The effects of resveratrol in rats with simultaneous type 2 diabetes and renal hypertension: A study of antihypertensive mechanisms

Iranian Journal of Medical Sciences

Volumn 40, Issue 2, 2015, Pages 152-160

  Mozafari, Masoud ^a   Nekooeian, Ali Akbar ^a   Panjeshahin, Mohammad Reza ^a   Zare, Hamid Reza ^a  

^a SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Diabetes mellitus; Nitric oxide; Oxidative stress; Rat; Renal hypertension; Resveratrol

Indexed keywords

ACETYLCHOLINE; GLUCOSE; GLUTATHIONE REDUCTASE; MALONALDEHYDE; NITRIC OXIDE; PHENYLEPHRINE; RESVERATROL; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ANTIHYPERTENSIVE ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; ENZYME BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HEART RATE; IC50; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OUTCOME ASSESSMENT; OXIDATIVE STRESS; RAT; RENOVASCULAR HYPERTENSION; SYSTOLIC BLOOD PRESSURE; TREATMENT DURATION; VASCULAR RING;

EID: 84925298021     PISSN: 02530716     EISSN: 17353688     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Hung LM, Chen JK, Huang SS, Lee RS, Su MJ. Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes. Cardiovasc Res. 2000;47:549-55. doi: 10.1016/S0008-6363(00)00102-4. PubMed PMID: 10963727.
2. Bhatt SR, Lokhandwala MF, Banday AA. Resveratrol prevents endothelial nitric oxide synthase uncoupling and attenuates development of hypertension in spontaneously hypertensive rats. Eur J Pharmacol. 2011;667:258-64. doi: 10.1016/j.ejphar.2011.05.026. PubMed PMID: 21640096.
3. Chan V, Fenning A, Iyer A, Hoey A, Brown L. Resveratrol improves cardiovascular function in DOCA-salt hypertensive rats. Curr Pharm Biotechnol. 2011;12:429-36. PubMed PMID: 20874677.
4. de Oliveira JC, Antonietto CRK, Scalabrini AC, Marinho TS, Pernomian L, Corrêa JWN, et al. Antioxidant protective effects of the resveratrol on the cardiac and vascular tissues from renal hypertensive rats. Open Journal of Medicinal Chemistry. 2012;2:61-71.
5. Naderali EK, Doyle PJ, Williams G. Resveratrol induces vasorelaxation of mesenteric and uterine arteries from female guinea-pigs. Clin Sci (Lond). 2000;98:537-43. doi: 10.1042/CS19990303. PubMed PMID: 10781384.
6. Nicholson SK, Tucker GA, Brameld JM. Physiological concentrations of dietary polyphenols regulate vascular endothelial cell expression of genes important in cardiovascular health. Br J Nutr. 2010;103:1398-403. doi: 10.1017/S0007114509993485. PubMed PMID: 20021702.
7. Liu Z, Song Y, Zhang X, Liu Z, Zhang W, Mao W, et al. Effects of trans-resveratrol on hypertension-induced cardiac hypertrophy using the partially nephrectomized rat model. Clin Exp Pharmacol Physiol. 2005;32:1049-54. doi: 10.1111/j.1440-1681.2005.04303.x. PubMed PMID: 16445570.
8. Benter IF, Yousif MH, Dhaunsi GS, Kaur J, Chappell MC, Diz DI. Angiotensin-(1–7) prevents activation of NADPH oxidase and renal vascular dysfunction in diabetic hypertensive rats. Am J Nephrol. 2008;28:25-33. PubMed PMID: 17890855.
9. Cheng PW, Ho WY, Su YT, Lu PJ, Chen BZ, Cheng WH, et al. Resveratrol decreases fructose‐induced oxidative stress, mediated by NADPH oxidase via an AMPK‐dependent mechanism. Br J Pharmacol. 2014;171:2739-50. PubMed PMID: 24547812; PubMed Central PMCID: PMC4243851.
10. Akar F, Pektas MB, Tufan C, Soylemez S, Sepici A, Ulus AT, et al. Resveratrol shows vasoprotective effect reducing oxidative stress without affecting metabolic disturbances in insulin-dependent diabetes of rabbits. Cardiovasc Drugs Ther. 2011;25:119-31. doi: 10.1007/s10557-010-6255-7. PubMed PMID: 20676927.
11. Brasnyó P, Molnár GA, Mohás M, Markó L, Laczy B, Cseh J, et al. Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients. Br J Nutr. 2011;106:383-9. doi: 10.1017/S0007114511000316. PubMed PMID: 21385509.
12. Szkudelski T, Szkudelska K. Anti-diabetic effects of resveratrol. Ann N Y Acad Sci. 2011;1215:34-9. doi: 10.1111/j.1749-6632.2010.05844.x. PubMed PMID: 21261639.
13. Su HC, Hung LM, Chen JK. Resveratrol, a red wine antioxidant, possesses an insulin-like effect in streptozotocin-induced diabetic rats. Am J Physiol Endocrinol Metab. 2006;290:E1339-46. PubMed PMID: 16434553.
14. Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell. 2006;127:1109-22. doi: 10.1016/j.cell.2006.11.013. PubMed PMID: 17112576.
15. Palsamy P, Subramanian S. Ameliorative potential of resveratrol on proinflammatory cytokines, hyperglycemia mediated oxidative stress, and pancreatic beta-cell dysfunction in streptozotocin-nicotinamide-induced diabetic rats. J Cell Physiol. 2010;224:423-32. doi: 10.1002/jcp.22138. PubMed PMID: 20333650.
16. Du X, Ninomiya T, de Galan B, Abadir E, Chalmers J, Pillai A, et al. Risks of cardiovascular events and effects of routine blood pressure lowering among patients with type 2 diabetes and atrial fibrillation: results of the ADVANCE study. Eur Heart J. 2009;30:1128-35. doi: 10.1093/eurheartj/ehp055. PubMed PMID: 19282274.
17. Nekooeian AA, Eftekhari MH, Adibi S, Rajaeifard A. Effects of pomegranate seed oil on insulin release in rats with Type 2 diabetes. Iran J Med Sci. 2014;39:130-5. PubMed PMID: 24453394; PubMed Central PMCID: PMC3957012.
18. Nekooeian AA, Mashhoodi T. Solid plexiglass clips to induce reproducible renal hypertension in the rat. Indian Journal of Pharmacology. 2007;39:25-6. doi: 10.4103/0253-7613.30758.
19. Khalili A, Nekooeian AA, Khosravi MB, Fakher S. Simultaneous renal hypertension and type 2 diabetes exacerbate vascular endothelial dysfunction in rats. Int J Exp Pathol. 2012;93:210-7. doi: 10.1111/j.1365-2613.2012.00811.x. PubMed PMID: 22458508; PubMed Central PMCID: PMC3385919.
20. Pari L, Srinivasan S, Saddiq M. Preventive effect of diosmin, a bioflavonoid, on glycoprotein changes in streptozotocinnicotinamide-induced type 2 diabetic rats. IJPSR. 2010;1:89-95.
21. Nekooeian AA, Dehghani GA, Mostafavi H, Khalili A. The Effect of Hydroalcoholic Extract of Olive Leaves on Blood Pressure in Rat Model of Two-Kidney, One-Clip Goldblatt Hypertension. Iranian Cardiovascular Research Journal. 2011;5:1-6.
22. Khalili A, Nekooeian AA, Khosravi MB, Fakher S. Simultaneous renal hypertension and type 2 diabetes exacerbate vascular endothelial dysfunction in rats. Int J Exp Pathol. 2012;93:210-7. doi: 10.1111/j.1365-2613.2012.00811.x. PubMed PMID: 22458508; PubMed Central PMCID: PMC3385919.
23. Soylemez S, Sepici A, Akar F. Resveratrol supplementation gender independently improves endothelial reactivity and suppresses superoxide production in healthy rats. Cardiovasc Drugs Ther. 2009;23:449-58. doi: 10.1007/s10557-009-6198-z. PubMed PMID: 19809869.
24. Grujic Milanovic J, Mihailovic-Stanojevic N, Miloradovic Z, Jacevic V, Milosavljevic I, Milanovic S, et al. Resveratrol Reduces Blood Pressure, Changes of Antioxidant Enzyme Activity and Histological Parameters in Experimental Model of Malignant Hypertension. Journal of Hypertension. 2010;28:29-171. doi: 10.1097/01 hjh.0000379709.75759.98.
25. López-Sepúlveda R, Jiménez R, Romero M, Zarzuelo MJ, Sánchez M, Gómez-Guzmán M, et al. Wine polyphenols improve endothelial function in large vessels of female spontaneously hypertensive rats. Hypertension. 2008;51:1088-95. PubMed PMID: 18259008.
26. Roghani M, Baluchnejadmojarad T. Mechanisms underlying vascular effect of chronic resveratrol in streptozotocin‐diabetic rats. Phytother Res. 2010;24:S148-S54. doi: 10.1002/ptr.3032. PubMed PMID: 20013818.
27. Wong CM, Yao X, Au CL, Tsang SY, Fung KP, Laher I, et al. Raloxifene prevents endothelial dysfunction in aging ovariectomized female rats. Vascul Pharmacol. 2006;44:290-8. doi: 10.1016/j.vph.2005.12.005. PubMed PMID: 16542882.
28. De Gennaro Colonna V, Rossoni G, Rigamonti AE, Bonomo S, Manfredi B, Berti F, et al. Enalapril and quinapril improve endothelial vasodilator function and aortic eNOS gene expression in L-NAME-treated rats. Eur J Pharmacol. 2002;450:61-6.doi: 10.1016/S0014-2999(02)02046-0. PubMed PMID: 12176110.
29. Kalinowski L, Dobrucki LW, Szczepanska-Konkel M, Jankowski M, Martyniec L, Angielski S, et al. Third-generation β-blockers stimulate nitric oxide release from endothelial cells through ATP efflux a novel mechanism for antihypertensive action. Circulation. 2003;107:2747-52. PubMed PMID: 12742996.
30. Matsumoto T, Ishida K, Nakayama N, Taguchi K, Kobayashi T, Kamata K. Mechanisms underlying the losartan treatment-induced improvement in the endothelial dysfunction seen in mesenteric arteries from type 2 diabetic rats. Pharmacol Res. 2010;62:271-81. doi: 1010.1016/j.phrs.2010.03.003. PubMed PMID: 20304070.
31. Ashraf MZ, Hussain ME, Fahim M. Endothelium mediated vasorelaxant response of garlic in isolated rat aorta: role of nitric oxide. J Ethnopharmacol. 2004;90:5-9. doi: 10.1016/j.jep.2003.06.001. PubMed PMID: 14698500.
32. Brixius K, Willms S, Napp A, Tossios P, Ladage D, Bloch W, et al. Crataegus special extract WS® 1442 induces an endotheliumdependent, NO-mediated vasorelaxation via eNOS-phosphorylation at serine 1177. Cardiovasc Drugs Ther. 2006;20:177-84. PubMed PMID: 16779533.
33. Rivera L, Morón R, Zarzuelo A, Galisteo M. Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats. Biochem Pharmacol. 2009;77:1053-63. PubMed PMID: 19100718.
34. Gordish KL, Beierwaltes WH. Resveratrol induces acute endothelium-dependent renal vasodilation mediated through nitric oxide and reactive oxygen species scavenging. Am J Physiol Renal Physiol. 2014;306:F542-50. doi: 10.1152/ajprenal.00437.2013. PubMed PMID: 24431202; PubMed Central PMCID: PMC3949032.
35. Touyz RM, Tabet F, Schiffrin EL. Redox-dependent signalling by angiotensin II and vascular remodelling in hypertension. Clin Exp Pharmacol Physiol. 2003;30:860-6. PubMed PMID: 14678251.
36. Mizutani K, Ikeda K, Yamori Y. Resveratrol inhibits AGEs-induced proliferation and collagen synthesis activity in vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats. Biochemical and biophysical research communications. Biochem Biophys Res Commun. 2000;274:61-7. PubMed PMID: 10903896.
37. Liu ZP, Song Y, Liu ZQ, Zhang XP. Preventive effect of trans-resveratrol on hypertensioninduced cardiac hypertrophy in partially nephrectomized rats. Wei Sheng Yan Jiu. 2005;34:756-8. PubMed PMID: 16535856.
38. Robich MP, Osipov RM, Chu LM, Han Y, Feng J, Nezafat R, et al. Resveratrol modifies risk factors for coronary artery disease in swine with metabolic syndrome and myocardial ischemia. European journal of pharmacology. 2011;664:45-53. doi: 10.1016/j ejphar.2011.04.059. PubMed PMID: 21575630; PubMed Central PMCID: PMC3107708.
39. Chen G, McAlister FA, Walker RL, Hemmelgarn BR, Campbell NR. Cardiovascular Outcomes in Framingham Participants With Diabetes The Importance of Blood Pressure. Hypertension. 2011;57:891-7. doi: 10.1161/HYPERTENSIONAHA.110.162446. PubMed PMID: 21403089; PubMed Central PMCID: PMC3785072.
40. Endemann DH, Pu Q, De Ciuceis C, Savoia C, Virdis A, Neves MF, et al. Persistent remodeling of resistance arteries in type 2 diabetic patients on antihypertensive treatment. Hypertension. 2004;43:399-404. doi: 10.1161/01.HYP.0000112029.03691.e7. PubMed PMID: 14707158.