. Rev Endocr Metab Disord 2014; 15(4):277-87
35. Campello E, Zabeo E, Radu CM, et al. Hypercoagulability in overweight and obese subjects who are asymptomatic for thrombotic events. Thromb Haemost 2014; 113(1):85-96
36. Carbone F, Mach F, Montecucco F. The role of adipocytokines in atherogenesis and atheroprogression. Curr Drug Targets 2014[Epub ahead of print]
37. Zhang H, Sairam MR. Sex hormone imbalances and adipose tissue dysfunction impacting on metabolic syndrome; a paradigm for the discovery of novel adipokines. Horm Mol Biol Clin Investig 2014;17:89-97
38. Liu S, Manson JE, Lee IM, et al. Fruit and vegetable intake and risk of cardiovascular disease: the Women's Health Study. Am J Clin Nutr 2000;72:922-8
39. Lee IM, Paffenbarger RS Jr. Physical activity and stroke incidence: the Harvard Alumni Health Study. Stroke 1998;29(10):2049-54
40. Kurth T, Gaziano JM, Rexrode KM, et al. Prospective study of body mass index and risk of stroke in apparently healthy women. Circulation 2005;111:1992-8
41. Ross R, Lam M, Blair SN, et al. Trial of prevention and reduction of obesity through active living in clinical settings: a randomized controlled trial. Arch Intern Med 2012;172:414-24
42. Estruch R, Ros E, Salas-Salvado J, et al. Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med 2013;368:1279-90
43. Meschia JF, Bushnell C, Boden-Albala B, et al. Guidelines for the Primary Prevention of Stroke: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke 2014;45(12):3754-832
44. Feinberg WM, Blackshear JL, Laupacis A, et al. Prevalence, age distribution, and gender of patients with atrial fibrillation. Analysis and implications. Arch Intern Med 1995;155:469-73
45. Fuster V, Ryden LE, Cannom DS, et al. 2011 ACCF/AHA/HRS focused updates incorporated into the ACC/AHA/ESC 2006 Guidelines for the management of patients with atrial fibrillation: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines developed in partnership with the European Society of Cardiology and in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. J Am Coll Cardiol 2011;57:e101-98
46. Forslund T, Wettermark B, Wandell P, et al. Risks for stroke and bleeding with warfarin or aspirin treatment in patients with atrial fibrillation at different CHA2DS 2VASc scores: experience from the Stockholm region. Eur J Clin Pharmacol 2014;70:1477-85
47. Senoo K, Lip GY. Prediction of stroke in patients without atrial fibrillation using the CHADS2 and CHA2DS2-VASc scores: a justification for more widespread thromboprophylaxis'. Heart 2014;100: 1485-6
48. Mason PK, Lake DE, DiMarco JP, et al. Impact of the CHA2DS2-VASc score on anticoagulation recommendations for atrial fibrillation. Am J Med 2012;125:603.e1-6
49. European Heart Rhythm Association, European Association for Cardio-Thoracic Surgery. Camm AJ, Kirchhof P, Lip GY, et al. Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC). Europace 2010;12:1360-420
50. Olesen JB, Lip GY, Hansen ML, et al. Validation of risk stratification schemes for predicting stroke and thromboembolism in patients with atrial fibrillation: nationwide cohort study. BMJ 2011;342:d124
51. Reeves MJ, Fonarow GC, Zhao X, et al. Quality of care in women with ischemic stroke in the GWTG program. Stroke 2009;40:1127-33
52. Connolly SJ, Eikelboom J, Joyner C, et al. Apixaban in patients with atrial fibrillation. N Engl J Med 2011;364:806-17
53. Connolly SJ, Ezekowitz MD, Yusuf S, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 2009;361: 1139-51
54. Jonas DE, Feltner C, Amick HR, et al. Screening for asymptomatic carotid artery stenosis: a systematic review and meta-analysis for the U.S. preventive services task force. Ann Intern Med 2014;161: 336-46
55. Marquardt L, Fairhead JF, Rothwell PM. Lower rates of intervention for symptomatic carotid stenosis in women than in men reflect differences in disease incidence: a population-based study. Stroke 2010;41: 16-20
56. Jim J, Dillavou ED, Upchurch GR Jr, et al. Gender-specific 30-day outcomes after carotid endarterectomy and carotid artery stenting in the Society for Vascular Surgery Vascular Registry. J Vasc Surg 2014;59: 742-8
57. Randomised trial of endarterectomy for recently symptomatic carotid stenosis: final results of the MRC European Carotid Surgery Trial (ECST). Lancet 1998;351: 1379-87
58. Endarterectomy for asymptomatic carotid artery stenosis. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study. JAMA 1995;273:1421-8
59. Halliday A, Mansfield A, Marro J, et al. Prevention of disabling and fatal strokes by successful carotid endarterectomy in patients without recent neurological symptoms: randomised controlled trial. Lancet 2004;363:1491-502
60. Brott TG, Hobson RW 2nd, Howard G, et al. Stenting versus endarterectomy for treatment of carotid-artery stenosis. N Engl J Med 2010;363:11-23
61. Ridker PM, Cook NR, Lee IM, et al. A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women. N Engl J Med 2005;352: 1293-304
62. Caso V, Santalucia P, Acciarresi M, et al. Antiplatelet treatment in primary and secondary stroke prevention in women. Eur J Intern Med 2012;23(7):580-5
63. Canoy D, Beral V, Balkwill A, et al. Age at menarche and risks of coronary heart and other vascular diseases in a large UK cohort. Circulation 2015;131(3):237-44
64. Fukuda K, Takashima Y, Hashimoto M, et al. Early menopause and the risk of silent brain infarction in community-dwelling elderly subjects: the Sefuri brain MRI study. J Stroke Cerebrovasc Dis 2014;23:817-22
65. Ritzel RM, Capozzi LA, McCullough LD. Sex, stroke, and inflammation: the potential for estrogen-mediated immunoprotection in stroke. Horm Behav 2013;63:238-53
66. Rusa R, Alkayed NJ, Crain BJ, et al. 17beta-Estradiol Reduces Stroke Injury in Estrogen-Deficient Female Animals. Stroke 1999;30:1665-70
67. Li J, Siegel M, Yuan M, et al. Estrogen enhances neurogenesis and behavioral recovery after stroke. J Cereb Blood Flow Metab 2011;31:413-25
68. Lidegaard O, Lokkegaard E, Jensen A, et al. Thrombotic stroke and myocardial infarction with hormonal contraception. N Engl J Med 2012;366:2257-66
69. Lidegaard O. Hormonal contraception, thrombosis and age. Expert Opin Drug Saf 2014;13:1353-60
70. Saposnik G, Barinagarrementeria F, Brown RD Jr, et al. Diagnosis and management of cerebral venous thrombosis: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2011;42:1158-92
71. Wassertheil-Smoller S, Kaplan RC, Salazar CR. Stroke findings in the women's health initiative. Semin Reprod Med 2014;32:438-46
72. Wassertheil-Smoller S, Hendrix SL, Limacher M, et al. Effect of estrogen plus progestin on stroke in postmenopausal women: the Women's Health Initiative: a randomized trial. JAMA 2003;289: 2673-84
73. Liu F, McCullough LD. The middle cerebral artery occlusion model of transient focal cerebral ischemia. Methods Mol Biol 2014;1135:81-93
74. Prentice RL, Manson JE, Langer RD, et al. Benefits and risks of postmenopausal hormone therapy when it is initiated soon after menopause. Am J Epidemiol 2009;170:12-23
75. Rossouw JE, Prentice RL, Manson JE, et al. Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause. JAMA 2007;297:1465-77
76. Liu F, McCullough LD. Interactions between age, sex, and hormones in experimental ischemic stroke. Neurochem Int 2012;61:1255-65
77. Suzuki S, Brown CM, Wise PM. Neuroprotective effects of estrogens following ischemic stroke. Front Neuroendocrinol 2009;30:201-11
78. Harman SM, Black DM, Naftolin F, et al. Arterial imaging outcomes and cardiovascular risk factors in recently menopausal women: a randomized trial. Ann Intern Med 2014;161:249-60
79. Hodis HN. Testing the menopausal hormone therapy timing hypothesis: The early versus late intervention trial with estradiol. American Heart Association Conference 2014; Abstract 13283
80. Wharton W, Gleason CE, Miller VM, et al. Rationale and design of the Kronos Early Estrogen Prevention Study (KEEPS) and the KEEPS Cognitive and Affective sub study (KEEPS Cog). Brain Res 2013;1514:12-17
81. Wolff EF, He Y, Black DM, et al Self-reported menopausal symptoms, coronary artery calcification, and carotid intima-media thickness in recently menopausal women screened for the Kronos early estrogen prevention study (KEEPS). Fertil Steril 2013;99:1385-91
82. Hodis HN, Mack WJ, Shoupe D, et al. Methods and baseline cardiovascular data from the Early versus Late Intervention Trial with Estradiol testing the menopausal hormone timing hypothesis. Menopause 2014. [Epub ahead of print]
83. Bassuk SS, Manson JE. Oral contraceptives and menopausal hormone therapy: relative and attributable risks of cardiovascular disease, cancer, and other health outcomes. Ann Epidemiol 2014; pii: S1047-2797(14 00505-5
84. Manson JE. Current recommendations: what is the clinician to do?. Fertil Steril 2014;101(4):916-21
85. Leffert L, Clancy C, Bateman B, et al. Hypertensive disorders and pregnancy-related stroke: frequency, trends, risk factors, and outcomes. Obstet Gynecol 2015;125:124-31
86. James AH, Bushnell CD, Jamison MG, et al. Incidence and risk factors for stroke in pregnancy and the puerperium. Obstet Gynecol 2005;106:509-16
87. Feske SK, Singhal AB. Cerebrovascular disorders complicating pregnancy. Continuum (N Y) 2014;20:80-99
88. Razmara A, Bakhadirov K, Batra A, et al. Cerebrovascular complications of pregnancy and the postpartum period. Curr Cardiol Rep 2014;16:532
89. Lanska DJ, Kryscio RJ. Risk factors for peripartum and postpartum stroke and intracranial venous thrombosis. Stroke 2000;31:1274-82
90. Bramham K, Parnell B, Nelson-Piercy C, et al. Chronic hypertension and pregnancy outcomes: systematic review and meta-analysis. BMJ 2014;348:g2301
91. Cooper WO, Hernandez-Diaz S, Arbogast PG, et al. Major congenital malformations after first-Trimester exposure to ACE inhibitors. N Engl J Med 2006;354:2443-51
92. Martin U, Foreman MA, Travis JC, et al. Use of ACE inhibitors and ARBs in hypertensive women of childbearing age. J Clin Pharm Ther 2008;33:507-11
93. Easterling TR. Pharmacological management of hypertension in pregnancy. Semin Perinatol 2014;38(8):487-95
94. Jeng JS, Tang SC, Yip PK. Incidence and etiologies of stroke during pregnancy and puerperium as evidenced in Taiwanese women. Cerebrovasc Dis 2004;18:290-5
95. Crovetto F, Somigliana E, Peguero A, et al. Stroke during pregnancy and pre-eclampsia. Curr Opin Obstet Gynecol 2013;25:425-32
96. Chen CW, Jaffe IZ, Karumanchi SA. Pre-eclampsia and cardiovascular disease. Cardiovasc Res 2014;101:579-86
97. Brewer J, Owens MY, Wallace K, et al. Posterior reversible encephalopathy syndrome in 46 of 47 patients with eclampsia. Am J Obstet Gynecol 2013;208: 468.e1-6
98. Ducros A. Reversible cerebral vasoconstriction syndrome. Handb Clin Neurol 2014;121:1725-41
99. Fugate JE, Ameriso SF, Ortiz G, et al. Variable presentations of postpartum angiopathy. Stroke 2012;43:670-6
100. Cantu-Brito C, Arauz A, Aburto Y, et al. Cerebrovascular complications during pregnancy and postpartum: clinical and prognosis observations in 240 Hispanic women. Eur J Neurol 2011;18:819-25
101. Ferro JM, Canhao P. Cerebral venous sinus thrombosis: update on diagnosis and management. Curr Cardiol Rep 2014;16:523
102. Dauer LT, Thornton RH, Miller DL, et al. Radiation management for interventions using fluoroscopic or computed tomographic guidance during pregnancy: a joint guideline of the Society of Interventional Radiology and the Cardiovascular and Interventional Radiological Society of Europe with Endorsement by the Canadian Interventional Radiology Association. J Vasc Interv Radiol 2012;23:19-32
103. Patenaude Y, Pugash D, Lim K, et al. The use of magnetic resonance imaging in the obstetric patient. J Obstet Gynaecol Can 2014;36:349-63
104. Emberson J, Lees KR, Lyden P, et al. Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials. Lancet 2014;384: 1929-35
105. Schwamm LH, Ali SF, Reeves MJ, et al. Temporal trends in patient characteristics and treatment with intravenous thrombolysis among acute ischemic stroke patients at Get With The Guidelines-Stroke hospitals. Circ Cardiovasc Qual Outcomes 2013;6:543-9
106. Wiedmann S, Hillmann S, Abilleira S, et al. Variations in acute hospital stroke care and factors influencing adherence to quality indicators in 6 European audits. Stroke 2014;46(2):579-81
107. Lasek-Bal A, Puz P, Kazibutowska Z. Efficacy and safety assessment of alteplase in the treatment of stroke-gender differences. Neurol Res 2014;36:851-6
108. Kent DM, Price LL, Ringleb P, et al. Sex-based differences in response to recombinant tissue plasminogen activator in acute ischemic stroke: a pooled analysis of randomized clinical trials. Stroke 2005;36: 62-5
109. Forster A, Gass A, Kern R, et al. Gender differences in acute ischemic stroke: etiology, stroke patterns and response to thrombolysis. Stroke 2009;40:2428-32
110. Meseguer E, Mazighi M, Labreuche J, et al. Outcomes of intravenous recombinant tissue plasminogen activator therapy according to gender: a clinical registry study and systematic review. Stroke 2009;40:2104-10
111. Lutsep HL, Hill MD. Effects of sex on mechanical embolectomy outcome. J Stroke Cerebrovasc Dis 2012;21:240-2
112. Berkhemer OA, Fransen PS, Beumer D, et al. A randomized trial of intraarterial treatment for acute ischemic stroke. N Engl J Med 2015;372:11-20
113. Anderson JA, Weitz JI. Hypercoagulable states. Crit Care Clin 2011;27:933-52
114. Jauch EC, Saver JL, Adams HP Jr, et al. Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2013;44:870-947
115. Hacke W, Kaste M, Bluhmki E, et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 2008;359:1317-29
116. Wiese KM, Talkad A, Mathews M, Wang D. Intravenous recombinant tissue plasminogen activator in a pregnant woman with cardioembolic stroke. Stroke 2006;37: 2168-9
117. Greer IA. Prevention of venous thromboembolism in pregnancy. Eur J Med Res 2004;9:135-45
118. Bushnell CD, Reeves MJ, Zhao X, et al. Sex differences in quality of life after ischemic stroke. Neurology 2014;82:922-31
119. Irie F, Kamouchi M, Hata J, et al. Sex diffrences in short-Term outcomes after acute ischemic stroke: The Fukuoka Stroke Registry. Stroke 2014;46(2):471-6
120. Ullberg T, Zia E, Petersson J, et al. Changes in functional outcome over the first year after stroke: an observational study from the Swedish Stroke Register. Stroke 2014;46(2):389-94
121. Pan A, Okereke OI, Sun Q, et al. Depression and incident stroke in women. Stroke 2011;42:2770-5
122. Penninx BW, Milaneschi Y, Lamers F, et al. Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile. BMC Med 2013;11:129
123. Kessler RC, Berglund P, Demler O, et al The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA 2003;289:3095-105
124. Hackett ML, Pickles K. Part I: frequency of depression after stroke: an updated systematic review and meta-analysis of observational studies. Int J Stroke 2014;9: 1017-25
125. Ayerbe L, Ayis S, Crichton SL, et al. Explanatory factors for the increased mortality of stroke patients with depression. Neurology 2014;83(22):2007-12
126. Mazure CM, Weinberger AH, Pittman B, et al. Gender and stress in predicting depressive symptoms following stroke. Cerebrovasc Dis 2014;38:240-6
127. Chollet F, Tardy J, Albucher JF, et al. Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial. Lancet Neurol 2011;10:123-30
128. Mead GE, Hsieh CF, Hackett M. Selective serotonin reuptake inhibitors for stroke recovery. JAMA 2013;310:1066-7